Anatomy of a Hotspot: Chain and Seroepidemiology of Ebola Virus Transmission, Sukudu, Sierra Leone, 2015-16

Journal of Infectious Diseases

Volumn 217, Issue 8, 2018, Pages 1214-1221

  Daniel Kelly, J ^a,b   Barrie, Mohamed Bailor ^b,c   Mesman, Annelies W ^b   Karku, Sahr ^b   Quiwa, Komba ^b   Drasher, Michael ^b   Schlough, Gabriel Warren ^b   Dierberg, Kerry ^b   Koedoyoma, Songor ^d   Lindan, Christina P ^a   Jones, James Holland ^e   Chamie, Gabriel ^a   Worden, Lee ^a   Greenhouse, Bryan ^a   Weiser, Sheri D ^a   Porco, Travis C ^a   Rutherford, George W ^a   Richardson, Eugene T ^b,c,e,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PARTNERS IN HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Kono District Ebola Response   (Sierra Leone)

^e STANFORD UNIVERSITY   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Africa; Ebola virus; Ebola virus infection; epidemiology; public health; Sierra Leone; transmission chain

Indexed keywords

ADOLESCENT; ADULT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EBOLA HEMORRHAGIC FEVER; EPIDEMIC; FEMALE; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUARANTINE; REVIEW; SEROEPIDEMIOLOGY; SIERRA LEONE; VIRUS TRANSMISSION; EBOLAVIRUS; MIDDLE AGED; PHYSIOLOGY; TRANSMISSION; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; DISEASE OUTBREAKS; EBOLAVIRUS; FEMALE; HEMORRHAGIC FEVER, EBOLA; HUMANS; MALE; MIDDLE AGED; SEROEPIDEMIOLOGIC STUDIES; SIERRA LEONE; YOUNG ADULT;

EID: 85046902999     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiy004     Document Type: Review

References (27)

1. World Health Organization. Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Org 1978; 56:271-93.
2. Centers for Disease Control and Prevention. Outbreaks chronology: Ebola hemorrhagic fever. 2014. http://www. cdc.gov/vhf/ebola/resources/outbreak-table.html.
3. Leroy EM, Baize S, Volchkov VE, et al. Human asymptomatic Ebola infection and strong infammatory response. Lancet 2000; 355:2210-5.
4. Dean NE, Halloran ME, Yang Y, Longini IM. Transmissibility and pathogenicity of Ebola virus: a systematic review and meta-analysis of household secondary attack rate and asymptomatic infection. Clin Infect Dis 2016; 62:1277-86.
5. Schiefelin JS, Shafter JG, Goba A, et al; KGH Lassa Fever Program; Viral Hemorrhagic Fever Consortium; WHO Clinical Response Team. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 2014; 371:2092-100.
6. World Health Organization. Ebola situation reports. March 27, 2016. http://apps.who.int/ebola/ebola-situation-reports.
7. WHO Ebola Response Team. After Ebola in West Africa-unpredictable risks, preventable epidemics. N Engl J Med 2016; 375:587-96.
8. Richardson ET, Barrie MB, Nutt CT, et al. The Ebola suspect's dilemma. Lancet Glob Health 2017; 5:e254-6.
9. Becquart P, Wauquier N, Mahlakõiv T, et al. High prevalence of both humoral and cellular immunity to Zaire Ebolavirus among rural populations in Gabon. PLoS One 2010; 5:e9126.
10. Hefernan RT, Pambo B, Hatchett RJ, Leman PA, Swanepoel R, Ryder RW. Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooué-Ivindo region, Northeastern Gabon, 1997. J Infect Dis 2005; 191:964-8.
11. Meltzer MI, Atkins CY, Santibanez S, et al. Estimating the future number of cases in the Ebola epidemic-Liberia and Sierra Leone, 2014-2015. MMWR Suppl 2014; 63:1-14.
12. Feldmann H, Geisbert T W. Ebola haemorrhagic fever. Lancet 2011; 377:849-62.
13. Richardson ET, Barrie MB, Kelly JD, Dibba Y, Koedoyoma S, Farmer PE. Biosocial approaches to the 2013-2016 Ebola pandemic. Health Hum Rights 2016; 18:115-28.
14. Cancedda C, Davis SM, Dierberg KL, et al. Strengthening health systems while responding to a health crisis: lessons learned by a nongovernmental organization during the Ebola virus disease epidemic in Sierra Leone. J Infect Dis 2016; 214:153-63.
15. Faye O, Boëlle PY, Heleze E, et al. Chains of transmission and control of Ebola virus disease in Conakry, Guinea, in 2014: an observational study. Lancet Infect Dis 2015; 15:320-6.
16. Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR. Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. Int J Epidemiol 2016; 45:102-16.
17. Richardson ET, Kelly JD, Barrie MB, et al. Minimally symptomatic infection in an Ebola "hotspot": a cross-sectional serosurvey. PLoS Negl Trop Dis 2016; 10:e0005087.
18. World Health Organization. Case defnition recommendations for Ebola or Marburg virus diseases. 9 August 2014. http://apps.who.int/iris/bitstream/10665/146397/1/WHO- EVD-CaseDef-14.1-eng.pdf?ua=1&ua=1.
19. Bollobas B. Modern graph theory. Corrected ed. New York: Springer Verlag, 2013.
20. Diallo B, Sissoko D, Loman NJ, et al. Resurgence of Ebola virus disease in guinea linked to a survivor with virus persistence in seminal fuid for more than 500 days. Clin Infect Dis 2016; 63:1353-6.
21. Varkey JB, Shantha JG, Crozier I, et al. Persistence of Ebola virus in ocular fuid during convalescence. N Engl J Med 2015; 372:2423-7.
22. Fisman DN, Hauck TS, Tuite AR, Greer AL. An IDEA for short term outbreak projection: nearcasting using the basic reproduction number. PLoS One 2013; 8:e83622.
23. Glynn JR, Bower H, Johnson S, et al. Asymptomatic infection and unrecognised Ebola virus disease in Ebola-afected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus. Lancet Infect Dis 2017; 17:645-53.
24. Kennedy SB, Bolay F, Kieh M, et al; PREVAIL I Study Group. Phase 2 placebo-controlled trial of two vaccines to prevent Ebola in Liberia. N Engl J Med 2017; 377:1438-47.
25. Richards P, Amara J, Ferme MC, et al. Social pathways for Ebola virus disease in rural Sierra Leone, and some implications for containment. PLoS Negl Trop Dis 2015; 9:e0003567.
26. Richards P. Ebola: how a people's science helped end an epidemic. London: Zed Books Limited, 2016.
27. Atkins KE, Pandey A, Wenzel NS, et al. Retrospective analysis of the 2014-2015 Ebola epidemic in Liberia. Am J Trop Med Hyg 2016; 94:833-9.