High positive end-Expiratory pressure renders spontaneous effort noninjurious

American Journal of Respiratory and Critical Care Medicine

Volumn 197, Issue 10, 2018, Pages 1285-1296

  Morais, Caio C A ^a   Koyama, Yukiko ^b   Yoshida, Takeshi ^b,c   Plens, Glauco M ^a   Gomes, Susimeire ^a   Lima, Cristhiano A S ^a   Ramos, Ozires P S ^a   Pereira, Sérgio M ^a   Kawaguchi, Naomasa ^d   Yamamoto, Hirofumi ^d   Uchiyama, Akinori ^b   Borges, João B ^e   Vidal Melo, Marcos F ^f   Tucci, Mauro R ^a   Amato, Marcelo B P ^a   Kavanagh, Brian P ^c   Costa, Eduardo L V ^a   Fujino, Yuji ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e UPPSALA UNIVERSITY   (Sweden)

^f HARVARD UNIVERSITY   (United States)

Author keywords

Acute respiratory distress syndrome; PEEP; Spontaneous breathing; Ventilator induced lung injury

Indexed keywords

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; COMPUTER ASSISTED IMPEDANCE TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; ESOPHAGUS PRESSURE; FEMALE; HISTOPATHOLOGY; HUMAN; INJURY SEVERITY; LEPORIDAE; MALE; MANOMETRY; MIDDLE AGED; NONHUMAN; OXYGENATION; PARALYSIS; PIG; PNEUMONIA; POSITIVE END EXPIRATORY PRESSURE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RESPIRATORY DRIVE; THORAX PRESSURE; ANIMAL; ARTIFICIAL VENTILATION; COMPLICATION; DISEASE MODEL; LUNG; PATHOPHYSIOLOGY; PROCEDURES;

ANIMALS; DISEASE MODELS, ANIMAL; LUNG; POSITIVE-PRESSURE RESPIRATION; RABBITS; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; SWINE;

EID: 85045953532     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201706-1244OC     Document Type: Article

References (41)

1. Putensen C, Zech S, Wrigge H, Zinserling J, Stüber F, Von Spiegel T, et al. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 2001;164:43–49.
2. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al.; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 2016;315:788–800.
3. Sassoon CS, Zhu E, Caiozzo VJ. Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;170:626–632.
4. Goligher EC, Fan E, Herridge MS, Murray A, Vorona S, Brace D, et al. Evolution of diaphragm thickness during mechanical ventilation. impact of inspiratory effort. Am J Respir Crit Care Med 2015;192:1080–1088.
5. Orozco-Levi M, Lloreta J, Minguella J, Serrano S, Broquetas JM, Gea J. Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164: 1734–1739.
6. Vassilakopoulos T, Divangahi M, Rallis G, Kishta O, Petrof B, Comtois A, et al. Differential cytokine gene expression in the diaphragm in response to strenuous resistive breathing. Am J Respir Crit Care Med 2004;170:154–161.
7. Leray V, Bourdin G, Flandreau G, Bayle F, Wallet F, Richard JC, et al. A case of pneumomediastinum in a patient with acute respiratory distress syndrome on pressure support ventilation. Respir Care 2010;55:770–773.
8. Goligher EC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, et al. Mechanical ventilation–induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med 2018;197:204–213.
9. Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury. Crit Care Med 2012;40:1578–1585.
10. Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury. Crit Care Med 2013;41:536–545.
11. Yoshida T, Torsani V, Gomes S, De Santis RR, Beraldo MA, Costa EL, et al. Spontaneous effort causes occult pendelluft during mechanical ventilation. Am J Respir Crit Care Med 2013;188:1420–1427.
12. Yoshida T, Roldan R, Beraldo MA, Torsani V, Gomes S, De Santis RR, et al. Spontaneous effort during mechanical ventilation: maximal injury with less positive end-expiratory pressure. Crit Care Med 2016; 44:e678–e688.
13. Yoshida T, Nakahashi S, Nakamura MAM, Koyama Y, Roldan R, Torsani V, et al. Volume-controlled ventilation does not prevent injurious inflation during spontaneous effort. Am J Respir Crit Care Med 2017;196:590–601.
14. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al.; ACURASYS Study Investigators. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363: 1107–1116.
15. Yoshida T, Fujino Y, Amato MB, Kavanagh BP. Fifty years of research in ARDS. Spontaneous breathing during mechanical ventilation. risks, mechanisms, and management. Am J Respir Crit Care Med 2017;195:985–992.
16. Brochard L, Slutsky A, Pesenti A. Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir Crit Care Med 2017;195:438–442.
17. Carteaux G, Millán-Guilarte T, De Prost N, Razazi K, Abid S, Thille AW, et al. Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume. Crit Care Med 2016;44:282–290.
18. Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, et al.; LUNG SAFE Investigators; ESICM Trials Group. Noninvasive ventilation of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE study. Am J Respir Crit Care Med 2017;195:67–77.
19. Hoppin FG Jr, Green ID, Mead J. Distribution of pleural surface pressure in dogs. J Appl Physiol 1969;27:863–873.
20. D’Angelo E, Agostoni E. Continuous recording of pleural surface pressure at various sites. Respir Physiol 1973;19:356–368.
21. D’Angelo E, Sant’Ambrogio G, Agostoni E. Effect of diaphragm activity or paralysis on distribution of pleural pressure. J Appl Physiol 1974; 37:311–315.
22. Borges JB, Okamoto VN, Matos GF, Caramez MP, Arantes PR, Barros F, et al. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 2006;174: 268–278.
23. Maeda Y, Fujino Y, Uchiyama A, Matsuura N, Mashimo T, Nishimura M. Effects of peak inspiratory flow on development of ventilator-induced lung injury in rabbits. Anesthesiology 2004;101:722–728.
24. Martin CJ, Young AC, Ishikawa K. Regional lung mechanics in pulmonary disease. J Clin Invest 1965;44:906–913.
25. Costa EL, Borges JB, Melo A, Suarez-Sipmann F, Toufen C Jr, Bohm SH, et al. Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography. Intensive Care Med 2009;35:1132–1137.
26. Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A; Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301–1308.
27. Borges JB, Costa EL, Suarez-Sipmann F, Widström C, Larsson A, Amato M, et al. Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury. Crit Care Med 2014;42:e279–e287.
28. Tsuchida S, Engelberts D, Peltekova V, Hopkins N, Frndova H, Babyn P, et al. Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med 2006;174:279–289.
29. Bellani G, Messa C, Guerra L, Spagnolli E, Foti G, Patroniti N, et al. Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study. Crit Care Med 2009;37: 2216–2222.
30. Bellani G, Guerra L, Musch G, Zanella A, Patroniti N, Mauri T, et al. Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med 2011;183:1193–1199.
31. Borges JB, Costa EL, Bergquist M, Lucchetta L, Widström C, Maripuu E, et al. Lung inflammation persists after 27 hours of protective acute respiratory distress syndrome network strategy and is concentrated in the nondependent lung. Crit Care Med 2015;43: e123–e132.
32. Muscedere JG, Mullen JB, Gan K, Slutsky AS. Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 1994;149:1327–1334.
33. Chu EK, Whitehead T, Slutsky AS. Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines. Crit Care Med 2004;32:168–174.
34. Retamal J, Bergamini BC, Carvalho AR, Bozza FA, Borzone G, Borges JB, et al. Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation. Crit Care 2014;18:505.
35. Evans CL, Hill AV. The relation of length to tension development and heat production on contraction in muscle. J Physiol 1914;49: 10–16.
36. Pengelly LD, Alderson AM, Milic-Emili J. Mechanics of the diaphragm. J Appl Physiol 1971;30:797–805.
37. Kim MJ, Druz WS, Danon J, Machnach W, Sharp JT. Mechanics of the canine diaphragm. J Appl Physiol 1976;41:369–382.
38. Rossi A, Brandolese R, Milic-Emili J, Gottfried SB. The role of PEEP in patients with chronic obstructive pulmonary disease during assisted ventilation. Eur Respir J 1990;3:818–822.
39. Haberthür C, Guttmann J. Short-term effects of positive end-expiratory pressure on breathing pattern: an interventional study in adult intensive care patients. Crit Care 2005;9:R407–R415.
40. De Troyer A, Leduc D, Cappello M, Mine B, Gevenois PA, Wilson TA. Mechanisms of the inspiratory action of the diaphragm during isolated contraction. J Appl Physiol (1985) 2009;107:1736–1742.
41. Guervilly C, Bisbal M, Forel JM, Mechati M, Lehingue S, Bourenne J, et al. Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome. Intensive Care Med 2017;43:408–418.