Prospective and Retrospective Evaluation of the Performance of the FDA-Approved Cepheid Xpert Flu/RSV XC Assay

Lab Medicine

Volumn 48, Issue 4, 2017, Pages E53-E56

  Arbefeville, Sophie ^a   Thonen Kerr, Elizabeth ^a   Ferrieri, Patricia ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Flu A; Flu B; Rapid molecular testing; Respiratory virus; RSV

Indexed keywords

VIRUS ANTIGEN;

ARTICLE; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFECTION PREVENTION; INFLUENZA; INFLUENZA A; INFLUENZA B; NONHUMAN; PATIENT CARE; PROSPECTIVE STUDY; RESPIRATORY VIRUS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR DIAGNOSIS; MULTIPLEX POLYMERASE CHAIN REACTION; ORTHOMYXOVIRIDAE; PNEUMOVIRUS; PROCEDURES; RESPIRATORY SYNCYTIAL VIRUS INFECTION;

HUMANS; INFLUENZA, HUMAN; MOLECULAR DIAGNOSTIC TECHNIQUES; MULTIPLEX POLYMERASE CHAIN REACTION; ORTHOMYXOVIRIDAE; PROSPECTIVE STUDIES; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RETROSPECTIVE STUDIES;

EID: 85045578820     PISSN: 00075027     EISSN: 19437730     Source Type: Journal    
DOI: 10.1093/LABMED/LMX038     Document Type: Article

References (13)

1. Havers F, Flannery B, Clippard JR, et al. Use of influenza antiviral medications among outpatients at high risk for influenza-associated complications during the 2013–2014 influenza season. Clin Infect Dis. 2015;60(11):1677–1680.
2. Novak-Weekley SM, Marlowe EM, Poulter M, et al. Evaluation of the Cepheid Xpert Flu Assay for rapid identification and differentiation of influenza A, influenza A 2009 H1N1, and influenza B viruses. J Clin Microbiol. 2012;50(5):1704–1710.
3. Boivin G. Detection and management of antiviral resistance for influenza viruses. Influenza Other Respir Viruses. 2013;7(suppl 3):18–23.
4. Thompson WW, Shay DK, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA. 2003;289(2):179–186.
5. Bont L, Checchia PA, Fauroux B, et al. Defining the epidemiology and burden of severe respiratory syncytial virus infection among infants and children in Western Countries. Infect Dis Ther. 2016;5(3):271–298.
6. Centers for Disease C, Prevention. Evaluation of 11 commercially available rapid influenza diagnostic tests—United States, 2011–2012. MMWR Morb Mortal Wkly Rep. 2012;61(43):873–876.
7. Blyth CC, Iredell JR, Dwyer DE. Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;361(25):2493.
8. Fox JW, Cohen DM, Marcon MJ, et al. Performance of rapid streptococcal antigen testing varies by personnel. J Clin Microbiol. 2006;44(11):3918–3922.
9. Arbefeville SS, Fickle AR, Ferrieri P. Sensitivity of the Quidel sofia fluorescent immunoassay compared with 2 nucleic acid assays and viral culture to detect pandemic influenza A(H1N1)pdm09. Lab Med. 2015;46(3):230–234.
10. Kumar S, Henrickson KJ. Update on influenza diagnostics: lessons from the novel H1N1 influenza A pandemic. Clin Microbiol Rev. 2012;25(2):344–361.
11. Pierro A, Gaibani P, Rossini G, et al. Clinical application of a molecular method based on real time RT-PCR for detection of influenza A(H1N1)v virus. New Microbiol. 2013;36(4):405–408.
12. Li M, Brenwald N, Bonigal S, et al. Rapid diagnosis of influenza: an evaluation of two commercially available RT-PCR assays. J Infect. 2012;65(1):60–63.
13. Dugas AF, Valsamakis A, Gaydos CA, et al. Evaluation of the Xpert Flu rapid PCR assay in high-risk emergency department patients. J Clin Microbiol. 2014;52(12):4353–4355.