The MDR1 C3435T polymorphism: Effects on P-glycoprotein expression/function and clinical significance

AAPS PharmSci

Volumn 3, Issue 3, 2001, Pages

  Dresser, Mark J ^a  

^a ALZA CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; DIGOXIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN INHIBITOR; RIFAMPICIN; CARDIOTONIC AGENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT REJECTION; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG TRANSPORT; ENZYME INDUCTION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; CLINICAL TRIAL; GENETICS; GENOTYPE; KIDNEY TRANSPLANTATION; METABOLISM; MULTIDRUG RESISTANCE;

CARDIOTONIC AGENTS; CLINICAL TRIALS; CYCLOSPORINE; DIGOXIN; DRUG RESISTANCE, MULTIPLE; GENOTYPE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC;

EID: 85045292708     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: 10.1208/ps0303_commentary3     Document Type: Article

References (6)

1. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3473-8.
2. Hitzl M, Drescher S, van der Kuip H, Schaffeler E, Fischer J, Schwab M, Eichelbaum M, Fromm MF. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics 2001 Jun;11(4):293-8.
3. von Ahsen N, Richter M, Grupp C, Ringe B, Oellerich M, Armstrong VW. No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. Clin Chem 2001 Jun;47(6):1048-52.
4. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001 Mar;69(3):169-74.
5. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, Takahashi M, Kurata Y, Kigawa J, Higuchi S, Terakawa N, Otsubo K. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther 2001 Jun;297(3):1137-43.
6. Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest 1999 Jul;104(2):147-53.