Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis

Journal of Pediatric Surgery

Volumn 53, Issue 6, 2018, Pages 1203-1207

  Isani, Mubina ^a   Illingworth, Laura ^a   Herman, Eliot ^b   Schmidt, Monica ^b   Barron, Lauren ^c   Bowling, Jordan ^a   Elizee, Melissa ^a   Bai, Iris ^a   Gayer, Christopher ^a,d   Grishin, Anatoly ^a,d   Erwin, Christopher R ^c   Ford, Henri R ^a,d   Warner, Brad W ^c  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

EGF; Necrotizing enterocolitis; Prophylaxis; Soybean

Indexed keywords

CYCLOOXYGENASE 2; GAMMA UROGASTRONE; INDUCIBLE NITRIC OXIDE SYNTHASE; JUNCTIONAL ADHESION MOLECULE A; MESSENGER RNA; PROTEIN ZO1; SOYBEAN EXTRACT; EPIDERMAL GROWTH FACTOR; JUNCTIONAL ADHESION MOLECULE; PLANT EXTRACT; PROTECTIVE AGENT; PTGS2 PROTEIN, RAT; RECOMBINANT PROTEIN; ZONULA OCCLUDENS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL MILK; CONTROLLED STUDY; HYPOXIA; IMMUNOFLUORESCENCE; MORTALITY; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE; SOYBEAN; TIGHT JUNCTION; ANIMAL; DISEASE MODEL; HUMAN; INTESTINE; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PREMATURITY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENTEROCOLITIS, NECROTIZING; EPIDERMAL GROWTH FACTOR; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTESTINAL MUCOSA; INTESTINES; JUNCTIONAL ADHESION MOLECULES; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; RNA, MESSENGER; SOYBEANS; ZONULA OCCLUDENS PROTEINS;

EID: 85044994237     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2018.02.084     Document Type: Article

References (29)

1. Henry, M.C., Henry, R.M., Necrotizing enterocolitis. 5th edition, 2010, Philadelphia Saunders.
2. Holman, R.C., Stoll, B.J., Curns, A.T. et al., Necrotising enterocolitis hospitalisations among neonates in the United States. Paediatr Perinat Epidemiol 20:6 (2006), 498–506.
3. Papillon, S., Castle, S.L., Gayer, C.P. et al., Necrotizing enterocolitis: contemporary management and outcomes. Adv Pediatr 60:1 (2013), 263–279.
4. Lim, J.C., Golden, J.M., Ford, H.R., Pathogenesis of neonatal necrotizing enterocolitis. Pediatr Surg Int 31:6 (2015), 509–518.
5. Neu, J., Walker, W.A., Necrotizing enterocolitis. N Engl J Med 364:3 (2011), 255–264.
6. Eichenwald, E.C., Stark, A.R., Management and outcomes of very low birth weight. N Engl J Med 358:16 (2008), 1700–1711.
7. Rowland, K.J., Choi, P.M., Warner, B.W., The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis. Semin Pediatr Surg 22:2 (2013), 101–111.
8. Meinzen-Derr, J., Poindexter, B., Wrage, L. et al., Role of human milk in extremely low birth weight infants’ risk of necrotizing enterocolitis or death. J Perinatol 29:1 (2009), 57–62.
9. Cohen, S., Carpenter, G., Human epidermal growth factor: isolation and chemical and biological properties. Proc Natl Acad Sci U S A 72:4 (1975), 1317–1321.
10. Sisk, P.M., Lovelady, C.A., Dillard, R.G. et al., Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants. J Perinatol 27:7 (2007), 428–433.
11. He, Y., Schmidt, M.A., Erwin, C. et al., Transgenic soybean production of bioactive human epidermal growth factor (EGF). PLoS One, 11(6), 2016, e0157034.
12. Dvorak, B., Halpern, M.D., Holubec, H. et al., Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 282:1 (2002), G156–64.
13. Clark, J.A., Doelle, S.M., Halpern, M.D. et al., Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol 291:5 (2006), G938–49.
14. Abud, H.E., Watson, N., Heath, J.K., Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp Cell Res 303:2 (2005), 252–262.
15. Clark, J.A., Lane, R.H., Maclennan, N.K. et al., Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 288:4 (2005), G755–62.
16. Coursodon, C.F., Dvorak, B., Epidermal growth factor and necrotizing enterocolitis. Curr Opin Pediatr 24:2 (2012), 160–164.
17. Singh, A.B., Harris, R.C., Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem 279:5 (2004), 3543–3552.
18. Hunter, C.J., Williams, M., Petrosyan, M. et al., Lactobacillus bulgaricus prevents intestinal epithelial cell injury caused by Enterobacter sakazakii-induced nitric oxide both in vitro and in the newborn rat model of necrotizing enterocolitis. Infect Immun 77:3 (2009), 1031–1043.
19. Nadler, E.P., Dickinson, E., Knisely, A. et al., Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis. J Surg Res 92:1 (2000), 71–77.
20. Grishin, A., Bowling, J., Bell, B. et al., Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 51:1 (2016), 13–17.
21. Helmrath, M.A., Shin, C.E., Erwin, C.R. et al., Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression. J Pediatr Surg 33:7 (1998), 980–984 [discussion 4-5].
22. Yoshida, K., Kanaoka, S., Takai, T. et al., EGF rapidly translocates tight junction proteins from the cytoplasm to the cell–cell contact via protein kinase C activation in TMK-1 gastric cancer cells. Exp Cell Res 309:2 (2005), 397–409.
23. Bazzoni, G., Martinez-Estrada, O.M., Orsenigo, F. et al., Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 275:27 (2000), 20520–20526.
24. Maynard, A.A., Dvorak, K., Khailova, L. et al., Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 299:3 (2010), G614–22.
25. Warner, B.W., Warner, B.B., Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis. Semin Pediatr Surg 14:3 (2005), 175–180.
26. Helmrath, M.A., Shin, C.E., Fox, J.W. et al., Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. Surgery 124:5 (1998), 848–854.
27. Helmrath, M.A., Shin, C.E., Fox, J.W. et al., Epidermal growth factor in saliva and serum of infants with necrotising enterocolitis. Lancet 351:9098 (1998), 266–267.
28. Warner, B.B., Ryan, A.L., Seeger, K. et al., Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. J Pediatr 150:4 (2007), 358–363.
29. Warner, B.B., Deych, E., Zhou, Y. et al., Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study. Lancet 387:10031 (2016), 1928–1936.