Association of hormonal contraception with suicide attempts and suicides

American Journal of Psychiatry

Volumn 175, Issue 4, 2018, Pages 336-342

  Skovlund, Charlotte Wessel ^a,b,c   Mørch, Lina Steinrud ^a,b,c   Kessing, Lars Vedel ^a,b,c   Lange, Theis ^a,b,c   Lidegaard, Jvind ^a,b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACEPTIVE AGENT; DESOGESTREL; ESTROGEN; GESTAGEN; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; NORETHISTERONE; ANTIDEPRESSANT AGENT; ORAL CONTRACEPTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; COHORT ANALYSIS; CONFOUNDING VARIABLE; CONTROLLED STUDY; DENMARK; FEMALE; FOLLOW UP; GROUPS BY AGE; HAZARD RATIO; HORMONAL CONTRACEPTION; HUMAN; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SUICIDE; SUICIDE ATTEMPT; CROSS-SECTIONAL STUDY; INCIDENCE; MENTAL DISEASE; RISK; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS; CONTRACEPTIVE AGENTS, FEMALE; CONTRACEPTIVES, ORAL, HORMONAL; CORRELATION OF DATA; CROSS-SECTIONAL STUDIES; DENMARK; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MENTAL DISORDERS; RISK; SUICIDE; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 85044836169     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2017.17060616     Document Type: Article

References (30)

1. Skovlund CW, Mørch LS, Kessing LV, et al: Association of hormonal contraception with depression.JAMA Psychiatry 2016; 73:1154-1162.
2. Schaffir J, Worly BL, Gur TL: Combined hormonal contraception and its effects on mood: A critical review. Eur J Contracept Reprod Health Care 2016; 21:347-355.
3. Bertolote JM, Fleischmann A, De Leo D, et al: Suicide and mental disorders: do we know enough? Br J Psychiatry 2003; 183:382-383.
4. Vessey MP, Villard-Mackintosh L, McPherson K, et al: Mortality among oral contraceptive users: 20 year follow up of women in a cohort study. BMJ 1989; 299:1487-1491.
5. Beral V, Hermon C, Kay C, et al: Mortality associated with oral contraceptive use: 25 year follow up of cohort of 46 000women from Royal College of General Practitioners' Oral Contraception Study. BMJ 1999; 318:96-100.
6. Colditz GA: Oral contraceptive use and mortality during 12 years of follow-up: The Nurses Health Study.Ann Intern Med 1994; 120:821-826.
7. Hannaford PC, Iversen L, Macfarlane TV, et al: Mortality among contraceptive pill users: cohort evidence from Royal College of General Practitioners' Oral Contraception Study. BMJ 2010; 340:c927.
8. Charlton BM, Rich-Edwards JW, Colditz GA, et al: Oral contraceptive use and mortality after 36 years of follow-up in the Nurses' Health Study: prospective cohort study. BMJ 2014; 349:g6356.
9. Rosenberg MJ, Waugh MS: Oral contraceptive discontinuation: A prospective evaluation of frequency and reasons. Am J Obstet Gynecol 1998; 179:577-582.
10. Sanders SA, Graham CA, Bass JL, et al: A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception 2001; 64: 51-58.
11. Poromaa IS, Segebladh B: Adverse mood symptoms with oral contraceptives. Acta Obstet Gynecol Scand 2012; 91:420-427.
12. Mørch LS, Løkkegaard E, Andreasen AH, et al: Hormone therapy and ovarian cancer. JAMA 2009; 302:298-305.
13. Lidegaard Ø, Løkkegaard E, Jensen A, et al: Thrombotic stroke and myocardial infarction with hormonal contraception. N Engl J Med 2012; 366:2257-2266.
14. Lange T, Vansteelandt S, Bekaert M: A simple unified procedure for estimating natural direct and indirect effects. Am J Epidemiol 2012; 176:190-195.
15. Joffe H, Cohen LS: Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol Psychiatry 1998; 44:798-811.
16. Schmidt PJ, Nieman LK, Danaceau MA, et al: Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome. N Engl J Med 1998; 338:209-216.
17. McEwen BS: Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol (1985) 2001; 91: 2785-2801.
18. Hall KS, White KO, Rickert VI, et al: Influence of depressed mood and psychological stress symptoms on perceived oral contraceptive side effects and discontinuation in young minority women. Contraception 2012; 86:518-525.
19. Inoue K, Barratt A, Richters J: Does research into contraceptive method discontinuation address women's own reasons? A critical review. J Fam Plann Reprod Health Care 2015; 41:292-299.
20. Frokjaer VG, PinborgA, Holst KK, et al: Role of serotonin transporter changes in depressive responses to sex-steroid hormone manipulation: A positron emission tomography study. Biol Psychiatry 2015; 78:534-543.
21. Morthorst B, Krogh J, Erlangsen A, et al: Effect of assertive outreach after suicide attempt in the AID(Assertive Intervention forDeliberate Self Harm) trial: randomised controlled trial. BMJ 2012; 345:e4972.
22. National Board of Health (Denmark): Survey of 11-15 year-old lifestyle and health habits, 1997-2008. (Danish) http://www.sst.dk/∼/media/BBDFA57CB8CD47E99B08F6328429C538.ashx.
23. Beautrais AL, Joyce PR, Mulder RT, et al: Prevalence and comorbidity of mental disorders in persons making serious suicide attempts: A case-control study. Am J Psychiatry 1996; 153:1009-1014.
24. Mortensen PB, Agerbo E, Erikson T, et al: Psychiatric illness and risk factors for suicide in Denmark. Lancet 2000; 355:9-12.
25. Agerbo E, Nordentoft M, Mortensen PB: Familial, psychiatric, and socioeconomic risk factors for suicide in young people: nested casecontrol study. BMJ 2002; 325:74.
26. Sørensen HJ, Mortensen EL, Wang AG, et al: Suicide and mental illness in parents and risk of suicide in offspring: A birth cohort study. Soc Psychiatry Psychiatr Epidemiol 2009; 44:748-751.
27. Dervic K, Oquendo MA, Grunebaum MF, et al: Religious affiliation and suicide attempt. Am J Psychiatry 2004; 161:2303-2308.
28. Lawrence RE, Oquendo MA, Stanley B: Religion and suicide risk: A systematic review. Arch Suicide Res 2016; 20:1-21.
29. Van den Heuvel MW, van Bragt AJM, Alnabawy A, et al: Comparison of ethinylestradiol pharmacokinetics in three hormonal contraceptive formulations: The vaginal ring, the transdermal patch, and an oral contraceptive. Contraception 2005; 72:168-174.
30. Sokolowski M, Wasserman J, Wasserman D: An overview of the neurobiology of suicidal behaviors as one meta-system. Mol Psychiatry 2015; 20:56-71.