메뉴 건너뛰기




Volumn 37, Issue 2, 2018, Pages 143-154

Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: A systematic review and meta-analysis of randomized double-blind placebo-controlled trials

Author keywords

Flavonoids; Quality of life; Signs and symptoms; Vascular diseases

Indexed keywords

DAFLON; CARDIOVASCULAR AGENT; DIOSMIN;

EID: 85044506101     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: 10.23736/S0392-9590.18.03975-5     Document Type: Review
Times cited : (99)

References (53)
  • 1
    • 84925020478 scopus 로고    scopus 로고
    • Management of chronic venous disorders of the lower limbs - Guidelines according to scientific evidence
    • Nicolaides A, Kakkos S, Eklof B, Perrin M, Nelzen O, Neglen P, et al. Management of chronic venous disorders of the lower limbs - guidelines according to scientific evidence. Int Angiol 2014;33:87-208.
    • (2014) Int Angiol , vol.33 , pp. 87-208
    • Nicolaides, A.1    Kakkos, S.2    Eklof, B.3    Perrin, M.4    Nelzen, O.5    Neglen, P.6
  • 2
    • 84930179987 scopus 로고    scopus 로고
    • Editor's choice - Management of chronic venous disease: Clinical practice guidelines of the european society for vascular surgery (ESVS)
    • Wittens C, Davies AH, Baekgaard N, Broholm R, Cavezzi A, Chastanet S, et al. Editor's Choice - Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg 2015;49:678-737.
    • (2015) Eur J Vasc Endovasc Surg , vol.49 , pp. 678-737
    • Wittens, C.1    Davies, A.H.2    Baekgaard, N.3    Broholm, R.4    Cavezzi, A.5    Chastanet, S.6
  • 3
    • 84978394303 scopus 로고    scopus 로고
    • Venous symptoms: The SYM vein consensus statement developed under the auspices of the European venous forum
    • Perrin M, Eklof B, Van Rij A, Labropoulos N, Vasquez M, Nicolaides A, et al. Venous symptoms: the SYM Vein Consensus statement developed under the auspices of the European Venous Forum. Int Angiol 2016;35:374-98.
    • (2016) Int Angiol , vol.35 , pp. 374-398
    • Perrin, M.1    Eklof, B.2    Van Rij, A.3    Labropoulos, N.4    Vasquez, M.5    Nicolaides, A.6
  • 5
    • 0019174359 scopus 로고
    • Action du Daflon sur la douleur, les crampes et l'oedeme en pathologie veineuse. Etude multicentrique 1200 cas
    • Krief I. Action du Daflon sur la douleur, les crampes et l'oedeme en pathologie veineuse. Etude multicentrique 1200 cas. Lille Med 1980;25:470-2.
    • (1980) Lille Med , vol.25 , pp. 470-472
    • Krief, I.1
  • 6
    • 0023712599 scopus 로고
    • Clinical evaluation of a venotropic drug in man. Example of Daflon 500 mg
    • Laurent R, Gilly R, Frileux C. Clinical evaluation of a venotropic drug in man. Example of Daflon 500 mg. Int Angiol 1988;7:39-43.
    • (1988) Int Angiol , vol.7 , pp. 39-43
    • Laurent, R.1    Gilly, R.2    Frileux, C.3
  • 7
    • 0024389092 scopus 로고
    • The efficacy of daflon 500 mg in 1931 patients suffering from chronic venous insufficiency
    • Elbaz C. The efficacy of daflon 500 mg in 1931 patients suffering from chronic venous insufficiency. Gaz Med 1989;96:30-2.
    • (1989) Gaz Med , vol.96 , pp. 30-32
    • Elbaz, C.1
  • 8
    • 0024918151 scopus 로고
    • A long term treatment with a venotropic drug. Results on efficacy and safety of Daflon 500 mg in chronic venous insufficiency
    • Guillot B, Guilhou JJ, De Champvallins M, Mallet C, Moccatti D, Pointel JP. A long term treatment with a venotropic drug. Results on efficacy and safety of Daflon 500 mg in chronic venous insufficiency. Int Angiol 1989;8:67-71.
    • (1989) Int Angiol , vol.8 , pp. 67-71
    • Guillot, B.1    Guilhou, J.J.2    De Champvallins, M.3    Mallet, C.4    Moccatti, D.5    Pointel, J.P.6
  • 9
    • 0024317888 scopus 로고
    • The efficacy of daflon 500 mg in 1779 patients with vein insufficiency
    • Henriet JP. The efficacy of daflon 500 mg in 1779 patients with vein insufficiency. Gaz Med 1989;96:85-9.
    • (1989) Gaz Med , vol.96 , pp. 85-89
    • Henriet, J.P.1
  • 10
    • 0024310937 scopus 로고
    • Edema reduction by daflon 500 mg: Pharmacological study
    • Labrid C. Edema reduction by daflon 500 mg: Pharmacological study. Gaz Med 1989;96:24-9.
    • (1989) Gaz Med , vol.96 , pp. 24-29
    • Labrid, C.1
  • 11
    • 0027168994 scopus 로고
    • A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility
    • Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol 1993;12:69-72.
    • (1993) Int Angiol , vol.12 , pp. 69-72
    • Galley, P.1    Thiollet, M.2
  • 12
    • 84962729304 scopus 로고
    • Correlation between haemodynamic parameters of venous tone and clinical symptoms improvement in patients with chronic venous insufficiency. A controlled randomized study Daflon 500 mg 2 tablets per day versus placebo during two months of treatment
    • Granger C, Laveille C, Vilain C, Jochemsen R. Correlation between haemodynamic parameters of venous tone and clinical symptoms improvement in patients with chronic venous insufficiency. A controlled randomized study Daflon 500 mg 2 tablets per day versus placebo during two months of treatment. Int Angiol 1995;14:343.
    • (1995) Int Angiol , vol.14 , pp. 343
    • Granger, C.1    Laveille, C.2    Vilain, C.3    Jochemsen, R.4
  • 13
    • 0031869757 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo controlled trial of Daflon 500 mg in the treatment of symptomatic capillary fragility
    • Galley P, Thiollet M. A double-blind, randomized, placebo controlled trial of Daflon 500 mg in the treatment of symptomatic capillary fragility. Angeiologie 1998;50:101-4.
    • (1998) Angeiologie , vol.50 , pp. 101-104
    • Galley, P.1    Thiollet, M.2
  • 14
    • 21644463605 scopus 로고    scopus 로고
    • Venous leg ulcer: A metaanalysis of adjunctive therapy with micronized purified flavonoid fraction
    • Coleridge-Smith P, Lok C, Ramelet AA. Venous leg ulcer: a metaanalysis of adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc Endovasc Surg 2005;30:198-208.
    • (2005) Eur J Vasc Endovasc Surg , vol.30 , pp. 198-208
    • Coleridge-Smith, P.1    Lok, C.2    Ramelet, A.A.3
  • 15
    • 14644402486 scopus 로고    scopus 로고
    • Benefit of Daflon 500 mg in chronic venous disease-related symptoms
    • Pitsch F. Benefit of Daflon 500 mg in chronic venous disease-related symptoms. Phlebolymphology 2005:359-64.
    • (2005) Phlebolymphology , pp. 359-364
    • Pitsch, F.1
  • 16
    • 29344466184 scopus 로고    scopus 로고
    • Benefit of daflon 500 mg in chronic venous disease-related edema
    • Pitsch F. Benefit of daflon 500 mg in chronic venous disease-related edema. Phlebolymphology 2006;13:17-21.
    • (2006) Phlebolymphology , vol.13 , pp. 17-21
    • Pitsch, F.1
  • 17
    • 85044505530 scopus 로고    scopus 로고
    • Efficacy of Daflon 500 on venous pain: Results and perspectives
    • Jawien A. Efficacy of Daflon 500 on venous pain: results and perspectives. Phlebology 2008;23:232.
    • (2008) Phlebology , vol.23 , pp. 232
    • Jawien, A.1
  • 18
    • 56849094629 scopus 로고    scopus 로고
    • Assessment of treatment efficacy on venous symptoms: The example of Daflon 500 mg
    • Pitsch F. Assessment of treatment efficacy on venous symptoms: The example of Daflon 500 mg. Phlebolymphology 2008;15:137-42.
    • (2008) Phlebolymphology , vol.15 , pp. 137-142
    • Pitsch, F.1
  • 19
    • 84865336639 scopus 로고    scopus 로고
    • Benefit of Daflon 500 mg in the reduction of chronic venous disease-related symptoms
    • Lenkovic M, Zgombic ZS, Blazic TM, Brajac I, Perisa D. Benefit of Daflon 500 mg in the reduction of chronic venous disease-related symptoms. Phlebolymphology 2012;19:79-83.
    • (2012) Phlebolymphology , vol.19 , pp. 79-83
    • Lenkovic, M.1    Zgombic, Z.S.2    Blazic, T.M.3    Brajac, I.4    Perisa, D.5
  • 20
    • 84890363236 scopus 로고    scopus 로고
    • ∗ (MPFF) improve outcomes of lower extremity varicose veinendovenous treatment? First results from the decision study
    • ∗ (MPFF) improve outcomes of lower extremity varicose veinendovenous treatment? First results from the decision study. Phlebolymphology 2013;20:181-7.
    • (2013) Phlebolymphology , vol.20 , pp. 181-187
    • Bogachev, V.Y.1    Golovanova, O.V.2    Kuznetsov, A.N.3    Sheokyan, A.O.4
  • 21
    • 84909972225 scopus 로고    scopus 로고
    • Benefits of MPFF on primary chronic venous disease-related symptoms and quality of life: The DELTA study
    • Yanushko VA, Bayeshko AA, Sushkov SA, Nebylitsyn YS, Nazaruk AM. Benefits of MPFF on primary chronic venous disease-related symptoms and quality of life: The DELTA study. Phlebolymphology 2014;21:146-51.
    • (2014) Phlebolymphology , vol.21 , pp. 146-151
    • Yanushko, V.A.1    Bayeshko, A.A.2    Sushkov, S.A.3    Nebylitsyn, Y.S.4    Nazaruk, A.M.5
  • 22
    • 0020025669 scopus 로고
    • Zur Therapie sogenannt venoser Beinbeschwerden. (Kontrollierte Doppelblind-studie zur Untersuchung der therapeutischen Wirksamkeit von Daflon)
    • Biland L, Blattler P, Scheibler P, Studer S, Widmer LK. Zur Therapie sogenannt venoser Beinbeschwerden. (Kontrollierte Doppelblind-Studie zur Untersuchung der therapeutischen Wirksamkeit von Daflon). Vasa 1982;11:53-8.
    • (1982) Vasa , vol.11 , pp. 53-58
    • Biland, L.1    Blattler, P.2    Scheibler, P.3    Studer, S.4    Widmer, L.K.5
  • 24
    • 84962684989 scopus 로고
    • Activité thérapeutique de Daflon 500 mg dans l'insuffisance veineuse chronique des membres inférieurs
    • Frileux C, Gilly R. Activité thérapeutique de Daflon 500 mg dans l'insuffisance veineuse chronique des membres inférieurs. Journal International de Médicine 1987:36-9.
    • (1987) Journal International de Médicine , pp. 36-39
    • Frileux, C.1    Gilly, R.2
  • 25
    • 0024929097 scopus 로고
    • Are the phlebotonic properties shown in clinical pharmacology predictive of a therapeutic benefit in chronic venous insufficiency? Our experience with Daflon 500 mg
    • Tsouderos Y. Are the phlebotonic properties shown in clinical pharmacology predictive of a therapeutic benefit in chronic venous insufficiency? Our experience with Daflon 500 mg. Int Angiol 1989;8:53-9.
    • (1989) Int Angiol , vol.8 , pp. 53-59
    • Tsouderos, Y.1
  • 26
    • 84865923327 scopus 로고
    • Insuffisance veineuse et Daflon 500 mg
    • Planchon B. Insuffisance veineuse et Daflon 500 mg. Arteres et Veines 1990;9:376-80.
    • (1990) Arteres et Veines , vol.9 , pp. 376-380
    • Planchon, B.1
  • 27
    • 84962701908 scopus 로고
    • Evaluation of a new micronized diosmin in the treatment of chronic venous incompetence: A double-blind, placebo controlled trial
    • Thiollet M, Frileux CRG. Evaluation of a new micronized diosmin in the treatment of chronic venous incompetence: a double-blind, placebo controlled trial. J Vasc Surg 1992;15:447.
    • (1992) J Vasc Surg , vol.15 , pp. 447
    • Thiollet, M.1    Frileux, C.R.G.2
  • 28
    • 0028237771 scopus 로고
    • Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: A double-blind, placebo-controlled study
    • Gilly R, Pillion G, Frileux C. Evaluation of a New Venoactive Micronized Flavonoid Fraction (S 5682) in Symptomatic Disturbances of the Venolymphatic Circulation of the Lower Limb: A Double-Blind, Placebo-Controlled Study. Phlebology 1994;9:67-70.
    • (1994) Phlebology , vol.9 , pp. 67-70
    • Gilly, R.1    Pillion, G.2    Frileux, C.3
  • 29
    • 0036133970 scopus 로고    scopus 로고
    • A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease
    • Danielsson G, Jungbeck C, Peterson K, Norgren L. A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg 2002;23:73-6.
    • (2002) Eur J Vasc Endovasc Surg , vol.23 , pp. 73-76
    • Danielsson, G.1    Jungbeck, C.2    Peterson, K.3    Norgren, L.4
  • 30
    • 84927737561 scopus 로고    scopus 로고
    • Venoactive drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial
    • Belczak SQ, Sincos IR, Campos W, Beserra J, Nering G, Aun R. Venoactive drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial. Phlebology 2014;29:454-60.
    • (2014) Phlebology , vol.29 , pp. 454-460
    • Belczak, S.Q.1    Sincos, I.R.2    Campos, W.3    Beserra, J.4    Nering, G.5    Aun, R.6
  • 31
    • 84946900108 scopus 로고    scopus 로고
    • Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: From a prospective randomized trial
    • Rabe E, Agus GB, Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol 2015;34:428-36.
    • (2015) Int Angiol , vol.34 , pp. 428-436
    • Rabe, E.1    Agus, G.B.2    Roztocil, K.3
  • 32
    • 38949194556 scopus 로고    scopus 로고
    • Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients
    • Aguilar Peralta GR, Arevalo Gardoqui J, Llamas Macias FJ, Navarro Ceja VH, Mendoza Cisneros SA, Martinez Macias CG. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol 2007;26:378-84.
    • (2007) Int Angiol , vol.26 , pp. 378-384
    • Aguilar Peralta, G.R.1    Arevalo Gardoqui, J.2    Llamas Macias, F.J.3    Navarro Ceja, V.H.4    Mendoza Cisneros, S.A.5    Martinez Macias, C.G.6
  • 35
    • 0030918551 scopus 로고    scopus 로고
    • Effects of oral administration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/reperfusion in the hamster cheek pouch
    • Bouskela E, Donyo KA. Effects of oral administration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/reperfusion in the hamster cheek pouch. Angiology 1997;48:391-9.
    • (1997) Angiology , vol.48 , pp. 391-399
    • Bouskela, E.1    Donyo, K.A.2
  • 36
    • 84992482222 scopus 로고    scopus 로고
    • Chronic venous disorders: Pharmacological and clinical aspects of micronized purified flavonoid fraction
    • Maggioli A. Chronic venous disorders: pharmacological and clinical aspects of micronized purified flavonoid fraction Phlebolymphology 2016;23:82-9.
    • (2016) Phlebolymphology , vol.23 , pp. 82-89
    • Maggioli, A.1
  • 37
    • 33947606352 scopus 로고    scopus 로고
    • Essentials of daflon 500 mg: From early valve protection to long-term benefits in the management of chronic venous disease
    • Pascarella L. Essentials of Daflon 500 mg: from early valve protection to long-term benefits in the management of chronic venous disease. Curr Pharm Des 2007;13:431-44.
    • (2007) Curr Pharm des , vol.13 , pp. 431-444
    • Pascarella, L.1
  • 38
    • 84949999756 scopus 로고    scopus 로고
    • Daflon and the protection of venous valves
    • Pascarella L. Daflon and the protection of venous valves. Phlebolymphology 2016;23:20-30.
    • (2016) Phlebolymphology , vol.23 , pp. 20-30
    • Pascarella, L.1
  • 39
    • 6744264220 scopus 로고
    • An original microhaemorheological approach to the pharmacological effects of Daflon 500 mg in severe chronic venous insufficiency
    • Allegra C, Bartolo M Jr, Carioti B, Cassiani D. An original microhaemorheological approach to the pharmacological effects of Daflon 500 mg in severe chronic venous insufficiency. Int J Microcirc Clin Exp 1995;15 50-4.
    • (1995) Int J Microcirc Clin Exp , vol.15 , pp. 50-54
    • Allegra, C.1    Bartolo, M.2    Carioti, B.3    Cassiani, D.4
  • 40
    • 0034889731 scopus 로고    scopus 로고
    • Therapeutic approach to chronic venous insufficiency and its complications: Place of Daflon 500 mg
    • Bergan JJ, Schmid-Schonbein GW, Takase S. Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg. Angiology 2001;52 S43-7.
    • (2001) Angiology , vol.52 , pp. S43-S47
    • Bergan, J.J.1    Schmid-Schonbein, G.W.2    Takase, S.3
  • 41
    • 0031451383 scopus 로고    scopus 로고
    • Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch
    • Bouskela E, Cyrino FZ, Lerond L. Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch. Br J Pharmacol 1997;122:1611-6.
    • (1997) Br J Pharmacol , vol.122 , pp. 1611-1616
    • Bouskela, E.1    Cyrino, F.Z.2    Lerond, L.3
  • 42
    • 0028191818 scopus 로고
    • Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: In vivo observations in the hamster skin fold
    • Friesenecker B, Tsai AG, Allegra C, Intaglietta M. Oral administration of purified micronized flavonoid fraction suppresses leukocyte adhesion in ischemia-reperfusion injury: in vivo observations in the hamster skin fold. Int J Microcirc Clin Exp 1994;14:50-5.
    • (1994) Int J Microcirc Clin Exp , vol.14 , pp. 50-55
    • Friesenecker, B.1    Tsai, A.G.2    Allegra, C.3    Intaglietta, M.4
  • 43
    • 0031305686 scopus 로고    scopus 로고
    • Postischemic leukocyte/endothelial cell interactions and microvascular barrier dysfunction in skeletal muscle: Cellular mechanisms and effect of Daflon 500 mg
    • Korthuis RJ, Gute DC. Postischemic leukocyte/endothelial cell interactions and microvascular barrier dysfunction in skeletal muscle: cellular mechanisms and effect of Daflon 500 mg. Int J Microcirc Clin Exp 1997;17:11-7.
    • (1997) Int J Microcirc Clin Exp , vol.17 , pp. 11-17
    • Korthuis, R.J.1    Gute, D.C.2
  • 44
    • 0033120805 scopus 로고    scopus 로고
    • Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease-a prospective study
    • Shoab SS, Porter J, Scurr JH, Coleridge-Smith PD. Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease-a prospective study. Eur J Vasc Endovasc Surg 1999;17:313-8.
    • (1999) Eur J Vasc Endovasc Surg , vol.17 , pp. 313-318
    • Shoab, S.S.1    Porter, J.2    Scurr, J.H.3    Coleridge-Smith, P.D.4
  • 45
    • 0033213858 scopus 로고    scopus 로고
    • Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction - A pilot study
    • Shoab SS, Scurr JH, Coleridge-Smith PD. Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction - a pilot study. Eur J Vasc Endovasc Surg 1999;18:334-8.
    • (1999) Eur J Vasc Endovasc Surg , vol.18 , pp. 334-338
    • Shoab, S.S.1    Scurr, J.H.2    Coleridge-Smith, P.D.3
  • 46
    • 0034064656 scopus 로고    scopus 로고
    • Effect of oral micronized purified flavonoid fraction treatment on leukocyte adhesion molecule expression in patients with chronic venous disease: A pilot study
    • Shoab SS, Porter JB, Scurr JH, Coleridge-Smith PD. Effect of oral micronized purified flavonoid fraction treatment on leukocyte adhesion molecule expression in patients with chronic venous disease: a pilot study. J Vasc Surg 2000;31:456-61.
    • (2000) J Vasc Surg , vol.31 , pp. 456-461
    • Shoab, S.S.1    Porter, J.B.2    Scurr, J.H.3    Coleridge-Smith, P.D.4
  • 52
    • 84867591212 scopus 로고    scopus 로고
    • Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema
    • Allaert FA. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema. Int Angiol 2012;31:310-5.
    • (2012) Int Angiol , vol.31 , pp. 310-315
    • Allaert, F.A.1
  • 53
    • 85013477733 scopus 로고    scopus 로고
    • Recommendations for the medical management of chronic venous disease: The role of Micronized Purified Flavanoid Fraction (MPFF)
    • Bush R, Comerota A, Meissner M, Raffetto JD, Hahn SR, Freeman K. Recommendations for the medical management of chronic venous disease: The role of Micronized Purified Flavanoid Fraction (MPFF). Phlebology 2017;32:3-19.
    • (2017) Phlebology , vol.32 , pp. 3-19
    • Bush, R.1    Comerota, A.2    Meissner, M.3    Raffetto, J.D.4    Hahn, S.R.5    Freeman, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.