A probe in the connection between inflammation, cognition and suicide

Journal of Psychopharmacology

Volumn 32, Issue 4, 2018, Pages 482-488

  Cáceda, Ricardo ^a   Griffin, W Sue T ^b   Delgado, Pedro L ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CRP; IL6; impulsivity; inpatient; psychological pain; Suicide

Indexed keywords

ADOLESCENT; ADULT; ANXIETY DISORDER; DELAY DISCOUNTING; DEPRESSION; FEMALE; HUMAN; IMPULSIVENESS; INFLAMMATION; MALE; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; RISK FACTOR; SUICIDAL IDEATION; SUICIDE ATTEMPT; YOUNG ADULT;

ADOLESCENT; ADULT; ANXIETY DISORDERS; DELAY DISCOUNTING; DEPRESSION; DEPRESSIVE DISORDER; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; INFLAMMATION; MALE; MIDDLE AGED; RISK FACTORS; SUICIDAL IDEATION; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 85044302352     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881118764022     Document Type: Article

References (57)

1. Alesci S, Martinez PE, Kelkar S. (2005) Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: Clinical implications. J Clin Endocrinol Metab 90: 2522–2530.
2. American Psychiatric Association (2000) Diagnostic Criteria from DSM-IV-TR. Washington, DC: American Psychiatric Association.
3. Aweid O, Gallie R, Morrissey D. (2014) Medial tibial pain pressure threshold algometry in runners. Knee Surg Sports Traumatol Arthrosc 22: 1549–1555.
4. Batty GD, Bell S, Stamatakis E. (2016) Association of systemic inflammation with risk of completed suicide in the general population. JAMA Psychiatry 73: 993–995.
5. Baumeister RF, (1990) Suicide as escape from self. Psychol Rev 97: 90–113.
6. Bay-Richter C, Linderholm KR, Lim CK. (2015) A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. Brain Behav Immun 43: 110–117.
7. Beck AT, (1988) Beck Hopelessness Scale. San Antonio: The Psychological Corporation.
8. Beck AT, Steer RA, (1990) Beck Anxiety Inventory: Mannual. San Antonio: Psychological Corporation/Harcourt Brace Jovanovich.
9. Beck AT, Steer RA, Ball R. (1996) Comparison of Beck depression inventories -IA and -II in psychiatric outpatients. J Pers Assess 67: 588–597.
10. Brundin L, Erhardt S, Bryleva EY. (2015) The role of inflammation in suicidal behaviour. Acta Psychiatr Scand 132: 192–203.
11. Cáceda R, Durand D, Cortes E. (2014) Impulsive choice and psychological pain in acutely suicidal depressed patients. Psychosom Med 76: 445–451.
12. Caceda R, Kordsmeier NC, Golden E. (2017) Differential processing of physical and psychological pain during acute suicidality. Psychother Psychosom 86: 116–118.
13. Charlson ME, Pompei P, Ales KL. (1987) A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 40: 373–383.
14. Courtet P, Giner L, Seneque M. (2016) Neuroinflammation in suicide: Toward a comprehensive model. World J Biol Psychiatry 17: 564–586.
15. Courtet P, Jaussent I, Genty C. (2015) Increased CRP levels may be a trait marker of suicidal attempt. Eur Neuropsychopharmacol 25: 1824–1831.
16. Dantzer R, O’Connor JC, Freund GG. (2008) From inflammation to sickness and depression: When the immune system subjugates the brain. Nat Rev Neurosci 9: 46–56.
17. Dickerson F, Stallings C, Origoni A. (2007) Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 31: 952–955.
18. Dombrovski AY, Siegle GJ, Szanto K. (2012) The temptation of suicide: Striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression. Psychol Med 42: 1203–1215.
19. Dowlati Y, Herrmann N, Swardfager W. (2010) A meta-analysis of cytokines in major depression. Biol Psychiatry 67: 446–457.
20. Dunn AJ, (2006) Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res 6: 52–68.
21. Engelmann JB, Maciuba B, Vaughan C. (2013) Posttraumatic stress disorder increases sensitivity to long term losses among patients with major depressive disorder. PLoS One 8: e78292.
22. Fazel S, Wolf A, Pillas D. (2014) Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: A 41-year Swedish population study. JAMA Psychiatry 71: 326–333.
23. Felger JC, Li Z, Haroon E. (2016) Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol Psychiatry 21: 1358–1365.
24. Fredrikson S, Cheng Q, Jiang GX. (2003) Elevated suicide risk among patients with multiple sclerosis in Sweden. Neuroepidemiology 22: 146–152.
25. Gabbay V, Klein RG, Guttman LE. (2009) A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression. J Child Adolesc Psychopharmacol 19: 423–430.
26. Gananca L, Oquendo MA, Tyrka AR. (2016) The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology 63: 296–310.
27. Gibbs HM, Davis L, Han X. (2016) Association between C-reactive protein and suicidal behavior in an adult inpatient population. J Psychiatr Res 79: 28–33.
28. Green L, Myerson J, Oliveira L. (2014) Discounting of delayed and probabilistic losses over a wide range of amounts. J Exp Anal Behav 101: 186–200.
29. Gvion Y, Horesh N, Levi-Belz Y. (2015) A proposed model of the development of suicidal ideations. Compr Psychiatry 56: 93–102.
30. Hoogland IC, Houbolt C, van Westerloo DJ. (2015) Systemic inflammation and microglial activation: Systematic review of animal experiments. J Neuroinflammation 12: 114.
31. Jollant F, Near J, Turecki G. (2017) Spectroscopy markers of suicidal risk and mental pain in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 73: 64–71.
32. Juengst SB, Kumar RG, Arenth PM. (2014) Exploratory associations with tumor necrosis factor-alpha, disinhibition and suicidal endorsement after traumatic brain injury. Brain Behav Immun 41: 134–143.
33. Karlovic D, Serretti A, Vrkic N. (2012) Serum concentrations of CRP, IL-6, TNF-alpha and cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Res 198: 74–80.
34. Kessler RC, Berglund P, Borges G. (2005) Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990–1992 to 2001–2003. JAMA 293: 2487–2495.
35. Kirby KN, Petry NM, Bickel WK, (1999) Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 128: 78–87.
36. Klonsky ED, Qiu T, Saffer BY, (2017) Recent advances in differentiating suicide attempters from suicide ideators. Curr Opin Psychiatry 30: 15–20.
37. Lund-Sorensen H, Benros ME, Madsen T. (2016) A nationwide cohort study of the association between hospitalization with infection and risk of death by suicide. JAMA Psychiatry 73: 912–919.
38. Martinez JM, Garakani A, Yehuda R. (2012) Proinflammatory and “resiliency” proteins in the CSF of patients with major depression. Depress Anxiety 29: 32–38.
39. Marzuk PM, Hartwell N, Leon AC. (2005) Executive functioning in depressed patients with suicidal ideation. Acta Psychiatr Scand 112: 294–301.
40. Mendlovic S, Mozes E, Eilat E. (1999) Immune activation in non-treated suicidal major depression. Immunol Lett 67: 105–108.
41. Miller BJ, Mellor A, Buckley P, (2013) Total and differential white blood cell counts, high-sensitivity C-reactive protein, and the metabolic syndrome in non-affective psychoses. Brain Behav Immun 31: 82–89.
42. Monfrim X, Gazal M, De Leon PB. (2014) Immune dysfunction in bipolar disorder and suicide risk: Is there an association between peripheral corticotropin-releasing hormone and interleukin-1beta? Bipolar Disord 16: 741–747.
43. Myerson J, Baumann AA, Green L, (2014) Discounting of delayed rewards: (A)theoretical interpretation of the Kirby questionnaire. Behav Processes 107: 99–105.
44. Newcombe F, (1969) Missile Wounds of the Brain: A Study of Psychological Deficits. London: Oxford UP.
45. O’Donovan A, Rush G, Hoatam G. (2013) Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anxiety 30: 307–314.
46. Olie E, Guillaume S, Jaussent I. (2010) Higher psychological pain during a major depressive episode may be a factor of vulnerability to suicidal ideation and act. J Affect Disord 120: 226–230.
47. Orbach I, Stein D, Palgi Y. (1996) Perception of physical pain in accident and suicide attempt patients: Self-preservation vs self-destruction. J Psychiatr Res 30: 307–320.
48. Pandey GN, Rizavi HS, Ren X. (2012) Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res 46: 57–63.
49. Posner K, Brown GK, Stanley B. (2011) The Columbia-suicide severity rating scale: Initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry 168: 1266–1277.
50. Reitan R, Wolfson D, (1985) The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson: Neuropsychology Press.
51. Richard-Devantoy S, Berlim MT, Jollant F, (2014) A meta-analysis of neuropsychological markers of vulnerability to suicidal behavior in mood disorders. Psychol Med 44: 1663–1673.
52. Richard-Devantoy S, Ding Y, Lepage M. (2016) Cognitive inhibition in depression and suicidal behavior: A neuroimaging study. Psychol Med 46: 933–944.
53. Serafini G, Pompili M, Elena Seretti M. (2013) The role of inflammatory cytokines in suicidal behavior: A systematic review. Eur Neuropsychopharmacol 23: 1672–1686.
54. Steptoe A, Hamer M, Chida Y, (2007) The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain Behav Immun 21: 901–912.
55. Vargas HO, Nunes SO, de Castro MR. (2013) Oxidative stress and inflammatory markers are associated with depression and nicotine dependence. Neurosci Lett 544: 136–140.
56. Wang YY, Jiang NZ, Cheung EF. (2015) Role of depression severity and impulsivity in the relationship between hopelessness and suicidal ideation in patients with major depressive disorder. J Affect Disord 183: 83–89.
57. Wolff JC, Davis S, Liu RT. (2018) Trajectories of suicidal ideation among adolescents following psychiatric hospitalization. J Abnorm Child Psychol 46: 355–363.