The efficacy of pre-operative preparation with intravenous iron and/or erythropoietin in anaemic patients undergoing orthopaedic surgery

European Journal of Anaesthesiology

Volumn 35, Issue 4, 2018, Pages 289-297

  Heschl, Martina ^a   Gombotz, Hans ^a   Haslinger Eisterer, Bettina ^a   Hofmann, Axel ^b   Böhler, Nikolaus ^a   Meier, Jens ^a  

^a JOHANNES KEPLER UNIVERSITY LINZ   (Austria)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; FERRITIN; IRON; TRANSFERRIN; EPO PROTEIN, HUMAN;

AGED; ANEMIA; ARTICLE; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HIP REPLACEMENT; HUMAN; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; ORTHOPEDIC SURGERY; PATIENT ASSESSMENT; PREOPERATIVE CARE; PREOPERATIVE COMPLICATION; PROPENSITY SCORE; RETROSPECTIVE STUDY; SURVIVAL TIME; TOTAL KNEE ARTHROPLASTY; TRANSFUSION; BLOOD TRANSFUSION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PROCEDURES; TREATMENT OUTCOME; TRENDS; VERY ELDERLY;

ADMINISTRATION, INTRAVENOUS; AGED; AGED, 80 AND OVER; ANEMIA; BLOOD TRANSFUSION; ERYTHROPOIETIN; FEMALE; HUMANS; IRON; MALE; MIDDLE AGED; ORTHOPEDIC PROCEDURES; PREOPERATIVE CARE; TREATMENT OUTCOME;

EID: 85044211134     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0000000000000752     Document Type: Article

References (34)

1. Gombotz H, Rehak PH, Shander A, et al. Blood use in elective surgery: the Austrian benchmark study. Transfusion 2007; 47:1468-1480.
2. Goodnough LT, Maniatis A, Earnshaw P, et al. Detection, evaluation and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J Anaesth 2011; 106:13-22.
3. Jans Ø, Jørgensen C, Kehlet H, et al., Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group. Role of preoperative anemia for risk of transfusion and postoperative morbidity in fast-track hip and knee arthroplasty. Transfusion 2014; 54:717-726.
4. Baron DM, Hochrieser H, Posch M, et al. Preoperative anaemia is associated with poor clinical outcome in noncardiac surgery patients. Br J Anaesth 2014; 113:416-423.
5. Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996; 348:1055-1060.
6. Wu W-C, Schifftner TL, Henderson WG, et al. Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery. JAMA 2007; 297:2481-2488.
7. Shander A, Javidroozi M, Gianatiempo C, et al. Outcomes of protocoldriven care of critically ill severely anemic patients for whom blood transfusion is not an option. Crit Care Med 2016; 44:1109-1115.
8. Musallam KM, Tamim HM, Richards T, et al. Preoperative anaemia and postoperative outcomes in noncardiac surgery: a retrospective cohort study. Lancet 2011; 378:1396-1407.
9. Shander A, Isbister J, Gombotz H. Patient blood management: the global view. Transfusion 2016; 56 (Suppl 1):S94-S102.
10. Meybohm P, Herrmann E, Steinbicker AU, et al. Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient's outcome: a prospective, multicenter cohort study with a noninferiority design. Ann Surg 2016; 264:203-211.
11. Rineau E, Chaudet A, Chassier C, et al. Implementing a blood management protocol during the entire perioperative period allows a reduction in transfusion rate in major orthopedic surgery: a before-after study. Transfusion 2016; 56:673-681.
12. Spahn DR, Goodnough LT. Alternatives to blood transfusion. Lancet 2013; 381:1855-1865.
13. Auerbach M, Goodnough LT, Picard D, et al. The role of intravenous iron in anemia management and transfusion avoidance. Transfusion 2008; 48:988-1000.
14. Theusinger OM, Leyvraz P-F, Schanz U, et al. Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. Anesthesiology 2007; 107:923-927.
15. Shander A, Spence RK, Auerbach M. Can intravenous iron therapy meet the unmet needs created by the new restrictions on erythropoietic stimulating agents? Transfusion 2010; 50:719-732.
16. Mercuriali F, Zanella A, Barosi G, et al. Use of erythropoietin to increase the volume of autologous blood donated by orthopedic patients. Transfusion 1993; 33:55-60.
17. Kozek-Langenecker SA, Ahmed AB, Afshari A, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: first update 2016. Eur J Anaesthesiol 2017; 34: 332-395.
18. Mercuriali F, Inghilleri G. Proposal of an algorithm to help the choice of the best transfusion strategy. Curr Med Res Opin 1996; 13:465-478.
19. Munõz M, Gomez-Ramírez S, Kozek-Langeneker S, et al. 'Fit to fly': overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth 2015; 115:15-24.
20. Spahn DR, Zacharowski K. Nontreatment of preoperative anaemia is substandard clinical practice. Br J Anaesth 2015; 115:1-3.
21. Goodnough LT, Shander A. Patient blood management. Anesthesiology 2012; 116:1367-1376.
22. Spahn DR. Patient blood management: success and potential in the future. Ann Surg 2016; 264:212-213.
23. Leal-Noval SR, Munõz M, Asuero M, et al. Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the 'Seville Document'. Blood Transfus 2013; 11:585-610.
24. Munõz M, Acheson AG, Auerbach M, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia 2017; 72:233-247.
25. Hofmann A, Farmer S, Towler SC. Strategies to preempt and reduce the use of blood products: an Australian perspective. Curr Opin Anaesthesiol 2012; 25:66-73.
26. Isbister JP. Clinicians as gatekeepers: what is the best route to optimal blood use? Dev Biol (Basel) 2007; 127:9-14.
27. Rineau E, Chaudet A, Carlier L, et al. Ferric carboxymaltose increases epoetin-a response and prevents iron deficiency before elective orthopaedic surgery. Br J Anaesth 2014; 113:296-298.
28. Lin DM, Lin ES, Tran M-H. Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review. Transfus Med Rev 2013; 27:221-234.
29. Stowell CP, Jones SC, Enny C, et al. An open-label, randomized, parallelgroup study of perioperative epoetin alfa versus standard of care for blood conservation in major elective spinal surgery: safety analysis. Spine 2009; 34:2479-2485.
30. de Andrade JR, Frei D, Guilfoyle M. Integrated analysis of thrombotic/ vascular event occurrence in epoetin alfa-treated patients undergoing major, elective orthopedic surgery. Orthopedics 1999; 22 (1 Suppl): s113-s118.
31. Rosencher N, Poisson D, Albi A, et al. Two injections of erythropoietin correct moderate anemia in most patients awaiting orthopedic surgery. Can J Anaesth 2005; 52:160-165.
32. Camaschella C, Pagani A, Nai A, et al. The mutual control of iron and erythropoiesis. Int J Lab Hematol 2016; 38 (Suppl 1):20-26.
33. Silverberg DS, Blum M, Agbaria Z, et al. The effect of i. v. iron alone or in combination with low-dose erythropoietin in the rapid correction of anemia of chronic renal failure in the predialysis period. Clin Nephrol 2001; 55:212-219.
34. Dittrich E, Schillinger M, Sunder-Plassmann G, et al. Efficacy of a low-dose intravenous iron sucrose regimen in peritoneal dialysis patients. Perit Dial Int 2002; 22:60-66.