Reduced inflammation and cytokine production in NKLAM deficient mice during Streptococcus pneumoniae infection

PLoS ONE

Volumn 13, Issue 3, 2018, Pages

  Lawrence, Donald W ^a   Kornbluth, Jacki ^a,b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA St Louis Healthcare System   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; CYTOKINE; MEMBRANE PROTEIN; NK LYTIC-ASSOCIATED MOLECULE; STAT1 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NATURAL KILLER CELL; NEUTROPHIL COUNT; NONHUMAN; PNEUMOCOCCAL INFECTION; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MICROBIOLOGY; PATHOLOGY; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PNEUMONIA, PNEUMOCOCCAL; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STREPTOCOCCUS PNEUMONIAE;

EID: 85043377233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0194202     Document Type: Article

References (38)

1. Center for Disease Control and Prevention. Pneumococcal Disease 2015 [updated June 10, 2015March 3. 2017]. Available from: https://www.cdc.gov/pneumococcal/clinicians/streptococcuspneumoniae.html.
2. Appelbaum PC. Resistance among Streptococcus pneumoniae: Implications for drug selection. Clin Infect Dis. 2002; 34(12):1613-20. https://doi.org/10.1086/340400 PMID: 12032897
3. Center for Disease Control and Prevention. Antibiotic/Antimicrobial Resisitance 2016 [March 3, 2017]. Available from: https://www.cdc.gov/drugresistance/biggest-threats.html.
4. Eisenhaber B, Chumak N, Eisenhaber F, Hauser MT. The ring between ring fingers (RBR) protein family. Genome Biol. 2007; 8(3):209. https://doi.org/10.1186/gb-2007-8-3-209 PMID: 17367545
5. Lawrence DW, Kornbluth J. E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing. Cell Immunol. 2012; 279(1):46-52. https://doi.org/10.1016/j.cellimm.2012.09.004 PMID: 23085241
6. Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013; 501(7468):512-6. https://doi.org/10.1038/nature12566 PMID: 24005326
7. Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, et al. Susceptibility to leprosy is associated with PARK2 and PACRG. Nature. 2004; 427(6975):636-40. https://doi.org/10.1038/nature02326 PMID: 14737177
8. Lawrence DW, Kornbluth J. E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity. Cell Signal. 2016; 28(12):1833-41. https://doi.org/10.1016/j.cellsig.2016.08.014 PMID: 27570112
9. Chapgier A, Boisson-Dupuis S, Jouanguy E, Vogt G, Feinberg J, Prochnicka-Chalufour A, et al. Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. PLoS Genet. 2006; 2(8):e131. https://doi.org/10.1371/journal.pgen.0020131 PMID: 16934001
10. Chapgier A, Kong XF, Boisson-Dupuis S, Jouanguy E, Averbuch D, Feinberg J, et al. A partial form of recessive STAT1 deficiency in humans. J Clin Invest. 2009; 119(6):1502-14. https://doi.org/10.1172/JCI37083 PMID: 19436109
11. Dupuis S, Jouanguy E, Al-Hajjar S, Fieschi C, Al-Mohsen IZ, Al-Jumaah S, et al. Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency. Nat Genet. 2003; 33(3):388-91. https://doi.org/10.1038/ng1097 PMID: 12590259
12. Lawrence DW, Gullickson G, Kornbluth J. E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression. Immunobiology. 2015; 220(1):83-92. https://doi.org/10.1016/j.imbio.2014.08.016 PMID: 25182373
13. Letsiou E, Sammani S, Wang H, Belvitch P, Dudek SM. Parkin regulates lipopolysaccharide-induced proinflammatory responses in acute lung injury. Transl Res. 2017; 181:71-82. https://doi.org/10.1016/j.trsl.2016.09.002 PMID: 27693468
14. de Leseleuc L, Orlova M, Cobat A, Girard M, Huong NT, Ba NN, et al. PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. PLoS Negl Trop Dis. 2013; 7(1):e2015. https://doi.org/10.1371/journal.pntd.0002015 PMID: 23350010
15. Inn K-S, Gack MU, Tokunaga F, Shi M, Wong L-Y, Iwai K, et al. Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction. Mol Cell. 2011; 41 (3):354-65. https://doi.org/10.1016/j.molcel.2010.12.029 PMID: 21292167
16. Hoover RG, Gullickson G, Kornbluth J. Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice. J Immunol. 2009; 183(11):6913-21. https://doi.org/10.4049/jimmunol.0901679 PMID: 19915045
17. Swamydas M, Lionakis MS. Isolation, purification and labeling of mouse bone marrow neutrophils for functional studies and adoptive transfer experiments. J Vis Exp. 2013(77):e50586. https://doi.org/10.3791/50586 PMID: 23892876
18. Kozlowski M, Schorey J, Portis T, Grigoriev V, Kornbluth J. NK lytic-associated molecule: a novel gene selectively expressed in cells with cytolytic function. J Immunol. 1999; 163(4):1775-85. PMID: 10438909
19. Menten P, Wuyts A, Van Damme J. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 2002; 13(6):455-81. PMID: 12401480
20. Standiford TJ, Kunkel SL, Lukacs NW, Greenberger MJ, Danforth JM, Kunkel RG, et al. Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J Immunol. 1995; 155(3):1515-24. PMID: 7636213
21. Satoh J, Tabunoki H. A Comprehensive Profile of ChIP-Seq-Based STAT1 Target Genes Suggests the Complexity of STAT1-Mediated Gene Regulatory Mechanisms. Gene regulation and systems biology. 2013; 7:41-56. https://doi.org/10.4137/GRSB.S11433 PMID: 23645984
22. Parker D, Martin FJ, Soong G, Harfenist BS, Aguilar JL, Ratner AJ, et al. Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract. mBio. 2011; 2(3):e00016-11. https://doi.org/10.1128/mBio.00016-11 PMID: 21586648
23. Amory-Rivier CF, Mohler J, Bedos JP, Azoulay-Dupuis E, Henin D, Muffat-Joly M, et al. Nuclear factorkappaB activation in mouse lung lavage cells in response to Streptococcus pneumoniae pulmonary infection. Crit Care Med. 2000; 28(9):3249-56. PMID: 11008989
24. Liu L, Oliveira NM, Cheney KM, Pade C, Dreja H, Bergin AM, et al. A whole genome screen for HIV restriction factors. Retrovirology. 2011; 8:94. https://doi.org/10.1186/1742-4690-8-94 PMID: 22082156
25. Chappell VL, Le LX, LaGrone L, Mileski WJ. Stat proteins play a role in tumor necrosis factor alpha gene expression. Shock. 2000; 14(3):400-2; discussion 2-3. PMID: 11028563
26. Takagi K, Takagi M, Kanangat S, Warrington KJ, Shigemitsu H, Postlethwaite AE. Modulation of TNFalpha gene expression by IFN-gamma and pamidronate in murine macrophages: regulation by STAT1-dependent pathways. J Immunol. 2005; 174(4):1801-10. PMID: 15699106
27. Vila-del Sol V, Punzon C, Fresno M. IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages. J Immunol. 2008; 181(7):4461-70. PMID: 18802049
28. Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol. 2012; 13 (8):722-8. https://doi.org/10.1038/ni.2366 PMID: 22814351
29. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003; 3(2):133-46. https://doi.org/10.1038/nri1001 PMID: 12563297
30. Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM. Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Mol Cell Biol. 1995; 15(10):5258-67. PMID: 7565674
31. Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, et al. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012; 13(3):290-9. https://doi.org/10.1038/ni.2227 PMID: 22306691
32. Balamayooran G, Batra S, Balamayooran T, Cai S, Jeyaseelan S. Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection. Infect Immun. 2011; 79(7):2567-77. https://doi.org/10.1128/IAI.00067-11 PMID: 21518788
33. Matsukawa A, Hogaboam CM, Lukacs NW, Lincoln PM, Strieter RM, Kunkel SL. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J Immunol. 1999; 163(11):6148-54. PMID: 10570305
34. Fardilha M, Esteves SL, Korrodi-Gregorio L, Pelech S, da Cruz ESOA, da Cruz ESE. Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility. Mol Hum Reprod. 2011; 17(8):466-77. https://doi.org/10.1093/molehr/gar004 PMID: 21257602
35. Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, et al. STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease. Proc Natl Acad Sci U S A. 2015; 112 (4):1202-7. https://doi.org/10.1073/pnas.1417423112 PMID: 25583483
36. Cooper JA, Kaneko T, Li SS. Cell regulation by phosphotyrosine-targeted ubiquitin ligases. Mol Cell Biol. 2015; 35(11):1886-97. https://doi.org/10.1128/MCB.00098-15 PMID: 25776560
37. Narayana Moorthy A, Narasaraju T, Rai P, Perumalsamy R, Tan KB, Wang S, et al. In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection. Frontiers in immunology. 2013; 4:56. https://doi.org/10.3389/fimmu.2013.00056 PMID: 23467809
38. Neill DR, Fernandes VE, Wisby L, Haynes AR, Ferreira DM, Laher A, et al. T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice. PLoS Pathog. 2012; 8(4):e1002660. https://doi.org/10.1371/journal.ppat.1002660 PMID: 22563306