Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach

Acta Psychiatrica Scandinavica

Volumn 137, Issue 6, 2018, Pages 516-527

  Sole B ^a   Bonnin, C M ^a   Jimenez E ^a   Torrent, C ^a   Torres, I ^a   Varo, C ^a   Valls, E ^a   Montejo, L ^a   Gomez Ocana C ^b   Tomioka, Y ^a   Vieta, E ^a   Martinez Aran, A ^a   Reinares, M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

bipolar disorder; cluster analysis; functioning; psychosocial outcome

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

ADULT; ARTICLE; ASSESSMENT OF HUMANS; BIPOLAR DISORDER; CLUSTER ANALYSIS; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; DSM-IV-TR; FEMALE; FUNCTIONING ASSESSMENT SHORT TEST; HAMILTON DEPRESSION RATING SCALE; HUMAN; HUMAN RELATION; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOSOCIAL REHABILITATION; SOCIAL PSYCHOLOGY; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; UNEMPLOYMENT; YOUNG MANIA RATING SCALE; CLASSIFICATION; COGNITIVE DEFECT; COMPLICATION; CROSS-SECTIONAL STUDY; DAILY LIFE ACTIVITY; EMPLOYMENT; MIDDLE AGED; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

ACTIVITIES OF DAILY LIVING; ADULT; BIPOLAR DISORDER; CLUSTER ANALYSIS; COGNITIVE DYSFUNCTION; CROSS-SECTIONAL STUDIES; EMPLOYMENT; HUMANS; INTERPERSONAL RELATIONS; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 85043258725     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12871     Document Type: Article

References (68)

1. Michalak EE, Murray G. A clinician's guide to psychosocial functioning and quality of life in bipolar disorder. In: Young A, Ferrier N, Michalak EE, eds. Practical management of bipolar disorder. Cambridge: Cambridge University Press, 2010:163–174.
2. MacQueen GM, Young LT, Joffe RT. A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand 2001;103:163–170.
3. Duarte W, Becerra R, Cruise K. The relationship between neurocognitive functioning and occupational functioning in bipolar disorder: a literature review. Eur J Psychol 2016;12:659–678.
4. Catala-Lopez F, Genova-Maleras R, Vieta E, Tabares-Seisdedos R. The increasing burden of mental and neurological disorders. Eur Neuropsychopharmacol 2013;23:1337–1339.
5. Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. Lancet 2016;387(10027):1561–1572.
6. Sanchez-Moreno J, Martinez-Aran A, Tabares-Seisdedos R, Torrent C, Vieta E, Ayuso-Mateos JL. Functioning and disability in bipolar disorder: an extensive review. Psychother Psychosom 2009;78:285–297.
7. Sanchez-Moreno J, Martinez-Aran A, Vieta E. Treatment of functional impairment in patients with bipolar disorder. Curr Psychiatry Rep 2017;19:3.
8. Depp CA, Mausbach BT, Harmell AL et al. Meta-analysis of the association between cognitive abilities and everyday functioning in bipolar disorder. Bipolar Disord 2012;143:217–226.
9. Bowie CR, Depp C, McGrath JA et al. Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry 2010;167:1116–1124.
10. Burdick KE, Russo M, Frangou S et al. Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. Psychol Med 2014;44:3083–3096.
11. Sole B, Jimenez E, Torrent C et al. Cognitive variability in bipolar II disorder: who is cognitively impaired and who is preserved. Bipolar Disord 2016;18:288–299.
12. Jensen JH, Knorr U, Vinberg M, Kessing LV, Miskowiak KW. Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder: Associations with functional abilities. J Affect Disord 2016;205:378–386.
13. Jimenez E, Sole B, Arias B et al. Impact of childhood trauma on cognitive profile in bipolar disorder. Bipolar Disord 2017;19:363–374.
14. Bora E, Hidiroglu C, Ozerdem A et al. Executive dysfunction and cognitive subgroups in a large sample of euthymic patients with bipolar disorder. Eur Neuropsychophamacol 2016;26:1338–1347.
15. Van Rheenen TE, Lewandowski KE, Tan EJ et al. Characterizing cognitive heterogeneity on the schizophrenia-bipolar disorder spectrum. Psychol Med 2017;47:1848–1864.
16. Reinares M, Papachristou E, Harvey P et al. Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome. J Affect Disord 2013;144:65–71.
17. Cotrena C, Branco LD, Kochhann R, Shansis FM, Fonseca RP. Quality of life, functioning and cognition in bipolar disorder and major depression: a latent profile analysis. Psychiatry Res 2016;241:289–296.
18. Michalak EE, Jones S, Lobban F et al. Harnessing the potential of community-based participatory research approaches in bipolar disorder. Int J Bipolar Disord 2016;4:4.
19. Rosa AR, Sanchez-Moreno J, Martinez-Aran A et al. Validity and reliability of the functioning assessment short test (FAST) in bipolar disorder. Clin Pract Epidemol Ment Health 2007;3:5.
20. Vieta E. Pros and cons of specialised care in bipolar disorder: an international perspective. Br J Psychiatry 2013;202:170–171.
21. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.
22. Ramos-Brieva JA, Cordero VA. [Validation of the Castillian version of the Hamilton Rating Scale for depression]. Actas Luso Esp Neurol Psiquiatr Cienc Afines 1986;14:324–334.
23. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429–435.
24. Colom F, Vieta E, Martinez-Aran A et al. Spanish version of a scale for the assessment of mania: validity and reliability of the Young Mania Rating Scale. Med Clin (Barc) 2002;119:366–371.
25. First MB, Spitzer R, Gibbon M. Structured clinical interview for DSM-IV Axis I disorders. Biometrics Research Department ed. Washington, DC: American Psychiatric Press Inc, 1997.
26. Grande I, Magalhaes PV, Chendo I et al. Staging bipolar disorder: clinical, biochemical, and functional correlates. Acta Psychiatr Scand 2014;129:437–444.
27. Pinho M, Sehmbi M, Cudney LE et al. The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi-center study. Acta Psychiatr Scand 2016;133:102–108.
28. Weschler D. The Wechsler Adult Intelligence Scale -III (WAIS-III). 1997.
29. Reitan RM. Validity of the trailmaking test as a indication of organic brain damage. Percept Mot Skills 1958;8:271–276.
30. Benton AL, Hamsher K. Multilingual aphasia examination. Iowa City, IA: University of Iowa; 1976.
31. Delis DC, Kramer JH, Kaplan E, Ober B. California verbal learning test. New York, NY: Psychological Corporation; 1987.
32. Wechsler D Wechsler Memory Scale, 3rd ed. San Antonio, TX: Psychological Corp; 1997.
33. Rey A. Test de copia de una figura compleja. Manual adaptación española. Madrid: TEA ediciones, 1997.
34. Heaton RK. Wisconsin card sorting test manual. Odessa, FL: Psychological Assessment Resources, 1981.
35. Golden CJ. Stroop colour and word test. Chicago, IL: Stoelting; 1978.
36. Conners CK, Inventor; Conner's continuous performance test for Windows (CPT-II). North Tonawanda, NY: Multi-Health Systems Inc., 2000.
37. Rosa AR, Reinares M, Franco C et al. Clinical predictors of functional outcome of bipolar patients in remission. Bipolar Disord 2009;11:401–409.
38. Pope M, Dudley R, Scott J. Determinants of social functioning in bipolar disorder. Bipolar Disord 2007;9:38–44.
39. Altshuler LL, Post RM, Black DO et al. Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study. J Clin Psychiatry 2006;67:1551–1560.
40. Samalin L, Boyer L, Murru A et al. Residual depressive symptoms, sleep disturbance and perceived cognitive impairment as determinants of functioning in patients with bipolar disorder. J Affect Disord 2017;210:280–286.
41. Murru A, Pacchiarotti I, Verdolini N et al. Modifiable and non-modifiable factors associated with functional impairment during the inter-episodic periods of bipolar disorder. Eur Arch Psychiatry Clin Neurosci 2017; [Epub ahead of print]. https//doi.org/10.1007/s00406-017-0811-0
42. Strejilevich SA, Martino DJ, Murru A et al. Mood instability and functional recovery in bipolar disorders. Acta Psychiatr Scand 2013;128:194–202.
43. Mur M, Portella MJ, Martinez-Aran A, Pifarre J, Vieta E. Influence of clinical and neuropsychological variables on the psychosocial and occupational outcome of remitted bipolar patients. Psychopathology 2009;42:148–156.
44. Tabares-Seisdedos R, Balanza-Martinez V, Sanchez-Moreno J et al. Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord 2008;109:286–299.
45. Martinez-Aran A, Vieta E, Torrent C et al. Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disord 2007;9:103–113.
46. Burdick KE, Goldberg JF, Harrow M. Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand 2010;122:499–506.
47. Bonnin CM, Martinez-Aran A, Torrent C et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. J Affect Disord 2010;121:156–160.
48. Bonnin CM, Gonzalez-Pinto A, Sole B et al. Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder. J Affect Disord 2014;160:50–54.
49. Moore RC, Harmell AL, Harvey PD et al. Improving the understanding of the link between cognition and functional capacity in schizophrenia and bipolar disorder. Schizophr Res 2015;169:121–127.
50. Eklund M, Hansson L, Ahlqvist C. The importance of work as compared to other forms of daily occupations for wellbeing and functioning among persons with long-term mental illness. Community Ment Health J 2004;40:465–477.
51. Nordt C, Muller B, Rossler W, Lauber C. Predictors and course of vocational status, income, and quality of life in people with severe mental illness: a naturalistic study. Soc Sci Med 2007;65:1420–1429.
52. McGurk SR, Mueser KT, Pascaris A. Cognitive training and supported employment for persons with severe mental illness: one-year results from a randomized controlled trial. Schizophr Bull 2005;31:898–909.
53. Ikebuchi E, Sato S, Yamaguchi S et al. Does improvement of cognitive functioning by cognitive remediation therapy effect work outcomes in severe mental illness? A secondary analysis of a randomized controlled trial. Psychiatry Clin Neurosci 2017;71:301–308.
54. Torrent C, Bonnin CM, Martinez-Aran A et al. Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 2013;170:852–859.
55. Vieta E, Torrent C. Functional remediation: the pathway from remission to recovery in bipolar disorder. World Psychiatry 2016;15:288–289.
56. Sanchez-Moreno J, Bonnin C, Gonzalez-Pinto A et al. Do patients with bipolar disorder and subsyndromal symptoms benefit from functional remediation? A 12-month follow-up study. Eur Neuropsychopharmacol 2017;27:350–359.
57. Deckersbach T, Nierenberg AA, Kessler R et al. RESEARCH: cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 2010;16:298–307.
58. Demant KM, Vinberg M, Kessing LV, Miskowiak KW. Assessment of subjective and objective cognitive function in bipolar disorder: Correlations, predictors and the relation to psychosocial function. Psychiatry Res 2015;229:565–571.
59. Tarbox SI, Brown LH, Haas GL. Diagnostic specificity of poor premorbid adjustment: comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features. Schizophr Res 2012;141:91–97.
60. Velthorst E, Fett AJ, Reichenberg A et al. The 20-year longitudinal trajectories of social functioning in individuals with psychotic disorders. Am J Psychiatry 2016;174:1075–1085.
61. Sanchez-Moreno J, Martinez-Aran A, Gadelrab HF et al. The role and impact of contextual factors on functioning in patients with bipolar disorder. Disabil Rehabil 2010;32(Suppl 1):S94–S104.
62. Varo C, Jimenez E, Sole B et al. Social cognition in bipolar disorder: focus on emotional intelligence. J Affect Disord 2017;217:210–217.
63. Konstantakopoulos G, Ioannidi N, Typaldou M, Sakkas D, Oulis P. Clinical and cognitive factors affecting psychosocial functioning in remitted patients with bipolar disorder. Psychiatriki 2016;27:182–191.
64. Amoretti S, Bernardo M, Bonnin CM et al. The impact of cognitive reserve in the outcome of first-episode psychoses: 2-year follow-up study. Eur Neuropsychopharmacol 2016;26:1638–1648.
65. Anaya C, Torrent C, Caballero FF, Vieta E, Bonnin CM, Ayuso-Mateos JL. Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life. Acta Psychiatr Scand 2016;133:386–398.
66. Grande I, Sanchez-Moreno J, Sole B et al. High cognitive reserve in bipolar disorders as a moderator of neurocognitive impairment. J Affect Disord 2017;208:621–627.
67. Gitlin MJ, Miklowitz DJ. The difficult lives of individuals with bipolar disorder: A review of functional outcomes and their implications for treatment. J Affect Disord 2017;209:147–154.
68. Sole B, Jimenez E, Torrent C et al. Cognitive impairment in bipolar disorder: treatment and prevention strategies. Int J Neuropsychopharmacol 2017;20:670–680.