Pathophysiology and Treatment of Alien Hand Syndrome

Tremor and Other Hyperkinetic Movements

Volumn 2014, Issue 1, 2014, Pages

  Sarva, Harini ^a   Deik, Andres ^b   Lawrence Severt, William ^a  

^a MAIMONIDES MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alien hand; Alien hand pathophysiology; Alien hand treatment; Callosal variant; Frontal variant; Posterior variant

Indexed keywords

BOTULINUM TOXIN; CLONAZEPAM;

ALIEN HAND SYNDROME; ANOMIA; APHASIA; ARTICLE; ATAXIA; CINGULATE GYRUS; COGNITIVE THERAPY; CONFLICT; CORPUS CALLOSUM; DEMYELINATION; DISTRESS SYNDROME; ELECTROENCEPHALOGRAPHY; HEMIANOPIA; IDEOMOTOR APRAXIA; INJURY; NEOPLASM; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHENOMENOLOGY; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; SUPPLEMENTARY MOTOR AREA; VASCULAR LESION;

EID: 85042951195     PISSN: None     EISSN: 21608288     Source Type: Journal    
DOI: 10.7916/D8VX0F48     Document Type: Article

References (109)

1. Park YW, Kim CH, Kim MO, Jeong HJ, Jung HY. Alien hand syndrome in stroke - case report & neurophysiologic study. Ann Rehabil Med 2012;36:556– 560, doi: http://dx.doi.org/10.5535/arm.2012.36.4.556.
2. Chan JL, Chen RS, Ng KK. Leg manifestation in alien hand syndrome. J Formos Med Assoc1996;95:342–346.
3. Carrilho PE, Caramelli P, Cardoso F, Barbosa ER, Buchpiguel CA. Nitrini R. Involuntary hand levitation associated with parietal damage: Another alien hand syndrome. Arq.Neuropsiquiatr 2001;59:521–525, doi: http://dx.doi. org/10.1590/S0004-282X2001000400007.
4. Doody RS, Jankovic J. The alien hand and related signs. J Neurol Neurosurg Psychiatry 1992;55:806–810, doi: http://dx.doi.org/10.1136/jnnp.55.9.806.
5. Brainin M, Seiser A, Matz K. The mirror world of motor inhibition: The alien hand syndrome in chronic stroke. J Neurol Neurosurg Psychiatry 2008;79:246– 252, doi: http://dx.doi.org/10.1136/jnnp.2007.116046.
6. Park YW, Kim CH, Kim MO, Jeong HJ, Jung HY. Alien hand syndrome in stroke - case report & neurophysiologic study -. Ann Rehabil Med 2012;36(4): 556–560, doi: http://dx.doi.10.5535/arm.2012.36.4.556.
7. Nash R, Wilson M, Adams M, Kitchen N. Spontaneous pneumocephalus presenting with alien limb phenomena. J Laryngol Otol 2012;126:733–736, doi: http://dx.doi.org/10.1017/S002221511200093X.
8. Vincent MB, Hadjikhani N. Migraine aura and related phenomena: Beyond scotomata and scintillations. Cephalalgia 2007;27:1368–1377, doi: http://dx.doi.org/10.1111/j.1468-2982.2007.01388.x.
9. Feinberg TE, Roane DM, Cohen J. Partial status epilepticus associated with asomatognosia and alien hand-like behaviors [corrected]. Arch Neurol 1998: 55:1574–1576, doi: http://dx.doi.org/10.1001/archneur.55.12.1574.
10. Carrazana E, Rey G, Rivas-Vazquez R, Tatum W. “Ictal” alien hand syndrome. Epilepsy Behav 2001;2:61–64, doi: http://dx.doi.org/10.1006/ebeh. 2000.0139.
11. Takenouchi T, Solomon GE. Alien hand syndrome in Parry-Romberg syndrome. Pediatr Neurol 2010;42:280–282, doi: http://dx.doi.org/10.1016/j. pediatrneurol.2009.11.010.
12. Brion S, Jedynak CP. [Disorders of internemispheric transfer (callosal disconnection). 3 cases of tumor of the corpus callosum. The strange hand sign]. Rev Neurol (Paris)1972;126:257–266.
13. Biran I, Chatterjee A. Alien hand syndrome. Arch Neurol 2004;61:292– 294, doi: http://dx.doi.org/10.1001/archneur.61.2.292.
14. Feinberg TE, Schindler RJ, Flanagan NG, Haber LD. Two alien hand syndromes. Neurology 1992;42:19–24, doi: http://dx.doi.org/10.1212/WNL.42. 1.19.
15. Huang Y, Jia J. Corpus callosum hematoma secondary to cerebral venous malformation presenting as alien hand syndrome..Neurocase 2013;19: 377–381, doi: http://dx.doi.org/10.1080/13554794.2012.690420.
16. Geschwind DH, Iacoboni M, Mega MS, Zaidel DW, Cloughesy T, Zaidel E. Alien hand syndrome: Interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum. Neurology 1995;45:802–808, doi: http://dx.doi.org/10.1212/WNL.45.4.802.
17. Nandhagopal R, Al-Asmi A, Johnston WJ, Jacob PC, Arunodaya GR. Callosal warning syndrome. J Neurol Sci 2012;314:178–180, doi: http://dx.doi. org/10.1016/j.jns.2011.10.007.
18. Kloesel B, Czarnecki K, Muir JJ, Keller AS. Sequelae of a left-sided parietal stroke: Posterior alien hand syndrome. Neurocase 2010;16:488–493, doi: http://dx.doi.org/10.1080/13554794.2010.497154.
19. Prakash KM, Ting SK, Ahmad MT. Unusually increased arm swing in an apraxic upper limb in corticobasal syndrome. Parkinsonism Relat Disord 2011: 17:126–127, doi: http://dx.doi.org/10.1016/j.parkreldis.2010.09.008.
20. Rohde S, Weidauer S, Lanfermann H, Zanella F. Posterior alien hand syndrome: Case report..Neuroradiology 2002;44:921–923, doi: http://dx.doi.org/ 10.1007/s00234-002-0839-2.
21. Gondim FA, Oliveira GR, Cruz-Flores S. Position-dependent levitation of the dominant arm after left parietal stroke: An unreported feature of posterior alien limb syndrome? Mov Disord 2005;20:632–633, doi: http://dx.doi.org/10. 1002/mds.20404.
22. Yuan JL, Wang SK, Guo XJ, Hu WL. Acute infarct of the corpus callosum presenting as alien hand syndrome: Evidence of diffusion weighted imaging and magnetic resonance angiography. BMC Neurol 2011;11:142, doi: http://dx.doi.org/10.1186/1471-2377-11-142.
23. Levine DN, Rinn WE. Opticosensory ataxia and alien hand syndrome after posterior cerebral artery territory infarction. Neurology 1986;36:1094–1097. doi: http://dx.doi.org/10.1212/WNL.36.8.1094.
24. Spector AR, Freeman WD, Cheshire WP. The stroke that struck back: An unusual alien hand presentation. J Stroke Cerebrovasc Dis 2009;18:72–73, doi: http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2008.08.003.
25. Chand P, Grafman J, Dickson D, Ishizawa K, Litvan I. Alzheimer’s disease presenting as corticobasal syndrome. Mov Disord 2006;21:2018–2022. doi: http://dx.doi.org/10.1002/mds.21055.
26. Rubin M, Graff-RadfordJ, Boeve B, Josephs KA, Aksamit AJ. The alien limb phenomenon and Creutzfeldt-Jakob disease. Parkinsonism Relat Disord 2012: 18:842–846, doi: http://dx.doi.org/10.1016/j.parkreldis.2012.04.009.
27. Kumral E. Compulsive grasping hand syndrome: A variant of anarchic hand. Neurology 2001;57:2143–2144, doi: http://dx.doi.org/10.1212/WNL.57. 11.2143.
28. MacGowan DJ, Delanty N, Petito F, Edgar M, Mastrianni J, DeArmond SJ. Isolated myoclonic alien hand as the sole presentation of pathologically established Creutzfeldt-Jakob disease: A report of two patients. J Neurol Neurosurg Psychiatry 1997;63:404–407, doi: http://dx.doi.org/10.1136/jnnp.63.3.404.
29. Hidalgo-Borrajo R, Belaunzaran-Mendizabal J, Hernaez-Goni P. Tirapu-Ustarroz J, Luna-Lario P. [Alien hand syndrome: A review of the literature]. Rev Neurol2009;48:534–539.
30. Scepkowski LA, Cronin–Golomb A. The alien hand: Cases, categorizations, and anatomical correlates. Behav Cogn Neurosci Rev 2003;2:261–277, doi: http://dx.doi.org/10.1177/1534582303260119.
31. Schaefer M, Heinze HJ, Galazky I. Alien hand syndrome: Neural correlates of movements without conscious will. PLoS One 2010;5:el5010, doi: http://dx.doi.org/10.1371/journal.pone.0015010.
32. Delrieu J, Payoux P, Toulza O, Esquerre JP, Vellas B, Voisin T. Sensory alien hand syndrome in corticobasal degeneration: A cerebral blood flow study. Mov Disord 2010;25:1288–1291, doi: http://dx.doi.org/10.1002/mds.23064.
33. Kim HY, Kim JY, Kim GU, Han HJ, Shin DI. Alien hand syndrome after epilepsia partialis continua: FDG PET and MRI studies. Epilepsy Behav 2012;23:71–73, doi: http://dx.doi.org/10.1016/j.yebeh.2011.08.043.
34. Kritikos A, Breen N, Mattingley JB. Anarchic hand syndrome: Bimanual coordination and sensitivity to irrelevant information in unimanual reaches. Brain Res Cogn Brain Rss 2005;24:634–647, doi: http://dx.doi.org/10.1016/j. cogbrainres. 2005.03.015.
35. Aboitiz F, Carrasco X, Schroter C, Zaidel D, Zaidel E, Lavados M. The alien hand syndrome: Classification of forms reported and discussion of a new condition. Neurol Sci 2003;24:252–257, doi: http://dx.doi.org/10.1007/s10072-003-0149-4.
36. Banks G, Short P, Martinez J, Latchaw R, Ratcliff G, Boiler F. The alien hand syndrome. Clinical and postmortem findings. Arch Neurol 1989;46:456– 459, doi: http://dx.doi.org/10.1001/archneur.1989.00520400116030.
37. Giovannetti T, Buxbaum LJ, Biran I, Chatterjee A. Reduced endogenous control in alien hand syndrome: Evidence from naturalistic action. Neuropsychologia 2005;43:75–88, doi: http://dx.doi.org/10.1016/j. neuropsychologia.2004.06.017.
38. McBride J, Sumner P, Jackson SR, Bajaj N, Husain M. Exaggerated object affordance and absent automatic inhibition in alien hand syndrome. Cortex 2013;49:2040–2054, doi: http://dx.doi.org/10.1016/jxortex.2013.01. 004.
39. Leiguarda R, Starkstein S, Nogues M, Berthier M, Arbelaiz R. Paroxysmal alien hand syndrome. J Neurol Neurosurg Psychiatry 1993;56:788– 792, doi: http://dx.doi.org/10.1136/jnnp.56.7.788.
40. Brazdil M, Kuba R, Rektor I. Rostral cingulate motor area and paroxysmal alien hand syndrome. J Neurol Neurosurg Psychiatry 2006;77:992–993, doi: http://dx.doi.org/10.1136/jnnp.2005.082529.
41. Jang SH, Lee J, Yeo SS, Chang MC. Callosal disconnection syndrome after corpus callosum infarct: A diffusion tensor tractography study. J Stroke Cerebrovasc Dis 2013;22:e240–244, doi: http://dx.doi.org/10.1016/j. jstrokecerebrovasdis.2012.10.015.
42. Verleger R, Binkofski F, Friedrich M, Sedlmeier P, Kompf D. Anarchic-hand syndrome: ERP reflections of lost control over the right hemisphere. Brain Cogn 2011;77:138–150, doi: http://dx.doi.org/10.1016/j.bandc.2011.05.004.
43. Bundick T, Jr., Spinella M. Subjective experience, involuntary movement, and posterior alien hand syndrome. J Neurol Neurosurg Psychiatry 2000;68: 83–85, doi:http://dx.doi.org/10.1136/jnnp.68.1.83.
44. Garbarini F, Pia L, Piedimonte A, Rabuffetti M, Gindri P, Berti A. Embodiment of an alien hand interferes with intact-hand movements. Curr Biol 2013;23:R57–58, doi: http://dx.doi.org/10.1016/j.cub.2012.12.003.
45. Perez Velazquez JL. The biophysical bases of will-less behaviors. Front Integr Neurosci2012;6:98.
46. Graff-Radford J, Rubin MN, Jones DT, et al. The alien limb phenomenon. J Neurol2013;260:1880–1888.
47. Kessler J, Hathout G. Dominant posterior-variant alien hand syndrome after acute left parietal infarction. Clin Neurol Neurosurg 2009; 111:633–635, doi: http://dx.doi.org/10.1016/j.clineuro.2009.05.006.
48. Shereef H, Cavanna AE. The “brother’s arm:” alien hand syndrome after right posterior parietal lesion. J Neuropsychiatry Clin Neurosci 2013;25:E02. doi: http://dx.doi.org/10.1176/appi.neuropsych.12080193.
49. Filevich E, Kuhn S, Haggard P. Intentional inhibition in human action: The power of 'no'. Neurosci Biobehav Rev 2012;36:1107–1118, doi:http://dx.doi. org/10.1016/j.neubiorev.2012.01.006.
50. Marey-Lopez J, Rubio-Nazabal E, Alonso-Magdalena L, Lopez-Facal S. Posterior alien hand syndrome after a right thalamic infarct. J Neurol Neurosurg Psychiatry 2002;73:447–449, doi: http://dx.doi.org/10.1136/jnnp.73.4.447.
51. Bartolo M, Zucchella C, Pichiecchio A, Pucci E, Sandrini G, Sinforiani E. Alien hand syndrome in left posterior stroke. Neurol Sci 2011;32:483–486, doi: http://dx.doi.org/10.1007/s10072-011-0490-y.
52. Groom KN, Ng WK, Kevorkian CG, Levy JK. Ego-syntonic alien hand syndrome after right posterior cerebral artery stroke. Arch Phys Med Rehabil 1999: 80:162–165, doi: http://dx.doi.org/10.1016/S0003-9993(99)90114-4.
53. Jang SH, Yeo SS, Chang MC. Unusual compensatory neural connections following disruption of corpus callosum fibers in a patient with corpus callosum hemorrhage. Int J Neurosci2013;123:892–895.
54. Schaefer M, Heinze HJ, Galazky I. Alien hand syndrome: Neural correlates of movements without conscious will. PLoS ONE2010;5:e1501.
55. Assal F, Schwartz S, Vuilleumier P. Moving with or without will: Functional neural correlates of alien hand syndrome. Ann Neurol 2007;62:301–306, doi: http://dx.doi.org/10.1002/ana.21173.
56. Pappalardo A, Ciancio MR, Reggio E, Patti F. Posterior alien hand syndrome: Case report and rehabilitative treatment. Neurorehabil Neural Repair 2004;18:176–181, doi: http://dx.doi.org/10.1177/0888439004269031.
57. Trojano L, Crisci C, Lanzillo B, Elefante R, Caruso G. How many alien hand syndromes? Follow-up of a case. Neurology 1993;43:2710–2712, doi: http://dx.doi.org/10.1212/WNL.43.12.2710.
58. 58.Lin JH, Kwan SY, Wu D. Mixed alien hand syndrome coexisting with left-sided extinction secondary to a left corpus callosal lesion: A case report. Mov Disord 2007;22:248–251, doi: http://dx.doi.org/10.1002/mds.21241.
59. Rafiei N, Chang GY. Right sensory alien hand phenomenon from a left pontine hemorrhage. J Clin Neurol 2009;5:46–48, doi: http://dx.doi.org/10. 3988/jcn.2009.5.1.46.
60. Wolpe N, Moore JW, Rae CL, et al. The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome. Brain 2014;137:208–220, doi: http://dx.doi.org/10.1093/brain/awt302.
61. Haq IU, Malaty IA, Okun MS, Jacobson CE, Fernandez HH, Rodriguez RR. Clonazepam and botulinum toxin for the treatment of alien limb phenomenon. Neurologist 2010;16:106–108, doi: http://dx.doi.org/10. 1097/NRL.0b013e3181a0d670.
62. Pooyania S, Mohr S, Gray S. Alien hand syndrome: A case report and description to rehabilitation. Disabil Rehabil 2011;33:1715–1718, doi: http://dx.doi.org/10.3109/09638288.2010.540290.
63. Bakheit AM, Brennan A, Gan P, Green H, Roberts S. Anarchic hand syndrome following resection of a frontal lobe tumor. Neurocase 2013; 19:36–40. doi: http://dx.doi.org/10.1080/13554794.2011.654213.
64. Kikkert MA, Ribbers GM, Koudstaal PJ. Alien hand syndrome in stroke: A report of 2 cases and review of the literature. Arch Phys Med Rehabil 2006;87: 728–732, doi: http://dx.doi.org/10.1016/j.apmr.2006.02.002.
65. Cantagallo A, Spinazzola L, Rabuffetti M, Delia Sala S. Verbal commands help the execution of endogenous movements in anarchic hand..Neuropsychol Rehabil 2010;20:406–422, doi: http://dx.doi.org/10.1080/09602010903345298.
66. Romano D, Sedda A, Dell’aquila R, et al. Controlling the alien hand through the mirror box. A single case study of alien hand syndrome. Neurocase 2014;20:307–316, doi: http://dx.doi.org/10.1080/13554794.2013.770882.
67. Nowak DA, Bosl K, Ludemann-Podubecka J, Gdynia HJ, Ponfick M. Recovery and outcome of frontal alien hand syndrome after anterior cerebral artery stroke. J Neurol Sci 2014;338:203–206, doi: http://dx.doi.org/10.1016/j. jns.2014.01.007.
68. Pack BC, Stewart KJ, Diamond PT, Gale SD. Posterior-variant alien hand syndrome: Clinical features and response to rehabilitation. Disabil Rehabil 2002;24:817–818, doi: http://dx.doi.org/10.1080/09638280210142202.
69. Goldstein K. Zur Lehre der motorischen apraxia. J Psychol Neurol1908: 11:169–187.
70. Akelaitis A. Studies on the corpus callosum, IV. Diagnostic dyspraxia in epileptics following partial and complete section of the corpus callosum. Am J Psychiatry1945;101:594–599.
71. Goldberg G, Mayer NH, Toglia JU. Medial frontal cortex infarction and the alien hand sign. Arch Neurol 1981;38:683–686, doi: http://dx.doi.org/10.1001/archneur.1981.00510110043004.
72. McNabb AW, Carroll WM, Mastaglia FL. “Alien hand” and loss of bimanual coordination after dominant anterior cerebral artery territory infarction. J Neurol Neurosurg Psychiatry 1988;51:218–222, doi: http://dx.doi. org/10.1136/jnnp.51.2.218.
73. Goldberg G, Bloom KK. The alien hand sign. Localization, lateralization and recovery. Am J Phys Med Rehabil 1990;69:228–238, doi: http://dx.doi.org/10.1097/00002060-199010000-00002.
74. Kuhn MJ, Shekar PC, Schuster J, Buckler RA, Couch SM. CT and MR findings in a patient with alien hand sign. AJNR Am J Neuroradiol1990;11:1162–1163.
75. 75.Delia Sala S, Marchetti C, Spinnler H. Right-sided anarchic (alien) hand: A longitudinal study. Neuropsychologia 1991;29:1113–1127, doi: http://dx.doi.org/10.1016/0028-3932(91)90081-1.
76. Hanakita J, Nishi S. Left alien hand sign and mirror writing after left anterior cerebral artery infarction. Surg Neurol 1991;35:290–293, doi: http://dx.doi.org/10.1016/0090-3019(91)90007-V.
77. Gottlieb D, Robb K, Day B. Mirror movements in the alien hand syndrome. Case report. Am J Phys Med Rehabil 1992;71:297–300, doi: http://dx.doi.org/10.1097/00002060-199210000-00009.
78. Dolado AM, Castrillo C, Urra DG, Varela de Seijas E. Alien hand sign or alien hand syndrome? J Neurol Neurosurg Psychiatry 1995;59:100–101, doi: http://dx.doi.org/10.1136/jnnp.59.1.100.
79. 79.Green RC, Goldstein FC, Mirra SS, Alazraki NP, Baxt JL, Bakay RA. Slowly progressive apraxia in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1995;59:312–315, doi: http://dx.doi.org/10.1136/jnnp.59.3.312.
80. Ventura MG, Goldman S, Hildebrand J. Alien hand syndrome without a corpus callosum lesion. J Neurol Neurosurg Psychiatry 1995;58:735–737, doi: http://dx.doi.org/10.1136/jnnp.58.6.735.
81. 81.Giroud M, Dumas R. Clinical and topographical range of callosal infarction: A clinical and radiological correlation study. J Neurol Neurosurg Psychiatry 1995;59:238–242, doi: http://dx.doi.org/10.1136/jnnp.59.3.238.
82. Nagumo T, Yamadori A. Callosal disconnection syndrome and knowledge of the body: A case of left hand isolation from the body schema with names. J Neurol Neurosurg Psychiatry 1995;59:548–551, doi: http://dx.doi.org/10. 1136/jnnp.59.5.548.
83. Papagno C, Marsile C. Transient left-sided alien hand with callosal and unilateral fronto-mesial damage: A case study. Neuropsychologia 1995;33:1703–1709, doi: http://dx.doi.org/10.1016/0028-3932(95)00044-5.
84. Kischka U, Ettlin TM, Lichtenstern L, Riedo C. Alien hand syndrome of the dominant hand and ideomotor apraxia of the nondominant hand. Eur Neurol 1996;36:39–42, doi: http://dx.doi.org/10.1159/000117198.
85. Tanaka Y, Yoshida A, Kawahata N, Hashimoto R, Obayashi T. Diagonistic dyspraxia. Clinical characteristics, responsible lesion and possible underlying mechanism. Brain 1996; 119 (Pt 3):859–873, doi: http://dx.doi.org/ 10.1093/brain/119.3.859.
86. Andre C, Dominques RC. Transient alien hand syndrome: Is this a seizure or a transient ischaemic attack? J Neurol Neurosurg Psychiatry 1996;60:232–233, doi: http://dx.doi.org/10.1136/jnnp.60.2.232.
87. Chan JL, Ross ED. Alien hand syndrome: Influence of neglect on the clinical presentation of frontal and callosal variants. Cortex 1997;33:287–299. doi: http://dx.doi.org/10.1016/S0010-9452(08)70005-4.
88. Nicholas JJ, Wichner MH, Gorelick PB, Ramsey MM. “Naturalization” of the alien hand: Case report. Arch Phys Med Rehabil 1998;79:113–114, doi: http://dx.doi.org/10.1016/S0003-9993(98)90218-0.
89. Tow AM, Chua HC. The alien hand sign—case report and review of the literature. Ann Acad Med Singapore1998;27:582–585.
90. Ay H, Buonanno FS, Price BH, Le DA, Koroshetz WJ. Sensory alien hand syndrome: Case report and review of the literature. J Neurol Neurosurg Psychiatry 1998;65:366–369, doi: http://dx.doi.org/10.1136/jnnp.65.3.366.
91. Marti-Fabregas J, Kulisevsky J, Baro E, Mendoza G, Valencia C, Marti-Vilalta JL. Alien hand sign after a right parietal infarction. Cerebrovasc Dis 2000: 10:70–72, doi: http://dx.doi.org/10.1159/000016028.
92. Fisher CM. Alien hand phenomena: A review with the addition of six personal cases. Can J Neurol Sci2000;27:192–203.
93. Ong Hai BG, Odderson IR. Involuntary masturbation as a manifestation of stroke-related alien hand syndrome. Am J Phys Med Rehabil 2000;79:395–398. doi: http://dx.doi.org/10.1097/00002060-200007000-00012.
94. Inzelberg R, Nisipeanu P, Blumen SC, Carasso RL. Alien hand sign in Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 2000;68:103–104, doi: http://dx.doi.org/10.1136/jnnp.68.1.103.
95. Nishikawa T, Okuda J, Mizuta I, et al. Conflict of intentions due to callosal disconnection. J Neurol Neurosurg Psychiatry 2001;71:462–471, doi: http://dx.doi.org/10.1136/jnnp.71.4.462.
96. Lavados M, Carrasco X, Pena M, Zaidel E, Zaidel D, Aboitiz F. A new sign of callosal disconnection syndrome: Agonistic dyspraxia. A case study. Neurocase 2002;8:480–483, doi: http://dx.doi.org/10.1076/neur.8.5.480. 16178.
97. Suwanwela NC, Leelacheavasit N. Isolated corpus callosal infarction secondary to pericallosal artery disease presenting as alien hand syndrome. J Neurol Neurosurg Psychiatry2002;72:533–536.
98. Iwashita T, Kitazawa K, Koyama J, et al. A saccular-like dissecting aneurysm of the anterior cerebral artery that developed 2 years after an ischemic event. Surg Neurol 2005;64:538–541, discussion 541, doi: http://dx.doi. org/10.1016/j.surneu.2005.01.023.
99. Espinosa PS, Smith CD, Berger JR. Alien hand syndrome. Neurology 2006;67:E21, doi: http://dx.doi.org/10.1212/01.wnl.0000249303.88754.48.
100. Kurne A, Cakmakli GY, Karabudak R. Recurrent alien hand syndrome in a multiple sclerosis case. Neurologist 2008;14:316–317, doi: http://dx.doi.org/10.1097/NRL.0b013e318172cf5e.
101. Caixeta L. Altered state of corporal consciousness related to alien hand syndrome and schizophrenic motor passivity. Rev Bras Psiquiatr 2008;30:290–291, doi: http://dx.doi.org/10.1590/S1516-44462008000300017.
102. Bejot Y, Caillier M, Osseby GV, et al. Involuntary masturbation and hemiballismus after bilateral anterior cerebral artery infarction. Clin Neurol Neurosurg 2008;110:190–193, doi: http://dx.doi.org/10.1016/j.clineuro.2007.09.007.
103. Soman T, Steeves TD, Lang AE. Alien hand syndrome and dystonia in a pediatric patient. Mov Disord 2009;24:1557–1559, doi: http://dx.doi.org/10. 1002/mds.22620.
104. Kim YD, Lee ES, Lee KS, Kim JS. Callosal alien hand sign following a right parietal lobe infarction. J Clin Neurosci 2010;17:796–797, doi: http://dx.doi.org/10.1016/j.jocn.2009.10.018.
105. Faber R, Azad A, Reinsvold R. A case of the corpus callosum and alien hand syndrome from a discrete paracallosal lesion. Neurocase 2010;16:281–285. doi: http://dx.doi.org/10.1080/13554790903456217.
106. Terazzi E, Mittino D, Monaco F. Posterior alien hand in a left-handed person. BMJ Case Rep 2010; doi: http://dx.doi.org/10.1136/bcr.10.2010.3401.
107. Hertza J, Davis AS, Barisa M, Lemann ER. Atypical sensory alien hand syndrome: A case study. Appl Neuropsychol Adult 2012;19:71–77, doi: http://dx.doi.org/10.1080/09084282.2011.643950.
108. Lunardelli A SA, Mengotti P, Rumiati RI, Pesavento V. Intermittent alien hand syndrome and callosal apraxia in multiple sclerosis: Implications for internemispheric communication. Behavioral Neurology 2014;2014:873541, doi: http://dx.doi.org/10.1155/2014/873541.
109. Chokar GCA, Gough A, Hasan S, Scullion D, El-Sayeh H, Buccoliero R. A case of Parry-Romberg syndrome and alien hand. J Neurol Sci 2014;341: 153–157, doi: http://dx.doi.org/10.1016/j.jns.2014.04.004.