Comparison of the Alere i Strep A test and the BD veritor system in the detection of group a streptococcus and the hypothetical impact of results on antibiotic utilization

Journal of Clinical Microbiology

Volumn 56, Issue 3, 2018, Pages

  Berry, Gregory J ^b   Miller, Catherine R ^a   Prats, Mariana Moreno ^a   Marquez, Christopher ^a   Oladipo, Olajumoke O ^a,c   Loeffelholz, Michael J ^a   Petersen, John R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Department of Pathology and Laboratory Medicine ^*  (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Alere i; Antibiotic utilization; BD veritor; Group A streptococcus; Point of care testing (POCT)

Indexed keywords

ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG USE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MOLECULAR DIAGNOSIS; NONHUMAN; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STREPTOCOCCAL PHARYNGITIS; STREPTOCOCCUS GROUP A; CLINICAL TRIAL; DIAGNOSTIC TEST; IMMUNOASSAY; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTICENTER STUDY; NUCLEIC ACID AMPLIFICATION; PHARYNX; REPRODUCIBILITY; STANDARDS; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES;

ANTIINFECTIVE AGENT;

ANTI-BACTERIAL AGENTS; DIAGNOSTIC TESTS, ROUTINE; HUMANS; IMMUNOASSAY; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PHARYNX; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES;

EID: 85042619194     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01310-17     Document Type: Article

References (15)

1. Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, Martin JM, Van Beneden C. 2012. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis 55:e86–e102. https://doi.org/10.1093/cid/cis629.
2. Bisno AL. 1996. Acute pharyngitis: etiology and diagnosis. Pediatrics 97(6 Part 2):949–954.
3. Ebell MH, Smith MA, Barry HC, Ives K, Carey M. 2000. The rational clinical examination. Does this patient have strep throat? JAMA 284:2912–2918.
4. Vaz LE, Kleinman KP, Raebel MA, Nordin JD, Lakoma MD, Dutta-Linn MM, Finkelstein JA. 2014. Recent trends in outpatient antibiotic use in children. Pediatrics 133:375–385. https://doi.org/10.1542/peds.2013-2903.
5. Carapetis JR, Steer AC, Mulholland EK, Weber M. 2005. The global burden of group A streptococcal diseases. Lancet Infect Dis 5:685–694. https://doi.org/10.1016/S1473-3099(05)70267-X.
6. Centers for Disease Control and Prevention. 2015. Active bacterial core surveillance report. Emerging Infections Program Network. Group A Streptococcus—2015. Centers for Disease Control and Prevention, Atlanta, GA.
7. Wannamaker LW. 1972. Perplexity and precision in the diagnosis of streptococcal pharyngitis. Am J Dis Child 124:352–358.
8. Gurol Y, Akan H, Izbirak G, Tekkanat ZT, Gunduz TS, Hayran O, Yilmaz G. 2010. The sensitivity and the specificity of rapid antigen test in streptococcal upper respiratory tract infections. Int J Pediatr Otorhinolaryngol 74:591–593. https://doi.org/10.1016/j.ijporl.2010.02.020.
9. Tanz RR, Gerber MA, Kabat W, Rippe J, Seshadri R, Shulman ST. 2009. Performance of a rapid antigen-detection test and throat culture in community pediatric offices: implications for management of pharyngitis. Pediatrics 123:437–444. https://doi.org/10.1542/peds.2008-0488.
10. Gerber MA, Shulman ST. 2004. Rapid diagnosis of pharyngitis caused by group A streptococci. Clin Microbiol Rev 17:571–580. https://doi.org/10.1128/CMR.17.3.571-580.2004.
11. Fleiss JL. 1981. Statistical methods for rates and proportions, 2nd ed, p xviii. John Wiley & Sons, Inc, New York, NY.
12. Wang F, Tian Y, Chen L, Luo R, Sickler J, Liesenfeld O, Chen S. 2016. Accurate detection of Streptococcus pyogenes at the point of care using the Cobas Liat Strep A nucleic acid test. Clin Pediatr (Phila) 56:1128–1134. https://doi.org/10.1177/0009922816684602.
13. Uhl JR, Patel R. 2016. Fifteen-minute detection of Streptococcus pyogenes in throat swabs by use of a commercially available point-of-care PCR assay. J Clin Microbiol 54:815. https://doi.org/10.1128/JCM.03387-15.
14. Cohen DM, Russo ME, Jaggi P, Kline J, Gluckman W, Parekh A. 2015. Multicenter clinical evaluation of the novel Alere i Strep A isothermal nucleic acid amplification test. J Clin Microbiol 53:2258–2261. https://doi.org/10.1128/JCM.00490-15.
15. Brendish NJ, Malachira AK, Armstrong L, Houghton R, Aitken S, Nyimbili E, Ewings S, Lillie PJ, Clark TW. 2017. Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial. Lancet Respir Med 5:401–411. https://doi.org/10.1016/S2213-2600(17)30120-0.