Inhibitory and bactericidal effect of Artilysin® Art-175 against colistin-resistant mcr-1-positive Escherichia coli isolates

International Journal of Antimicrobial Agents

Volumn 51, Issue 3, 2018, Pages 528-529

  Schirmeier, Eva ^a   Zimmermann, Pia ^b   Hofmann, Veronika ^a   Biebl, Manfred ^a   Gerstmans, Hans ^c,d,e   Maervoet, Veerle E T ^c   Briers, Yves ^c  

^a Lisando GmbH   (Germany)

^b Bavarian Health and Food Safety Authority   (Germany)

^c GHENT UNIVERSITY   (Belgium)

^d LABORATORY OF GENE TECHNOLOGY   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ART 175; ARTILYSIN; BACTERICIDE; COLISTIN; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ART-175; CATHELICIDIN; ESCHERICHIA COLI PROTEIN; FUSION PROTEIN; MCR-1 PROTEIN, E COLI; PROTEINASE;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL OUTER MEMBRANE; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; BROTH DILUTION; COMPARATIVE EFFECTIVENESS; CROSS RESISTANCE; DRUG EFFECT; DRUG EFFICACY; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; LETTER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MCR 1 GENE; MINIMUM INHIBITORY CONCENTRATION; MOLECULE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; ANIMAL; BOVINE; ESCHERICHIA COLI INFECTION; GENETICS; GERMANY; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PIG; VETERINARY MEDICINE;

ANIMALS; ANTI-BACTERIAL AGENTS; CATHELICIDINS; CATTLE; COLISTIN; DRUG RESISTANCE, BACTERIAL; ENDOPEPTIDASES; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; GERMANY; MICROBIAL SENSITIVITY TESTS; RECOMBINANT FUSION PROTEINS; SWINE;

EID: 85041608574     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2017.08.027     Document Type: Letter

References (5)

1. Liu, Y.Y., Wang, Y., Walsh, T.R., Yi, L.X., Zhang, R., Spencer, J., et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16 (2016), 161–168.
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3. Gerstmans, H., Rodriguez-Rubio, L., Lavigne, R., Briers, Y., From endolysins to Artilysin®s: novel enzyme-based approaches to kill drug-resistant bacteria. Biochem Soc Trans 44 (2016), 123–128.
4. Defraine, V., Schuermans, J., Grymonprez, B., Govers, S.K., Aertsen, A., Fauvart, M., et al. Efficacy of Artilysin Art-175 against resistant and persistent Acinetobacter baumannii. Antimicrob Agents Chemother 60 (2016), 3480–3488.
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