Circulating, cell-free DNA as a marker for exercise load in intermittent sports

PLoS ONE

Volumn 13, Issue 1, 2018, Pages

  Haller, Nils ^a   Helmig, Susanne ^a   Taenny, Pascal ^a   Petry, Julian ^a   Schmidt, Sebastian ^a   Simon, Perikles ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CELL FREE DNA; LACTIC ACID; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CELL FREE NUCLEIC ACID;

ADULT; ARTICLE; BODY HEIGHT; BODY WEIGHT; COHORT ANALYSIS; CONTROLLED STUDY; EXERCISE; FEMALE; FOOTBALL PLAYER; HUMAN; HUMAN EXPERIMENT; INFORMED CONSENT; LIMIT OF QUANTITATION; LONG INTERSPERSED REPEAT; MALE; NORMAL HUMAN; REAL TIME POLYMERASE CHAIN REACTION; STANDARDIZATION; METABOLISM; SPORT;

BIOMARKERS; CELL-FREE NUCLEIC ACIDS; EXERCISE; FEMALE; HUMANS; MALE; SPORTS;

EID: 85041091074     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0191915     Document Type: Article

References (34)

1. Ispirlidis I, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Michailidis I, Douroudos I, et al. Time-course of changes in inflammatory and performance responses following a soccer game. Clinical journal of sport medicine: official journal of the Canadian Academy of Sport Medicine. 2008; 18(5): 423-31. Epub 2008/09/23.
2. Halson SL. Monitoring training load to understand fatigue in athletes. Sports medicine. 2014; 44 Suppl 2: S139-47. Epub 2014/09/10.
3. Marques-Jimenez D, Calleja-Gonzalez J, Arratibel I, Delextrat A, Terrados N. Fatigue and Recovery in Soccer: Evidence and Challenges. The Open Sports Sciences Journal. 2017; 10(Suppl 1: M5): 52-70.
4. Akenhead R, Nassis GP. Training Load and Player Monitoring in High-Level Football: Current Practice and Perceptions. International journal of sports physiology and performance. 2016; 11(5): 587-93. Epub 2015/10/13. https://doi.org/10.1123/ijspp.2015-0331 PMID: 26456711
5. Swarup V, Rajeswari MR. Circulating (cell-free) nucleic acids-A promising, non-invasive tool for early detection of several human diseases. FEBS letters. 2007; 581(5): 795-9. Epub 2007/02/10. https://doi.org/10.1016/j.febslet.2007.01.051 PMID: 17289032
6. Breitbach S, Tug S, Simon P. Circulating cell-free DNA: an up-coming molecular marker in exercise physiology. Sports medicine. 2012; 42(7): 565-86. Epub 2012/06/15. https://doi.org/10.2165/11631380-000000000-00000 PMID: 22694348
7. Atamaniuk J, Vidotto C, Tschan H, Bachl N, Stuhlmeier KM, Muller MM. Increased concentrations of cell-free plasma DNA after exhaustive exercise. Clin Chem. 2004; 50(9): 1668-70. Epub 2004/08/28. https://doi.org/10.1373/clinchem.2004.034553 PMID: 15331502
8. Atamaniuk J, Stuhlmeier KM, Vidotto C, Tschan H, Dossenbach-Glaninger A, Mueller MM. Effects of ultra-marathon on circulating DNA and mRNA expression of pro-And anti-Apoptotic genes in mononuclear cells. Eur J Appl Physiol. 2008; 104(4): 711-7. Epub 2008/07/25. https://doi.org/10.1007/s00421-008-0827-2 PMID: 18651163
9. Fatouros IG, Destouni A, Margonis K, Jamurtas AZ, Vrettou C, Kouretas D, et al. Cell-free plasma DNA as a novel marker of aseptic inflammation severity related to exercise overtraining. Clinical chemistry. 2006; 52(9): 1820-4. Epub 2006/07/15. https://doi.org/10.1373/clinchem.2006.070417 PMID: 16840584
10. Atamaniuk J, Vidotto C, Kinzlbauer M, Bachl N, Tiran B, Tschan H. Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise. European journal of applied physiology. 2010; 110(4): 695-701. Epub 2010/06/26. https://doi.org/10.1007/s00421-010-1532-5 PMID: 20577758
11. Fatouros IG, Jamurtas AZ, Nikolaidis MG, Destouni A, Michailidis Y, Vrettou C, et al. Time of sampling is crucial for measurement of cell-free plasma DNA following acute aseptic inflammation induced by exercise. Clin Biochem. 2010; 43(16-17): 1368-70. Epub 2010/08/31. https://doi.org/10.1016/j. clinbiochem.2010.08.020 PMID: 20800058
12. Beiter T, Fragasso A, Hudemann J, Niess AM, Simon P. Short-Term treadmill running as a model for studying cell-free DNA kinetics in vivo. Clinical chemistry. 2011; 57(4): 633-6. Epub 2011/02/08. https://doi.org/10.1373/clinchem.2010.158030 PMID: 21296972
13. Breitbach S, Sterzing B, Magallanes C, Tug S, Simon P. Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise. Journal of applied physiology. 2014; 117 (2): 119-30. Epub 2014/05/31. https://doi.org/10.1152/japplphysiol.00002.2014 PMID: 24876361
14. Helmig S, Fruhbeis C, Kramer-Albers EM, Simon P, Tug S. Release of bulk cell free DNA during physical exercise occurs independent of extracellular vesicles. European journal of applied physiology. 2015; 115(11): 2271-80. Epub 2015/07/02. https://doi.org/10.1007/s00421-015-3207-8 PMID: 26126838
15. Tug S, Mehdorn M, Helmig S, Breitbach S, Ehlert T, Simon P. Exploring the Potential of cfDNA Measurements After an Exhaustive Cycle Ergometer Test as a Marker for Performance Related Parameters. International journal of sports physiology and performance. 2016: 1-24. Epub 2016/09/13.
16. Velders M, Treff G, Machus K, Bosnyak E, Steinacker J, Schumann U. Exercise is a potent stimulus for enhancing circulating DNase activity. Clin Biochem. 2014; 47(6): 471-4. Epub 2014/01/01. https://doi.org/10.1016/j.clinbiochem.2013.12.017 PMID: 24373926
17. Haller N, Tug S, Breitbach S, Jorgensen A, Simon P. Increases in Circulating, Cell-Free DNA During Aerobic Running Depend on Intensity and Duration. International journal of sports physiology and performance. 2016: 1-21. Epub 2016/09/13.
18. Krustrup P, Mohr M, Steensberg A, Bencke J, Kjaer M, Bangsbo J. Muscle and blood metabolites during a soccer game: implications for sprint performance. Medicine and science in sports and exercise. 2006; 38(6): 1165-74. Epub 2006/06/16. https://doi.org/10.1249/01.mss.0000222845.89262.cd PMID: 16775559
19. Fatouros IG, Chatzinikolaou A, Douroudos II, Nikolaidis MG, Kyparos A, Margonis K, et al. Time-course of changes in oxidative stress and antioxidant status responses following a soccer game. Journal of strength and conditioning research/National Strength & Conditioning Association. 2010; 24(12): 3278-86. Epub 2009/12/10.
20. Breitbach S, Tug S, Helmig S, Zahn D, Kubiak T, Michal M, et al. Direct quantification of cell-free, circulating DNA from unpurified plasma. PloS one. 2014; 9(3): e87838. Epub 2014/03/07. https://doi.org/10.1371/journal.pone.0087838 PMID: 24595313
21. Cunniffe B, Hore AJ, Whitcombe DM, Jones KP, Baker JS, Davies B. Time course of changes in immuneoendocrine markers following an international rugby game. European journal of applied physiology. 2010; 108(1): 113-22. Epub 2009/09/17. https://doi.org/10.1007/s00421-009-1200-9 PMID: 19756700
22. Ascensao A, Rebelo A, Oliveira E, Marques F, Pereira L, Magalhaes J. Biochemical impact of a soccer match-Analysis of oxidative stress and muscle damage markers throughout recovery. Clinical biochemistry. 2008; 41(10-11): 841-51. Epub 2008/05/07. https://doi.org/10.1016/j.clinbiochem.2008.04. 008 PMID: 18457670
23. Chatzinikolaou A, Draganidis D, Avloniti A, Karipidis A, Jamurtas AZ, Skevaki CL, et al. The microcycle of inflammation and performance changes after a basketball match. Journal of sports sciences. 2014; 32(9): 870-82. Epub 2014/02/01. https://doi.org/10.1080/02640414.2013.865251 PMID: 24479464
24. Andersson H, Bohn SK, Raastad T, Paulsen G, Blomhoff R, Kadi F. Differences in the inflammatory plasma cytokine response following two elite female soccer games separated by a 72-h recovery. Scandinavian journal of medicine & science in sports. 2010; 20(5): 740-7. Epub 2009/09/22.
25. Romagnoli M, Sanchis-Gomar F, Alis R, Risso-Ballester J, Bosio A, Graziani RL, et al. Changes in muscle damage, inflammation, and fatigue-related parameters in young elite soccer players after a match. The Journal of sports medicine and physical fitness. 2016; 56(10): 1198-205. Epub 2016/11/04. PMID: 26558831
26. Nedelec M, McCall A, Carling C, Legall F, Berthoin S, Dupont G. Recovery in soccer: part I-postmatch fatigue and time course of recovery. Sports medicine. 2012; 42(12): 997-1015. Epub 2012/10/11. https://doi.org/10.2165/11635270-000000000-00000 PMID: 23046224
27. Thorpe R, Sunderland C. Muscle Damage, Endocrine, and Immune Marker Response to a Soccer Match. Journal of Strength and Conditioning Research. 2012; 26(10): 2783-90. https://doi.org/10.1519/JSC.0b013e318241e174 PMID: 22124357
28. Coutts AJ, Rampinini E, Marcora SM, Castagna C, Impellizzeri FM. Heart rate and blood lactate correlates of perceived exertion during small-sided soccer games. Journal of science and medicine in sport/Sports Medicine Australia. 2009; 12(1): 79-84. Epub 2007/12/11.
29. Tug S, Helmig S, Deichmann ER, Schmeier-Jurchott A, Wagner E, Zimmermann T, et al. Exerciseinduced increases in cell free DNA in human plasma originate predominantly from cells of the haematopoietic lineage. Exercise immunology review. 2015; 21: 164-73. Epub 2015/04/01. PMID: 25826002
30. Beiter T, Fragasso A, Hudemann J, Schild M, Steinacker J, Mooren FC, et al. Neutrophils release extracellular DNA traps in response to exercise. Journal of applied physiology. 2014; 117(3): 325-33. https://doi.org/10.1152/japplphysiol.00173.2014 PMID: 24833781
31. Villa F. Detection of Circulating Tumor DNA Moves Closer To Clinical Use. Prevention and Infection Control. 2015.
32. Evans CJ, Aguilera RJ. DNase II: genes, enzymes and function. Gene. 2003; 322: 1-15. Epub 2003/12/04. PMID: 14644493
33. Hermansen L, Osnes JB. Blood and muscle pH after maximal exercise in man. J Appl Physiol. 1972; 32 (3): 304-8. Epub 1972/03/01. https://doi.org/10.1152/jappl.1972.32.3.304 PMID: 5010039
34. Osnes JB, Hermansen L. Acid-base balance after maximal exercise of short duration. J Appl Physiol. 1972; 32(1): 59-63. Epub 1972/01/01. https://doi.org/10.1152/jappl.1972.32.1.59 PMID: 5007019