Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up

International Journal of Cancer

Volumn 142, Issue 11, 2018, Pages 2244-2253

  Heikkilä, Pia ^a,b   But, Anna ^d   Sorsa, Timo ^a,b,c   Haukka, Jari ^d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

cancer; low grade inflammation; mortality; pancreatic cancer; periodontitis

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CANCER MORTALITY; CANCER RISK; COHORT ANALYSIS; CONTROLLED STUDY; DENTAL PROCEDURE; DENTAL SURGERY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE REGISTRY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUTH HYGIENE; PERIODONTITIS; PRIORITY JOURNAL; PUBLICATION; RISK FACTOR; SEX; SOCIAL STATUS; TIME FACTOR; COMPLICATION; FINLAND; HEALTH SURVEY; MORTALITY; NEOPLASM; REGISTER; SOCIOECONOMICS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FINLAND; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PERIODONTITIS; POPULATION SURVEILLANCE; REGISTRIES; SOCIOECONOMIC FACTORS;

EID: 85040867484     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.31254     Document Type: Article

References (44)

1. Kassebaum NJ, Bernabé E, Dahiya M, et al. Global burden of severe periodontitis in 1990–2010. J Dent Res 2014;93:1045–53.
2. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366:1809–20.
3. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol 2011;7:738–48.
4. D'Aiuto F, Parkar M, Andreou G, et al. Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res. 2004;83:156–60.
5. Tonetti MS, D'Aiuto F, Nibali L, et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007;356:911–20.
6. Plummer M, de Martel C, Vignat J. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health. 2016;4:609–16.
7. Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008;454:436–44.
8. Tezal M, Sullivan MA, Hyland A, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prevent 2009;18:2406–12.
9. Meyer MS, Joshipura K, Giovannucci E, et al. A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control 2008;19:895–907.
10. Moraes RC, de Dias FL, Figueredo Cm da S, Fischer RG. Association between chronic periodontitis and oral/oropharyngeal cancer. Braz Dent J 2016;27:261–6.
11. Ansai T, Takata Y, Yoshida A, et al. Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study. BMC Public Health 2013;13:814
12. Ahn J, Segers S, Hayes RB. Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis 2012;33:1055–8.
13. Grover V, Kapoor A, Sehgal K, et al. Chronic inflammation and carcinogenesis – emerging role of chronic inflammatory periodontal disease. Cancer Res Front 2016;2:200–225.
14. Statistics Finland - Health - Causes of death [Internet]. [cited 2016 Nov 7] Available from: http://www.stat.fi/til/ksyyt/index_en.html
15. Overview of benefit programmes 2007. Finland: Social Insurance Institution, 2007.
16. WHO | International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3) [Internet]. [cited 2014 Feb 25]; Available from: http://www.who.int/classifications/icd/adaptations/oncology/en/
17. Teppo L, Pukkala E, Lehtonen M. Data quality and quality control of a population-based cancer registry. Experience in Finland. Acta Oncol 1994;33:365–9.
18. Korhonen P, Malila N, Pukkala E, et al. The Finnish Cancer Registry as follow-up source of a large trial cohort–accuracy and delay. Acta Oncol 2002;41:381–8.
19. Ainamo J, Barmes D, Beagrie G, et al. Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN). Int Dent J 1982;32:281–91.
20. World Health Organization. Oral health surveys: basic methods. Enquêtes sur la santé bucco-dentaire: méthodes fondamentales [Internet] 1997 [cited 2016 Nov 7]; Available from: http://www.who.int/iris/handle/10665/41905
21. R Core Team. R: A language and environment for statistical computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing, 2016. Available from: https://www.R-project.org/
22. Plummer M, Carstensen B. Lexis: an R class for epidemiological studies with long-term follow-up. J Stat Soft 2011;38:1–12.
23. Boshuizen HC, Feskens EJ. Fitting additive Poisson models. Epidemiol Perspect Innov 2010;7:4
24. Carstensen B, Plummer M, Laara MH, et al. Epi: A package for statistical analysis in epidemiology. [Internet]. 2008. Available from: http://www.pubhealth.ku.dk/bxc/Epi/
25. Widström E, Nihtilä A. Aikuisten hammashoito suurten ja keskisuurten kaupunkien terveyskeskuksissa. 2004 [cited 2016 Dec 19]; Available from: http://www.julkari.fi/handle/10024/100487
26. Irfan UM, Dawson DV, Bissada NF. Epidemiology of periodontal disease: a review and clinical perspectives. J Int Acad Periodontol 2001;3:14–21.
27. Papapanou PN. Periodontal diseases: epidemiology. Ann Periodontol 1996;1:1–36.
28. Liljestrand JM, Havulinna AS, Paju S, Männistö S, Salomaa V, Pussinen PJ. Missing teeth predict incident cardiovascular events, diabetes, and death. J Dent Res. 2015;0022034515586352.
29. Cancer of the Pancreas - SEER Stat Fact Sheets [Internet]. [cited 2016 Nov 7]; Available from: http://seer.cancer.gov/statfacts/html/pancreas.html Abnet CC, Qiao YL, Mark SD, Dong ZW, Taylor PR, Dawsey SM. Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes Control 2001;12:847–54.
30. Cancer statistics - Cancer Society of Finland [Internet]. [cited 2016 Nov 7];Available from: http://www.cancer.fi/syoparekisteri/en/statistics/cancer-statistics/
31. Fitzpatrick SG, Katz J, The association between periodontal disease and cancer: A review of the literature. J Dent 2003;13:312–95.
32. Abnet CC, Qiao Y-L, Dawsey SM, et al. Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol 2005;34:467–74.
33. Abnet CC, Qiao YL, Mark SD, et al. Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes Control 2001;12:847–54.
34. Cabrera C, Hakeberg M, Ahlqwist M, et al. Can the relation between tooth loss and chronic disease be explained by socio-economic status? A 24-year follow-up from the population study of women in Gothenburg, Sweden. Eur J Epidemiol 2005;20:229–36.
35. Hujoel PP, Drangsholt M, Spiekerman C, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol 2003;13:312–6.
36. Tu Y-K, Galobardes B, Smith GD, et al. Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort. Heart 2007;93:1098–103.
37. Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol 2008;9:550–8.
38. Stolzenberg-Solomon RZ, Dodd KW, Blaser MJ, et al. Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr 2003;78:176–81.
39. Michaud DS, Joshipura K, Giovannucci E, et al. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst 2007;99:171–5.
40. Michaud DS, Izard J, Wilhelm-Benartzi CS, et al. Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut 2013;62:1764–70.
41. Fan X, Alekseyenko AV, Wu J, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2016;
42. Preshaw PM, Alba AL, Herrera D, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia 2012;55:21–31.
43. Petersen PE, Yamamoto T. Improving the oral health of older people: the approach of the WHO Global Oral Health Prpgramme. Community Dent Oral Epidemiol 2005;33:81–92.
44. Sorsa T, Gieselmann D, Arweiler NB, et al. A quantitative point-of-care test for periodontal and dental peri-implant diseases. Nat Rev Dis Primers 2017;3:17069.