Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual Review of Pharmacology and Toxicology

Volumn 58, Issue , 2018, Pages 65-82

  Ewart, Lorna ^a   Dehne, Eva Maria ^b   Fabre, Kristin ^a   Gibbs, Susan ^c,d   Hickman, James ^e   Hornberg, Ellinor ^f   Ingelman Sundberg, Magnus ^g   Jang, Kyung Jin ^h   Jones, David R ⁱ   Lauschke, Volker M ^g   Marx, Uwe ^b   Mettetal, Jerome T ^a   Pointon, Amy ^a   Williams, Dominic ^a   Zimmermann, Wolfram Hubertus ^j,k   Newham, Peter ^a  

^a ASTRAZENECA   (United Kingdom)

^b TISSUSE GMBH   (Germany)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF CENTRAL FLORIDA   (United States)

^f ASTRAZENECA R AND D   (Sweden)

^g KAROLINSKA INSTITUTE   (Sweden)

^h Emulate Inc   (United States)

ⁱ MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

^j UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^k DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

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Author keywords

drug discovery; microphysiological systems; toxicology

Indexed keywords

DRUG DEVELOPMENT; DRUG METABOLISM; DRUG SAFETY; GASTROINTESTINAL TRACT; HEART; HUMAN; IN VITRO STUDY; INFORMATION SYSTEM; KIDNEY; LIVER; LUNG; MATHEMATICAL MODEL; MICROPHYSIOLOGICAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SKIN; ANIMAL; CHEMISTRY; PRECLINICAL STUDY; PROCEDURES;

DRUG;

ANIMALS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; PHARMACEUTICAL PREPARATIONS;

EID: 85040620605     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010617-052722     Document Type: Review

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