Automated Collagen Proportional Area Extraction in Liver Biopsy Images Using a Novel Classification via Clustering Algorithm

Proceedings - IEEE Symposium on Computer-Based Medical Systems

Volumn 2017-June, Issue , 2017, Pages 30-34

  Tsouros, Dimosthenis C ^a   Smyrlis, Panagiotis N ^a   Tsipouras, Markos G ^a   Tsalikakis, Dimitrios G ^a   Giannakeas, Nikolaos ^b   Tzallas, Alexandros T ^b   Manousou, Pinelopi ^c  

^a UNIVERSITY OF WESTERN MACEDONIA   (Greece)

^b Epirus Institute of Technology Arta   (Greece)

^c NATIONAL HEALTH SERVICE   (United Kingdom)

Author keywords

collagen proportional area; liver biobsy image processing; liver fibrosis

Indexed keywords

BIOPSY; CLUSTERING ALGORITHMS; COLLAGEN; DIAGNOSIS; GEOMETRY; IMAGE CLASSIFICATION; IMAGE SEGMENTATION;

CLASSIFICATION RESULTS; EFFECTIVE TOOL; K-MEANS CLUSTERING; LIVER BIOPSIES; LIVER FIBROSIS; OBJECTIVE ASSESSMENT; STATE OF THE ART; THERAPEUTIC EFFICACY;

IMAGE PROCESSING;

EID: 85040366968     PISSN: 10637125     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/CBMS.2017.99     Document Type: Conference Paper

References (15)

1. Y. Huang, W. B. de Boer, L. A. Adams, G. MacQuillan, M. K. Bulsara, and G. P. Jeffrey, "Image analysis of liver biopsy samples measures fibrosis and predicts clinical outcome," Journal of Hepatology, vol. 61, pp. 22-27, 2014..
2. R. G. Knodell, K. G. Ishak, W. C. Black, T. S. Chen, R. Craig, N. Kaplowitz, T. W. Kiernan, and J. Wollman, "Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis," Hepatology, vol. 1, pp. 431-435, 1981.
3. P. J. Scheuer, "Classification of chronic viral hepatitis: a need for reassessment," Journal of Hepatology, vol. 13, pp. 372-374, 1991.
4. P. Bedossa, T. Poynard, and the French METAVIR Cooperative Study Group, "An algorithm for grading activity in chronic hepatitis C," Hepatology, vol. 24, pp. 289-293, 1996.
5. K. Ishak, A. Baptista, L. Bianchi, F. Callea, J. DeGroote, F. Gudat, H. Denk, et al., "Histological grading and staging of chronic hepatitis," Journal of Hepatology, vol. 22, pp. 696-699, 1995.
6. P. Manousou, A. P. Dhillon, G. Isgro, V. Calvaruso, T. V. Luong, E. Tsochatzis, E. Xirouchakis, G. Kalambokis, T. J. Cross, N. Rolando, J. O'Beirne, D. Patch, D. Thornburn, and A. K. Burroughs, "Digital image analysis of liver collagen predicts clinical outcome of recurrent hepatitis C virus 1 year after liver transplantation," Liver Transplantation, vol. 17, pp. 178-188, 2011.
7. M. G. Tsipouras, N. Giannakeas, A. T. Tzallas, Z. E. Tsianou, P. Manousou, A. Hall, I. Tsoulos, and E. Tsianos, "A Methodology for Automated CPA Extraction using Liver Biopsy Image Analysis and Machine Learning Techniques," Computer Methods and Programs in Biomedicine, vol. 140, pp. 61-68, 2016.
8. C. F. F. Campos, D. D. Paiva, H. Perazzo, P. S. Moreira, L. F. F. Areco, C. Terra, R. Perez, and F. A. F. Figueiredo, "An inexpensive and worldwide available digital image analysis technique for histological fibrosis quantification in chronic hepatitis C," Journal of Viral Hepatitis, vol. 21, pp. 216-222, 2014.
9. V. Calvaruso, A. P. Dhillon, E. Tsochatzis, P. Manousou, F. Grillo, G. Germani, D. Patch, J. O'Beirne, and A. K. Burroughs, "Liver collagen proportionate area predicts decompensation in patients with recurrent hepatitis C virus cirrhosis after liver transplantation. Journal of Gastroenterology and Hepatology, vol. 27, pp. 1227-1232, 2012.
10. S. C. Raftopoulos, J. George, M. Bourliere, E. Rossi, W. B. de Boer, G. P. Jeffrey, M. Bulsara, D. J. Speers, G. MacQuillan, H. L. I. Ching, N. Kontorinis, W. Cheng, J. Flexman, S. Fermoyle, P. Rigby, L. Walsh, D. McLeod, and L. A. Adams, "Comparison of noninvasive models of fibrosis in chronic hepatitis," Hepatology International, vol. 6, pp. 457-67, 2012.
11. C. Pilette, M. C. Rousselet, P. Bedossa, D. Chappard, F. Oberti, H. Rifflet, et al., "Histopathological evaluation of liver fibrosis: quantitative image analysis vs semi-quantitative scores," Journal of Hepatology, vol. 28, pp. 439-446, 1998.
12. M. Masseroli, T. Caballero, F. O'Valle, R. M. G Del Moral, A. Perez-Milena, and R. G Del Moral, "Automatic quantification of liver fibrosis design and validation of a new image analysis method: comparison with semiquantitative indexes of fibrosis," Journal of Hepatology, vol. 32, pp. 453-464, 2000.
13. S. Xu, Y. Wang, D. C. S. Tai, S. Wang, C. L. Cheng, Q. Peng, J. Yan, Y. Chen, J. Sun, X. Liang, Y. Zhu, J. C. Rajapakse, R. E. Welsch, P. T. C. So, A. Wee, J. Hou, and H. Yu, "qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients," Journal of Hepatology, vol. 61, pp. 260-269, 2014.
14. N. Giannakeas, M. G. Tsipouras, A. T. Tzallas, K. Kyriakidi, Z. E. Tsianou, P. Manousou, A. Hall, E. Karvounis, V. Tsianos, and E. Tsianos, "A clustering based method for collagen proportional area extraction in liver biopsy images," 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Milano, Italy, pp. 3097-3100, 2015.
15. J. B. MacQueen, "Some Methods for classification and Analysis of Multivariate Observations," in Proceedings of 5th Berkeley Symposium on Mathematical Statistics and Probability, Berkeley, University of California Press, vol.1, pp.281-297, 1967.