Chasing seasonal influenza - The need for a universal influenza vaccine

New England Journal of Medicine

Volumn 378, Issue 1, 2018, Pages 7-9

  Paules, Catharine I ^a   Sullivan, Sheena G ^b   Subbarao, Kanta ^b   Fauci, Anthony S ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b WHO COLLABORATING CENTRE FOR REFERENCE AND RESEARCH ON INFLUENZA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; RECOMBINANT VACCINE;

ANTIBODY RESPONSE; ANTIGENICITY; DISEASE BURDEN; DRUG EFFICACY; EPIDEMIC; HOSPITALIZATION; HUMAN; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA VACCINATION; PRIORITY JOURNAL; REVIEW; SEASONAL INFLUENZA; VIRUS STRAIN; EGG; GENETICS; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS; MUTATION; TREATMENT OUTCOME;

EGGS; HUMANS; INFLUENZA A VIRUS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MUTATION; TREATMENT OUTCOME;

EID: 85040363548     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp1714916     Document Type: Review

References (5)

1. Sullivan SG, Chilver MB, Carville KS, et al. Low interim influenza vaccine effectiveness, Australia, 1 May to 24 September 2017. Euro Surveill 2017;22:17-00707.
2. Influenza (flu). Atlanta: Centers for Disease Control and Prevention (https://www.cdc.gov/flu/index.htm).
3. Wu NC, Zost SJ, Thompson AJ, et al. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog 2017;13(10):e1006682.
4. Zost SJ, Parkhouse K, Gumina ME, et al. Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proc Natl Acad Sci U S A 2017 November 6 (Epub ahead of print).
5. Paules CI, Marston HD, Eisinger RW, Baltimore D, Fauci AS. The pathway to a universal influenza vaccine. Immunity 2017;47:599-603.