메뉴 건너뛰기




Volumn 9, Issue 2, 2018, Pages 2912-2922

The dawn of the liquid biopsy in the fight against cancer

Author keywords

CfDNA; CtDNA; Diagnostics; Early detection; Liquid biopsy

Indexed keywords

BIOLOGICAL MARKER; CELL FREE DNA; CIRCULATING TUMOR DNA; DNA; MICRORNA; UNCLASSIFIED DRUG;

EID: 85039993648     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.23131     Document Type: Review
Times cited : (91)

References (90)
  • 1
    • 85039978108 scopus 로고    scopus 로고
    • Definition of liquid biopsy-NCI Dictionary of Cancer Terms-National Cancer Institute
    • National Cancer Institute. Definition of liquid biopsy-NCI Dictionary of Cancer Terms-National Cancer Institute
  • 2
    • 84957852098 scopus 로고
    • [Les acides nucléiques du plasma sanguin chez l'homme]. [Article in French]
    • Mandel P, Metais P. [Les acides nucléiques du plasma sanguin chez l'homme]. [Article in French]. C R Seances Soc Biol Fil. 1948; 142:241-3
    • (1948) C R Seances Soc Biol Fil , vol.142 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 3
    • 84934912108 scopus 로고    scopus 로고
    • Circulating cell-free DNA: The blood biopsy in cancer management
    • McLarty JL, Yeh CH. Circulating cell-free DNA: The blood biopsy in cancer management. Cell Sci Rep. 2015; 2:00021
    • (2015) Cell Sci Rep , vol.2 , pp. 00021
    • McLarty, J.L.1    Yeh, C.H.2
  • 4
    • 85044697273 scopus 로고    scopus 로고
    • Cell-free DNA screening for fetal aneuploidy. Obs Gynecol. 2015; 126: e31-e37
    • (2015) Obs Gynecol , vol.126
  • 8
    • 84855564475 scopus 로고    scopus 로고
    • Next-Generation Sequencing for Cancer Diagnostics: a Practical Perspective
    • Meldrum C, Doyle MA, Tothill RW. Next-Generation Sequencing for Cancer Diagnostics: a Practical Perspective. Clin Biochem Rev. 2011; 32:177-95
    • (2011) Clin Biochem Rev , vol.32 , pp. 177-195
    • Meldrum, C.1    Doyle, M.A.2    Tothill, R.W.3
  • 9
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008; 455:1061-8
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 10
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • The Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011; 474:609-15
    • (2011) Nature , vol.474 , pp. 609-615
  • 11
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • The Cancer Genome Atlas Research Network. Integrated genomic characterization of endometrial carcinoma. Nature. 2013; 497:67-73
    • (2013) Nature , vol.497 , pp. 67-73
  • 12
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • The Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014; 511:543-50
    • (2014) Nature , vol.511 , pp. 543-550
  • 13
    • 84873979331 scopus 로고    scopus 로고
    • Assessment of clinical analytical sensitivity and specificity of next-generation sequencing for detection of simple and complex mutations
    • Chin EL, da Silva C, Hegde M. Assessment of clinical analytical sensitivity and specificity of next-generation sequencing for detection of simple and complex mutations. BMC Genet. 2013; 14:6
    • (2013) BMC Genet , vol.14 , pp. 6
    • Chin, E.L.1    da Silva, C.2    Hegde, M.3
  • 14
    • 84953438804 scopus 로고    scopus 로고
    • Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices
    • Ko J, Carpenter E, Issadore D. Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices. Analyst. 2015; 141:450-60
    • (2015) Analyst , vol.141 , pp. 450-460
    • Ko, J.1    Carpenter, E.2    Issadore, D.3
  • 16
    • 84931563886 scopus 로고    scopus 로고
    • Liquid biopsy for cancer patients: Principles and practice
    • Cree IA. Liquid biopsy for cancer patients: Principles and practice. Pathogenesis. 2015; 2:1-4
    • (2015) Pathogenesis , vol.2 , pp. 1-4
    • Cree, I.A.1
  • 17
    • 84920508228 scopus 로고    scopus 로고
    • Circulating tumor DNA as a liquid biopsy for cancer
    • Heitzer E, Ulz P, Geigl JB. Circulating tumor DNA as a liquid biopsy for cancer. Clin Chem. 2015; 61:112-23
    • (2015) Clin Chem , vol.61 , pp. 112-123
    • Heitzer, E.1    Ulz, P.2    Geigl, J.B.3
  • 18
    • 84983518002 scopus 로고    scopus 로고
    • Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?
    • Lewis AR, Valle JW, McNamara MG. Pancreatic cancer: Are 'liquid biopsies' ready for prime-time? World J Gastroenterol. 2016; 22:7175-85
    • (2016) World J Gastroenterol , vol.22 , pp. 7175-7185
    • Lewis, A.R.1    Valle, J.W.2    McNamara, M.G.3
  • 21
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: Genotyping circulating tumor DNA
    • Diaz LA, Bardelli A. Liquid biopsies: Genotyping circulating tumor DNA. Journal of Clinical Oncology. 2014; 32:579-86
    • (2014) Journal of Clinical Oncology , vol.32 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 26
    • 84964700391 scopus 로고    scopus 로고
    • Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy
    • Alix-Panabières C, Pantel K. Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy. Cancer Discov. 2016; 6:479-91
    • (2016) Cancer Discov , vol.6 , pp. 479-491
    • Alix-Panabières, C.1    Pantel, K.2
  • 27
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011; 11:426-37
    • (2011) Nat Rev Cancer , vol.11 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 28
    • 84982782719 scopus 로고    scopus 로고
    • Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer
    • Cheng F, Su L, Qian C. Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer. Oncotarget. 2016; 7:48832-41. https://doi.org/10.18632/ oncotarget.9453
    • (2016) Oncotarget , vol.7 , pp. 48832-48841
    • Cheng, F.1    Su, L.2    Qian, C.3
  • 30
    • 85029058356 scopus 로고    scopus 로고
    • Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: A prospective study
    • Soave A, Chun FK, Hillebrand T, Rink M, Weisbach L, Steinbach B, Fisch M, Pantel K, Schwarzenbach H. Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: A prospective study. Oncotarget. 2017; 8:56398-407. https://doi.org/10.18632/ oncotarget.17657
    • (2017) Oncotarget , vol.8 , pp. 56398-56407
    • Soave, A.1    Chun, F.K.2    Hillebrand, T.3    Rink, M.4    Weisbach, L.5    Steinbach, B.6    Fisch, M.7    Pantel, K.8    Schwarzenbach, H.9
  • 32
    • 84979620819 scopus 로고    scopus 로고
    • Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing
    • Li Z, Guo X, Tang L, Peng L, Chen M, Luo X, Wang S, Xiao Z, Deng Z, Dai L, Xia K, Wang J. Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing. Tumour Biol. 2016; 37:13111-9
    • (2016) Tumour Biol , vol.37 , pp. 13111-13119
    • Li, Z.1    Guo, X.2    Tang, L.3    Peng, L.4    Chen, M.5    Luo, X.6    Wang, S.7    Xiao, Z.8    Deng, Z.9    Dai, L.10    Xia, K.11    Wang, J.12
  • 33
    • 33845476677 scopus 로고    scopus 로고
    • Circulating nucleic acids (CNAs) and cancer-A survey
    • Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancer-A survey. Biochim Biophys Acta. 2007; 1775:181-232
    • (2007) Biochim Biophys Acta , vol.1775 , pp. 181-232
    • Fleischhacker, M.1    Schmidt, B.2
  • 34
    • 84964314311 scopus 로고    scopus 로고
    • Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance
    • Siravegna G, Bardelli A. Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance. Genome Biol. 2014; 15:449
    • (2014) Genome Biol , vol.15 , pp. 449
    • Siravegna, G.1    Bardelli, A.2
  • 37
    • 0000110505 scopus 로고
    • A case of cancer in which cells similar to those in the tumors were seen in the blood after death
    • Ashworth TR. A case of cancer in which cells similar to those in the tumors were seen in the blood after death. The Australian Medical Journal. 1869; 14:146-9
    • (1869) The Australian Medical Journal , vol.14 , pp. 146-149
    • Ashworth, T.R.1
  • 38
    • 84899583483 scopus 로고    scopus 로고
    • Circulating tumor cells as promising novel biomarkers in solid cancers
    • Lianidou ES, Strati A, Markou A. Circulating tumor cells as promising novel biomarkers in solid cancers. Crit Rev Clin Lab Sci. 2014; 51:160-71
    • (2014) Crit Rev Clin Lab Sci , vol.51 , pp. 160-171
    • Lianidou, E.S.1    Strati, A.2    Markou, A.3
  • 39
    • 84868287226 scopus 로고    scopus 로고
    • Detection methods of circulating tumor cells
    • Pantel K, Alix-Panabières C. Detection methods of circulating tumor cells. J Thorac Dis. 2012; 4:446-7
    • (2012) J Thorac Dis , vol.4 , pp. 446-447
    • Pantel, K.1    Alix-Panabières, C.2
  • 40
    • 84857749998 scopus 로고    scopus 로고
    • Expected clinical applications of circulating tumor cells in breast cancer
    • Park Y, Kitahara T, Urita T, Yoshida Y, Kato R. Expected clinical applications of circulating tumor cells in breast cancer. World J Clin Oncol. 2011; 2:303-10
    • (2011) World J Clin Oncol , vol.2 , pp. 303-310
    • Park, Y.1    Kitahara, T.2    Urita, T.3    Yoshida, Y.4    Kato, R.5
  • 43
    • 84958741995 scopus 로고    scopus 로고
    • Cell lines from circulating tumor cells
    • Pantel K, Alix-Panabières C. Cell lines from circulating tumor cells. Oncoscience. 2015; 2:1-2. https://doi. org/10.18632/oncoscience.195
    • (2015) Oncoscience , vol.2 , pp. 1-2
    • Pantel, K.1    Alix-Panabières, C.2
  • 44
    • 84939535871 scopus 로고    scopus 로고
    • Isolation, primary culture, morphological and molecular characterization of circulating tumor cells in gynecological cancers
    • Kolostova K, Spicka J, Matkowski R, Bobek V. Isolation, primary culture, morphological and molecular characterization of circulating tumor cells in gynecological cancers. Am J Transl Res. 2015; 7:1203-13
    • (2015) Am J Transl Res , vol.7 , pp. 1203-1213
    • Kolostova, K.1    Spicka, J.2    Matkowski, R.3    Bobek, V.4
  • 45
    • 84919497950 scopus 로고    scopus 로고
    • In vitro culture and characterization of human lung cancer circulating tumor cells isolated by size exclusion from an orthotopic nude-mouse model expressing fluorescent protein
    • Kolostova K, Zhang Y, Hoffman RM, Bobek V. In vitro culture and characterization of human lung cancer circulating tumor cells isolated by size exclusion from an orthotopic nude-mouse model expressing fluorescent protein. J Fluoresc. 2014; 24:1531-6
    • (2014) J Fluoresc , vol.24 , pp. 1531-1536
    • Kolostova, K.1    Zhang, Y.2    Hoffman, R.M.3    Bobek, V.4
  • 46
    • 84942895082 scopus 로고    scopus 로고
    • Ex vivo culture of CTCs: An emerging resource to guide cancer therapy
    • Maheswaran S, Haber DA. Ex vivo culture of CTCs: An emerging resource to guide cancer therapy. Cancer Res. 2015; 75:2411-5
    • (2015) Cancer Res , vol.75 , pp. 2411-2415
    • Maheswaran, S.1    Haber, D.A.2
  • 47
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9:654-9
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 49
    • 84983028401 scopus 로고    scopus 로고
    • Exosome cancer diagnostic reaches market
    • Sheridan C. Exosome cancer diagnostic reaches market. Nat Biotechnol. 2016; 34:359-60
    • (2016) Nat Biotechnol , vol.34 , pp. 359-360
    • Sheridan, C.1
  • 53
    • 85017099250 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy
    • An M, Lohse I, Tan Z, Zhu J, Wu J, Kurapati H, Morgan MA, Lawrence TS, Cuneo KC, Lubman DM. Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy. J Proteome Res. 2017; 16:1763-72
    • (2017) J Proteome Res , vol.16 , pp. 1763-1772
    • An, M.1    Lohse, I.2    Tan, Z.3    Zhu, J.4    Wu, J.5    Kurapati, H.6    Morgan, M.A.7    Lawrence, T.S.8    Cuneo, K.C.9    Lubman, D.M.10
  • 54
    • 85016421621 scopus 로고    scopus 로고
    • UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer
    • Ning K, Wang T, Sun X, Zhang P, Chen Y, Jin J, Hua D. UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer. J Surg Oncol. 2017; 115:932-40
    • (2017) J Surg Oncol , vol.115 , pp. 932-940
    • Ning, K.1    Wang, T.2    Sun, X.3    Zhang, P.4    Chen, Y.5    Jin, J.6    Hua, D.7
  • 56
    • 85017134879 scopus 로고    scopus 로고
    • Circulating exosomal microRNA-21 as a biomarker in each tumor stage of colorectal cancer
    • Tsukamoto M, Iinuma H, Yagi T, Matsuda K, Hashiguchi Y. Circulating exosomal microRNA-21 as a biomarker in each tumor stage of colorectal cancer. Oncology. 2017; 92:360-70
    • (2017) Oncology , vol.92 , pp. 360-370
    • Tsukamoto, M.1    Iinuma, H.2    Yagi, T.3    Matsuda, K.4    Hashiguchi, Y.5
  • 57
    • 85014008862 scopus 로고    scopus 로고
    • TWEAKstimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA
    • Hu Y, Li D, Wu A, Qiu X, Di W, Huang L, Qiu L. TWEAKstimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA. Cancer Lett. 2017; 393:60-7
    • (2017) Cancer Lett , vol.393 , pp. 60-67
    • Hu, Y.1    Li, D.2    Wu, A.3    Qiu, X.4    Di, W.5    Huang, L.6    Qiu, L.7
  • 58
    • 84872917584 scopus 로고    scopus 로고
    • [MicroRNAs in cancer: from research to clinical practice]. [Article in Spanish]
    • Frontela Noda M. [MicroRNAs in cancer: from research to clinical practice]. [Article in Spanish]. Rev Cubana Med. 2012; 51:325-35
    • (2012) Rev Cubana Med , vol.51 , pp. 325-335
    • Frontela Noda, M.1
  • 59
    • 82755187564 scopus 로고    scopus 로고
    • Extracellular microRNA: A new source of biomarkers
    • Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: A new source of biomarkers. Mutat Res. 2011; 717:85-90
    • (2011) Mutat Res , vol.717 , pp. 85-90
    • Etheridge, A.1    Lee, I.2    Hood, L.3    Galas, D.4    Wang, K.5
  • 60
    • 57649091633 scopus 로고    scopus 로고
    • The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform
    • Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE. The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol Oncol. 2009; 112:55-9
    • (2009) Gynecol Oncol , vol.112 , pp. 55-59
    • Resnick, K.E.1    Alder, H.2    Hagan, J.P.3    Richardson, D.L.4    Croce, C.M.5    Cohn, D.E.6
  • 61
    • 84964301309 scopus 로고    scopus 로고
    • Sequential serum let-7 is a novel biomarker to predict accelerated reproliferation during fractional radiotherapy in lung cancer
    • Xie P, Li X, Tan X, Sun X, Wang C, Yu J. Sequential serum let-7 is a novel biomarker to predict accelerated reproliferation during fractional radiotherapy in lung cancer. Clin Lung Cancer. 2016; 17: e95-e101
    • (2016) Clin Lung Cancer , vol.17
    • Xie, P.1    Li, X.2    Tan, X.3    Sun, X.4    Wang, C.5    Yu, J.6
  • 62
    • 84929467928 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese
    • Shen LQ, Xie YZ, Qian XF, Zhuang ZX, Jiao Y, Qi XF. A single nucleotide polymorphism in the promoter region of let-7 family is associated with lung cancer risk in Chinese. Genet Mol Res. 2015; 14:4505-12
    • (2015) Genet Mol Res , vol.14 , pp. 4505-4512
    • Shen, L.Q.1    Xie, Y.Z.2    Qian, X.F.3    Zhuang, Z.X.4    Jiao, Y.5    Qi, X.F.6
  • 64
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene. 2007; 26:5017-22
    • (2007) Oncogene , vol.26 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 65
    • 34848868157 scopus 로고    scopus 로고
    • Tumorsuppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Tumorsuppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A. 2007; 104:15472-7
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 66
    • 41949102707 scopus 로고    scopus 로고
    • miRiad roles for the miR-17-92 cluster in development and disease
    • Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell. 2008; 133:217-22
    • (2008) Cell , vol.133 , pp. 217-222
    • Mendell, J.T.1
  • 69
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007; 133:647-58
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 70
    • 38149042783 scopus 로고    scopus 로고
    • Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
    • Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 2008; 283:1026-33
    • (2008) J Biol Chem , vol.283 , pp. 1026-1033
    • Frankel, L.B.1    Christoffersen, N.R.2    Jacobsen, A.3    Lindow, M.4    Krogh, A.5    Lund, A.H.6
  • 71
  • 72
    • 85018979823 scopus 로고    scopus 로고
    • Tumor suppressor PTPRJ is a target of miR-155 in colorectal cancer
    • Zhang XF, Tu R, Li K, Ye P, Cui X. Tumor suppressor PTPRJ is a target of miR-155 in colorectal cancer. J Cell Biochem. 2017; 118:3391-400
    • (2017) J Cell Biochem , vol.118 , pp. 3391-3400
    • Zhang, X.F.1    Tu, R.2    Li, K.3    Ye, P.4    Cui, X.5
  • 74
    • 84872353766 scopus 로고    scopus 로고
    • Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer
    • Kan CW, Hahn MA, Gard GB, Maidens J, Huh JY, Marsh DJ, Howell VM. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BMC Cancer. 2012; 12:627
    • (2012) BMC Cancer , vol.12 , pp. 627
    • Kan, C.W.1    Hahn, M.A.2    Gard, G.B.3    Maidens, J.4    Huh, J.Y.5    Marsh, D.J.6    Howell, V.M.7
  • 78
    • 85039983434 scopus 로고    scopus 로고
    • ThunderBolts Cancer Panel
    • RainDance Technologies. ThunderBolts Cancer Panel. 2017
    • (2017) RainDance Technologies
  • 79
    • 85039983434 scopus 로고    scopus 로고
    • ThunderBolts Myeloid Panel
    • RainDance Technologies. ThunderBolts Myeloid Panel. 2017
    • (2017) RainDance Technologies
  • 80
    • 85040015700 scopus 로고    scopus 로고
    • Inviata. Invision
    • Inviata. Invision. 2017
    • (2017)
  • 81
    • 85039980598 scopus 로고    scopus 로고
    • Cancer Monitoring Liquid Biopsy Blood Testing
    • Pathway Genomics. Cancer Monitoring Liquid Biopsy Blood Testing. 2017
    • (2017) Pathway Genomics
  • 83
    • 85006990389 scopus 로고    scopus 로고
    • Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer
    • Spindler KL. Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer. Acta Oncol (Madr). 2017; 56:7-16
    • (2017) Acta Oncol (Madr) , vol.56 , pp. 7-16
    • Spindler, K.L.1
  • 84
    • 84904061727 scopus 로고    scopus 로고
    • Blood-based analysis of cancer: Circulating tumor cells and circulating tumor DNA
    • Haber D, Velculescu V. Blood-based analysis of cancer: Circulating tumor cells and circulating tumor DNA. Cancer Discov. 2014; 4:650-61
    • (2014) Cancer Discov , vol.4 , pp. 650-661
    • Haber, D.1    Velculescu, V.2
  • 86
    • 85007403075 scopus 로고    scopus 로고
    • A comparison of ddPCR and ARMS for detecting EGFR T790M status in ctDNA from advanced NSCLC patients with acquired EGFR-TKI resistance
    • Wang W, Song Z, Zhang Y. A comparison of ddPCR and ARMS for detecting EGFR T790M status in ctDNA from advanced NSCLC patients with acquired EGFR-TKI resistance. Cancer Med. 2017; 6:154-62
    • (2017) Cancer Med , vol.6 , pp. 154-162
    • Wang, W.1    Song, Z.2    Zhang, Y.3
  • 87
    • 84960423132 scopus 로고    scopus 로고
    • Monitoring of treatment responses and clonal evolution of tumor cells by circulating tumor DNA of heterogeneous mutant EGFR genes in lung cancer
    • Imamura F, Uchida J, Kukita Y, Kumagai T, Nishino K, Inoue T, Kimura M, Oba S, Kato K. Monitoring of treatment responses and clonal evolution of tumor cells by circulating tumor DNA of heterogeneous mutant EGFR genes in lung cancer. Lung Cancer. 2016; 94:68-73
    • (2016) Lung Cancer , vol.94 , pp. 68-73
    • Imamura, F.1    Uchida, J.2    Kukita, Y.3    Kumagai, T.4    Nishino, K.5    Inoue, T.6    Kimura, M.7    Oba, S.8    Kato, K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.