Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats

Pharmacological Research

Volumn 130, Issue , 2018, Pages 172-179

  Huć, Tomasz ^a   Nowinski, Artur ^a   Drapala, Adrian ^a   Konopelski, Piotr ^a   Ufnal, Marcin ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Arterial blood pressure; Gut bacteria; Indole; Metabolites; Serotonin receptors

Indexed keywords

FLUPENTIXOL; INDICAN; INDOLE; ONDANSETRON; PIZOTIFEN; INDOLE DERIVATIVE; SEROTONIN; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; HEART RATE; HEMODYNAMICS; HOST PATHOGEN INTERACTION; INTESTINE FLORA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ARTERIAL PRESSURE; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; WISTAR RAT;

ANIMALS; ARTERIAL PRESSURE; GASTROINTESTINAL MICROBIOME; INDICAN; INDOLES; INFUSIONS, INTRAVENOUS; INFUSIONS, INTRAVENTRICULAR; MALE; RATS, WISTAR; SEROTONIN; TRYPTOPHAN;

EID: 85039544852     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2017.12.025     Document Type: Article

References (30)

1. Dampney, R.A., Coleman, M.J., Fontes, M.A., Hirooka, Y., Horiuchi, J., Li, Y.W., Polson, J.W., Potts, P.D., Tagawa, T., Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 29:4 (2002), 261–268.
2. Guyton, A.C., Coleman, T.G., Cowley, A.V. Jr., Scheel, K.W., Manning, R.D. Jr., Norman, R.A. Jr., Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am. J. Med. 52:5 (1972), 584–594.
3. Ufnal, M., Jazwiec, R., Dadlez, M., Drapala, A., Sikora, M., Skrzypecki, J., Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats. Can. J. Cardiol. 30:12 (2014), 1700–1705.
4. Tomasova, L., Dobrowolski, L., Jurkowska, H., Wrobel, M., Huc, T., Ondrias, K., Ostaszewski, R., Ufnal, M., Intracolonic hydrogen sulfide lowers blood pressure in rats. Nitric Oxide 60 (2016), 50–58.
5. Jose, P.A., Raj, D., Gut microbiota in hypertension. Curr. Opin. Nephrol. Hypertens. 24:5 (2015), 403–409.
6. Jaworska, K., Huc, T., Samborowska, E., Dobrowolski, L., Bielinska, K., Gawlak, M., Ufnal, M., Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS One, 12(12), 2017, e0189310.
7. Huc, T., Jurkowska, H., Wrobel, M., Jaworska, K., Onyszkiewicz, M., Ufnal, M., Colonic hydrogen sulfide produces portal hypertension and systemic hypotension in rats. Exp. Biol. Med. (Maywood), 2017 (1535370217741869).
8. Ufnal, M., Skrzypecki, J., Blood borne hormones in a cross-talk between peripheral and brain mechanisms regulating blood pressure, the role of circumventricular organs. Neuropeptides 48:2 (2014), 65–73.
9. Michael, A.F., Drummond, K.N., Doeden, D., Anderson, J.A., Good, R.A., Tryptophan metabolism in man. J. Clin. Invest. 43 (1964), 1730–1746.
10. Rose, D.P., Aspects of tryptophan metabolism in health and disease: a review. J. Clin. Pathol. 25:1 (1972), 17–25.
11. Lee, J.H., Lee, J., Indole as an intercellular signal in microbial communities. FEMS Microbiol. Rev. 34:4 (2010), 426–444.
12. Bansal, T., Alaniz, R.C., Wood, T.K., Jayaraman, A., The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation. Proc. Natl. Acad. Sci. U. S. A. 107:1 (2010), 228–233.
13. Niwa, T., Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120. Ther. Apher. Dial 15:2 (2011), 120–124.
14. Barreto, F.C., Barreto, D.V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R., Massy, Z.A., G. European Uremic Toxin Work, Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin. J. Am. Soc. Nephrol. 4:10 (2009), 1551–1558.
15. Huber, G., Schuster, F., Raasch, W., Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases. Pharmacol. Res. 125:Pt A (2017), 72–90.
16. Simpson, J.B., The circumventricular organs and the central actions of angiotensin. Neuroendocrinology 32:4 (1981), 248–256.
17. Drapala, A., Aleksandrowicz, M., Zera, T., Sikora, M., Skrzypecki, J., Kozniewska, E., Ufnal, M., The effect of simvastatin and pravastatin on arterial blood pressure, baroreflex, vasoconstrictor, and hypertensive effects of angiotensin II in Sprague-Dawley rats. J. Am. Soc. Hypertens. 8:12 (2014), 863–871.
18. Smookler, H.H., Severs, W.B., Kinnard, W.J., Buckley, J.P., Centrally mediated cardiovascular effects of angiotensin II. J. Pharmacol. Exp. Ther. 153:3 (1966), 485–494.
19. Gaskell, J.R., Jones, R.K., Shapiro, A.P., Hyperresponsiveness of renal hypertensive rats to intravenous angiotensin ii. Proc. Soc. Exp. Biol. Med. 115 (1964), 179–182.
20. Alexander, N., Haun, C.K., Cardiovascular responses to central catecholamines of sinoaortic denervated rats. Eur. J. Pharmacol. 63:2–3 (1980), 117–125.
21. Borkowski, K.R., Finch, L., Cardiovascular responses to intraventricular adrenaline in spontaneous hypertensive rats. Eur. J. Pharmacol. 47:3 (1978), 281–290.
22. Kawabe, H., Kondo, K., Saruta, T., Effect of the intracerebroventricular injection of dopamine on blood pressure in the spontaneously hypertensive rat. Clin. Exp. Hypertens. A 5:10 (1983), 1703–1716.
23. Eble, J.N., Gowdey, C.W., Vane, J.R., The potentiation of the cardiovascular responses of the dog to noradrenaline by desmethylimipramine. Br. J. Pharmacol. 39:1 (1970), 185P–186P.
24. Takahashi, H., Cardiovascular and sympathetic responses to intracarotid and intravenous injections of serotonin in rats. Naunyn. Schmiedebergs Arch. Pharmacol. 329:3 (1985), 222–226.
25. Montes, R., Johnson, A.K., Efferent mechanisms mediating renal sodium and water excretion induced by centrally administered serotonin. Am. J. Physiol. 259:6 Pt. 2 (1990), R1267–73.
26. Ferreira, H.S., de Castro e Silva, E., Cointeiro, C., Oliveira, E., Faustino, T.N., Fregoneze, J.B., Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats. Brain Res. 1028:1 (2004), 48–58.
27. Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., Zhang, W., Weldon, R., Auguste, K., Yang, L., Liu, X., Chen, L., Yang, X., Zhu, B., Cai, J., Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome, 5(1), 2017, 14.
28. Tang, W.H., Kitai, T., Hazen, S.L., Gut microbiota in cardiovascular health and disease. Circ. Res. 120:7 (2017), 1183–1196.
29. Qi, Y., Kim, S., Richards, E.M., Raizada, M.K., Pepine, C.J., Gut microbiota potential for a unifying hypothesis for prevention and treatment of hypertension. Circ. Res. 120:11 (2017), 1724–1726.
30. Yang, T., Santisteban, M.M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J.M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., Sahay, B., Pepine, C.J., Raizada, M.K., Mohamadzadeh, M., Gut dysbiosis is linked to hypertension. Hypertension 65:6 (2015), 1331–1340.