Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota

Microbiome

Volumn 5, Issue 1, 2017, Pages 135-

  Wu, Richard Y ^a,b   Määttänen, Pekka ^a,c   Napper, Scott ^d,e   Scruten, Erin ^d   Li, Bo ^a   Koike, Yuhki ^a   Johnson Henry, Kathene C ^a   Pierro, Agostino ^a,f   Rossi, Laura ^g   Botts, Steven R ^a   Surette, Michael G ^g   Sherman, Philip M ^a,b,h  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Burman University   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g MCMASTER UNIVERSITY   (Canada)

^h UNIVERSITY OF TORONTO   (Canada)

Author keywords

E. coli; Kinome; Lipopolysaccharide; Non digestible oligosaccharides; Prebiotics

Indexed keywords

LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NF-KAPPA B KINASE; OLIGOSACCHARIDE; PREBIOTIC AGENT; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL; CACO-2 CELL LINE; CHEMISTRY; DRUG EFFECT; ENDOTOXEMIA; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; MOUSE; PHYSIOLOGY; PROTEIN MICROARRAY; PROTEOMICS; SIGNAL TRANSDUCTION;

ANIMALS; CACO-2 CELLS; ENDOTOXEMIA; GASTROINTESTINAL MICROBIOME; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OLIGOSACCHARIDES; PREBIOTICS; PROTEIN ARRAY ANALYSIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 85037828714     PISSN: None     EISSN: 20492618     Source Type: Journal    
DOI: 10.1186/s40168-017-0357-4     Document Type: Article

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