Development to enable precision medicine in Africa

Personalized Medicine

Volumn 14, Issue 6, 2017, Pages 467-470

  Mulder, Nicola ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Africa; genetic variant; genomic medicine; translational medicine

Indexed keywords

CYTOCHROME P450 2B6; EFAVIRENZ; HEMOGLOBIN S; HYDROXYUREA;

AFRICA; ALGORITHM; BETA GLOBIN GENE; DISEASE BURDEN; DRUG INDUSTRY; DRUG RESPONSE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HEALTH CARE ACCESS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KNOWLEDGE; LAMELLAR ICHTHYOSIS; MENTAL DISEASE; NOTE; PATHOPHYSIOLOGY; PATIENT CARE; PERSONALIZED MEDICINE; PHARMACOGENOMICS; PHENOTYPE; PRIORITY JOURNAL; SICKLE CELL ANEMIA; SINGLE NUCLEOTIDE POLYMORPHISM; SLCO1B1 GENE; TGM1 GENE; TRANSLATIONAL RESEARCH; WHOLE GENOME SEQUENCING; DEVELOPING COUNTRY; HEALTH CARE DELIVERY; HEALTH CARE PLANNING; ORGANIZATION AND MANAGEMENT; PHARMACOGENETICS; PROCEDURES; TRENDS;

AFRICA; DELIVERY OF HEALTH CARE; DEVELOPING COUNTRIES; HEALTH RESOURCES; HUMANS; PHARMACOGENETICS; PRECISION MEDICINE; TRANSLATIONAL MEDICAL RESEARCH;

EID: 85037748369     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme-2017-0055     Document Type: Note

References (15)

1. Schlebusch CM, Skoglund P, Sjödin P et al. Genomic variation in seven khoe-san groups reveals adaptation and complex african history. Science 338(6105), 374-379 (2012).
2. Popejoy AB, Fullerton SM. Genomics is failing on diversity. Nature 538, 161-164 (2016).
3. Uthman OA, Wiysonge CS, Ota MO et al. Increasing the value of health research in the WHO African region beyond 2015-reflecting on the past, celebrating the present and building the future: a bibliometric analysis. BMJ Open 5(3), e006340 (2016).
4. Koshy R, Ranawat A, Scaria V. al mena: a comprehensive resource of human genetic variants integrating genomes and exomes from Arab, Middle Eastern and North African populations. J. Hum. Genet. 62(10), 889-894 (2017).
5. Makani J, Ofori-Acquah SF, Tluway F, Mulder N, Wonkam A. Sickle cell disease: tipping the balance of genomic research to catalyse discoveries in Africa. Lancet 389(10087), 2355-2358 (2017).
6. Mnika K, Pule GD, Dandara C, Wonkam A. An expert review of pharmacogenomics of sickle cell disease therapeutics: not yet ready for global precision medicine. OMICS 20(10), 565-574 (2016).
7. Geard A, Pule GD, Chelo D, Bitoungui VJ, Wonkam A. Genetics of sickle cell-associated cardiovascular disease: an expert review with lessons learned in Africa. OMICS 20(10), 581-592 (2016).
8. Aklillu E, Habtewold A, Ngaimisi E et al. SLCO1B1 gene variations among Tanzanians, Ethiopians, and Europeans: relevance for African and worldwide precision medicine. OMICS 20(9), 538-545 (2016).
9. Masimirembwa C, Dandara C, Leutscher PD. Rolling out efavirenz for HIV precision medicine in Africa: are we ready for pharmacovigilance and tackling neuropsychiatric adverse effects? OMICS 20(10), 575-580 (2016).
10. The H3Africa Consortium. Enabling African scientists to engage fully in the genomic revolution. Science 344(6190), 1346-1348 (2014).
11. Mulder NJ, Adebiyi E, Alami R et al. H3ABioNet, a sustainable pan African bioinformatics network for human heredity and health in Africa. Genome Res. 26, 271-277 (2015).
12. Peprah E, Wiley K, Troyer J et al. Building a platform to enable NCD research to address population health in Africa: CVD working group discussion at the sixth H3Africa consortium meeting in Zambia. Glob. Heart 11(1), 165-170 (2016).
13. The Global Alliance for Genomics and Health. Page A, Baker D, Bobrow M et al. Enabling a federated data ecosystem for sharing genomic and clinical information. Science 352(6291), 1278-1280 (2016).
14. Global Alliance for Genomics and Health. http://genomicsandhealth. org/
15. Kotze MJ, Lückhoff HK, Peeters AV et al. Genomic medicine and risk prediction across the disease spectrum. Crit. Rev. Clin. Lab. Sci. 52(3), 120-137 (2015).