The use of del Nido cardioplegia in adult cardiac surgery: A prospective randomized trial

Journal of Thoracic and Cardiovascular Surgery

Volumn 155, Issue 3, 2018, Pages 1011-1018

  Ad, Niv ^a,b,c   Holmes, Sari D ^d   Massimiano, Paul S ^b   Rongione, Anthony J ^b   Fornaresio, Lisa M ^d   Fitzgerald, David ^e  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b ADVENTIST HEALTHCARE   (United States)

^c INOVA FAIRFAX HOSPITAL   (United States)

^d WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

cardiac surgery; cardioplegia; del Nido cardioplegia; RCT

Indexed keywords

ACETIC ACID PLUS GLUCONATE SODIUM PLUS MAGNESIUM CHLORIDE PLUS POTASSIUM CHLORIDE PLUS SODIUM CHLORIDE; CREATININE; TROPONIN I; BIOLOGICAL MARKER; CARDIOPLEGIC AGENT;

ADULT; ARTICLE; ASSISTED CIRCULATION; BODY SURFACE; CARDIAC MUSCLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CEREBROVASCULAR ACCIDENT; CLINICAL OUTCOME; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY CARE UNIT; DEL NIDO CARDIOPLEGIA; EXTRACORPOREAL CIRCULATION; FEMALE; HEART INFARCTION; HEART MUSCLE INJURY; HEART PROTECTION; HEART VALVE SURGERY; HEMATOCRIT; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SOCIETY OF THORACIC SURGEONS SCORE; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; ADVERSE EVENT; AGED; BLOOD; COMPARATIVE STUDY; HEART ARREST; HEART VALVE; HOSPITAL ADMISSION; INTENSIVE CARE UNIT; MIDDLE AGED; OPERATION DURATION; POSTOPERATIVE COMPLICATION; PROCEDURES; RISK FACTOR; SURGERY; TIME FACTOR; TREATMENT OUTCOME; WORKFLOW;

AGED; BIOMARKERS; CARDIOPLEGIC SOLUTIONS; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; FEMALE; HEART ARREST, INDUCED; HEART VALVES; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OPERATIVE TIME; PATIENT ADMISSION; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TROPONIN I; WORKFLOW;

EID: 85037725698     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2017.09.146     Document Type: Article

References (30)

1. Ovrum, E., Tangen, G., Tollofsrud, S., Oystese, R., Ringdal, M.A., Istad, R., Cold blood versus cold crystalloid cardioplegia: a prospective randomised study of 345 aortic valve patients. Eur J Cardiothorac Surg 38 (2010), 745–749.
2. Reitz, B.A., Myocardial protection during cardiac surgery. Annu Rev Med 33 (1982), 151–162.
3. Melrose, D.G., Dreyer, B., Bentall, H.H., Baker, J.B.E., Elective cardiac arrest. Lancet 266 (1955), 21–23.
4. Cordell, A.R., Milestones in the development of cardioplegia. Ann Thorac Surg 60 (1995), 793–796.
5. Fallouh, H.B., Chambers, D.J., Is blood versus crystalloid cardioplegia relevant? Significantly improved protection may require new cardioplegic concepts. Interact CardioVasc Thorac Surg 7 (2008), 1162–1163.
6. Sá M., Rueda, F.G., Ferraz, P.E., Chalegre, S.T., Vasconcelos, F.P., Lima, R.C., Is there any difference between blood and crystalloid cardioplegia for myocardial protection during cardiac surgery? A meta-analysis of 5576 patients from 36 randomized trials. Perfusion 27 (2012), 535–546.
7. Matte, G.S., del Nido, P.J., History and use of del Nido cardioplegia solution at Boston Children's Hospital. J Extra Corporeal Technol 44 (2012), 98–103.
8. Govindapillai, A., Hua, R., Rose, R., Friesen, C.H., O'Blenes, S.B., Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts. J Thorac Cardiovasc Surg 146 (2013), 940–948.
9. O'Blenes, S.B., Friesen, C.H., Ali, A., Howlett, S., Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia. J Thorac Cardiovasc Surg 141 (2011), 762–770.
10. Harvey, B., Shann, K.G., Fitzgerald, D., Mejak, B., Likosky, D.S., Puis, L., et al. International pediatric perfusion practice: 2011 survey results. J Extra Corporeal Technol 44 (2012), 186–193.
11. Kotani, Y., Tweddell, J., Gruber, P., Pizarro, C., Austin, E.H. IIIrd, Woods, R.K., et al. Current cardioplegia practice in pediatric cardiac surgery: a North American multiinstitutional survey. Ann Thorac Surg 96 (2013), 923–929.
12. Yerebakan, H., Sorabella, R.A., Najjar, M., Castillero, E., Mongero, L., Beck, J., et al. Del Nido cardioplegia can be safely administered in high-risk coronary artery bypass grafting surgery after acute myocardial infarction: a propensity matched comparison. J Cardiothorac Surg, 9, 2014, 141.
13. Timek, T., Willekes, C., Hulme, O., Himelhoch, B., Nadeau, D., Borgman, A., et al. Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting: initial experience with 100 consecutive patients. Ann Thorac Surgery 101 (2016), 2237–2241.
14. Smigla, G., Jaquiss, R., Walczak, R., Bonadonna, D., Kaemmer, D., Schwimer, C., et al. Assessing the safety of del Nido cardioplegia solution in adult congenital cases. Perfusion 29 (2014), 554–558.
15. Ota, T., Yerebakan, H., Neely, R.C., Mongero, L., George, I., Takayama, H., et al. Short-term outcomes in adult cardiac surgery in the use of del Nido cardioplegia solution. Perfusion 31 (2016), 27–33.
16. Mick, S.L., Robich, M.P., Houghtaling, P.L., Gillinov, A.M., Soltesz, E.G., Johnston, D.R., et al. Del Nido versus Buckberg cardioplegia in adult isolated valve surgery. J Thorac Cardiovasc Surg 149 (2015), 626–636.
17. Guajardo Salinas, G.E., Nutt, R., Rodriguez-Araujo, G., Del Nido cardioplegia in low risk adults undergoing first time coronary artery bypass surgery. Perfusion 32 (2017), 68–73.
18. Sorabella, R.A., Akashi, H., Yerebakan, H., Najjar, M., Mannan, A., Williams, M.R., et al. Myocardial protection using del Nido cardioplegia solution in adult reoperative aortic valve surgery. J Cardiac Surg 29 (2014), 445–449.
19. Valooran, G.J., Nair, S.K., Chandrasekharan, K., Simon, R., Dominic, C., Del Nido cardioplegia in adult cardiac surgery - scopes and concerns. Perfusion 31 (2016), 6–14.
20. Lan, K.K.G., DeMets, D.L., Discrete sequential boundaries for clinical trials. Biometrika 70 (1983), 659–663.
21. Reboussin, D.M., DeMets, D.L., Kim, K.M., Lan, K.K.G., Computations for group sequential boundaries using the Lan-DeMets spending function method. Control Clin Trials 21 (2000), 190–207.
22. Kim, K., Ball, C., Grady, P., Mick, S., Use of del Nido cardioplegia for adult cardiac surgery at The Cleveland Clinic: perfusion implications. J Extra Corporeal Technol 46 (2014), 317–323.
23. Morrow, D.A., Cannon, C.P., Jesse, R.L., Newby, L.K., Ravkilde, J., Storrow, A.B., et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. Circulation, 115, 2007, e375.
24. Croal, B.L., Hillis, G.S., Gibson, P.H., Fazal, M.T., El-Shafei, H., Gibson, G., et al. Relationship between postoperative cardiac troponin I levels and outcome of cardiac surgery. Circulation 114 (2006), 1468–1475.
25. Lasocki, S., Provenchère, S., Bénessiano, J., Vicaut, E., Lecharny, J., Desmonts, J., et al. Cardiac troponin I is an independent predictor of in-hospital death after adult cardiac surgery. Anesthesiology 97 (2002), 405–411.
26. Stammers, A.H., Vang, S.N., Mejak, B.L., Rauch, E.D., Quantification of the effect of altering hematocrit and temperature on blood viscosity. J Extra Corporeal Technol 35 (2003), 143–151.
27. O'Brien, J.D., Howlett, S.E., Burton, H.J., O'Blenes, S.B., Litz, D.S., Friesen, C.L.H., Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T. Ann Thorac Surg 87 (2009), 1517–1523.
28. Newton, D.J., McLeod, G.A., Khan, F., Belch, J.J., Mechanisms influencing the vasoactive effects of lidocaine in human skin. Anaesthesia 62 (2007), 146–150.
29. Yammine, M., Neely, R.C., Loberman, D., Rajab, T.K., Grewal, A., McGurk, S., et al. The use of lidocaine containing cardioplegia in surgery for adult acquired heart disease. J Cardiac Surg 30 (2015), 677–684.
30. Hummel, B.W., Buss, R.W., DiGiorgi, P.L., Laviano, B.N., Yaeger, N.A., Lucas, M.L., et al. Myocardial protection and financial considerations of Custodiol cardioplegia in minimally invasive and open valve surgery. Innovations (Phila) 11 (2016), 420–424.