Ebola virus disease and pregnancy: A review of the current knowledge of Ebola virus pathogenesis, maternal, and neonatal outcomes

Birth Defects Research

Volumn 109, Issue 5, 2017, Pages 353-362

  Bebell, Lisa M ^a   Oduyebo, Titilope ^b,c   Riley, Laura E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Birth; Ebola; Fetus; Hemorrhagic; Outcomes; Pregnancy; Pregnant; Sexually; Transmission; Women

Indexed keywords

BLOOD SAMPLING; CASE FATALITY RATE; CONGENITAL MALFORMATION; DESCRIPTIVE RESEARCH; EBOLAVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUID RESUSCITATION; HEALTH CARE PERSONNEL; HEMORRHAGIC FEVER; HUMAN; MAJOR CLINICAL STUDY; MATERNAL MORTALITY; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEXUAL TRANSMISSION; VIRUS PATHOGENESIS; AFRICA; COHORT ANALYSIS; COMPLICATION; CYTOPATHOGENIC EFFECT; EBOLA HEMORRHAGIC FEVER; EPIDEMIC; FEMALE; INFANT; PATHOGENICITY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; VIROLOGY;

AFRICA, WESTERN; COHORT STUDIES; CYTOPATHOGENIC EFFECT, VIRAL; DISEASE OUTBREAKS; EBOLAVIRUS; FEMALE; HEALTH PERSONNEL; HEMORRHAGIC FEVER, EBOLA; HUMANS; INFANT; MATERNAL MORTALITY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY OUTCOME;

EID: 85035346552     PISSN: None     EISSN: 24721727     Source Type: Journal    
DOI: 10.1002/bdra.23558     Document Type: Review

References (81)

1. Adjemian J, Farnon EC, Tschioko F, et al. 2011. Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. J Infect Dis 204(Suppl 3): S796-S799.
2. Agnandji ST, Huttner A, Zinser ME, et al. 2016. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. N Engl J Med 374: 1647-1660.
3. Akerlund E, Prescott J, Tampellini L. 2015. Shedding of Ebola Virus in an asymptomatic pregnant woman. N Engl J Med 372: 2467-2469.
4. Ansari AA. 2014. Clinical features and pathobiology of Ebolavirus infection. J Autoimmun 55: 1-9
5. Baggi F, Taybi A, Kurth A, et al. 2014. Management of pregnant women infected with Ebola virus in a treatment centre in Guinea, June 2014. Eurosurveillance 19: 2-5.
6. Baize S, Pannetier D, Oestereich L, et al. 2014. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 371: 1418-1425.
7. Bausch DG, Towner JS, Dowell SF, et al. 2007. Assessment of the risk of Ebola virus transmission from bodily fluids and fomites. J Infect Dis 196(Suppl 2): S142-S147.
8. Bebell LM, Riley LE. 2015. Ebola virus disease and marburg disease in pregnancy: a review and management considerations for filovirus infection. Obstet Gynecol 125: 1293-1298.
9. Bower H, Grass JE, Veltus E, et al. 2016a. Delivery of an ebola virus-positive stillborn infant in a rural community health center, Sierra Leone, 2015. Am J Trop Med Hyg 94: 417-419.
10. Bower H, Johnson S, Bangura MS, et al. 2016b. Effects of mother’s illness and breastfeeding on risk of Ebola virus disease in a cohort of very young children. PLoS Negl Trop Dis 10: e0004622.
11. Brauburger K, Hume AJ, Muhlberger E, Olejnik J. 2012. Forty-five years of Marburg virus research. Viruses 4: 1878-927.
12. Bwaka MA, Bonnet MJ, Calain P, et al. 1999. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J Infect Dis 179(Suppl 1): S1-S7.
13. Caluwaerts S, Fautsch T, Lagrou D, et al. 2016. Dilemmas in managing pregnant women with Ebola: 2 case reports. Clin Infect Dis 62: 903-905.
14. CDC. 2014a. Review of human-to-human transmission of Ebola virus [Online]. Atlanta: Centers for Disease Control. Available at: http://www.cdc.gov/vhf/ebola/transmission/human-transmission. html-sixteen. Accessed October 20, 2014.
15. CDC. 2014b. Guidance for Screening and Caring for PregnantWomen with Ebola Virus Disease for Healthcare Providers in U.S. Hospitals [Online]. Atlanta: CDC. Available at: http://www.cdc.gov/vhf/ebola/ hcp/guidance-maternal-health.html. Accessed November 20, 2014.
16. CDC. 2014c. Infection Prevention and Control Recommendations for Hospitalized Patients with Known or Suspected Ebola Virus Disease in U.S. Hospitals [Online]. Atlanta: Centers for Disease Control. Available at: http://www.cdc.gov/vhf/ebola/hcp/infection-prevention-and-control-recommendations.html. Accessed November 3, 2014.
17. CDC. 2015a. Ebola (Ebola virus disease)-Q&As on transmission. Atlanta, GA: Centers for Disease Control and Prevention.
18. CDC. 2015b. Ebola (Ebola virus disease): transmission. Atlanta, GA: Centers for Disease Control and Prevention.
19. CDC. 2015c. Guidance for safe handling of human remains of Ebola patients in U. S. hospitals and mortuaries. Atlanta, GA: Centers for Disease Control and Prevention.
20. CDC. 2015d. Guidance for screening and caring for pregnant women with Ebola virus disease for healthcare providers in U.S. hospitals. Atlanta, GA: Centers for Disease Control and Prevention.
21. CDC. 2015e. Recommendations for breastfeeding/infant feeding in the context of Ebola. Atlanta, GA: Centers for Disease Control and Prevention.
22. CDC. 2016a. 2014 Ebola outbreak in West Africa: case counts [Online]. Atlanta: Centers for Disease Control. Available at: http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/casecounts. html. Accessed June 18, 2016.
23. CDC. 2016b. Care of a neonate born to a mother who is confirmed to have Ebola, is a person under investigation, or has been exposed to Ebola.
24. Chertow DS, Kleine C, Edwards JK, et al. 2014. Ebola virus disease in West Africa-clinical manifestations and management. N Engl J Med 371: 2054-2057.
25. Chowell G, Nishiura H. 2014. Transmission dynamics and control of Ebola virus disease (EVD): a review. BMC Med 12: 196.
26. Christie A, Davies-Wayne GJ, Cordier-Lasalle T, et al. 2015. Possible sexual transmission of Ebola virus-Liberia, 2015. MMWR Morb Mortal Wkly Rep 64: 479-481.
27. Chughtai AA, Barnes M, Macintyre CR. 2016. Persistence of Ebola virus in various body fluids during convalescence: evidence and implications for disease transmission and control. Epidemiol Infect 144: 1652-1660.
28. Clark DV, Jahrling PB, Lawler JV. 2012. Clinical management of filovirus-infected patients. Viruses 4: 1668-1686.
29. De La Vega MA, Caleo G, Audet J, et al. 2015. Ebola viral load at diagnosis associates with patient outcome and outbreak evolution. J Clin Invest 125: 4421-4428.
30. Deaver JE, Cohen WR. 2015. Ebola virus screening during pregnancy in West Africa: unintended consequences. J Perinat Med 43: 649-655.
31. Deen GF, Knust B, Broutet N, et al. 2015a. Ebola RNA persistence in semen of Ebola virus disease survivors-preliminary report. N Engl J Med [Epub ahead of print].
32. Deen J, Dondorp AM, White NJ. 2015b. Treatment of Ebola. N Engl J Med 372: 1673-1674.
33. Dornemann J, Burzio C, Ronsse A, et al. 2017. First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease. J Infect Dis.
34. Ebola ça Suffit Ring Vaccination Trial Consortium. 2015. The ring vaccination trial: a novel cluster randomised controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola. BMJ 351: h3740.
35. Feldmann H, Geisbert TW. 2011. Ebola haemorrhagic fever. Lancet 377: 849-862.
36. Fowler RA, Fletcher T, Fischer WA Jr, et al. 2014. Caring for critically ill patients with ebola virus disease. Perspectives from west Africa. Am J Respir Crit Care Med 190: 733-737.
37. Gignoux E, Azman AS, De Smet M, et al. 2016. Effect of artesunate-amodiaquine on mortality related to Ebola virus disease. N Engl J Med 374: 23-32.
38. Green E, Hunt L, Ross JC, et al. 2016. Viraemia and Ebola virus secretion in survivors of Ebola virus disease in Sierra Leone: a crosssectional cohort study. Lancet Infect Dis [Epub ahead of print].
39. Hensley LE, Dyall J, Olinger GG Jr, Jahrling PB. 2015. Lack of effect of lamivudine on Ebola virus replication. Emerg Infect Dis 21: 550-552.
40. Jacobs M, Aarons E, Bhagani S, et al. 2015. Post-exposure prophylaxis against Ebola virus disease with experimental antiviral agents: a case-series of health-care workers. Lancet Infect Dis 15: 1300-1304.
41. Jacobs M, Rodger A, Bell DJ, et al. 2016. Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet [Epub ahead of print].
42. Jamieson DJ, Uyeki TM, Callaghan WM, et al. A. 2014. What obstetrician-gynecologists should know about Ebola: a perspective from the Centers for Disease Control and Prevention. Obstet Gynecol 124: 1005-1010.
43. Jeffs B. 2006. A clinical guide to viral haemorrhagic fevers: Ebola, Marburg and Lassa. Trop Doct 36: 1-4.
44. Kreuels B, Wichmann D, Emmerich P, et al. 2014. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 371: 2394-2401.
45. Kurosaki Y, Magassouba N, Oloniniyi OK, et al. 2016. Development and evaluation of Reverse Transcription-Loop-Mediated Isothermal Amplification (RT-LAMP) assay coupled with a portable device for rapid diagnosis of Ebola virus disease in Guinea. PLoS Negl Trop Dis 10: e0004472.
46. Lyon GM, Mehta AK, Varkey JB, et al. 2014. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 371: 2402-2409.
47. Maganga GD, Kapetshi J, Berthet N, et al. 2014. Ebola virus disease in the Democratic Republic of Congo. N Engl J Med 371: 2083-2091.
48. Martines RB, Ng DL, Greer PW, et al. 2014. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg Viruses. J Pathol 235: 153-174.
49. Mayor S. 2015. Ebola virus persists and may be transmitted in survivors’ semen, studies show. BMJ 351: h5511.
50. McLean AR, Ataide R, Simpson JA, et al. 2015. Malaria and immunity during pregnancy and postpartum: a tale of two species. Parasitology 142: 999-1015.
51. Mehedi M, Groseth A, Feldmann H, Ebihara H. 2011. Clinical aspects of Marburg hemorrhagic fever. Future Virol 6: 1091-1106.
52. Medecins sans Frontieres. 2015. Nubia-first newborn to survive Ebola. New York: Medecins sans Frontieres.
53. Mupapa K, Mukundu W, Bwaka MA, et al. 1999. Ebola hemorrhagic fever and pregnancy. J Infect Dis 179(Suppl 1): S11-S12.
54. No Authors Listed. 1978. Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ 56: 271-293.
55. Nordenstedt H, Bah EI, De La Vega MA, et al. 2016. Ebola virus in breast milk in an Ebola virus-positive mother with twin babies, Guinea, 2015. Emerg Infect Dis 22: 759-760.
56. Oduyebo T, Pineda D, Lamin M, et al. 2015. A pregnant patient with Ebola virus disease. Obstet Gynecol 126: 1273-1275.
57. Qin E, Bi J, Zhao M, et al. 2015. Clinical features of patients with Ebola virus disease in Sierra Leone. Clin Infect Dis 61: 491-495.
58. Regules JA, Beigel JH, Paolino KM, et al. 2015. A recombinant vesicular stomatitis virus Ebola vaccine-preliminary report. N Engl J Med [Epub ahead of print].
59. Rowe AK, Bertolli J, Khan AS, et al. 1999. Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidemies a Kikwit. J Infect Dis 179(Suppl 1): S28-S35.
60. Schieffelin JS, Shaffer JG, Goba A, et al. 2014. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 371: 2092-2100.
61. Smith DH, Johnson BK, Isaacson M, et al. 1982. Marburg-virus disease in Kenya. Lancet 1: 816-820.
62. Strecker T, Palyi B, Ellerbrok H, et al. 2015. Field evaluation of capillary blood samples as a collection specimen for the rapid diagnosis of Ebola virus infection during an outbreak emergency. Clin Infect Dis 61: 669-675.
63. Sueblinvong V, Johnson DW, Weinstein GL, et al. 2015. Critical care for multiple organ failure secondary to Ebola virus disease in the United States. Crit Care Med 43: 2066-2075.
64. Tiffany A, Vetter P, Mattia J, et al. 2016. Ebola virus disease complications as experienced by survivors in Sierra Leone. Clin Infect Dis 62: 1360-1366.
65. Towner JS, Amman BR, Sealy TK, et al. 2009. Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog 5: e1000536.
66. Towner JS, Rollin PE, Bausch DG, et al. 2004. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 78: 4330-4341.
67. Uyeki TM, Erickson BR, Brown S, et al. 2016a. Ebola virus persistence in semen of male survivors. Clin Infect Dis 62: 1552-1555.
68. Uyeki TM, Mehta AK, Davey RT Jr, et al. 2016b. Clinical Management of Ebola Virus Disease in the United States and Europe. N Engl J Med 374: 636-646.
69. Van Griensven J, Edwards T, De Lamballerie X, et al. 2016. Evaluation of convalescent plasma for Ebola virus disease in Guinea. N Engl J Med 374: 33-42.
70. Van Vuren PJ, Grobbelaar A, Storm N, et al. 2015. Comparative evaluation of the prototype Cepheid GeneXpert (R) Ebola Assay diagnostic performance. J Clin Microbiol.
71. Vogel G. 2014. Infectious disease. Are bats spreading Ebola across sub-Saharan Africa? Science 344: 140.
72. Walker DH, McCormick JB, Johnson KM, et al. 1982. Pathologic and virologic study of fatal Lassa fever inman. AmJ Pathol 107: 349-356.
73. WHO. 2014. Infection prevention and control guidance for care of patients in health-care settings, with focus on EbolaInterim guidance. Geneva, Switzerland: World Health Organization.
74. WHO. 2015a. Ebola vaccines, therapies, and diagnostics. Questions and answers. Geneva, Switzerland: World Health Organization.
75. WHO. 2015b. Interim advice on the sexual transmission of the Ebola virus disease. Geneva, Switzerland: World Health Organization.
76. WHO. 2015c. WHO meeting on survivors of Ebola virus disease: clinical care of EVD survivors, Freetown, 3-4 August 2015: meeting report. Geneva, Switzerland: World Health Organization.
77. WHO. 2016. Ebola data and statistics. Geneva, Switzerland: World Health Organization.
78. WHO Ebola Response Team. 2014. Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections. N Engl J Med 371: 1481-1495.
79. WHO Ebola Response Team. 2016. Ebola virus disease among male and female persons in West Africa. N Engl J Med 374: 96-98.
80. World Health Organization. 1978. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bull World Health Organ 56: 247-270.
81. Yan T, Mu J, Qin E, et al. 2015. Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak. Eur J Clin Microbiol Infect Dis 34: 2089-2095.