Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

Annual Review of Pharmacology and Toxicology

Volumn 58, Issue , 2018, Pages 37-64

  Prantil Baun, Rachelle ^a   Novak, Richard ^a   Das, Debarun ^b   Somayaji, Mahadevabharath R ^b   Przekwas, Andrzej ^b   Ingber, Donald E ^a,c,d  

^a HARVARD UNIVERSITY   (United States)

^b CFD RESEARCH CORPORATION   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

drug development; IVIVE; microfluidic; microphysiological system; organ on a chip; pharmacodynamics; pharmacokinetics

Indexed keywords

CISPLATIN; DOXORUBICIN; FEXOFENADINE; GENTAMICIN; OMEPRAZOLE; PHENACETIN; PROBIOTIC AGENT; TERFENADINE; DRUG;

AREA UNDER THE CURVE; BIOENGINEERING; CELL CULTURE; CELL TRANSPORT; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG METABOLISM; DRUG RESPONSE; DRUG SAFETY; ELIMINATION RATE CONSTANT; FLUID FLOW; HUMAN; IN VITRO IN VIVO EXTRAPOLATION; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM CONCENTRATION; MICROFLUIDICS; NONHUMAN; ORGAN PERFUSION; PHARMACODYNAMIC PARAMETERS; PHARMACODYNAMICS; PHARMACOKINETIC PARAMETERS; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE SPECIFICITY; VEIN; VOLUME OF DISTRIBUTION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE TECHNIQUE; CHEMISTRY; COMPUTER SIMULATION; DRUG APPROVAL; DRUG DEVELOPMENT; LAB ON A CHIP; METABOLISM; PHARMACOKINETICS; PROCEDURES;

ANIMALS; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; DRUG APPROVAL; DRUG DEVELOPMENT; HUMANS; LAB-ON-A-CHIP DEVICES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 85034812883     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010716-104748     Document Type: Review

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