Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial

Journal of Affective Disorders

Volumn 227, Issue , 2018, Pages 455-462

  Berger, Thomas ^a   Krieger, Tobias ^a   Sude, Kerstin ^b   Meyer, Björn ^c,d   Maercker, Andreas ^e  

^a UNIVERSITY OF BERN   (Switzerland)

^b DPtV   (Germany)

^c CITY UNIVERSITY   (United Kingdom)

^d GAIA AG   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANXIETY; ARTICLE; BECK DEPRESSION INVENTORY; CLINICAL OUTCOME; COGNITIVE BEHAVIORAL THERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; EVALUATION STUDY; FEMALE; FOLLOW UP; HUMAN; INTERNET; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL HEALTH; MENTAL PATIENT; PATIENT SATISFACTION; PRIORITY JOURNAL; PSYCHODYNAMIC PSYCHOTHERAPY; PSYCHOTHERAPY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SELF HELP; TELEPSYCHIATRY; TREATMENT DURATION; WEB BASED DEPRESSION PROGRAM; COMPUTER ASSISTED THERAPY; GERMANY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PROCEDURES; PSYCHOLOGY; SOFTWARE; SOMATOFORM DISORDER;

ADULT; COMBINED MODALITY THERAPY; DEPRESSIVE DISORDER, MAJOR; FEMALE; GERMANY; HUMANS; INTERNET; MALE; MIDDLE AGED; PSYCHOTHERAPY; SOFTWARE; SOMATOFORM DISORDERS; THERAPY, COMPUTER-ASSISTED;

EID: 85034089945     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2017.11.021     Document Type: Article

References (45)

1. Abramowitz, J.S., Foa, E.B., Franklin, M.E., Exposure and ritual prevention for obsessive-compulsive disorder: effects of intensive versus twice-weekly sessions. J. Consult Clin. Psychol. 71 (2003), 394–398.
2. Andersson, G., Cuijpers, P., Internet-based and other computerized psychological treatments for adult depression: a meta-analysis. Cogn. Behav. Ther. 38 (2009), 196–205.
3. Barkham, M., Connell, J., Stiles, W.B., Miles, J.N., Margison, F., Evans, C., Mellor-Clark, J., Dose-effect relations and responsive regulation of treatment duration: the good enough level. J. Consult. Clin. Psychol., 74, 2006, 160.
4. Beevers, C.G., Pearson, R., Hoffman, J.S., Foulser, A.A., Shumake, J., Meyer, B., Effectiveness of an internet intervention (deprexis) for depression in a united states adult sample: a parallel-group pragmatic randomized controlled trial. J. Consult. Clin. Psychol., 85, 2017, 367.
5. Berger, T., Hämmerli, K., Gubser, N., Andersson, G., Caspar, F., Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help. Cogn. Behav. Ther. 40 (2011), 251–266.
6. Cuijpers, P., Four decades of outcome research on psychotherapies for adult depression: an overview of a series of meta-analyses. Can. Psychol., 58, 2017, 7.
7. Cuijpers, P., Huibers, M., Ebert, D.D., Koole, S.L., Andersson, G., How much psychotherapy is needed to treat depression? A metaregression analysis. J. Affect Disord. 149 (2013), 1–13.
8. Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., Penninx, B.W., Comprehensive meta-analysis of excess mortality in depression in the general community versus patients with specific illnesses. Am. J. Psychiatry 171 (2014), 453–462.
9. Falkenström, F., Markowitz, J.C., Jonker, H., Philips, B., Holmqvist, R., Can psychotherapists function as their own controls? Meta-analysis of the “crossed therapist” design in comparative psychotherapy trials. J. Clin. Psychiatry 74 (2013), 482–491.
10. Fischer, A., Schröder, J., Vettorazzi, E., Wolf, O.T., Pöttgen, J., Lau, S., Heesen, C., Moritz, S., Gold, S.M., An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Lancet Psychiatry 2 (2015), 217–223.
11. Gilbody, S., Littlewood, E., Hewitt, C., Brierley, G., Tharmanathan, P., Araya, R., Barkham, M., Bower, P., Cooper, C., Gask, L., Kessler, D., Lester, H., Lovell, K., Parry, G., Richards, D.A., Andersen, P., Brabyn, S., Knowles, S., Shepherd, C., Tallon, D., White, D., Team, R., Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial. BMJ, 351, 2015, h5627.
12. Gueorguieva, R., Krystal, J.H., Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. Arch. Gen. Psychiatry 61 (2004), 310–317.
13. Gustavsson, A., Svensson, M., Jacobi, F., Allgulander, C., Alonso, J., Beghi, E., Dodel, R., Ekman, M., Faravelli, C., Fratiglioni, L., Cost of disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21 (2011), 718–779.
14. Jacobson, N.S., Truax, P., Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J. Consult. Clin. Psychol. 59 (1991), 12–19.
15. Johansson, R., Andersson, G., Internet-based psychological treatments for depression. Expert Rev. Neurother. 12 (2014), 861–870.
16. Karyotaki, E., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., Mira, A., Mackinnon, A., Meyer, B., Botella, C., Littlewood, E., Andersson, G., Christensen, H., Klein, J.P., Schroder, J., Breton-Lopez, J., Scheider, J., Griffiths, K., Farrer, L., Huibers, M.J., Phillips, R., Gilbody, S., Moritz, S., Berger, T., Pop, V., Spek, V., Cuijpers, P., Efficacy of self-guided internet-based cognitive behavioral therapy in the treatment of depressive symptoms: a meta-analysis of individual participant data. JAMA Psychiatry 74 (2017), 351–359.
17. Kazantzis, N., Whittington, C., Zelencich, L., Kyrios, M., Norton, P.J., Hofmann, S.G., Quantity and quality of homework compliance: a meta-analysis of relations with outcome in cognitive behavior therapy. Behav. Ther. 47 (2016), 755–772.
18. Kenter, R.M., van de Ven, P.M., Cuijpers, P., Koole, G., Niamat, S., Gerrits, R.S., Willems, M., van Straten, A., Costs and effects of internet cognitive behavioral treatment blended with face-to-face treatment: results from a naturalistic study. Internet Interv. 2 (2015), 77–83.
19. Kleiboer, A., Smit, J.H., Bosmans, J., Ruwaard, J., Andersson, G., Topooco, N., Berger, T., Krieger, T., Botella, C., Baños, R., Chevreul, K., Araya, R., Cerga-Pashoja, A., Cieślak, R., Rogala, A., Vis, C., Draisma, S., van Schaik, A., Kemmeren, L., Ebert, D.D., Berking, M., Funk, B., Cuijpers, P., Riper, H., European COMPARative effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries. Trials 17 (2016), 1–10.
20. Klein, J.P., Berger, T., Schröder, J., Späth, C., Meyer, B., Caspar, F., Lutz, W., Arndt, A., Greiner, W., Gräfe, V., Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother. Psychosom. 85 (2016), 218–228.
21. Klein, J.P., Berger, T., Schroder, J., Spath, C., Meyer, B., Caspar, F., Lutz, W., Arndt, A., Greiner, W., Grafe, V., Hautzinger, M., Fuhr, K., Rose, M., Nolte, S., Lowe, B., Anderssoni, G., Vettorazzi, E., Moritz, S., Hohagen, F., Effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the EVIDENT study, a randomized controlled trial. Psychother. Psychosom. 85 (2016), 218–228.
22. Kooistra, L.C., Ruwaard, J., Wiersma, J.E., van Oppen, P., van der Vaart, R., van Gemert-Pijnen, J.E.W.C., Riper, H., Development and initial evaluation of blended cognitive behavioural treatment for major depression in routine specialized mental health care. Internet Interv. 4:part 1 (2016), 61–71.
23. Krieger, T., Meyer, B., Sude, K., Urech, A., Maercker, A., Berger, T., Evaluating an e-mental health program (“deprexis”) as adjunctive treatment tool in psychotherapy for depression: design of a pragmatic randomized controlled trial. BMC Psychiatry, 14, 2014, 285.
24. Kroenke, K., Spitzer, R.L., Williams, J.B., The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom. Med. 64 (2002), 258–266.
25. Kuhner, C., Burger, C., Keller, F., Hautzinger, M., Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples. Nervenarzt 78 (2007), 651–656.
26. Månsson, K.N.T., Ruiz, E.S., Gervind, E., Dahlin, M., Andersson, G., Development and initial evaluation of an internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. J. Med. Internet Res., 15, 2013, e280.
27. Meyer, B., Berger, T., Caspar, F., Beevers, C., Andersson, G., Weiss, M., Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial. J. Med. Internet Res., 11, 2009, e15.
28. Meyer, B., Bierbrodt, J., Schröder, J., Berger, T., Beevers, C.G., Weiss, M., Jacob, G., Späth, C., Andersson, G., Lutz, W., Effects of an internet intervention (deprexis) on severe depression symptoms: randomized controlled trial. Internet Interv. 2 (2015), 48–59.
29. Moritz, S., Schilling, L., Hauschildt, M., Schröder, J., Treszl, A., A randomized controlled trial of internet-based therapy in depression. Behav. Res. Ther. 50 (2012), 513–521.
30. Munder, T., Wilmers, F., Leonhart, R., Linster, H.W., Barth, J., Working alliance inventory-short revised (WAI-SR): psychometric properties in outpatients and inpatients. Clin. Psychol. Psychother. 17 (2010), 231–239.
31. Olesen, J., Gustavsson, A., Svensson, M., Wittchen, H.U., Jönsson, B., The economic cost of brain disorders in Europe. Eur. J. Neurol. 19 (2012), 155–162.
32. Reese, R.J., Toland, M.D., Hopkins, N.B., Replicating and extending the good-enough level model of change: considering session frequency. Psychother. Res. 21 (2011), 608–619.
33. Richards, D., Prevalence and clinical course of depression: a review. Clin. Psychol. Rev. 31 (2011), 1117–1125.
34. Richards, D., Richardson, T., Computer-based psychological treatments for depression: a systematic review and meta-analysis. Clin. Psychol. Rev. 32 (2012), 329–342.
35. Schmidt, J., Wittmann, W.W., 2002. ZUF-8: Fragebogen zur Messung der Patientenzufriedenheit. Hogrefe, Göttingen.
36. Schramm, E., Kriston, L., Zobel, I., Baller, J., Wambach, K., Backenstrass, M., Härter, M., Effect of disorder-specific vs nonspecific psychotherapy for chronic depression: a randomized clinical trial. JAMA Psychiatry 74 (2017), 233–242.
37. Schröder, J., Berger, T., Meyer, B., Lutz, W., Hautzinger, M., Späth, C., Eichenberg, C., Klein, J.P., Klein, S., Attitudes towards internet interventions among psychotherapists and study participants with mild to moderate depression symptoms. Cogn. Behav. Ther. 41 (2017), 745–756.
38. Schröder, J., Brückner, K., Fischer, A., Lindenau, M., Köther, U., Vettorazzi, E., Moritz, S., Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia 55 (2014), 2069–2076.
39. Smit, F., Cuijpers, P., Oostenbrink, J., Batelaan, N., de Graaf, R., Beekman, A.T.F., Costs of nine common mental disorders: implications for curative and preventive psychiatry. J. Ment. Health Policy Econ., 2006.
40. Spitzer, R.L., Kroenke, K., Williams, J.B., Lowe, B., A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch. Intern. Med. 166 (2006), 1092–1097.
41. Topooco, N., Riper, H., Araya, R., Berking, M., Brunn, M., Chevreul, K., Cieslak, R., Ebert, D.D., Etchmendy, E., Herrero, R., Kleiboer, A., Krieger, T., Garcia-Palacios, A., Cerga-Pashoja, A., Smoktunowicz, E., Urech, A., Vis, C., Andersson, G., Attitudes towards digital treatment for depression: a European stakeholder survey. Internet Interv. 8 (2017), 1–9.
42. Waller, R., Gilbody, S., Barriers to the uptake of computerized cognitive behavioural therapy: a systematic review of the quantitative and qualitative evidence. Psychol. Med. 39 (2009), 705–712.
43. Twomey, C., O'Reilly, G., Meyer, B., Effectiveness of an individually-tailored computerised CBT programme (deprexis) for depression: a meta-analysis. Psychiatry Res. 27 (2017), 371–377.
44. Ware, J. Jr., Kosinski, M., Keller, S.D., A 12-Item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med. Care 34 (1996), 220–233.
45. Wright, J.H., Wright, A.S., Albano, A.M., Basco, M.R., Goldsmith, L.J., Raffield, T., Otto, M.W., Computer-assisted cognitive therapy for depression: maintaining efficacy while reducing therapist time. Am. J. Psychiatry 162 (2005), 1158–1164.