Compassionate Nitric Oxide Adjuvant Treatment of Persistent Mycobacterium Infection in Cystic Fibrosis Patients

Pediatric Infectious Disease Journal

Volumn 37, Issue 4, 2018, Pages 336-338

  Yaacoby Bianu, Karin ^a   Gur, Michal ^a   Toukan, Yazeed ^a,b   Nir, Vered ^a   Hakim, Fahed ^a,b   Geffen, Yuval ^c   Bentur, Lea ^a  

^a Ruth Rappaport Children's Hospital   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Microbiology Laboratory   (Israel)

Author keywords

cystic fibrosis; Mycobacterium abscessus complex infection; nitric oxide

Indexed keywords

AMIKACIN; AZITHROMYCIN; C REACTIVE PROTEIN; CIPROFLOXACIN; CLOFAZIMINE; LINEZOLID; MEROPENEM; METHEMOGLOBIN; MINOCYCLINE; MOXIFLOXACIN; NITRIC OXIDE; ANTIINFECTIVE AGENT;

ADJUVANT THERAPY; ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; CASE REPORT; CLINICAL ARTICLE; CLINICAL TRIAL; COLONY FORMING UNIT; COMPASSIONATE USE; CYSTIC FIBROSIS; DRUG WITHDRAWAL; FEMALE; FORCED EXPIRATORY VOLUME; HOMOZYGOTE; HOSPITAL READMISSION; HUMAN; INFLAMMATION; LUNG FUNCTION TEST; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIOSIS; MYCOBACTERIUM ABSCESSUS; OPEN STUDY; PERSISTENT INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPUTUM; SYSTEMIC DISEASE; THORAX RADIOGRAPHY; THROMBOCYTOPENIA; UNSPECIFIED SIDE EFFECT; X-RAY COMPUTED TOMOGRAPHY; YOUNG ADULT; ADVERSE DRUG REACTION; ATYPICAL MYCOBACTERIOSIS; BACTERIAL COUNT; BACTERIAL LOAD; COMPLICATION; INHALATIONAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOLOGY; PROSPECTIVE STUDY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; COLONY COUNT, MICROBIAL; CYSTIC FIBROSIS; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HUMANS; MYCOBACTERIUM ABSCESSUS; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; NITRIC OXIDE; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; SPUTUM;

EID: 85034085240     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001780     Document Type: Article

References (12)

1. Ratjen F Döring G Cystic fibrosis. Lancet. 2003; 361: 681-689.
2. Roux AL Catherinot E Soismier N OMA group. Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients. J Cyst Fibros. 2015; 14: 63-69.
3. Griffith DE Brown-Elliott BA Benwill JL Mycobacterium abscessus. "Pleased to meet you, hope you guess my name.". Ann Am Thorac Soc. 2015; 12: 436-439.
4. Floto RA Olivier KN Saiman L US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary. Thorax. 2016; 71: 88-90.
5. Fang FC Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J Clin Invest. 1997; 99: 2818-2825.
6. Fang FC Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol. 2004; 2: 820-832.
7. Miller C McMullin B Ghaffari A Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure. Nitric Oxide. 2009; 20: 16-23.
8. Miller CC Rawat M Johnson T Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol. Antimicrob Agents Chemother. 2007; 51: 3364-3366.
9. Miller C Miller M McMullin B A phase I clinical study of inhaled nitric oxide in healthy adults. J Cyst Fibros. 2012; 11: 324-331.
10. Deppisch C Herrmann G Graepler-Mainka U Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study. Infection. 2016; 44: 513-520.
11. Deschaght P Schelstraete P Van Simaey L Is the improvement of CF patients, hospitalized for pulmonary exacerbation, correlated to a decrease in bacterial load? PLoS One. 2013; 8: e79010.
12. Rogers GB Hoffman LR Döring G Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis. J Cyst Fibros. 2011; 10: 387-400.