Removal of antibiotics, antibiotic-resistant bacteria and their associated genes by graphene-based TiO2 composite photocatalysts under solar radiation in urban wastewaters

Applied Catalysis B: Environmental

Volumn 224, Issue , 2018, Pages 810-824

  Karaolia, Popi ^a   Michael Kordatou, Irene ^a   Hapeshi, Evroula ^a   Drosou, Catherine ^b   Bertakis, Yannis ^b   Christofilos, Dimitris ^c   Armatas, Gerasimos S ^d   Sygellou, Labrini ^e   Schwartz, Thomas ^f   Xekoukoulotakis, Nikolaos P ^b   Fatta Kassinos, Despo ^a  

^a UNIVERSITY OF CYPRUS   (Cyprus)

^b TECHNICAL UNIVERSITY OF CRETE   (Greece)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^d UNIVERSITY OF CRETE   (Greece)

^e INSTITUTE OF CHEMICAL ENGINEERING SCIENCES   (Greece)

^f KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Antibiotic resistance genes; Antibiotic resistant bacteria; Antibiotics; Graphene; TiO2 photocatalysis

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOREACTORS; DNA; DNA SEQUENCES; EFFLUENTS; ESCHERICHIA COLI; GENES; GRAPHENE; HYDROTHERMAL SYNTHESIS; RNA; SOLAR RADIATION; TITANIUM DIOXIDE; WASTEWATER TREATMENT;

ANTIBIOTIC RESISTANCE GENES; ANTIBIOTIC-RESISTANT BACTERIA; COMPOSITE PHOTOCATALYSTS; PHOTO CATALYTIC DEGRADATION; PHOTOCATALYTIC MATERIALS; PHOTOCATALYTIC TREATMENT; SIMULATED SOLAR RADIATIONS; TIO2 PHOTOCATALYSIS;

TITANIUM COMPOUNDS;

EID: 85034068686     PISSN: 09263373     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apcatb.2017.11.020     Document Type: Article

References (86)

1. UN-Water: Annual Report 2015, Geneve, Switzerland. < http://www.unwater.org/publications/publications-detail/en/c/428244//>, 2015 (Accessed 2 February 2017).
2. Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M.C., Michael, I., Fatta-Kassinos, D., Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. Sci. Total Environ. 447 (2013), 345–360, 10.1016/j.scitotenv.2013.01.032.
3. Berendonk, T.U., Manaia, C.M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F., Bürgmann, H., Sørum, H., Norström, M., Pons, M.-N., Kreuzinger, N., Huovinen, P., Stefani, S., Schwartz, T., Kisand, V., Baquero, F., Martinez, J.L., Tackling antibiotic resistance: the environmental framework. Nat. Rev. Microbiol. 13 (2015), 310–317, 10.1038/nrmicro3439.
4. Allen, H.K., Donato, J., Wang, H.H., Cloud-Hansen, K.A., Davies, J., Handelsman, J., Call of the wild: antibiotic resistance genes in natural environments. Nat. Rev. Microbiol. 8 (2010), 251–259, 10.1038/nrmicro2312.
5. Pachepsky, Y., Morrow, J., Guber, A., Shelton, D., Rowland, R., Davies, G., Effect of biofilm in irrigation pipes on microbial quality of irrigation water. Lett. Appl. Microbiol. 54 (2012), 217–224, 10.1111/j.1472-765X.2011.03192.x.
6. Al-Jassim, N., Ansari, M.I., Harb, M., Hong, P.Y., Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: is the treated wastewater safe to reuse for agricultural irrigation?. Water Res. 73 (2015), 277–290, 10.1016/j.watres.2015.01.036.
7. Yomoda, S., Okubo, T., Takahashi, A., Murakami, M., Iyobe, S., Presence of Pseudomonas putida strains harboring plasmids bearing the metallo-β-lactamase gene blaIMP in a hospital in Japan. J. Clin. Microbiol. 41 (2003), 4246–4251, 10.1128/JCM.41.9.4246-4251.2003.
8. Schwartz, T., Kohnen, W., Jansen, B., Obst, U., Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. FEMS Microbiol. Ecol. 43 (2003), 325–335, 10.1111/j.1574-6941.2003.tb01073.x.
9. Gomez-Alvarez, V., Revetta, R.P., Santo Domingo, J.W., Metagenomic analyses of drinking water receiving different disinfection treatments. Appl. Environ. Microbiol. 78 (2012), 6095–6102, 10.1128/AEM.01018-12.
10. Bouki, C., Venieri, D., Diamadopoulos, E., Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: a review. Ecotoxicol. Environ. Saf. 91 (2013), 1–9, 10.1016/j.ecoenv.2013.01.016.
11. Munir, M., Xagoraraki, I., Levels of antibiotic resistance genes in manure, biosolids, and fertilized soil. J. Environ. Qual., 40, 2011, 248, 10.2134/jeq2010.0209.
12. Alexander, J., Knopp, G., Dötsch, A., Wieland, A., Schwartz, T., Ozone treatment of conditioned wastewater selects antibiotic resistance genes, opportunistic bacteria, and induce strong population shifts. Sci. Total Environ. 559 (2016), 103–112, 10.1016/j.scitotenv.2016.03.154.
13. Alrousan, D.M.A., Polo-López, M.I., Dunlop, P.S.M., Fernández-Ibáñez, P., Byrne, J.A., Solar photocatalytic disinfection of water with immobilised titanium dioxide in re-circulating flow CPC reactors. Appl. Catal. B Environ. 128 (2012), 126–134, 10.1016/j.apcatb.2012.07.038.
14. Fernández-Ibáñez, P., Polo-López, M.I., Malato, S., Wadhwa, S., Hamilton, J.W.J., Dunlop, P.S.M., D'Sa, R., Magee, E., O'Shea, K., Dionysiou, D.D., Byrne, J.A., Solar photocatalytic disinfection of water using titanium dioxide graphene composites. Chem. Eng. J. 261 (2015), 36–44, 10.1016/j.cej.2014.06.089.
15. Tsang, C.H.A., Kwok, H.Y.H., Cheng, Z., Leung, D.Y.C., The applications of graphene-based materials in pollutant control and disinfection. Prog. Solid State Chem. 45 (2017), 1–8, 10.1016/j.progsolidstchem.2017.02.001.
16. Wang, W., Li, G., Xia, D., An, T., Zhao, H., Wong, P.K., Photocatalytic nanomaterials for solar-driven bacterial inactivation: recent progress and challenges. Environ. Sci. Nano 4 (2017), 782–799, 10.1039/C7EN00063D.
17. Reddy, P.V.L., Kavitha, B., Reddy, P.A.K., Kim, K.-H., TiO2-based photocatalytic disinfection of microbes in aqueous media: a review. Environ. Res. 154 (2017), 296–303, 10.1016/j.envres.2017.01.018.
18. Wang, W., Huang, G., Yu, J.C., Wong, P.K., Advances in photocatalytic disinfection of bacteria: development of photocatalysts and mechanisms. J. Environ. Sci. 34 (2015), 232–247, 10.1016/j.jes.2015.05.003.
19. Faraldos, M., Bahamonde, A., Environmental applications of titania-graphene photocatalysts. Catal. Today 285 (2017), 13–28, 10.1016/j.cattod.2017.01.029.
20. Kumar, V., Kim, K.-H., Park, J.-W., Hong, J., Kumar, S., Graphene and its nanocomposites as a platform for environmental applications. Chem. Eng. J. 315 (2017), 210–232, 10.1016/j.cej.2017.01.008.
21. Zhang, N., Yang, M.-Q., Liu, S., Sun, Y., Xu, Y.-J., Waltzing with the versatile platform of graphene to synthesize composite photocatalysts. Chem. Rev. 115 (2015), 10307–10377, 10.1021/acs.chemrev.5b00267.
22. Upadhyay, R.K., Soin, N., Roy, S.S., Role of graphene/metal oxide composites as photocatalysts, adsorbents and disinfectants in water treatment: a review. RSC Adv. 4 (2014), 3823–3851, 10.1039/C3RA45013A.
23. Huang, X., Qi, X., Boey, F., Zhang, H., Graphene-based composites. Chem. Soc. Rev. 41 (2012), 666–686, 10.1039/c1cs15078b.
24. Xiang, Q., Yu, J., Jaroniec, M., Graphene-based semiconductor photocatalysts. Chem. Soc. Rev. 41 (2012), 782–796, 10.1039/c1cs15172j.
25. Eigler, S., Hirsch, A., Chemistry with graphene and graphene oxide-challenges for synthetic chemists. Angew. Chem. Int. Ed. Engl. 53 (2014), 7720–7738, 10.1002/anie.201402780.
26. Novoselov, K.S., Geim, A.K., Morozov, S.V., Jiang, D., Zhang, Y., Dubonos, S.V., Grigorieva, I.V., Firsov, A.A., Electric field effect in atomically thin carbon films. Science 306 (2004), 666–669, 10.1126/science.1102896.
27. Geim, A.K., Novoselov, K.S., The rise of graphene. Nat. Mater. 6 (2007), 183–191, 10.1038/nmat1849.
28. Zeng, X., Wang, Z., Meng, N., McCarthy, D.T., Deletic, A., Pan, J., Zhang, X., Highly dispersed TiO2 nanocrystals and carbon dots on reduced graphene oxide: ternary nanocomposites for accelerated photocatalytic water disinfection. Appl. Catal. B Environ. 202 (2017), 33–41, 10.1016/j.apcatb.2016.09.014.
29. Cruz-Ortiz, B.R., Hamilton, J.W.J., Pablos, C., Díaz-Jiménez, L., Cortés-Hernández, D.A., Sharma, P.K., Castro-Alférez, M., Fernández-Ibañez, P., Dunlop, P.S.M., Byrne, J.A., Mechanism of photocatalytic disinfection using titania-graphene composites under UV and visible irradiation. Chem. Eng. J. 316 (2017), 179–186, 10.1016/j.cej.2017.01.094.
30. Liu, L.-P., Yang, X.-N., Ye, L., Xue, D.-D., Liu, M., Jia, S.-R., Hou, Y., Chu, L.-Q., Zhong, C., Preparation and characterization of a photocatalytic antibacterial material: graphene oxide/TiO2/bacterial cellulose nanocomposite. Carbohydr. Polym. 174 (2017), 1078–1086, 10.1016/j.carbpol.2017.07.042.
31. Wang, G., Feng, W., Zeng, X., Wang, Z., Feng, C., McCarthy, D.T., Deletic, A., Zhang, X., Highly recoverable TiO2–GO nanocomposites for stormwater disinfection. Water Res. 94 (2016), 363–370, 10.1016/j.watres.2016.02.067.
32. Rojas-Andrade, M.D., Chata, G., Rouholiman, D., Liu, J., Saltikov, C., Chen, S., Antibacterial mechanisms of graphene-based composite nanomaterials. Nanoscale 9 (2017), 994–1006, 10.1039/C6NR08733G.
33. Zhu, J., Wang, J., Hou, J., Zhang, Y., Liu, J., der Bruggen, B., Graphene-based antimicrobial polymeric membranes: a review. J. Mater. Chem. A 5 (2017), 6776–6793, 10.1039/C7TA00009J.
34. Ji, H., Sun, H., Qu, X., Antibacterial applications of graphene-based nanomaterials: recent achievements and challenges. Adv. Drug Deliv. Rev. 105 (2016), 176–189, 10.1016/j.addr.2016.04.009.
35. Wanag, A., Rokicka, P., Kusiak-Nejman, E., Kapica-Kozar, J., Wrobel, R.J., Markowska-Szczupak, A., Morawski, A.W., Antibacterial properties of TiO2 modified with reduced graphene oxide. Ecotoxicol. Environ. Saf. 147 (2018), 788–793, 10.1016/j.ecoenv.2017.09.039.
36. Chang, Y.-N., Ou, X.-M., Zeng, G.-M., Gong, J.-L., Deng, C.-H., Jiang, Y., Liang, J., Yuan, G.-Q., Liu, H.-Y., He, X., Synthesis of magnetic graphene oxide–TiO2 and their antibacterial properties under solar irradiation. Appl. Surf. Sci. 343 (2015), 1–10, 10.1016/j.apsusc.2015.03.082.
37. Rahimi, R., Zargari, S., Yousefi, A., Yaghoubi Berijani, M., Ghaffarinejad, A., Morsali, A., Visible light photocatalytic disinfection of E. coli with TiO2–graphene nanocomposite sensitized with tetrakis(4-carboxyphenyl)porphyrin. Appl. Surf. Sci. 355 (2015), 1098–1106, 10.1016/j.apsusc.2015.07.115.
38. Karimi, L., Yazdanshenas, M.E., Khajavi, R., Rashidi, A., Mirjalili, M., Using graphene/TiO2 nanocomposite as a new route for preparation of electroconductive, self-cleaning, antibacterial and antifungal cotton fabric without toxicity. Cellulose 21 (2014), 3813–3827, 10.1007/s10570-014-0385-1.
39. Gao, P., Li, A., Sun, D.D., Ng, W.J., Effects of various TiO2 nanostructures and graphene oxide on photocatalytic activity of TiO2. J. Hazard. Mater. 279 (2014), 96–104, 10.1016/j.jhazmat.2014.06.061.
40. Liu, L., Bai, H., Liu, J., Sun, D.D., Multifunctional graphene oxide-TiO2-Ag nanocomposites for high performance water disinfection and decontamination under solar irradiation. J. Hazard. Mater. 261 (2013), 214–223, 10.1016/j.jhazmat.2013.07.034.
41. Cao, B., Cao, S., Dong, P., Gao, J., Wang, J., High antibacterial activity of ultrafine TiO2/graphene sheets nanocomposites under visible light irradiation. Mater. Lett. 93 (2013), 349–352, 10.1016/j.matlet.2012.11.136.
42. Liu, J., Liu, L., Bai, H., Wang, Y., Sun, D.D., Gram-scale production of graphene oxide–TiO2 nanorod composites: towards high-activity photocatalytic materials. Appl. Catal. B Environ. 106 (2011), 76–82, 10.1016/j.apcatb.2011.05.007.
43. Akhavan, O., Ghaderi, E., Photocatalytic Reduction of Graphene Oxide Nanosheets on TiO2 Thin Film for Photoinactivation of Bacteria in Solar Light Irradiation. 2009 http://pubs.acs.org/doi/abs/10.1021/jp906325q. (Accessed 24 January 2016).
44. Official Journal of the European Union: Commission Implementing Decision (EU) 2015/495 of 20 March 2015 establishing a watch list of substances for Union-wide monitoring in the field of water policy pursuant to Directive 2008/105/EC of the European Parliament and of the council (2015). Available at: http://data.europa.eu/eli/dec_impl/2015/495/oj.
45. Hummers, W.S., Offeman, R.E., Preparation of Graphitic Oxide. J. Am. Chem. Soc., 80, 1958, 1339, 10.1021/ja01539a017.
46. Fan, W., Lai, Q., Zhang, Q., Wang, Y., Nanocomposites of TiO2 and reduced graphene oxide as efficient photocatalysts for hydrogen evolution. J. Phys. Chem. C 115 (2011), 10694–10701, 10.1021/jp2008804.
47. Williams, G., Seger, B., Kamat, P.V., TiO2-graphene nanocomposites. UV-assisted photocatalytic reduction of graphene oxide. ACS Nano 2 (2008), 1487–1491, 10.1021/nn800251f.
48. Galbavy, E.S., Ram, K., Anastasio, C., 2-Nitrobenzaldehyde as a chemical actinometer for solution and ice photochemistry. J. Photochem. Photobiol. A Chem. 209 (2010), 186–192, 10.1016/j.jphotochem.2009.11.013.
49. Gros, M., Petrović, M., Barceló, D., Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the Ebro river basin (Northeast Spain). Environ. Toxicol. Chem., 26, 2007, 1553, 10.1897/06-495R.1.
50. Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing; twenty second informational supplement, M100-S22. 2012, CLSI, Wayne, PA http://clsi.org//.
51. Oliver, J., The viable but nonculturable state in bacteria. J. Microbiol. 43 (2005), 93–100 https://www.researchgate.net/profile/James_Oliver4/publication/7969638_The_Viable_but_Nonculturable_State_in_Bacteria/links/00b7d51e5521d33219000000/The-Viable-but-Nonculturable-State-in-Bacteria.pdf. (Accessed 18 July 2017).
52. Ratkowsky, D.A., Olley, J., McMeekin, T.A., Ball, A., Relationship between temperature and growth rate of bacterial cultures. J. Bacteriol. 149 (1982), 1–5 http://jb.asm.org/content/149/1/1.abstract.
53. Davis, M.F., Iverson, S.A., Baron, P., Vasse, A., Silbergeld, E.K., Lautenbach, E., Morris, D.O., Household transmission of meticillin-resistant Staphylococcus aureus and other staphylococci. Lancet Infect. Dis. 12 (2012), 703–716, 10.1016/S1473-3099(12)70156-1.
54. Alexander, J., Bollmann, A., Seitz, W., Schwartz, T., Microbiological characterization of aquatic microbiomes targeting taxonomical marker genes and antibiotic resistance genes of opportunistic bacteria. Sci. Total Environ. 512–513 (2015), 316–325, 10.1016/j.scitotenv.2015.01.046.
55. Gros, M., Petrović, M., Barceló, D., Development of a multi-residue analytical methodology based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70 (2006), 678–690, 10.1016/j.talanta.2006.05.024.
56. Tobaldi, D.M., Pullar, R.C., Škapin, A.S., Seabra, M.P., Labrincha, J.A., Visible light activated photocatalytic behaviour of rare earth modified commercial TiO2. Mater. Res. Bull. 50 (2014), 183–190, 10.1016/j.materresbull.2013.10.033.
57. Reich, S., Thomsen, C., Raman spectroscopy of graphite. Philos. Trans. R. Soc. Lond. A Math. Phys. Eng. Sci., 362, 2004.
58. Kudin, K.N., Ozbas, B., Schniepp, H.C., Prud'homme, R.K., Aksay, I.A., Car, R., Raman spectra of graphite oxide and functionalized graphene sheets. Nano Lett. 8 (2007), 36–41, 10.1021/NL071822Y.
59. Wang, S., Sun, H., Ang, H.M., Tadé, M.O., Adsorptive remediation of environmental pollutants using novel graphene-based nanomaterials. Chem. Eng. J. 226 (2013), 336–347, 10.1016/j.cej.2013.04.070.
60. Hu, L., Flanders, P.M., Miller, P.L., Strathmann, T.J., Oxidation of sulfamethoxazole and related antimicrobial agents by TiO2 photocatalysis. Water Res. 41 (2007), 2612–2626, 10.1016/j.watres.2007.02.026.
61. Xekoukoulotakis, N.P., Drosou, C., Brebou, C., Chatzisymeon, E., Hapeshi, E., Fatta-Kassinos, D., Mantzavinos, D., Kinetics of UV-A/TiO2 photocatalytic degradation and mineralization of the antibiotic sulfamethoxazole in aqueous matrices. Catal. Today 161 (2011), 163–168, 10.1016/j.cattod.2010.09.027.
62. Abellán, M.N., Bayarri, B., Giménez, J., Costa, J., Photocatalytic degradation of sulfamethoxazole in aqueous suspension of TiO2. Appl. Catal. B Environ. 74 (2007), 233–241, 10.1016/j.apcatb.2007.02.017.
63. Xekoukoulotakis, N.P., Xinidis, N., Chroni, M., Venieri, D., Hapeshi, E., Fatta-Kassinos, D., Mantzavinos, D., Venieri, D., Hapeshi, E., Fatta-Kassinos, D., UV-A/TiO2 photocatalytic decomposition of erythromycin in water: factors affecting mineralization and antibiotic activity. Catal. Today 151 (2010), 29–33, 10.1016/j.cattod.2010.01.040.
64. Vignesh, K., Rajarajan, M., Suganthi, A., Photocatalytic degradation of erythromycin under visible light by zinc phthalocyanine-modified titania nanoparticles. Mater. Sci. Semicond. Process. 23 (2014), 98–103, 10.1016/j.mssp.2014.02.050.
65. Mordi, M.N., Pelta, M.D., Boote, V., Morris, G.A., Barber, J., Acid-catalyzed degradation of clarithromycin and erythromycin B: a comparative study using NMR spectroscopy. J. Med. Chem. 43 (2000), 467–474, 10.1021/jm9904811.
66. Abegglen, C., Joss, A., McArdell, C.S., Fink, G., Schlüsener, M.P., Ternes, T.A., Siegrist, H., The fate of selected micropollutants in a single-house MBR. Water Res. 43 (2009), 2036–2046, 10.1016/j.watres.2009.02.005.
67. Göbel, A., Thomsen, A., McArdell, C.S., Alder, A.C., Giger, W., Theiß, N., Löffler, D., Ternes, T.A., Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge. J. Chromatogr. A 1085 (2005), 179–189, 10.1016/j.chroma.2005.05.051.
68. McArdell, C.S., Molnar, E., Suter, M.J.-F., Giger, W., Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley Watershed, Switzerland. Environ. Sci. Technol. 37 (2003), 5479–5486, 10.1021/es034368i.
69. Dunlop, P.S.M., Sheeran, C.P., Byrne, J.A., McMahon, M.A.S., Boyle, M.A., McGuigan, K.G., Inactivation of clinically relevant pathogens by photocatalytic coatings. J. Photochem. Photobiol. A Chem. 216 (2010), 303–310, 10.1016/j.jphotochem.2010.07.004.
70. Bandala, E.R., Bustos, E., Hernández-Ramírez, A., Medina-Ramírez, I., (eds.) Photocatalytic Semiconductors, 2015, Springer International Publishing, Cham, 255–278, 10.1007/978-3-319-10999-2.
71. Süß, J., Volz, S., Obst, U., Schwartz, T., Application of a molecular biology concept for the detection of DNA damage and repair during UV disinfection. Water Res. 43 (2009), 3705–3716, 10.1016/j.watres.2009.05.048.
72. Foster, H.A., Ditta, I.B., Varghese, S., Steele, A., Photocatalytic disinfection using titanium dioxide: spectrum and mechanism of antimicrobial activity. Appl. Microbiol. Biotechnol. 90 (2011), 1847–1868, 10.1007/s00253-011-3213-7.
73. Maness, P.-C., Smolinski, S., Blake, D.M., Huang, Z., Wolfrum, E.J., Jacoby, W.A., Bactericidal activity of photocatalytic TiO2 reaction: toward an understanding of its killing mechanism. Appl. Environ. Microbiol. 65 (1999), 4094–4098 http://aem.asm.org/content/65/9/4094.short. (Accessed 24 January 2016).
74. Huang, Z., Maness, P.-C., Blake, D.M., Wolfrum, E.J., Smolinski, S.L., Jacoby, W.A., Bactericidal mode of titanium dioxide photocatalysis. J. Photochem. Photobiol. A Chem. 130 (2000), 163–170, 10.1016/S1010-6030(99)00205-1.
75. Sunada, K., Watanabe, T., Hashimoto, K., Studies on photokilling of bacteria on TiO2 thin film. J. Photochem. Photobiol. A Chem. 156 (2003), 227–233, 10.1016/S1010-6030(02)00434-3.
76. Shen, X.-C., Zhang, Z.-L., Zhou, B., Peng, J., Xie, M., Zhang, M., Pang, D.-W., Visible light-induced plasmid DNA damage catalyzed by a XdSe/ZnS-photosensitized nano-TiO2 film. Environ. Sci. Technol. 42 (2008), 5049–5054, 10.1021/es800668g.
77. Tsai, T.-M., Chang, H.-H., Chang, K.-C., Liu, Y.-L., Tseng, C.-C., A comparative study of the bactericidal effect of photocatalytic oxidation by TiO2 on antibiotic-resistant and antibiotic-sensitive bacteria. J. Chem. Technol. Biotechnol. 85 (2010), 1642–1653, 10.1002/jctb.2476.
78. Sato, T., Taya, M., Enhancement of phage inactivation using photocatalytic titanium dioxide particles with different crystalline structures. Biochem. Eng. J. 28 (2006), 303–308, 10.1016/j.bej.2006.01.004.
79. Liu, L., Liu, J., Sun, D.D., Graphene oxide enwrapped Ag3PO4 composite: towards a highly efficient and stable visible-light-induced photocatalyst for water purification. Catal. Sci. Technol., 2, 2012, 2525, 10.1039/c2cy20483e.
80. Gogniat, G., Dukan, S., TiO2 photocatalysis causes DNA damage via fenton reaction-generated hydroxyl radicals during the recovery period. Appl. Environ. Microbiol. 73 (2007), 7740–7743, 10.1128/AEM.01079-07.
81. Hirakawa, K., Mori, M., Yoshida, M., Oikawa, S., Kawanishi, S., Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radic. Res., 2009 http://www.tandfonline.com/doi/abs/10.1080/1071576042000206487. (Accessed 24 January 2016).
82. Pigeot-Rémy, S., Simonet, F., Errazuriz-Cerda, E., Lazzaroni, J.C., Atlan, D., Guillard, C., Photocatalysis and disinfection of water: identification of potential bacterial targets. Appl. Catal. B Environ. 104 (2011), 390–398, 10.1016/j.apcatb.2011.03.001.
83. Giannakis, S., Darakas, E., Escalas-Cañellas, A., Pulgarin, C., Elucidating bacterial regrowth: effect of disinfection conditions in dark storage of solar treated secondary effluent. J. Photochem. Photobiol. A Chem. 290 (2014), 43–53, 10.1016/j.jphotochem.2014.05.016.
84. Volkmann, H., Schwartz, T., Bischoff, P., Kirchen, S., Obst, U., Detection of clinically relevant antibiotic-resistance genes in municipal wastewater using real-time PCR (TaqMan). J. Microbiol. Methods 56:2 (2004), 277–286, 10.1016/j.mimet.2003.10.014.
85. Czekalski, N., Berthold, T., Caucci, S., Egli, A., Bürgmann, H., Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into lake geneva, Switzerland. Front. Microbiol., 3, 2012, 106, 10.3389/fmicb.2012.00106.
86. Clifford, R.J., Milillo, M., Prestwood, J., Quintero, R., Zurawski, D.V., Kwak, Y.I., Mc Gann, P., Detection of bacterial 16S rRNA and identification of four clinically important bacteria by real-time PCR. PLoS One, 7(11), 2012, e48558, 10.1371/journal.pone.0048558.