A murine model of genetic susceptibility to lead bioaccumulation

Fundamental and Applied Toxicology

Volumn 35, Issue 1, 1997, Pages 84-90

  Claudio, Luz ^a   Lee, Tania ^a   Wolff, Mary S ^a   Wetmur, James G ^b  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD; PORPHOBILINOGEN SYNTHASE; PROTOPORPHYRIN ZINC;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; ENZYME ACTIVITY; FEMALE; GENETIC SUSCEPTIBILITY; KIDNEY; LEAD BLOOD LEVEL; LIVER; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION;

ANIMALIA; MURINAE;

EID: 85033514632     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.2265     Document Type: Article

References (34)

1. Ahotupa, M., Bereziat, J. C., Mantyla, E., and Bartsch, H. (1993). Dietary fat and phenobarbital-induced alterations in hepatic antioxidant functions of mice. Carcinogenesis 14, 1225-1228.
2. Ammassari-Teule, M., Hoffmann, H. J., and Rossi-Arnaud, C. (1993). Learning in inbred mice. Strain-specific abilities across three radial maze problems. Behav. Genet. 23, 405-412.
3. Astrin, K. H., Bishop, D. F., Wetmur, J. G., Kaul, B. C., Davidow, B., and Desnick, R. J. (1987). Aminolevulinic acid dehydratase isozymes and lead toxicity. Ann. NY Acad. Sci. 514, 23-29.
4. Benkman, H. G., Gogdaanski, P., and Goedde, H. W. (1983). Polymorphism of delta-aminolevulinic acid dehydratase in various populations. Hum. Hered. 33, 62-64.
5. Bentivoglio, A. R., Altavista, M. C., Granata, R., and Albanese, A. (1994). Genetically determined cholinergic deficiency in the forebrain of C57BL/ 6 mice. Brain Res. 637, 181-189.
6. Beri, R., and Chandra, R. (1993). Chemistry and biology of heme. Drug Metab. Rev. 25, 49-152.
7. Bishop, T. R., Cohen, P. J., Boyer, S. H., Noyes, A. N., and Frelin, L. P. (1986). Isolation of a rat liver δ-aminolevulinate dehydratase (ALAD) cDNA clone. Evidence for unequal ALAD gene dosage among inbred mouse strains. Proc. Natl. Acad. Sci. USA 83, 5568-5572.
8. Blumberg, W. E., Eisinger, J., Lamola, A. A., and Zuckerman, D. M. (1984). Principles and applications of hematofluorometry. J. Clin. Lab. Automation 4, 29-42.
9. Cory-Slechta, D. A., Weiss, B., and Cox, C. (1989). Tissue distribution of Pb in adult vs. old rats, a pilot study. Toxicology 59, 139-150.
10. Cory-Slechta, D. A. (1990). Lead exposure during advanced age. Alterations in kinetic and biochemical effects. Toxicol. Appl. Pharmacol. 104, 67-78.
11. Doyle, D., and Schimke, R. T. (1969). The genetic and developmental regulation of hepatic delta-aminolevulinate dehydratase in mice. J. Biol. Chem. 244, 5449-5459.
12. Eisinger, J. (1978). Biochemistry and measurement of environmental lead intoxication. Q. Rev. Biophys. II 4, 439-466.
13. Esplin, M. S., Abbott, J. R., Smart, M. L., Burroughs, A. F., Frandsen, T. C., and Litzinger, M. J. (1994). Voltage-sensitive calcium channel development in epileptic DBA/2J mice suggests altered presynaptic function. Epilepsia 35, 911-914.
14. Fordyce, D. E., and Wehner, J. M. (1993). Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Res. 619, 111-119.
15. González, F. J. (1995). Genetic polymorphism and cancer susceptibility. Fourteenth Sapporo Cancer Seminar. Cancer Res. 55, 710-715.
16. Hutton, J. J., and Coleman, D. L. (1969). Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem. Genet. 3, 517-523.
17. Lamola, A. A., and Yamane, T. (1974). Zinc protoporphyrin in the erythrocytes of patients with lead intoxication and iron deficiency anemia. Science 186, 936-938.
18. National Research Council (1992). Environmental Neurotoxicology (P. J. Landrigan, Ed.). National Academy Press, Washington, DC.
19. Petrucci, R., Leonardi, A., and Battistuzzi, G. (1982). The genetic polymorphism of delta aminolevulinate dehydratase in Italy. Hum. Genet. 60, 289-290.
20. Rebuffé-Scrive, M., Surwit, R., Feinglos, M., Kuhn, C., and Rodin, J. (1993). Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism 42, 1405-1409.
21. Regoli, F., and Orlando, E. (1994). Bioavailability of biologically detoxified lead, risks arising from consumption of polluted mussels. Environ. Health Perspect. 102 (Suppl. 3), 335-338.
22. Schifman, R. B., Rivers, S. L., Rinley, P. R., and Thies, C. (1982). RBC zinc protoporphyrin to screen blood donors for iron deficiency anemia. J. Am. Med. Assoc.(JAMA) 248, 2012-2015.
23. Schwartz, B. S., Bolla, K. I., Stewart, W., Ford, D. P., Agnew, J., and Frumkin, H. (1993). Decrements in neurobehavioral performance associated with mixed exposure to organic and inorganic lead. Am. J. Epidemiol. 137, 1006-1021.
24. Schwartz, B. S., Lee, B. K., Stewart, W., Ahn, K. D., Springer, K., and Kelsey, K. (1995). Associations of delta-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers. Am. J. Epidemiol. 142, 738-745.
25. Secchi, G. C., Erba, L., and Cambiaghi, G. (1974). Delta-aminolevulinic acid dehydratase activity of erythrocytes and liver tissue in man, relationship to lead exposure. Arch. Environ. Health 8, 130-132.
26. Smith, C. M., Wang, X., Hu, H., and Kelsey, K. T. (1995). A polymorphism in the d-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ. Health Perspect. 103, 248-253.
27. Thunell, S., Holmberg, L., and Lundgren, J. (1987). Aminolevulinate dehydratase porphyria in infancy. A clinical and biochemical study. Clin. Chem. Clin. Biochem. 25, 5-14.
28. Tomokuni, K., Ichiba, M., and Hirai, Y. (1991). Elevated urinary excretion of b-aminoisobutyric acid and g-aminolevulinic acid (ALA) and the inhibition of ALA-synthase and ALA-dehydratase activities in both liver and kidney in mice exposed to lead. Toxicol. Lett. 59, 169-173.
29. U.S. Congress Office of Technology Assessment (1990). Neurotoxicity. Identifying and Controlling Poisons of the Nervous System, OTA-BA-436. U.S. Govt. Printing Office, Washington, DC.
30. Wetmur, J. G., Lehnert, G., and Desnick, R. J. (1991a). The δ-aminolevulinate dehydratase polymorphism, higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 22 isozymes. Environ. Res. 56, 109-119.
31. Wetmur, J. G., Kaya, A. H., Plewinska, M., and Desnick, R. J. (1991b). Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: Implications for molecular screening of individuals for genetic susceptibility to lead. Am. J. Hum. Genet. 49, 757-763.
32. Wetmur, J. G. (1994). Influence of the common human d-aminolevulinate dehydratase polymorphism on lead body burden. Environ. Health Perspect. 102 (Suppl. 3), 215-219.
33. Willott, J. F., Carlson, S., and Chen, H. (1994). Prepulse inhibition of the startle response in mice: Relationship to hearing loss and auditory system plasticity. Behav. Neurosci. 108, 703-713.
34. World Health Organization (1977). Lead. In WHO Environmental Health Criteria 3. World Health Organization, Geneva.