Prechronic toxicity studies on 2-ethylhexanol in F334 rats and B6C3F1 mice

Fundamental and Applied Toxicology

Volumn 29, Issue 1, 1996, Pages 31-39

  Astill, B D ^a   Deckardt, K ^b   Gembardt, Chr ^b   Gingell, R ^a   Guest, D ^a   Hodgson, J R ^a   Mellert, W ^b   Murphy, S R ^a   Tyler, T R ^a  

^a AMERICAN CHEMISTRY COUNCIL   (United States)

^b BASF SE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYLHEXANOL; PEROXISOME PROLIFERATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARCINOGENICITY; CENTRAL NERVOUS SYSTEM; CHRONIC TOXICITY; CONTROLLED STUDY; FEMALE; FORESTOMACH; HISTOPATHOLOGY; KIDNEY; LIVER; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; RAT; SEX DIFFERENCE; SPECIES DIFFERENCE; SPLEEN; STOMACH; THYMUS;

ANIMALIA;

EID: 85033056463     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0003     Document Type: Article

References (25)

1. Albro, P. W. (1975). The metabolism of 2-ethylhexanol in rats. Xenobiotica 5, 625-636.
2. Albro, P. W. (1986). Absorption, metabolism, and excretion of di(2-ethylphthalate) by rats and mice. Environ. Health Perspect. 65, 293-298.
3. Astill, B. D., Gingell, R., Guest, D., Hodgson, J. R., Murphy, S. R., Tyler, T. R., Mellert, W., Deckardt, K., and Gembardt, Chr. (1993). Subacute and subchronic oral toxicity of 2-ethylhexanol to Fischer 344 rats and B6C3F1 mice. The Toxicologist 13(1), Abs 172.
4. BIBRA (1990). Toxicity Profile for 2-Ethylhexanol. Report by the British Industries Biological Research Association. Carshalton, England.
5. Chemical Manufacturers Association (1987). Preliminary Report, 1987 Survey of 2-Ethylhexanol Uses, Production Potential Exposures, and Safety Procedures. Washington, DC.
6. Dean, J. A. (1985). Lange's Handbook of Chemistry, 13th Ed. McGraw-Hill, New York, NY.
7. Deisinger, P. J., Boatman, R. J., and Guest, D. (1993). Pharmacokinetic studies with 2-ethylhexanol in the female Fischer 344 rat. The Toxicologist 13(1), Abs 631.
8. Dunnett, C. W. (1955). A multiple comparison procedure for comparing several treatments with a control. J. Am. Statist. Assoc. 50, 1096-1121.
9. Dunnett, C. W. (1964). New tables for multiple comparison with a control. Biometrics 20, 482-491.
10. Gray, T. J. B., and Beaumand, J. A. (1984). Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells. Food Chem. Toxicol. 22, 123-131.
11. Gray, T. J. B., and Gangolli, S. D. (1986). Aspects of the testicular toxicity of phthalate esters. Environ. Health Perspect. 65, 229-235.
12. Hodgson, J. R. (1987). Results of peroxisome induction studies on tris(2-ethylhexyl mellitate) and 2-ethylhexanol. Toxicol. Ind. Health 3, 49-60.
13. Keith, Y., Canning, P. M., LHuguenot, J.-C., and Elcombe, C. R. (1985). Peroxisome proliferation due to di-(2-ethylhexyladipate) and 2-ethylhexanol. Human Toxicol. 4, 551-552.
14. Lake, B. G., Gangolli, S. D., Grasso, P., and Lloyd, A. G. (1975). Studies on the effects of orally administered di(2-ethylhexylphthalate) in the rat. Toxicol. Appl. Pharmacol. 32, 355-367.
15. Lazarow, P. B. (1981). Methods Enzymol. 72, 315-319.
16. Lowry, O. H., Roseborough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
17. Moody, D. E., and Reddy, J. K. (1978). Hepatic Peroxisome Proliferation in rats fed plasticizers and related compounds. Toxicol. Appl. Pharmacol. 45, 497-504.
18. National Institute of Occupational Safety and Health (1984). National Occupational Survey Data Base. US Dept. of Health and Human Services, Washington, DC.
19. Rowe, V. K., and McCollister, S. B. (1982). In Patty's Industrial and Toxicology (G. D. Clayton and F. E. Clayton, Eds.) 3rd. Ed. Wiley Interscience, New York.
20. Scala, R. A., and Burris, E. G. (1973). Acute toxicity of a homologous series of branched-chain primary alcohols. Am. Indust. Hyg. Assoc. J. 34, 493-499.
21. Sjoberg, P., Bondesson, U., Gray, T. J. B., and Ploen, L. (1986). Effects of di-(2-ethyl-hexyl-phthalate) and five of its metabolites on rat testis in vivo and in vitro. Acta Pharmacol. Toxicol. 32, 355-367.
22. U.S. EPA (Environmental Protection Agency) (1987a). 2-Ethylhexanol. Final Test Rule. Fed. Reg. 52, 28698-28705.
23. U.S. EPA (Environmental Protection Agency) (1987b). Health effects guidelines: Oncogenicity (40 CFR 798. 3300). Fed. Reg. 52, 19056.
24. U.S. EPA (Environmental Protection Agency) (1987c). Health effects guidelines: Subchronic exposure; Oral toxicity (40 CFR 798. 2650). Fed. Reg. 52, 19074.
25. Winer, B. J. (1971). In Statistical Principles in Experimental Design, 2nd. Ed. McGraw-Hill, New York, NY.