Is load-induced ventricular hypertrophy ever compensatory?

Circulation

Volumn 136, Issue 14, 2017, Pages 1273-1275

  Schiattarella, Gabriele G ^a   Hill, Theodore M ^a   Hill, Joseph A ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Animal models; Cardiac myocytes; Clinical trial; Growth; Hypertrophy; Left ventricle

Indexed keywords

ARTICLE; EVIDENCE BASED MEDICINE; HEART AFTERLOAD; HEART CONTRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART STRESS; HEART WORK; PRIORITY JOURNAL; ADAPTATION; ANIMAL; BIOLOGICAL MODEL; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; HUMAN; PATHOPHYSIOLOGY; RISK FACTOR; TIME FACTOR;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MODELS, CARDIOVASCULAR; RISK FACTORS; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 85032862993     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.030730     Document Type: Article

References (5)

1. Woods RH. A few applications of a physical theorem to membranes in the human body in a state of tension. J Anat Physiol. 1892;26:362-370.
2. Meerson FZ. Compensatory hyperfunction of the heart and cardiac insufficiency. Circ Res. 1962;10:250-258.
3. Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest. 1975;56:56-64. doi: 10.1172/JCI108079.
4. Schiattarella GG, Hill JA. Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload. Circulation. 2015;131:1435-1447. doi: 10.1161/CIRCULATIONAHA.115.013894.
5. Hill JA, Karimi M, Kutschke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation. 2000;101:2863-2869.