메뉴 건너뛰기




Volumn 61, Issue 11, 2017, Pages

Drug susceptibility and replicative capacity of multidrug-resistant recombinant human cytomegalovirus harboring mutations in UL56 and UL54 genes

Author keywords

Antiviral agents; Cytomegalovirus; Resistance

Indexed keywords

ANTIVIRUS AGENT; BRINCIDOFOVIR; CIDOFOVIR; FOSCARNET; GANCICLOVIR; LETERMOVIR; DNA DIRECTED DNA POLYMERASE; UL54 PROTEIN, HUMAN HERPESVIRUS 5; UL56 PROTEIN, CYTOMEGALOVIRUS; VIRAL PROTEIN;

EID: 85032513480     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01044-17     Document Type: Article
Times cited : (17)

References (18)
  • 1
    • 84877965931 scopus 로고    scopus 로고
    • CMV: Prevention, diagnosis and therapy
    • quiz 40
    • Kotton CN. 2013. CMV: prevention, diagnosis and therapy. Am J Transplant 13(Suppl 3):24–40; quiz 40. https://doi.org/10.1111/ajt.12006.
    • (2013) Am J Transplant , vol.13 , pp. 24-40
    • Kotton, C.N.1
  • 2
    • 84876232770 scopus 로고    scopus 로고
    • Viral DNA polymerase inhibitors
    • In Cameron CE, Gotte M, Raney K (ed), Springer, New York, NY
    • Andrei G, de Clercq E, Snoeck R. 2009. Viral DNA polymerase inhibitors, p 481–526. In Cameron CE, Gotte M, Raney K (ed), Viral genome replication. Springer, New York, NY.
    • (2009) Viral Genome Replication , pp. 481-526
    • Andrei, G.1    De Clercq, E.2    Snoeck, R.3
  • 3
    • 78049355534 scopus 로고    scopus 로고
    • Antiviral drug resistance of human cytomegalovirus
    • Lurain NS, Chou S. 2010. Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev 23:689–712. https://doi.org/10.1128/CMR.00009-10.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 689-712
    • Lurain, N.S.1    Chou, S.2
  • 4
    • 84908333260 scopus 로고    scopus 로고
    • Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping
    • Drouot E, Piret J, Lebel MH, Boivin G. 2014. Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping. J Clin Microbiol 52:4043–4046. https://doi.org/10.1128/JCM.02205-14.
    • (2014) J Clin Microbiol , vol.52 , pp. 4043-4046
    • Drouot, E.1    Piret, J.2    Lebel, M.H.3    Boivin, G.4
  • 5
    • 79952147366 scopus 로고    scopus 로고
    • Synthesis and early development of hexadecyl-oxypropylcidofovir: An oral antipoxvirus nucleoside phosphonate
    • Hostetler KY. 2010. Synthesis and early development of hexadecyl-oxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate. Viruses 2:2213–2225. https://doi.org/10.3390/v2102213.
    • (2010) Viruses , vol.2 , pp. 2213-2225
    • Hostetler, K.Y.1
  • 6
    • 80055021608 scopus 로고    scopus 로고
    • The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase
    • Goldner T, Hewlett G, Ettischer N, Ruebsamen-Schaeff H, Zimmermann H, Lischka P. 2011. The novel anticytomegalovirus compound AIC246 (letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase. J Virol 85: 10884–10893. https://doi.org/10.1128/JVI.05265-11.
    • (2011) J Virol , vol.85 , pp. 10884-10893
    • Goldner, T.1    Hewlett, G.2    Ettischer, N.3    Ruebsamen-Schaeff, H.4    Zimmermann, H.5    Lischka, P.6
  • 7
    • 84891504725 scopus 로고    scopus 로고
    • Geno- And phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure
    • Goldner T, Hempel C, Ruebsamen-Schaeff H, Zimmermann H, Lischka P. 2014. Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure. Antimicrob Agents Chemother 58:610 – 613. https://doi.org/10.1128/AAC.01794-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 610-613
    • Goldner, T.1    Hempel, C.2    Ruebsamen-Schaeff, H.3    Zimmermann, H.4    Lischka, P.5
  • 8
    • 84961989855 scopus 로고    scopus 로고
    • Characterization of cytomegalovirus breakthrough events in a phase 2 prophylaxis trial of letermovir (AIC246, MK (8228)
    • Lischka P, Michel D, Zimmermann H. 2016. Characterization of cytomegalovirus breakthrough events in a phase 2 prophylaxis trial of letermovir (AIC246, MK (8228). J Infect Dis 213:23–30. https://doi.org/10.1093/infdis/jiv352.
    • (2016) J Infect Dis , vol.213 , pp. 23-30
    • Lischka, P.1    Michel, D.2    Zimmermann, H.3
  • 9
    • 85032488411 scopus 로고    scopus 로고
    • A phase III randomized, double-blind, placebo-controlled trial of letermovir for prevention of cytomegalovirus infection in adult CMV-seropositive recipients of allo-geneic hematopoietic cell transplantation, abstr LBA2
    • Orlando, FL
    • Marty FM, Ljungman PT, Chemaly RF et al. 2017. A phase III randomized, double-blind, placebo-controlled trial of letermovir for prevention of cytomegalovirus infection in adult CMV-seropositive recipients of allo-geneic hematopoietic cell transplantation, abstr LBA2. Abstr 2017 BMT Tandem Meetings, Orlando, FL.
    • (2017) Abstr 2017 BMT Tandem Meetings
    • Marty, F.M.1    Ljungman, P.T.2    Chemaly, R.F.3
  • 10
    • 85021716180 scopus 로고    scopus 로고
    • Cytomegalovirus disease in hematopoietic stem cell transplant patients: Current and future therapeutic options
    • Fuji S, Einsele H, Kapp M. 2017. Cytomegalovirus disease in hematopoietic stem cell transplant patients: current and future therapeutic options. Curr Opin Infect Dis 30:372–376. https://doi.org/10.1097/ QCO.0000000000000375.
    • (2017) Curr Opin Infect Dis , vol.30 , pp. 372-376
    • Fuji, S.1    Einsele, H.2    Kapp, M.3
  • 11
    • 0032824127 scopus 로고    scopus 로고
    • Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: A new approach for construction of HCMV mutants
    • Borst EM, Hahn G, Koszinowski UH, Messerle M. 1999. Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants. J Virol 73:8320 – 8329.
    • (1999) J Virol , vol.73 , pp. 8320-8329
    • Borst, E.M.1    Hahn, G.2    Koszinowski, U.H.3    Messerle, M.4
  • 12
    • 84884806690 scopus 로고    scopus 로고
    • Novel method based on “en passant” mutagenesis coupled with a Gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations
    • Drouot E, Piret J, Boivin G. 2013. Novel method based on “en passant” mutagenesis coupled with a Gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations. J Clin Microbiol 51:3216–3224. https://doi.org/10.1128/JCM.01275-13.
    • (2013) J Clin Microbiol , vol.51 , pp. 3216-3224
    • Drouot, E.1    Piret, J.2    Boivin, G.3
  • 13
    • 79955159135 scopus 로고    scopus 로고
    • En passant mutagenesis: A two step markerless red recombination system
    • Tischer BK, Smith GA, Osterrieder N. 2010. En passant mutagenesis: a two step markerless red recombination system. Methods Mol Biol 634: 421–430. https://doi.org/10.1007/978-1-60761-652-8_30.
    • (2010) Methods Mol Biol , vol.634 , pp. 421-430
    • Tischer, B.K.1    Smith, G.A.2    Osterrieder, N.3
  • 14
    • 0038574429 scopus 로고    scopus 로고
    • Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus
    • Chou S, Lurain NS, Thompson KD, Miner RC, Drew WL. 2003. Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus. J Infect Dis 188:32–39. https://doi.org/10.1086/375743.
    • (2003) J Infect Dis , vol.188 , pp. 32-39
    • Chou, S.1    Lurain, N.S.2    Thompson, K.D.3    Miner, R.C.4    Drew, W.L.5
  • 15
    • 70349149423 scopus 로고    scopus 로고
    • Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness
    • Chevillotte M, Schubert A, Mertens T, von Einem J. 2009. Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness. Antimicrob Agents Chemother 53:3752–3761. https://doi.org/10.1128/AAC.00165-09.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3752-3761
    • Chevillotte, M.1    Schubert, A.2    Mertens, T.3    Von Einem, J.4
  • 16
    • 84922718014 scopus 로고    scopus 로고
    • Phenotypic characterization of two naturally occurring human Cytomegalovirus sequence polymorphisms located in a distinct region of ORF UL56 known to be involved in in vitro resistance to letermovir
    • Goldner T, Zimmermann H, Lischka P. 2015. Phenotypic characterization of two naturally occurring human Cytomegalovirus sequence polymorphisms located in a distinct region of ORF UL56 known to be involved in in vitro resistance to letermovir. Antiviral Res 116:48–50. https://doi.org/10.1016/j.antiviral.2015.01.006.
    • (2015) Antiviral Res , vol.116 , pp. 48-50
    • Goldner, T.1    Zimmermann, H.2    Lischka, P.3
  • 18
    • 84942888781 scopus 로고    scopus 로고
    • Rapid in vitro evolution of human cytomegalovirus UL56 mutations that confer letermovir resistance
    • Chou S. 2015. Rapid in vitro evolution of human cytomegalovirus UL56 mutations that confer letermovir resistance. Antimicrob Agents Chemother 59:6588–6593. https://doi.org/10.1128/AAC.01623-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 6588-6593
    • Chou, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.