Iron and Vitamin D levels among autism spectrum disorders children

Annals of African Medicine

Volumn 16, Issue 4, 2017, Pages 186-191

  Bener, Abdulbari ^a,b   Khattab, Azhar ^c,d   Bhugra, Dinesh ^e   Hoffmann, Georg ^f  

^a ISTANBUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c HAMAD GENERAL HOSPITAL   (Qatar)

^d WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autism spectrum disorders; epidemiology; ferritin; iron deficiency; risk factors; Vitamin D

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; CALCIUM; FERRITIN; GLUCOSE; HEMOGLOBIN; IRON; MAGNESIUM; POTASSIUM; VITAMIN D; BIOLOGICAL MARKER;

ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; AUTISM; AUTISM DIAGNOSTIC OBSERVATION SCHEDULE; BODY MASS; CALCIUM BLOOD LEVEL; CASE CONTROL STUDY; CHILD; CONSANGUINITY; CONTROLLED STUDY; ETHNICITY; FEMALE; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; PHYSICAL ACTIVITY; POTASSIUM BLOOD LEVEL; PRESCHOOL CHILD; QATAR; RISK FACTOR; SCHOOL CHILD; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; BLOOD; COMPLICATION; DEFICIENCY;

ANEMIA, IRON-DEFICIENCY; AUTISM SPECTRUM DISORDER; BIOMARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FERRITINS; HUMANS; IRON; MALE; QATAR; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 85032438030     PISSN: 15963519     EISSN: 09755764     Source Type: Journal    
DOI: 10.4103/aam.aam_17_17     Document Type: Article

References (28)

1. Mefford HC, Batshaw ML, Hoffman EP. Genomics, intellectual disability, and autism. N Engl J Med 2012;366:733-43.
2. Landrigan PJ, Lambertini L, Birnbaum LS. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect 2012;120:a258-60.
3. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington: American Psychiatric Association; 1994.
4. Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology 2008;29:190-201.
5. Grabrucker AM. Environmental factors in autism. Front Psychiatry 2012;3:118.
6. Lord C, Risi S, Lambrecht L, Cook EH Jr., Leventhal BL, DiLavore PC, et al. The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 2000;30:205-23.
7. Dosman CF, Drmic IE, Brian JA, Senthilselvan A, Harford M, Smith R, et al. Ferritin as an indicator of suspected iron deficiency in children with autism spectrum disorder: Prevalence of low serum ferritin concentration. Dev Med Child Neurol 2006;48:1008-9.
8. Bener A, Khattab AO, Al-dabbagh MM. Is high prevalence of Vitamin D deficiency evidence for autism disorder: In a highly endogamous population. J Pediatr Neurosci 2014;9:227-33.
9. Moy RJ. Prevalence, consequences and prevention of childhood nutritional iron deficiency: A child public health perspective. Clin Lab Haematol 2006;28:291-8.
10. Shattuck PT, Durkin M, Maenner M, Newschaffer C, Mandell DS, Wiggins L, et al. Timing of identification among children with an autism spectrum disorder: Findings from a population-based surveillance study. J Am Acad Child Adolesc Psychiatry 2009;48:474-83.
11. Latif A, Heinz P, Cook R. Iron deficiency in autism and asperger syndrome. Autism 2002;6:103-14.
12. Hergüner S, Kele-o-lu FM, Tan-d-r C, Cöpür M. Ferritin and iron levels in children with autistic disorder. Eur J Pediatr 2012;171:143-6.
13. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, et al. Association between psychiatric disorders and iron deficiency anemia among children and adolescents: A nationwide population-based study. BMC Psychiatry 2013;13:161.
14. Sidrak S, Yoong T, Woolfenden S. Iron deficiency in children with global developmental delay and autism spectrum disorder. J Paediatr Child Health 2014;50:356-61.
15. Bilgic A, Gurkan K, Turkoglu S, Faruk O, Kilic B, Uslu R. Iron deficiency in preschool children with autistic spectrum disorders. Res Autism Spectr Disord 2010;4:639-44.
16. Gotham K, Risi S, Dawson G, Tager-flusberg H, Joseph R, Carter A, et al. A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms. J Am Acad Child Adolesc Psychiatry 2008;47:642-51.
17. Kamal M, Bener A, Ehlayel MS. Is high prevalence of Vitamin D deficiency a correlate for attention deficit hyperactivity disorder Atten Defic Hyperact Disord 2014;6:73-8.
18. Bener A, Al-Hamaq AO, Saleh NM. Association between Vitamin D insufficiency and adverse pregnancy outcome: Global comparisons. Int J Womens Health 2013;5:523-31.
19. Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol 2012;157:168-75.
20. Bener A, Al-ali M, Hoffmann GF. High prevalence of Vitamin D deficiency in young children in a highly sunny humid country: A global health problem. Minerva Pediatr 2009;61:15-22.
21. Bener A, Kamal M, Bener H, Bhugra D. Higher prevalence of iron deficiency as strong predictor of attention deficit hyperactivity disorder in children. Ann Med Health Sci Res 2014;4:S291-7.
22. Bener A, Hoffmann GF. Nutritional rickets among children in a sun rich country. Int J Pediatr Endocrinol 2010;2010:410502.
23. Sari M, de Pee S, Martini E, Herman S, Sugiatmi, Bloem MW, et al. Estimating the prevalence of anaemia: A comparison of three methods. Bull World Health Organ 2001;79:506-11.
24. World Health Organization. Iron Deficiency Anaemia: Assessment, Prevention, and Control-a Guide for Program Managers. Geneva: WHO; 2001. p. 115. Available: from: http://www. who. int/nut/ documents/ida-assessment-prevention-control. pdf. [Last accessed on 2016 Aug 04].
25. Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics 2010;126:1040-50.
26. Xia W, Zhou Y, Sun C, Wang J, Wu L. A preliminary study on nutritional status and intake in Chinese children with autism. Eur J Pediatr 2010;169:1201-6.
27. Johnson CP, Myers SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007;120:1183-215.
28. Walsh JA, Creighton SE, Rutherford MD. Emotion perception or social cognitive complexity: What drives face processing deficits in autism spectrum disorder J Autism Dev Disord 2016;46:615-23.