Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

Microbiome

Volumn 5, Issue 1, 2017, Pages 95-

  Caparrós Martín, Jose A ^a   Lareu, Ricky R ^a   Ramsay, Joshua P ^a   Peplies, Jörg ^a   Reen, F Jerry ^a   Headlam, Henrietta A ^a   Ward, Natalie C ^a   Croft, Kevin D ^a   Newsholme, Philip ^a   Hughes, Jeffery D ^a   O'Gara, Fergal ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Bile acids; Dysbiosis; Gut microbiota; Pregnane X receptor; Short chain fatty acids; Statins; Type 2 diabetes mellitus

Indexed keywords

BILE ACID; BUTYRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PREGNANE X RECEPTOR; STEROID RECEPTOR;

ANALYSIS; ANIMAL; BODY WEIGHT GAIN; DRUG EFFECTS; DYSBIOSIS; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; INTESTINE; INTESTINE FLORA; KNOCKOUT MOUSE; LIPID METABOLISM; MALE; MICROBIOLOGY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY;

ANIMALS; BILE ACIDS AND SALTS; BLOOD GLUCOSE; BUTYRATES; DIABETES MELLITUS, TYPE 2; DYSBIOSIS; GASTROINTESTINAL MICROBIOME; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTESTINES; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, STEROID; WEIGHT GAIN;

EID: 85032220203     PISSN: None     EISSN: 20492618     Source Type: Journal    
DOI: 10.1186/s40168-017-0312-4     Document Type: Article

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