Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 23, 2017, Pages 5322-5325

  Bezençon, Olivier ^a   Remeň, Luboš ^a   Richard, Sylvia ^a   Roch, Catherine ^a   Kessler, Melanie ^a   Moon, Richard ^a   Mawet, Jacques ^a   Ertel, Eric A ^a   Pfeifer, Thomas ^a   Capeleto, Bruno ^a  

^a IDORSIA PHARMACEUTICALS LTD   (Switzerland)

Author keywords

Pyrazoles; Selective Cav3.1 blockers; T type calcium channel

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; PYRAZOLE DERIVATIVE; AMIDE; PYRROLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; METABOLISM; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; MOLECULAR STRUCTURE; PYRROLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85031766422     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2017.09.063     Document Type: Article

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