Bipolar Disorder as a Mitochondrial Disease

Biological Psychiatry

Volumn 83, Issue 9, 2018, Pages 720-721

  Andreazza, Ana C ^a,b   Duong, Angela ^a   Young, L Trevor ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; CREATINE PHOSPHATE; GLUCOSE; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

BIPOLAR DISORDER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEALTH CARE COST; HUMAN; INDUCED PLURIPOTENT STEM CELL; MENTAL DISEASE; MITOCHONDRIAL GENETICS; MITOCHONDRIAL VOLUME; NOTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; COMPLICATION; GENETICS;

BIPOLAR DISORDER; DNA, MITOCHONDRIAL; HUMANS; MITOCHONDRIAL DISEASES;

EID: 85031497477     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2017.09.018     Document Type: Note

References (10)

1. Scola, G., Kim, H.K., Young, L.T., Andreazza, A.C., A fresh look at complex I in microarray data: clues to understanding disease-specific mitochondrial alterations in bipolar disorder. Biol Psychiatry 73 (2013), e4–e5.
2. Stork, C., Renshaw, P.F., Mitochondrial dysfunction in bipolar disorder: Evidence from magnetic resonance spectroscopy research. Mol Psychiatry 10 (2005), 900–919.
3. Yoshimi, N., Futamura, T., Bergen, S.E., Iwayama, Y., Ishima, T., Sellgren, C., et al. Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis. Mol Psychiatry 21 (2016), 1504–1510.
4. Anglin, R.E., Garside, S.L., Tarnopolsky, M.A., Mazurek, M.F., Rosebush, P.I., The psychiatric manifestations of mitochondrial disorders: a case and review of the literature. J Clin Psychiatry 73 (2012), 506–512.
5. Schuelke, M., Smeitink, J., Mariman, E., Loeffen, J., Plecko, B., Trijbels, F., et al. Mutant NDUFV1 subunit of mitochondrial complex I causes leukodystrophy and myoclonic epilepsy. Nat Genet 21 (1999), 260–261.
6. Munakata, K., Tanaka, M., Mori, K., Washizuka, S., Yoneda, M., Tajima, O., et al. Mitochondrial DNA 3644T–>C mutation associated with bipolar disorder. Genomics 84 (2004), 1041–1050.
7. Doyle, G.A., Dahl, J.P., Bloch, P.J., Weller, A.E., Lohoff, F.W., Ferraro, T.N., et al. Association study of polymorphisms in the autosomal mitochondrial complex I subunit gene, NADH dehydrogenase (ubiquinone) flavoprotein 2, and bipolar disorder. Psychiatr Genet 21 (2011), 51–52.
8. Frye, M.A., Ryu, E., Nassan, M., Jenkins, G.D., Andreazza, A.C., Evans, J.M., et al. Mitochondrial DNA sequence data reveals association of haplogroup U with psychosis in bipolar disorder. J Psychiatr Res 84 (2017), 221–226.
9. Li, C.T., Bai, Y.M., Hsieh, J.C., Lee, H.C., Yang, B.H., Chen, M.H., et al. Peripheral and central glucose utilizations modulated by mitochondrial DNA 10398A in bipolar disorder. Psychoneuroendocrinology 55 (2015), 72–80.
10. Andreazza, A.C., Shao, L., Wang, J.F., Young, L.T., Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry 67 (2010), 360–368.