Evolutional change in epicardial fat and its correlation with myocardial diffuse fibrosis in heart failure patients

Journal of Clinical Lipidology

Volumn 11, Issue 6, 2017, Pages 1421-1431

  Wu, Cho Kai ^a   Tsai, Hao Yuan ^b   Su, Mao Yuan M ^a   Wu, Yi Fan ^c   Hwang, Juey Jen ^a   Lin, Jiunn Lee ^a   Lin, Lian Yu ^a   Chen, Jien Jiun ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Cardiac magnetic resonance imaging; Epicardial fat; Heart failure; Myocardial fibrosis

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GADOLINIUM;

ADULT; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CONTROLLED STUDY; DIABETES MELLITUS; EPICARDIAL FAT; EXTRACELLULAR SPACE; FEMALE; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE MASS; HEART MUSCLE FIBROSIS; HEART VOLUME; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SYSTOLIC HEART FAILURE; ADIPOSE TISSUE; AGED; BODY FAT DISTRIBUTION; CARDIOMYOPATHY; DIAGNOSTIC IMAGING; HEART LEFT VENTRICLE FUNCTION; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PERICARDIUM; PHYSIOLOGY;

ADIPOSE TISSUE; AGED; BODY FAT DISTRIBUTION; CARDIOMYOPATHIES; ENDOMYOCARDIAL FIBROSIS; FEMALE; HEART FAILURE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PERICARDIUM; VENTRICULAR FUNCTION, LEFT;

EID: 85031406636     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2017.08.018     Document Type: Article

References (38)

1. Deswal, A., Petersen, N.J., Feldman, A.M., Young, J.B., White, B.G., Mann, D.L., Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 103:16 (2001), 2055–2059.
2. Iacobellis, G., Willens, H.J., Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr 22:12 (2009), 1311–1319.
3. Sacks, H.S., Fain, J.N., Human epicardial adipose tissue: a review. Am Heart J 153:6 (2007), 907–917.
4. Doesch, C., Haghi, D., Fluchter, S., et al. Epicardial adipose tissue in patients with heart failure. J Cardiovasc Magn Reson, 12, 2010, 40.
5. Kankaanpaa, M., Lehto, H.R., Parkka, J.P., et al. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab 91:11 (2006), 4689–4695.
6. Wong, C.X., Abed, H.S., Molaee, P., et al. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol 57:17 (2011), 1745–1751.
7. Mascherbauer, J., Marzluf, B.A., Tufaro, C., et al. Cardiac magnetic resonance postcontrast T1 time is associated with outcome in patients with heart failure and preserved ejection fraction. Circ Cardiovasc Imaging 6:6 (2013), 1056–1065.
8. Lee, J.J., Liu, S., Nacif, M.S., et al. Myocardial T1 and extracellular volume fraction mapping at 3 tesla. J Cardiovasc Magn Reson, 13, 2011, 75.
9. Mottram, P.M., Haluska, B., Leano, R., Cowley, D., Stowasser, M., Marwick, T.H., Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation 110:5 (2004), 558–565.
10. McMurray, J.J., Adamopoulos, S., Anker, S.D., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 14:8 (2012), 803–869.
11. Wu, C.K., Lee, J.K., Chiang, F.T., et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 are associated with diastolic heart failure through downregulation of sarcoplasmic reticulum Ca2+ ATPase. Crit Care Med 39:5 (2011), 984–992.
12. Wu, C.K., Tsai, C.T., Chang, Y.C., et al. Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure. J Hypertens 27:3 (2009), 502–507.
13. Yancy, C.W., Jessup, M., Bozkurt, B., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62:16 (2013), e147–e239.
14. Bland, J.M., Altman, D.G., Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:8476 (1986), 307–310.
15. Kellman, P., Arai, A.E., McVeigh, E.R., Aletras, A.H., Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med 47:2 (2002), 372–383.
16. Wong, T.C., Piehler, K., Meier, C.G., et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 126:10 (2012), 1206–1216.
17. Tseng, W.Y., Liao, T.Y., Wang, J.L., Normal systolic and diastolic functions of the left ventricle and left atrium by cine magnetic resonance imaging. J Cardiovasc Magn Reson 4:4 (2002), 443–457.
18. Nelson, A.J., Worthley, M.I., Psaltis, P.J., et al. Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume. J Cardiovasc Magn Reson, 11, 2009, 15.
19. Rosito, G.A., Massaro, J.M., Hoffmann, U., et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 117:5 (2008), 605–613.
20. Fluchter, S., Haghi, D., Dinter, D., et al. Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging. Obesity (Silver Spring) 15:4 (2007), 870–878.
21. Gronemeyer, S.A., Steen, R.G., Kauffman, W.M., Reddick, W.E., Glass, J.O., Fast adipose tissue (FAT) assessment by MRI. Magn Reson Imaging 18:7 (2000), 815–818.
22. Mazurek, T., Zhang, L., Zalewski, A., et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108:20 (2003), 2460–2466.
23. Issac, T.T., Dokainish, H., Lakkis, N.M., Role of inflammation in initiation and perpetuation of atrial fibrillation: a systematic review of the published data. J Am Coll Cardiol 50:21 (2007), 2021–2028.
24. Iozzo, P., Myocardial, perivascular, and epicardial fat. Diabetes Care 34:Suppl 2 (2011), S371–S379.
25. Greenstein, A.S., Khavandi, K., Withers, S.B., et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119:12 (2009), 1661–1670.
26. Nguyen, B.L., Fishbein, M.C., Chen, L.S., Chen, P.S., Masroor, S., Histopathological substrate for chronic atrial fibrillation in humans. Heart Rhythm 6:4 (2009), 454–460.
27. Al Chekakie, M.O., Welles, C.C., Metoyer, R., et al. Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol 56:10 (2010), 784–788.
28. Wu, C.K., Tsai, H.Y., Su, M.Y., et al. Pericardial fat is associated with ventricular tachyarrhythmia and mortality in patients with systolic heart failure. Atherosclerosis 241:2 (2015), 607–614.
29. Pellman, J., Zhang, J., Sheikh, F., Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: mechanisms and model systems. J Mol Cell Cardiol 94 (2016), 22–31.
30. Rook, M.B., Jongsma, H.J., de Jonge, B., Single channel currents of homo- and heterologous gap junctions between cardiac fibroblasts and myocytes. Pflugers Arch 414:1 (1989), 95–98.
31. Oyamada, M., Kimura, H., Oyamada, Y., Miyamoto, A., Ohshika, H., Mori, M., The expression, phosphorylation, and localization of connexin 43 and gap-junctional intercellular communication during the establishment of a synchronized contraction of cultured neonatal rat cardiac myocytes. Exp Cell Res 212:2 (1994), 351–358.
32. Lloyd-Jones, D.M., Wang, T.J., Leip, E.P., et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 110:9 (2004), 1042–1046.
33. Kuruvilla, S., Adenaw, N., Katwal, A.B., Lipinski, M.J., Kramer, C.M., Salerno, M., Late gadolinium enhancement on cardiac magnetic resonance predicts adverse cardiovascular outcomes in nonischemic cardiomyopathy: a systematic review and meta-analysis. Circ Cardiovasc Imaging 7:2 (2014), 250–258.
34. Iozzo, P., Lautamaki, R., Borra, R., et al. Contribution of glucose tolerance and gender to cardiac adiposity. J Clin Endocrinol Metab 94:11 (2009), 4472–4482.
35. Whayne, T.F. Jr., Epicardial fat thickness in heart failure and other clinical conditions. Angiology 64:3 (2013), 169–172.
36. Schejbal, V., Epicardial fatty tissue of the right ventricle–morphology, morphometry and functional significance. Pneumologie 43 (1989), 490–499.
37. Bulluck, H., White, S.K., Rosmini, S., et al. T1 mapping and T2 mapping at 3T for quantifying the area-at-risk in reperfused STEMI patients. J Cardiovasc Magn Reson, 17, 2015, 73.
38. Rommel, K.P., von Roeder, M., Latuscynski, K., et al. Extracellular volume fraction for characterization of patients with heart failure and preserved ejection fraction. J Am Coll Cardiol 67:15 (2016), 1815–1825.