Topical sinecatechins, 10%, ointment for superficial basal cell carcinoma: A randomized clinical trial

JAMA Dermatology

Volumn 153, Issue 10, 2017, Pages 1061-1063

  Kessels, Janneke ^a,b   Voeten, Lotte ^a,c   Nelemans, Patty ^a   Cleutjens, Jack ^a,d   Hillen, Lisa Maria ^a,b   Mosterd, Klara ^a,b   Kelleners Smeets, Nicole W J ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c CATHARINA HOSPITAL   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EPIGALLOCATECHIN GALLATE; PLACEBO; SINECATECHINS; CATECHIN; GREEN TEA EXTRACT POLYPHENONE E;

ARTICLE; BASAL CELL CARCINOMA; BLISTER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EROSION; ERYTHEMA; HUMAN; MAJOR CLINICAL STUDY; OINTMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN BURNING SENSATION; SKIN EDEMA; SKIN PRURITUS; TOPICAL TREATMENT; VESICULAR RASH; ANALOGS AND DERIVATIVES; BIOPSY; CAMELLIA SINENSIS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FOLLOW UP; MALE; PATHOLOGY; RETROSPECTIVE STUDY; SKIN; SKIN TUMOR; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; BIOPSY; CAMELLIA SINENSIS; CARCINOMA, BASAL CELL; CATECHIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; OINTMENTS; RETROSPECTIVE STUDIES; SKIN; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 85031320401     PISSN: 21686068     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamadermatol.2017.2529     Document Type: Article

References (6)

1. Singh T, Katiyar SK. Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling. Toxicol Appl Pharmacol. 2013;273(2):418-424.
2. Roop D, Toftgård R. Hedgehog in Wnterland. Nat Genet. 2008;40(9): 1040-1041.
3. Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 2006;5(12):997-1014.
4. Vidal D, Matías-Guiu X, Alomar A. Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis. Br J Dermatol. 2004;151(3): 656-662.
5. Brinkhuizen T, Frencken KJ, Nelemans PJ, et al. The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): a phase II, randomized controlled trial. J Am Acad Dermatol. 2016;75(1):126-134.
6. Tjeerdsma F, Jonkman MF, Spoo JR. Temporary arrest of basal cell carcinoma formation in a patient with basal cell naevus syndrome (BCNS) since treatment with a gel containing various plant extracts. J Eur Acad Dermatol Venereol. 2011; 25(2):244-245.