Influence of sex on the association between epicardial adipose tissue and left atrial transport function in patients with atrial fibrillation: A multislice computed tomography study

Journal of the American Heart Association

Volumn 6, Issue 8, 2017, Pages

  Kim, Jin Seok ^a   Shin, Seung Yong ^b   Kang, Jun Hyuk ^a   Yong, Hwan Seok ^a   Na, Jin Oh ^a   Choi, Cheol Ung ^a   Kim, Seong Hwan ^a   Kim, Eung Ju ^a   Rha, Seung Woon ^a   Park, Chang Gyu ^a   Seo, Hong Seog ^a   Oh, Dong Joo ^a   Hwang, Chun ^c   Kim, Young Hoon ^a   Lim, Hong Euy ^a  

^a Korea University College of Medicine   (South Korea)

^b Chung Ang University   (South Korea)

^c UTAH VALLEY REGIONAL MEDICAL CENTER   (United States)

Author keywords

Atrial fibrillation; Computed tomography; Epicardial fat; Left atrial function; Sex differences

Indexed keywords

ADIPONECTIN; ADIPOQ PROTEIN, HUMAN; BIOLOGICAL MARKER;

ABLATION THERAPY; ADULT; AGED; ARTICLE; ATRIAL FIBRILLATION; BLOOD SAMPLING; BODY MASS; CHADS2 SCORE; CORONARY SINUS; DEMOGRAPHY; DISEASE ASSOCIATION; EPICARDIAL FAT; FEMALE; HEART FUNCTION; HUMAN; LABORATORY TEST; LEFT ATRIAL TRANSPORT FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; ADIPOSE TISSUE; BLOOD; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; HEART ATRIUM FUNCTION; HEART ATRIUM REMODELING; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PATHOPHYSIOLOGY; PERICARDIUM; PREDICTIVE VALUE; PROSPECTIVE STUDY; RISK FACTOR; SEX FACTOR; STATISTICAL MODEL;

ADIPONECTIN; ADIPOSE TISSUE; ADIPOSITY; AGED; ATRIAL FIBRILLATION; ATRIAL FUNCTION, LEFT; ATRIAL REMODELING; BIOMARKERS; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; MULTIVARIATE ANALYSIS; PERICARDIUM; POSTMENOPAUSE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS;

EID: 85030694317     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.117.006077     Document Type: Article

References (35)

1. Fang MC, Singer DE, Chang Y, Hylek EM, Henault LE, Jensvold NG, Go AS. Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the anticoagulation and risk factors in atrial fibrillation (ATRIA) study. Circulation. 2005;112:1687-1691
2. Poli D, Antonucci E, Grifoni E, Abbate R, Gensini GF, Prisco D. Gender differences in stroke risk of atrial fibrillation patients on oral anticoagulant treatment. Thromb Haemost. 2009;101:938-942
3. Olesen JB, Lip GY, Hansen ML, Hansen PR, Tolstrup JS, Lindhardsen J, Selmer C, AhlehoffO, Olsen AM, Gislason GH, Torp-Pedersen C. Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study. BMJ. 2011;342:d124
4. Benjamin EJ, D'Agostino RB, Belanger AJ, Wolf PA, Levy D. Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation. 1995;92:835-841
5. Wong JM, Welles CC, Azarbal F, Whooley MA, Schiller NB, Turakhia MP. Relation of left atrial dysfunction to ischemic stroke in patients with coronary heart disease (from the Heart and Soul Study). Am J Cardiol. 2014;113:1679-1684
6. Russo C, Jin Z, Liu R, Iwata S, Tugcu A, Yoshita M, Homma S, Elkind MS, Rundek T, Decarli C, Wright CB, Sacco RL, Di Tullio MR. LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (cardiovascular abnormalities and brain lesions) study. JACC Cardiovasc Imaging. 2013;6:313-323
7. Al Chekakie MO, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol. 2010;56:784-788
8. Thanassoulis G, Massaro JM, O'Donnell CJ, Hoffmann U, Levy D, Ellinor PT, Wang TJ, Schnabel RB, Vasan RS, Fox CS, Benjamin EJ. Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ Arrhythm Electrophysiol. 2010;3:345-350
9. Shin SY, Yong HS, Lim HE, Na JO, Choi CU, Choi JI, Kim SH, Kim JW, Kim EJ, Park SW, Rha SW, Park CG, Seo HS, Oh DJ, Kim YH. Total and interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2011;22:647-655
10. Shin SY, Yong HS, Na JO, Choi CU, Kim SH, Kim JW, Kim EJ, Rha SW, Park CG, Seo HS, Oh DJ, Kim YH, Lim HE. A simplified method to determine left atrial volume and transport function using multi-slice computed tomography in patients with atrial fibrillation: comparison with transthoracic echocardiography. Int J Cardiovasc Imaging. 2012;28:1205-1216
11. Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, Sharma G, Leong DP, Lau DH, Middeldorp ME, Roberts-Thomson KC, Wittert GA, Abhayaratna WP, Worthley SG, Sanders P. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol. 2011;57:1745-1751
12. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460-2466
13. Abed HS, Samuel CS, Lau DH, Kelly DJ, Royce SG, Alasady M, Mahajan R, Kuklik P, Zhang Y, Brooks AG, Nelson AJ, Worthley SG, Abhayaratna WP, Kalman JM, Wittert GA, Sanders P. Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation. Heart Rhythm. 2013;10:90-100
14. Venteclef N, Guglielmi V, Balse E, Gaborit B, Cotillard A, Atassi F, Amour J, Leprince P, Dutour A, Clement K, Hatem SN. Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipofibrokines. Eur Heart J. 2015;36:795-805a
15. Mahajan R, Lau DH, Brooks AG, Shipp NJ, Manavis J, Wood JP, Finnie JW, Samuel CS, Royce SG, Twomey DJ, Thanigaimani S, Kalman JM, Sanders P. Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity. J Am Coll Cardiol. 2015;66:1-11
16. Pouliopoulos J, Chik WW, Kanthan A, Sivagangabalan G, Barry MA, Fahmy PN, Midekin C, Lu J, Kizana E, Thomas SP, Thiagalingam A, Kovoor P. Intramyocardial adiposity after myocardial infarction: new implications of a substrate for ventricular tachycardia. Circulation. 2013;128:2296-2308
17. Haemers P, Hamdi H, Guedj K, Suffee N, Farahmand P, Popovic N, Claus P, LePrince P, Nicoletti A, Jalife J, Wolke C, Lendeckel U, Jais P, Willems R, Hatem SN. Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria. Eur Heart J. 2017;38:53-61
18. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279-4295
19. Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol. 2006;24:150-154
20. Chilukoti RK, Giese A, Malenke W, Homuth G, Bukowska A, Goette A, Felix SB, Kanaan J, Wollert HG, Evert K, Verheule S, Jais P, Hatem SN, Lendeckel U, Wolke C. Atrial fibrillation and rapid acute pacing regulate adipocyte/adipositas-related gene expression in the atria. Int J Cardiol. 2015;187:604-613
21. Wong CX, Ganesan AN, Selvanayagam JB. Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions. Eur Heart J. 2017;38:1294-1302
22. Tsao HM, Hu WC, Tsai PH, Lee CL, Liu FC, Wang HH, Lo LW, Chang SL, Chao TF, Chen SA. The abundance of epicardial adipose tissue surrounding left atrium is associated with the occurrence of stroke in patients with atrial fibrillation. Medicine (Baltimore). 2016;95:e3260
23. Hinderliter AL, Sherwood A, Blumenthal JA, Light KC, Girdler SS, McFetridge J, Johnson K, Waugh R. Changes in hemodynamics and left ventricular structure after menopause. Am J Cardiol. 2002;89:830-833
24. Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, Tu JV, Levy D. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute. Circulation. 2009;119:3070-3077
25. Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation. 2006;113:296-304
26. Camhi SM, Bray GA, Bouchard C, Greenway FL, Johnson WD, Newton RL, Ravussin E, Ryan DH, Smith SR, Katzmarzyk PT. The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences. Obesity (Silver Spring). 2011;19:402-408
27. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation. 2008;117:605-613
28. Smith U, Hammersten J, Bjorntorp P, Kral JG. Regional differences and effect of weight-reduction on human fat-cell metabolism. Eur J Clin Invest. 1979;9:327-332
29. Lithell H, Boberg J. Lipoprotein-lipase activity of adipose-tissue from different sites in obese women and relationship to cell-size. Int J Obes. 1978;2:47-52
30. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2:536-543
31. Hatem SN, Redheuil A, Gandjbakhch E. Cardiac adipose tissue and atrial fibrillation: the perils of adiposity. Cardiovasc Res. 2016;109:502-509
32. Zhou Y, Wei Y, Wang L, Wang X, Du X, Sun Z, Dong N, Chen X. Decreased adiponectin and increased inflammation expression in epicardial adipose tissue in coronary artery disease. Cardiovasc Diabetol. 2011;10:2
33. Xu Y, Cheng X, Hong K, Huang C, Wan L. How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis. Coron Artery Dis. 2012;23:227-233
34. Zghaib T, Ipek EG, Zahid S, Balouch MA, Misra S, Ashikaga H, Berger RD, Marine JE, Spragg DD, Zimmerman SL, Zipunnikov V, Trayanova N, Calkins H, Nazarian S. Association of left atrial epicardial adipose tissue with electrogram bipolar voltage and fractionation: electrophysiologic substrates for atrial fibrillation. Heart Rhythm. 2016;13:2333-2339
35. Cove CL, Albert CM, Andreotti F, Badimon L, Van Gelder IC, Hylek EM. Female sex as an independent risk factor for stroke in atrial fibrillation: possible mechanisms. Thromb Haemost. 2014;111:385-391