Fine-scale genetic structure in Finland

G3: Genes, Genomes, Genetics

Volumn 7, Issue 10, 2017, Pages 3459-3468

  Kerminen, Sini ^a   Havulinna, Aki S ^a,c   Hellenthal, Garrett ^d   Martin, Alicia R ^e,f   Sarin, Antti Pekka ^a,c   Perola, Markus ^a,c,g   Palotie, Aarno ^a,e,f   Salomaa, Veikko ^c   Daly, Mark J ^a,b,e,f   Ripatti, Samuli ^a,h   Pirinen, Matti ^a,b  

^a Institute for Molecular Medicine   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g UNIVERSITY OF TARTU   (Estonia)

^h WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Haplotype sharing; population genetics; Population structure

Indexed keywords

FEMALE; FINLAND; FORENSIC GENETICS; GENE STRUCTURE; GENETIC ASSOCIATION STUDY; GENETIC DIFFERENCE; HAPLOTYPE; HUMAN; LANGUAGE; MAJOR CLINICAL STUDY; MALE; POPULATION GENETICS; POPULATION STRUCTURE; SAMPLING; ADULT; AGED; MIDDLE AGED;

ADULT; AGED; FINLAND; GENETICS, POPULATION; HAPLOTYPES; HUMANS; MIDDLE AGED;

EID: 85030625414     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.117.300217     Document Type: Article

References (34)

1. Athanasiadis, G., J. Y. Cheng, B. J. Vilhjalmsson, F. G. Jorgensen, T. D. Als et al., 2016 Nationwide genomic study in Denmark reveals remarkable population homogeneity. Genetics 204: 711-722
2. Bhatia, G., N. Patterson, S. Sankararaman, and A. Price, 2013 Estimating and interpreting FST: the impact of rare variants. Genome Res. 23: 1514
3. Delaneau, O., J. Zagury, and J. Marchini, 2013 Improved whole-chromosome phasing for disease and population genetic studies. Nat. Methods 10: 5-6
4. Duforet-Frebourg, N., L. M. Gattepaille, M. G. B. Blum, and M. Jakobsson, 2015 HaploPOP: a software that improves population assignment by combining markers into haplotypes. BMC Bioinformatics 16: 242
5. Gattepaille, L. M., and M. Jakobsson, 2011 Combining markers into haplotypes can improve population structure inference. Genetics 190: 159-174
6. Genome of the Netherlands Consortium, 2014 Whole-genome sequence variation, population structure and demographic history of the Dutch population. Nat. Genet. 46: 818-825
7. Itkonen, T., 1989 Nurmijärven murrekirja. Suomalaisen Kirjallisuuden Seura, Helsinki
8. Jakkula, E., K. Rehnström, T. Varilo, O. P. H. Pietiläinen, T. Paunio et al., 2008 The genome-wide patterns of variation expose significant substructure in a founder population. Am. J. Hum. Genet. 83: 787-794
9. Julku, K., 1987 Suomen itärajan synty. Pohjois-Suomen Historiallinen Yhdistys, Rovaniemi
10. Jutikkala, E., 1933 Asutuksen leviäminen Suomessa 1600-luvun alkuun mennessä, pp. 51-103 in Suomen Kulttuurihistoria, Vol. I, edited by Jutikkala, E., and G. Suolahti. Gummerus, Helsinki
11. Karakachoff, M., N. Duforet-Frebourg, F. Simonet, S. Le Scouarnec, N. Pellen et al., 2015 Fine-scale human genetic structure in Western France. Eur. J. Hum. Genet. 23: 831-836
12. Katajala, K., 2012 Drawing borders or dividing lands?: the peace treaty of 1323 between Sweden and Novgorod in a European context. Scand. J. Hist. 37: 23-48
13. Kayser, M., and P. de Knijff, 2011 Improving human forensics through advances in genetics, genomics and molecular biology. Nat. Rev. Genet. 12: 179-192
14. Korpela, J., 2002 Finland's eastern border after the treaty of Nöteborg: an ecclesiastical, political or cultural border? J. Balt. Stud. 33: 384-397
15. Lappalainen, T., S. Koivumäki, E. Salmela, K. Huoponen, P. Sistonen et al., 2006 Regional differences among the Finns: a Y-chromosomal perspective. Gene 376: 207-215
16. Leslie, S., B. Winney, G. Hellenthal, D. Davison, A. Boumertit et al., 2015 The fine-scale genetic structure of the British population. Nature 519: 309-314
17. Lim, E. T., P. Würtz, A. S. Havulinna, P. Palta, T. Tukiainen et al., 2014 Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genet. 10: 1-12
18. Mathieson, I., and G. McVean, 2012 Differential confounding of rare and common variants in spatially structured populations. Nat. Genet. 44: 243-246
19. Neuvonen, A. M., M. Putkonen, S. översti, T. Sundell, P. Onkamo et al., 2015 Vestiges of an ancient border in the contemporary genetic diversity of North-Eastern Europe. PLoS One 10: e0130331
20. Norio, R., 2003a The Finnish disease heritage III: the individual diseases. Hum. Genet. 112: 470-526
21. Norio, R., 2003b Finnish disease heritage II: population prehistory and genetic roots of Finns. Hum. Genet. 112: 457-469
22. Novembre, J., and B. M. Peter, 2016 Recent advances in the study of fine-scale population structure in humans. Curr. Opin. Genet. Dev. 41: 98-105
23. Patterson, N., A. L. Price, and D. Reich, 2006 Population structure and eigenanalysis. PLoS Genet. 2: 2074-2093
24. Peltonen, L., A. Jalanko, and T. Varilo, 1999 Molecular genetics of the Finnish disease heritage. Hum. Mol. Genet. 8: 1913-1923
25. Price, A. L., M. E. Weale, N. Patterson, S. R. Myers, A. C. Need et al., 2008 Long-range LD can confound genome scans in admixed populations. Am. J. Hum. Genet. 83: 132-135, author reply 135-139
26. Pritchard, J. K., M. Stephens, and P. Donnelly, 2000 Inference of population structure using multilocus genotype data. Genetics 155: 945-959
27. Purcell, S., 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81: 559-575
28. Sabatti, C., S. K. Service, A. Hartikainen, A. Pouta, S. Ripatti et al., 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet. 41: 35-46
29. Salmela, E., 2012 Genetic Structure in Finland and Sweden: Aspects of Population History and Gene Mapping. University of Helsinki, Helsinki
30. Salmela, E., T. Lappalainen, I. Fransson, P. M. Andersen, K. Dahlman-Wright et al., 2008 Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS One 3: e3519
31. The 1000 Genomes Project Consortium, A., Auton, L. D. Brooks, R. M. Durbin, E. P. Garrison et al., 2015 A global reference for human genetic variation. Nature 526: 68-74
32. Vartiainen, E., 1998 Finriski 1997. Kansanterveyslaitos, Helsinki
33. Winney, B., A. Boumertit, T. Day, D. Davison, C. Echeta et al., 2012 People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. Eur. J. Hum. Genet. 20: 203-210
34. Yang, J., S. H. Lee, M. E. Goddard, and P. M. Visscher, 2011 GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88: 76-82