Complement system dysregulation in patients affected by Idiopathic Generalized Epilepsy and the effect of antiepileptic treatment

Epilepsy Research

Volumn 137, Issue , 2017, Pages 107-111

  Liguori, Claudio ^a   Romigi, Andrea ^a,b   Izzi, Francesca ^a   Placidi, Fabio ^a   Nuccetelli, Marzia ^b   Cordella, Alberto ^a   Bernardini, Sergio ^b   Biagio, Mercuri Nicola ^a,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b SAN GIOVANNI ADDOLORATA HOSPITAL   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Anti epileptic drugs; C3; C4; Complement system; Idiopathic Generalized Epilepsy

Indexed keywords

ANTICONVULSIVE AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; FIBRINOGEN; LAMOTRIGINE; LEVETIRACETAM; PHENOBARBITAL; VALPROIC ACID; COMPLEMENT;

ABSENCE; ADULT; ARTICLE; CLINICAL ARTICLE; COMPLEMENT BLOOD LEVEL; COMPLEMENT SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; LIGHT SCATTERING; MALE; MYOCLONUS SEIZURE; PRIORITY JOURNAL; SPIKE WAVE; TONIC CLONIC SEIZURE; TREATMENT RESPONSE; BRAIN; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; GENERALIZED EPILEPSY; METABOLISM; PATHOPHYSIOLOGY; YOUNG ADULT;

ADULT; ANTICONVULSANTS; BRAIN; COMPLEMENT SYSTEM PROTEINS; ELECTROENCEPHALOGRAPHY; EPILEPSY, GENERALIZED; FEMALE; FIBRINOGEN; HUMANS; MALE; YOUNG ADULT;

EID: 85030485487     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2017.09.005     Document Type: Article

References (21)

1. Alapirtti, T., Waris, M., Fallah, M., et al. C-reactive protein and seizures in focal epilepsy: a video-electroencephalographic study. Epilepsia 53:May (5) (2012), 790–796.
2. Aronica, E., Boer, K., van Vliet, E.A., et al. Complement activation in experimental and human temporal lobe epilepsy. Neurobiol. Dis. 26 (2007), 497–511.
3. Başaran, N., Hincal, F., Kansu, E., et al. Humoral and cellular immune parameters in untreated and phenytoin-or carbamazepine-treated epileptic patients. Int. J. Immunopharmacol. 16 (1994), 1071–1077.
4. Bellander, B.M., Singhrao, S.K., Ohlsson, M., et al. Complement activation in the human brain after traumatic head injury. J. Neurotrauma 18 (2001), 1295–1311.
5. Blumenfeld, H., Westerveld, M., Ostroff, R.B., et al. Selective frontal, parietal, and temporal networks in generalized seizures. Neuroimage 19 (2003), 1556–1566.
6. Bostantjopoulou, S., Hatzizisi, O., Argyropoulou, O., et al. Immunological parameters in patients with epilepsy. Funct. Neurol. 9 (1994), 11–15.
7. Caraballo, R.H., Dalla Bernardina, B., Idiopathic generalized epilepsies. Handb. Clin. Neurol. 111 (2013), 579–589.
8. Choi, J., Nordli, D.R. Jr., Alden, T.D., et al. Cellular injury and neuroinflammation in children with chronic intractable epilepsy. J. Neuroinflamm., 6, 2009, 38.
9. Engel, J. Jr., Classification of epileptic disorders. Epilepsia, 42, 2001, 316.
10. Fattouch, J., Di Bonaventura, C., Lapenta, L., et al. Epilepsy, unawareness of seizures and driving license: the potential role of 24-h ambulatory EEG in defining seizure freedom. Epilepsia Behav. 25:September (1) (2012), 32–35.
11. Hakobyan, S., Luppe, S., Evans, D.R., et al. Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder. Mult. Scler. 23:June (7) (2017), 946–955.
12. McGeer, P.L., Lee, M., McGeer, E.G., A review of human diseases caused or exacerbated by aberrant complement activation. Neurobiol. Aging 52 (2016), 12–22.
13. Niedermayer, E., Lopes da Silva, F., Electroencephalography: basic principles, clinical applications and related fieldsElectroencephalography: Basic Principles, Clinical Applications and Related Fields. 2nd edition, 1987, Urban & Schwarzenberg, Baltimore-Munich, 189.
14. Nowak, M., Bauer, S., Haag, A., et al. Interictal alterations of cytokines and leukocytes in patients with active epilepsy. Brain Behav. Immun. 25:March (3) (2011), 423–428.
15. O'Muircheartaigh, J., Dean, D.C. 3rd, Dirks, H., et al. Interactions between white matter asymmetry and language during neurodevelopment. J. Neurosci. 33 (2013), 16170–16177.
16. Panayiotopoulos, C.P., Koutroumanidis, M., Giannakodimos, S., Agathonikou, A., Idiopathic generalisedgeneralized epilepsy in adults manifested by phantom absences, generalisedgeneralized tonic-clonic seizures, and frequent absence status. J. Neurol. Neurosurg. Psychiatry 63 (1997), 622–627.
17. Riazi, K., Galic, M.A., Pittman, Q.J., Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsia Res. 89 (2010), 34–42.
18. Sinha, S., Patil, S.A., Jayalekshmy, V., Satishchandra, P., Do cytokines have any role in epilepsy?. Epilepsia Res. 82:December (2–3) (2008), 171–176.
19. Vezzani, A., Friedman, A., Brain inflammation as a biomarker in epilepsy. Biomark. Med. 5 (2011), 607–614.
20. Vezzani, A., Granata, T., Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46 (2005), 1724–1743.
21. Xiong, Z.Q., Qian, W., Suzuki, K., et al. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. J. Neurosci. 23 (2003), 955–960.