An evaluation of the performance of the DynamikerR® Fungus (1-3)-β-D-Glucan Assay to assist in the diagnosis of invasive aspergillosis, invasive candidiasis and Pneumocystis pneumonia

Medical Mycology

Volumn 55, Issue 8, 2017, Pages 843-850

  White, P Lewis ^a   Price, Jessica S ^a   Posso, Raquel B ^b   Barnes, Rosemary A ^b  

^a PUBLIC HEALTH WALES   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Invasive aspergillosis; Invasive candidiasis; Pneumocystis pneumonia; D Glucan

Indexed keywords

(1-3) BETA DEXTRO GLUCAN; GLUCAN; UNCLASSIFIED DRUG; BETA GLUCAN; FUNGAL POLYSACCHARIDE;

ABDOMINAL SURGERY; ADULT; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FUNGUS (1-3) BETA DEXTRO GLUCAN ASSAY; GRAFT RECIPIENT; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HUMAN; INVASIVE ASPERGILLOSIS; INVASIVE CANDIDIASIS; KIDNEY TRANSPLANTATION; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; PNEUMOCYSTIS PNEUMONIA; SENSITIVITY AND SPECIFICITY; ASPERGILLOSIS; BLOOD; EVALUATION STUDY; STANDARDS;

ASPERGILLOSIS; BETA-GLUCANS; CANDIDIASIS, INVASIVE; DIAGNOSTIC TESTS, ROUTINE; FEMALE; FUNGAL POLYSACCHARIDES; HUMANS; MALE; MIDDLE AGED; PNEUMONIA, PNEUMOCYSTIS; SENSITIVITY AND SPECIFICITY;

EID: 85030476966     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1093/mmy/myx004     Document Type: Article

References (14)

1. Aguado JM, Vázquez L, Fernández-Ruiz M et al. Serum galactomannan versus a combination of galactomannan and PCR-based Aspergillus DNA detection for early therapy of invasive aspergillosis in high-risk hematological patients: a randomized controlled trial. Clin Infect Dis. 2014; 60: 405-414.
2. Barnes RA, Stocking K, Bowden S et al. Prevention and diagnosis of invasive fungal disease in high-risk patients within an integrative care pathway. J Infect. 2013; 67: 206-214.
3. Morrissey CO, Chen SC, Sorrell TC et al. Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients: a randomised controlled trial. Lancet Infect Dis. 2013; 13: 519-528.
4. Jordanides NE, Allan EK, McLintock LA et al. A prospective study of realtime panfungal PCR for the early diagnosis of invasive fungal infection in haemato-oncology patients. BMT. 2005; 35: 389-395.
5. Karageorgopoulos DE, Vouloumanou EK, Ntziora F et al. b-D-Glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin Infect Dis. 2011; 52: 750-770.
6. Karageorgopoulos DE, Qu J-M, Korbila IP et al. Accuracy of b-D-glucan for the diagnosis of Pneumocystis jirovecii pneumonia: a meta-analysis. Clin Microbiol Infect. 2013; 19: 39-49.
7. Lamoth F, Cruciani M, Mengoli C et al. B-Glucan antigenemia assay for the diagnosis of invasive fungal infections in patients with haematological malignancies: a systematic review and meta-analysis of cohort studies from the Third European Conference on Infections in Leukaemia (ECIL-3). Clin Infect Dis. 2012; 54: 633-643.
8. Onishi A, Sugiyama D, Kogata Y et al. Diagnostic Accuracy of serum 1,3-beta-D-Glucan for Pneumocystis jiroveci pneumonia, invasive candidiasis, and invasive aspergillosis: systematic review and meta-analysis. J Clin Microbiol. 2012; 50: 7-15.
9. White PL, Wingard JR, Bretagne S et al. Aspergillus polymerase chain reaction: systematic review of evidence for clinical use in comparison with antigen testing. Clin Infect Dis. 2015; 61: 1293-1303.
10. De Pauw B, Walsh TJ, Donnelly JP et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis. 2008; 46: 1813-1821.
11. Wang Y. Performance of the Dynamiker R (1-3)-β-D-glucan assay compared to Fungitell R for the diagnosis of invasive fungal disease from serum samples. Abstract no 5872; 26th European Congress of Clinical Microbiology and Infectious Diseases, 2016, Amsterdam, The Netherlands.
12. Nguyen MH, Wissel MC, Shields RK et al. Performance of Candida realtime polymerase chain reaction, b-D-glucan assay, and blood cultures in the diagnosis of invasive candidiasis. Clin Infect Dis. 2012; 54: 1240-1248.
13. Racil Z, Kocmanova I, Lengerova M et al. Difficulties in using 1,3-b-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies-high frequency of false-positive results and their analysis. J Med Microbiol. 2010; 59: 1016-1022.
14. Sulahian A, Porcher R, Bergeron A et al. Use and Limits of (1-3)-β-Dglucan assay (Fungitell®), compared to galactomannan determination (platelia Aspergillus), for diagnosis of invasive aspergillosis. J Clin Microbiol. 2014; 52: 2328-2333.