The effect of a micronutrient powder home fortification program on anemia and cognitive outcomes among young children in rural China: A cluster randomized trial

BMC Public Health

Volumn 17, Issue 1, 2017, Pages

  Luo, Renfu ^a   Yue, Ai ^b   Zhou, Huan ^c   Shi, Yaojiang ^b   Zhang, Linxiu ^d   Martorell, Reynaldo ^e   Medina, Alexis ^f   Rozelle, Scott ^f   Sylvia, Sean ^g  

^a PEKING UNIVERSITY   (China)

^b SHAANXI NORMAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e EMORY UNIVERSITY   (United States)

^f STANFORD UNIVERSITY   (United States)

^g IL   (United States)

Author keywords

Anemia; Cognition; Early childhood; Micronutrient supplementation

Indexed keywords

IRON; TRACE ELEMENT;

CHILD DEVELOPMENT; CHINA; CLUSTER ANALYSIS; COGNITION; CONTROLLED STUDY; DIET THERAPY; FEMALE; FOLLOW UP; FORTIFIED FOOD; HUMAN; INFANT; IRON DEFICIENCY ANEMIA; MALE; PHYSIOLOGY; POWDER; PROGRAM EVALUATION; RANDOMIZED CONTROLLED TRIAL; RURAL POPULATION; STATISTICS AND NUMERICAL DATA;

ANEMIA, IRON-DEFICIENCY; CHILD DEVELOPMENT; CHINA; CLUSTER ANALYSIS; COGNITION; FEMALE; FOLLOW-UP STUDIES; FOOD, FORTIFIED; HUMANS; INFANT; IRON; MALE; MICRONUTRIENTS; POWDERS; PROGRAM EVALUATION; RURAL POPULATION;

EID: 85029863031     PISSN: None     EISSN: 14712458     Source Type: Journal    
DOI: 10.1186/s12889-017-4755-0     Document Type: Article

References (58)

1. Luo R, Wang X, Zhang L, et al. High anemia prevalence in western China. Southeast Asian J Trop Med Public Health. 2011;42:1204-13.
2. Chen YC, Tang SC, Le H, Yu XM, Wang DG, Hao M. Compare health development of rural areas in different districts of China: about social economy and inhabitant's health condition [in Chinese]. Chin Health Econ. 2006;25:37-8.
3. Chang S, Wu H, Jia FM, Chen CM. Analysis on the changes of nutritional status in China anemia status of children under 5 in China [in Chinese]. Wei Sheng Yan Jiu. 2007;36(2):210-2.
4. Balarajan Y, Ramakrishnan U, Öaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123-35.
5. Stoltzfus RJ, Mullany L, Black RE. Iron deficiency anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CLJ, editors. Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization; 2004. p. 163-209.
6. Black RE, Victora CG, Walker SP, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013;382(9890):427-51.
7. The Nutrition Development Report of Chinese Children Aged 0-6. Beijing, China. Ministry of Health. 2012;2012:1-18.
8. Chen C, He W, Wang Y, Deng L, Jia F. Nutritional status of children during and post-global economic crisis in China. Biomed Environ Sci. 2011;24(4):321-8.
9. Cui Y, Yang L, Tan D, Du Q. Analysis on the status of anemia among children under 3 years old in 10 provinces in western China [in Chinese]. Chan J Epidemiol. 2007;28(12):1159-61.
10. Dong CX, Ge PF, Zhang CJ, et al. Effects of different feeding practices at 0-6 months and living economic conditions on anemia prevalence of infants and young children [in Chinese]. Wei Sheng Yan Jiu. 2013;42(4):596-9.
11. Cui Y, Qu Q, Yang L, Wu Q. Analysis on anemia status of children under 3 years old in western China [in Chinese]. Chin J Public Health. 2008;24(9):1052-3.
12. Luo R, Shi Y, Zhou H, Yue A, Zhang L, Sylvia S, Medina A, Rozelle S. Anemia and feeding practices among infants in rural Shaanxi Province in China. Nutrients. 2014;6:5975-91.
13. Census Office of the State Council, Division of Population and Employment Statistics in National Bureau of Statistics of the People's Republic of China. China 2010 census data. Beijing: China Statistics Press. http://www.stats.gov.cn/tjsj/pcsj/rkpc/6rp/indexch.htm. Accessed 29 May 2016
14. Lin LM, Song XF, Liu YL, Ma GF, Tan CW, Jiang JX, Liu M, Liu CY, Wang L. Relationship between vitamin a deficiency and anemia for Chinese children. Chin J Child Health Care. 2003;11:242-4. (in Chinese)
15. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131:649S-66S.
16. Akman M, Cebeci D, Okur V, et al. The effects of iron deficiency on infants' developmental test performance. Acta Paediatr. 2004;93:1391-6.
17. Hasanbegovic E, Sabanovic S. Effects of iron therapy on motor and mental development of infants and small children suffering from iron deficiency anaemia. Med Arh. 2004;58:227-9.
18. Idjradinata P, Pollitt E. Reversal of developmental delays in iron deficient anaemic infants treated with iron. Lancet. 1993;341:1-4.
19. Lozoff B, Brittenham GM, Wolf AW, et al. Iron deficiency anemia and iron therapy effects on infant developmental test performance. Pediatrics. 1987;79:981-95.
20. Lozoff B, Wolf AW, Jimenez E. Iron-deficiency anemia and infant development: effects of extended oral iron therapy. J Pediatr. 1996;129:382-9.
21. Walter T, de Andraca I, Chadud P, et al. Iron deficiency anemia: adverse effects on infant psychomotor development. Pediatrics. 1989;84:7-17.
22. Lozoff B, Klein NK, Nelson EC, et al. Behavior of infants with iron-deficiency anemia. Child Dev. 1998;69:24-36.
23. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 2005;8:117-32.
24. Lozoff B, Jimenez E, Hagen J, et al. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:e51.
25. Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006;160:1108-13.
26. Maluccio JA, Hoddinott J, Behrman JR, et al. The impact of improving nutrition during early childhood on education among Guatemalan adults. Econ J. 2009;119:734-63.
27. Haas JD, Brownlie T IV. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001;131:676S-88S. discussion 688S-690S
28. Walker SP, Wachs TD, Meeks Gardner J, et al. Child development: risk factors for adverse outcomes in developing countries. Lancet. 2007;369(9556):145-57.
29. WHO. Guideline: use of multiple micronutrient powders for home fortification of foods consumed by infants and children 6-23 months of age. 2011. http://apps.who.int/iris/handle/10665/44651. Accessed 4 May 2016.
30. De-Regil LM, Suchdev PS, Vist GE, Walleser S, Peña-Rosas JP. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age (review). Evid-Based Child Health Cochrane Rev J. 2013;8(1):112-201.
31. Andrew A, Attanasio O, Fitzsimons E, Rubio-Codina M. Why is multiple micronutrient powder ineffective at reducing anaemia among 12-24 month olds in Colombia? Evidence from a randomised controlled trial. SSM-Popul Health. 2016;2:95-104.
32. Attanasio OP, Fernández C, Fitzsimons EOA, Grantham-McGregor SM, Meghir C, Rubio-Codina M. Using the infrastructure of a conditional cash transfer program to deliver a scalable integrated early child development program in Colombia: cluster randomized controlled trial. BMJ. 2014;349:g5785.
33. General office of the National Health and Family Planning Commission and General office of All-China Women's Federation. Circular on the implementation of early child nutrition improvement project in poor rural China. 2014. http://www.moh.gov.cn/fys/s3585/201411/254523446f9241a3a3553e19dec77421.shtml. Accessed 29 May 2016.
34. Gertler P, Heckman J, Pinto R, et al. Labor market returns to an early childhood stimulation intervention in Jamaica. Science. 2014;344(6187):998-1001.
35. Heckman JJ, Moon SH, Pinto R, et al. The rate of return to the HighScope Perry preschool program. J Public Econ. 2010;94(1):114-28.
36. Walker SP, Chang SM, Vera-Hernandez M, Grantham-McGregor S. Early childhood stimulation benefits adult competence and reduces violent behavior. Pediatrics. 2011;127(5):849-57.
37. Ministry of Health and Standardization Administration of the People's Republic of China. General standard for complementary food supplement (GB-T 22570-2008). 2008.
38. Bayley N. The Bayley scales of infant development: the mental scale. New York: Psychological Corporation; 1974.
39. Yi S, Luo X, Yang Z, et al. The revising of Bayley scales of infant development (BSID) in China [in Chinese]. Chin J Clin Psychol. 1993;1:71-5.
40. Huang H, Tao SD, Zhang YW, et al. Standardization of Bayley scales of infant development in shanghai. Chin J Child Health. 1993;1:158-60.
41. Li Q, Yan H, Zeng L, et al. Effects of maternal micronutrient supplementation on the mental development of infants in rural western China: follow-up evaluation of a double-blind, randomized, controlled trial. Pediatrics. 2009;123:e685.
42. Rubio-Codina M, Araujo MC, Attanasio O, et al. Concurrent validity and feasibility of short tests currently used to measure early childhood development in large scale studies. PLoS One. 2016;11(8):e0160962. https://doi.org/10.1371/journal.pone.0160962
43. Chang S, Zeng L, Brouwer ID, et al. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013;131:e755-63.
44. Wu W, Sheng D, Shao J, et al. Mental and motor development and psychosocial adjustment of Chinese children with phenylketonuria. J Paediatr Child Health. 2011;47:441-7.
45. Bayley N. Bayley scales of infant development. New York: Psychological Corporation; 1969.
46. Ermis B, Demirel F, Demircan N, Gurel A. Effect of three different iron supplementations in term health infants after 5 months of life. J Trop Pediatr. 2002;48(5):280-4.
47. Berger J, Ninh NX, Khan NC, et al. Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants. Eur J Clin Nutr. 2006;60(4):443-54.
48. Pasricha S, Hayes E, Kalumba K, Biggs B. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-analysis of randomised controlled trials. Lancet Glob Health. 2013;1(2):e77-86.
49. Luo R, Shi Y, Zhang L, et al. Nutrition and educational performance in rural China's elementary schools: results of a randomized control trial in Shaanxi Province. Econ Dev Cult Change. 2012;60(1):735-72.
50. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 2011. http://apps.who.int/iris/handle/10665/85839. Accessed 15 May 2016.
51. Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006;107(5):1747-50. https://doi.org/10.1182/blood-2005-07-3046.
52. Greenland S. An introduction to instrumental variables for epidemiologists. International of Journal Epidemiology. 2000;29:722-9.
53. Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet. 2013;382(9886):29-40.
54. Jack SJ, Ou K, Chea M, Chhin L, Devenish R, Dunbar M, et al. Effect of micronutrient sprinkles on reducing anemia: a cluster-randomized effectiveness trial. Arch Pediatr Adolesc Med. 2012;166:842-50.
55. Zlotkin S, Arthur P, Schauer C, Antwi KY, Yeung G, Piekarz A. Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. J Nutr. 2003;133(4):1075-80.
56. Adu-Afarwuah S, Lartey A, Brown KH. Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. Am J Clin Nutr. 2008;87(4):929-38.
57. Kounnavong S, Sunahara T, Mascie-Taylor CGN, et al. Effect of daily versus weekly home fortification with multiple micronutrient powder on haemoglobin concentration of young children in a rural area, Lao People 's Democratic Republic: a randomised trial. Nutr J. 2011;10:129.
58. Menon P, Rue lMT, Loechl CU, et al. Micronutrient Sprinkles reduce anemia among 9-to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti. J Nutr. 2007;137(4):1023-30.