Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain

BMC Biochemistry

Volumn 18, Issue 1, 2017, Pages

  Chavda, Burzin ^a   Ling, Jun ^a   Majernick, Thomas ^a   Planey, Sonia Lobo ^a  

^a Geisinger Health Geisinger Commonwealth School of Medicine   (United States)

Author keywords

APF; Biomarker; Biosensor; CKAP4; Cytoskeleton; Interstitial cystitis; Surface plasmon resonance (SPR)

Indexed keywords

ANTIPROLIFERATIVE FACTOR; CELL RECEPTOR; CYTOSKELETON ASSOCIATED PROTEIN 4; GLYCOPEPTIDE; UNCLASSIFIED DRUG; ANTIPROLIFERATIVE FACTOR APF, HUMAN; CKAP4 PROTEIN, HUMAN; GLYCOPROTEIN; MEMBRANE PROTEIN; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; EXTRACELLULAR DOMAIN; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; SURFACE PLASMON RESONANCE; T24 CELL LINE; TRANSMEMBRANE DOMAIN; URINE; AMINO ACID SEQUENCE; CHEMISTRY; ENZYME SPECIFICITY; EXTRACELLULAR SPACE; GENE DELETION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; TUMOR CELL LINE;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE, TUMOR; EXTRACELLULAR SPACE; GLYCOPROTEINS; HUMANS; KINETICS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN DOMAINS; SEQUENCE DELETION; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE;

EID: 85029288103     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/s12858-017-0088-y     Document Type: Article

References (28)

1. Keay S, Kleinberg M, Zhang CO, Hise MK, Warren JW. Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production. J Urol. 2000;164(6):2112-8.
2. Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ Jr, Zhang CO, Koch KR, Michejda CJ. An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci U S A. 2004;101(32):11803-8.
3. Conrads TP, Tocci GM, Hood BL, Zhang CO, Guo L, Koch KR, Michejda CJ, Veenstra TD, Keay SK. Ckap4/p63 Is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. J Biol Chem. 2006;281(49):37836-43.
4. Schweizer A, Ericsson M, Bachi T, Griffiths G, Hauri HP. Characterization of a novel 63 kda membrane protein. Implications for the organization of the er-to-golgi pathway. J Cell Sci. 1993;104(Pt 3):671-83.
5. Schweizer A, Rohrer J, Hauri HP, Kornfeld S. Retention of p63 in an er-golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers. J Cell Biol. 1994;126(1):25-39.
6. Klopfenstein DR, Kappeler F, Hauri HP. A novel direct interaction of endoplasmic reticulum with microtubules. EMBO J. 1998;17(21):6168-77.
7. Vedrenne C, Hauri HP. Morphogenesis of the endoplasmic reticulum: beyond active membrane expansion. Traffic. 2006;7(6):639-46.
8. Vedrenne C, Klopfenstein DR, Hauri HP. Phosphorylation controls climp-63-mediated anchoring of the endoplasmic reticulum to microtubules. Mol Biol Cell. 2005;16(4):1928-37.
9. Planey SL, Zacharias DA. Palmitoyl acyltransferases, their substrates, and novel assays to connect them (review). Mol Membr Biol. 2009;26(1):14-31.
10. Shahjee HM, Koch KR, Guo L, Zhang CO, Keay SK. Antiproliferative factor decreases akt phosphorylation and alters gene expression via ckap4 in t24 bladder carcinoma cells. J Exp Clin Cancer Res. 2010;29:160.
11. Matika CA, Wasilewski M, Arnott JA, Planey SL. Antiproliferative factor regulates connective tissue growth factor (ctgf/ccn2) expression in t24 bladder carcinoma cells. Mol Biol Cell. 2012;23(10):1976-85.
12. Razzaq TM, Bass R, Vines DJ, Werner F, Whawell SA, Ellis V. Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-ii transmembrane protein p63 (ckap4). J Biol Chem. 2003;278(43):42679-85.
13. Gupta N, Manevich Y, Kazi AS, Tao JQ, Fisher AB, Bates SR. Identification and characterization of p63 (ckap4/ergic-63/climp-63), a surfactant protein a binding protein, on type ii pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291(3):L436-46.
14. Bates SR, Kazi AS, Tao JQ, Yu KJ, Gonder DS, Feinstein SI, Fisher AB. Role of p63 (ckap4) in binding of surfactant protein-a to type ii pneumocytes. Am J Physiol Lung Cell Mol Physiol. 2008;295(4):L658-69.
15. Kimura H, Fumoto K, Shojima K, Nojima S, Osugi Y, Tomihara H, Eguchi H, Shintani Y, Endo H, Inoue M, Doki Y, et al. Ckap4 Is a dickkopf1 receptor and is involved in tumor progression. J Clin Invest. 2016;126(7):2689-705.
16. Kikuchi A, Fumoto K, Kimura H. The dickkopf1-ckap4 axis creates a novel signaling pathway and may represent a molecular target for cancer therapy. Br J Pharmacol. 2017
17. Planey SL, Keay SK, Zhang CO, Zacharias DA. Palmitoylation of cytoskeleton associated protein 4 by dhhc2 regulates antiproliferative factor-mediated signaling. Mol Biol Cell. 2009;20(5):1454-63.
18. Zhang J, Planey SL, Ceballos C, Stevens SM Jr, Keay SK, Zacharias DA. Identification of ckap4/p63 as a major substrate of the palmitoyl acyltransferase dhhc2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics. 2008;7(7):1378-88.
19. Ling J, Liao H, Clark R, Wong MS, Lo DD. Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance. J Biol Chem. 2008;283(45):30585-95.
20. Haas J, Roth S, Arnold K, Kiefer F, Schmidt T, Bordoli L, Schwede T: The protein model portal - a comprehensive resource for protein structure and model information. Database (Oxford) 2013;2013:bat031.
21. Roy A, Kucukural A, Zhang Y. I-tasser: a unified platform for automated protein structure and function prediction. Nat Protoc. 2010;5(4):725-38.
22. Barchi JJ Jr, Kaczmarek P. Short and sweet: evolution of a small glycopeptide from a bladder disorder to an anticancer lead. Mol Interv. 2009;9(1):14-7.
23. Kaczmarek P, Tocci GM, Keay SK, Adams KM, Zhang CO, Koch KR, Grkovic D, Guo L, Michejda CJ, Barchi JJ Jr. Structure-activity studies on antiproliferative factor (apf) glycooctapeptide derivatives. ACS Med Chem Lett. 2010;1(8):390-4.
24. Mallajosyula SS, Adams KM, Barchi JJ, MacKerell AD. Conformational determinants of the activity of antiproliferative factor glycopeptide. J Chem Inf Model. 2013;53(5):1127-37.
25. Kaczmarek P, Keay SK, Tocci GM, Koch KR, Zhang CO, Barchi JJ Jr, Grkovic D, Guo L, Michejda CJ. Structure-activity relationship studies for the peptide portion of the bladder epithelial cell antiproliferative factor from interstitial cystitis patients. J Med Chem. 2008;51(19):5974-83.
26. Keay S, Zhang CO, Hise MK, Hebel JR, Jacobs SC, Gordon D, Whitmore K, Bodison S, Gordon N, Warren JW. A diagnostic in vitro urine assay for interstitial cystitis. Urology. 1998;52(6):974-8.
27. Keay S, Zhang CO, Marvel R, Chai T. Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor: sensitive and specific urine markers for interstitial cystitis. Urology. 2001;57(6 Suppl 1):104.
28. Keay S, Zhang CO, Shoenfelt JL, Chai TC. Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis. Urology. 2003;61(6):1278-84.