Pediatric cryptosporidiosis: An evaluation of health care and societal costs in Peru, Bangladesh and Kenya

PLoS ONE

Volumn 12, Issue 8, 2017, Pages

  Rafferty, Ellen R ^a   Schurer, Janna M ^b   Arndt, Michael B ^b,c   Choy, Robert K M ^c   De Hostos, Eugenio L ^c   Shoultz, David ^c   Farag, Marwa ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c PATH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BANGLADESH; CAREGIVER; COHORT ANALYSIS; CRYPTOSPORIDIOSIS; DIAGNOSTIC PROCEDURE; ECONOMIC ASPECT; ECONOMIC EVALUATION; ENVIRONMENTAL SANITATION; FOOD SAFETY; GOVERNMENT; HEALTH CARE COST; HEALTH CARE QUALITY; HELP SEEKING BEHAVIOR; HOSPITAL COST; HUMAN; INCIDENCE; KENYA; LIVESTOCK; MORTALITY RATE; PEDIATRICS; PEER REVIEW; PERU; POPULATION SIZE; PROPHYLAXIS; TRAVEL; INFANT;

BANGLADESH; CRYPTOSPORIDIOSIS; HUMANS; INFANT; KENYA; PERU;

EID: 85029229708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0182820     Document Type: Article

References (49)

1. Carr R. Excreta-related infections and the role of sanitation in the control of transmission. In: Fewtrell L, Bartram J, editors. Water Quality: Guidelines, Standards and Health. London, UK: IWA Publishing; 2001. (World Health Organization). http://www.who.int/water_sanitation_health/dwq/iwachap5.pdf
2. Kotloff K, Nataro J, Blackwelder W, Nasrin D, Farag T, Panchalingam S, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet. 2013; 382:209–22. https://doi.org/10.1016/S0140-6736(13)60844-2 PMID: 23680352
3. Platts-Mills J, Babji S, Badhidatta L, Gratz J, Haque R, Havt A, et al. Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED). Lancet. 2015; 3: e564–75. https://doi.org/10.1016/S2214-109X(15)00151-5 PMID: 26202075
4. Centers for Disease Control and Prevention. Parasites - Cryptosporidium. 2015. http://www.cdc.gov/parasites/crypto/
5. Molbak K, Andersen M, Aaby P, Hojlyng N, Jakobsen M, Sodemann M, et al. Cryptosporidium infection in infancy as a cause of malnutrition: a community study from Guinea-Bissau, West Africa. Am J Clin Nutr. 1997; 65:149–52. PMID: 8988927
6. Checkley W, Epstein L, Gilman R, Black R, Cabrera L, Sterling C. Effects of Cryptosporidium parvum infection in Peruvian children: Growth faltering and subsequent catch-up growth. Am J Epidemiol. 1998; 148:497–506. PMID: 9737562
7. Guerrant D, Moore S, Lima A, Patrick P, Schorling J, Guerrant R. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and conitive function four-seven years later in a poor urban community in northeast Brazil. Am J Trop Med Hyg. 1999; 61:707–13. PMID: 10586898
8. Berkman D, Lescano A, Gilman R, Lopez S, Black M. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet. 2002; 359:564–71. https://doi.org/10.1016/S0140-6736(02)07744-9 PMID: 11867110
9. Bartelt L, Lima A, Kosek M, Penataro Yori P, Lee G, Guerrant R. “Barriers” to child development and human potential: the case for including the “Neglected Enteric Protozoa” (NEP) and other enteropathy-associated pathogens in the NTDs. PLOS Negl Trop Dis. 2013; 7:e2125. https://doi.org/10.1371/journal.pntd.0002125 PMID: 23593514
10. Korpe P, Haque R, Gilchrist C, Valencia C, Niu F, Lu M, et al. Natural history of cryptosporidiosis in a longitudinal study of slum-dwelling Bangladeshi children: Association with severe malnutition. PLOS Negl Trop Dis. 2016; 10:e0004564. https://doi.org/10.1371/journal.pntd.0004564 PMID: 27144404
11. Centers for Disease Control and Prevention. Nitazoxanide. 2015. http://www.cdc.gov/parasites/crypto/nitazoxanide.html
12. Amadi B, Mwiya M, Musuku J, Watuka A, Sianongo S, Ayoub A, et al. Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: A randomized controlled trial. Lancet. 2002; 360:1375–80. https://doi.org/10.1016/S0140-6736(02)11401-2 PMID: 12423984
13. Checkley W, White A Jr, Jaganath D, Arrowood M, Chlamers R, Chen X-M, et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium. Lancet Infect Dis. 2015; 15:85–94. https://doi.org/10.1016/S1473-3099(14)70772-8 PMID: 25278220
14. Robertson L. Cryptosporidium as a foodborne pathogen. New York, USA: Springer; 2014. 90 p.
15. Shoultz D, de Hostos E, Choy R. Addressing Cryptosporidium infection among young children in low-income settings: The crucial role of new and existing drugs for reducing morbidity and mortality. PLoS Negl Trop Dis. 2016; 10:e0004242. https://doi.org/10.1371/journal.pntd.0004242 PMID: 26820408
16. Corso P, Kramer M, Blair K, Addiss D, Davis J, Haddix A. Cost of illness in the 1993 waterborne Cryptospordium outbreak, Milwaukee, Wisconsin. Emerg Infect Dis. 2003; 9:426–31. https://doi.org/10.3201/eid0904.020417 PMID: 12702221
17. Collier S, Stockman L, Hicks L, Garrison L, Zhou F, Beach M. Direct healthcare costs of selected diseases primarily or partially transmitted by water. Epidemiology and Infection. 2012; 140:2003–13. https://doi.org/10.1017/S0950268811002858 PMID: 22233584
18. Clark A, Walker D, Rocio Mosquiera N, Penny M, Lanata C, Fox-Rushby J, et al. Cost-effectiveness of rotavirus vaccination in Peru. J Infect Dis. 2009; 200:S114–24. https://doi.org/10.1086/605043 PMID: 19817591
19. Tate J, Rheingans R, O’Reilly C, Obonyo B, Burton D, Tornheim J, et al. Rotavirus disease burden and impact and cost-effectiveness of a rotavirus vaccination program in Kenya. J Infect Dis. 2009; 200:S76–84. https://doi.org/10.1086/605058 PMID: 19817618
20. Tan-Torres Edejer T, Baltussen R, Adam T, Hutubessy R, Acharya A, Evans D, et al., editors. WHO guide to cost-effectiveness analysis. 2003. http://www.who.int/choice/publications/p_2003_generalised_cea.pdf
21. The World Bank. World Bank Open Data. 2016. http://data.worldbank.org
22. United Nations Statistics Division. Population by age, sex and urban/rural residence. UNdata: A world of information. 2016. http://data.un.org/Data.aspx?d=POP&f=tableCode%3A22
23. Omore R, O’Reilly C, Williamson J, Moke F, Were V, Farag T, et al. Health care-seeking behavior during childhood diarrheal illness: Results of Health Care Utilization and Attitudes Surveys of caretakers in Western Kenya, 2007–2010. Am J Trop Med Hyg. 2013; 89:29–40. https://doi.org/10.4269/ajtmh.12-0755 PMID: 23629929
24. Olson C, Blum L, Patel K, Oria P, Feikin D, Laserson K, et al. Community case management of childhood diarrhea in a setting with declining use of oral rehydration therapy: Findings from cross-sectional studies among primary household caregivers, Kenya, 2007. Am J Trop Med Hyg. 2011; 85:1134–40. https://doi.org/10.4269/ajtmh.2011.11-0178 PMID: 22144458
25. Zwisler G, Simpson E, Moodley M. Treatment of diarrhea in young children: results from surveys on the perception and use of oral rehydration solutions, antibiotics, and other therapies in India and Kenya. J Glob Health. 2013; 3.
26. Institute for Health Metrics and Evaluation (IHME). Health service provision in Kenya: Assessing facility capacity, costs of care, and patient perspectives. Seattle, WA: IHME; 2014 p. 78.
27. Marete I, Simba J, Gisore P, Tenge C, Bosire D, Mwangi A, et al. Nutritional status of children admitted for diarrhoeal diseases in a referral hospital in western Kenya. East Afr Med J. 2013; 90:222–5. PMID: 26862620
28. Barasa E, Ayieko P, Cleary S, English M. Out-of-pocket costs of paediatric admissions in district hospitals in Kenya. Trop Med Int Health. 2012; 17:958–61. https://doi.org/10.1111/j.1365-3156.2012.03029.x PMID: 22716184
29. Andalon M, Pages C. Minimum wages in Kenya. Bonn, Germany: Institute for the Study of Labor (IZA); 2008. p. 42. Report No.: 3390. ftp://ftp.iza.org/RePEc/Discussionpaper/dp3390.pdf
30. Institute for Health Metrics and Evaluation (IHME). GBD Compare Data Visualization. Seattle, WA: IHME, University of Washington; 2016. http://vizhub.healthdata.org/gbd-compare
31. Kenya National Bureau of Statistics. Economic Survey 2015. Nairobi, Kenya; 2015. p. 339. www.knbs.or.ke
32. Grantham-McGregor S, Cheung Y, Cueto S, Glewwe P, Richter L, Strupp B, et al. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007; 369:60–70. https://doi.org/10.1016/S0140-6736(07)60032-4 PMID: 17208643
33. Moench-Pfanner R, Silo S, Laillou A, Wieringa F, Hong R, Hong R, et al. The economic burden of malnutrition in pregnant women and children under 5 years of age in Cambodia. Nutrients. 2016; 8:292.
34. Das S, Nasrin D, Ahmed S, Wu Y, Ferdous F, Farzana F, et al. Health care-seeking behavior for childhood diarrhea in Mirzapur, rural Bangladesh. Am J Trop Med Hyg. 2013; 89:62–8. https://doi.org/10.4269/ajtmh.13-0107 PMID: 23629937
35. Chowdhury F, Khan I, Patel S, Siddiq A, Saha N, Cravioto A, et al. Diarrheal illness and healthcare seeking behavior among a population at high risk for diarrhea in Dhaka, Bangladesh. PLOS One. 2015; 10:e0130105. https://doi.org/10.1371/journal.pone.0130105 PMID: 26121650
36. Rheingans R, Kukla M, Faruque A, Sur D, Zaidi A, Nasrin D, et al. Determinants of household costs associated with childhood diarrhea in 3 South Asian settings. Clin Infect Dis. 2012; 55:S327–335. https://doi.org/10.1093/cid/cis764 PMID: 23169945
37. Bhuiyan M, Luby S, Alamgir N, Homaira N, Mamun A, Khan J, et al. Economic burden of influenza-associated hospitalizations and outpatient visits in Bangladesh during 2010. Influenza Other Respir Viruses. 2014; 8:406–13. https://doi.org/10.1111/irv.12254 PMID: 24750586
38. Trading Economics. 2017. http://www.tradingeconomics.com/
39. Volpicelli K, Buttenheim A. Do social factors predict appropriate treatment of child diarrheal disease in Peru? Matern Child Health J. 2016; 20:2299–308. https://doi.org/10.1007/s10995-016-2049-2 PMID: 27449783
40. Winkler J, Bingham A, Coffey P, Penn Handwerker W. Women’s participation in a cervical cancer screening program in northern Peru. Health Educ Res. 2008; 23:10–24. https://doi.org/10.1093/her/cyl156 PMID: 17229778
41. Vera J. La carga económica de la enfermedad diarreica aguda en niños menores de tres años en localidades de la sierra y selva del Perú. Rev Fac Cien Econ Univ Nac Mayor de San Marcos. 2005; 10:71–84.
42. Liu L, Johnson H, Cousens S, Perin J, Scott S, Lawn J, et al. Global, regional, and national causes of child mortality: An updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012; 379:2151–61. https://doi.org/10.1016/S0140-6736(12)60560-1 PMID: 22579125
43. Rheingans R, Kukla M, Adegbola R, Saha D, Omore R, Breiman R, et al. Exploring household economic impacts of childhood diarrhea illnesses in 3 African settings. Clin Infect Dis. 2012; 55:S317–326. https://doi.org/10.1093/cid/cis763 PMID: 23169944
44. Sow S, Muhsen K, Nasrin D, Blackwelder W, Wu Y, Farag T, et al. The burden of Cryptosporidium diarrheal disease among children <24 months of age in moderate/high mortality regions of Sub-Saharan Aftrica and South Asia, utilizing data from the Global Enteric Multicenter Study (GEMS). PLOS Negl Trop Dis. 2016; 10:e0004729. https://doi.org/10.1371/journal.pntd.0004729 PMID: 27219054
45. Mbae C, Mulinge E, Ngugi B, Wainaina J, Kariuki S. Genetic diversity of Cryptosporidium in children in an urban informal settlement of Nairobi, Kenya. PLOS One. 2015; 10:e0142055. https://doi.org/10.1371/journal.pone.0142055 PMID: 26691531
46. Cama V, Bern C, Roberts J, Cabrera L, Sterling C, Ortega Y, et al. Cryptosporidium species and subtypes and clinical manifestations in children, Peru. Emerg Infect Dis. 2008; 14:1567–74. https://doi.org/10.3201/eid1410.071273 PMID: 18826821
47. Instituto Nacional de Estadística e Informática - INEI/Perú. Perú Encuesta Demográfica y de Salud Familiar - ENDES 2012. Lima, Peru: INEI-Peru; 2013. p. 529. https://dhsprogram.com/pubs/pdf/FR284/FR284.pdf
48. National Institute of Population Research and Training (NIPORT), Mitra and Associates, and ICF International. Bangladesh Demographic and Health Survey 2014. Dhaka, Bangladesh and Rockville, USA: NIPORT, Mitra and associates, and ICF International; 2016 p. 354.
49. Blum L, Oria P, Olson C, Breiman R, Ram P. Examining the use of Oral Rehydration Salts and other Oral Rehydration Therapy for childhood diarrhea in Kenya. Am J Trop Med Hyg. 2011; 85:1126–33. https://doi.org/10.4269/ajtmh.2011.11-0171 PMID: 22144457