Survival and cardiovascular outcomes of patients with secondary mitral regurgitation: A systematic review and meta-analysis

JAMA Cardiology

Volumn 2, Issue 10, 2017, Pages 1130-1139

  Sannino, Anna ^a,b   Smith, Robert L ^c   Schiattarella, Gabriele G ^b,d   Trimarco, Bruno ^b   Esposito, Giovanni ^b   Grayburn, Paul A ^a  

^a BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c THE HEART HOSPITAL BAYLOR PLANO   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE OUTCOME; ALL CAUSE MORTALITY; ARTICLE; CARDIOMYOPATHY; CARDIOVASCULAR MORTALITY; CLINICAL OUTCOME; CORRELATION ANALYSIS; DISEASE SEVERITY; HEART FAILURE; HEART GRAFT; HEART LEFT VENTRICLE FAILURE; HIGH RISK PATIENT; HOSPITALIZATION; HUMAN; IDIOPATHIC CARDIOMYOPATHY; IDIOPATHIC DISEASE; INCIDENCE; ISCHEMIC CARDIOMYOPATHY; META ANALYSIS; MITRAL VALVE REGURGITATION; MORTALITY RATE; MORTALITY RISK; OUTCOME ASSESSMENT; PRIMARY MITRAL REGURGITATION; PRIORITY JOURNAL; PROGNOSIS; QUALITATIVE ANALYSIS; REFERENCE VALUE; RISK ASSESSMENT; SECONDARY MITRAL REGURGITATION; SURVIVAL; SYSTEMATIC REVIEW; CAUSE OF DEATH; COMPLICATION; CONGESTIVE CARDIOMYOPATHY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; MORTALITY; STATISTICS AND NUMERICAL DATA;

CARDIOMYOPATHY, DILATED; CAUSE OF DEATH; HOSPITALIZATION; HUMANS; INCIDENCE; MITRAL VALVE INSUFFICIENCY; MYOCARDIAL ISCHEMIA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 85028914915     PISSN: 23806583     EISSN: 23806591     Source Type: Journal    
DOI: 10.1001/jamacardio.2017.2976     Document Type: Article

References (67)

1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005-1011.
2. Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001;103(13):1759-1764.
3. Pellizzon GG, Grines CL, Cox DA, et al. Importance of mitral regurgitation in patients undergoing percutaneous coronary intervention for acute myocardial infarction: the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. J Am Coll Cardiol. 2004;43(8):1368-1374.
4. Ellis SG, Whitlow PL, Raymond RE, Schneider JP. Impact of mitral regurgitation on long-term survival after percutaneous coronary intervention. Am J Cardiol. 2002;89(3):315-318.
5. Lamas GA, Mitchell GF, Flaker GC, et al; Survival and Ventricular Enlargement Investigators. Clinical significance of mitral regurgitation after acute myocardial infarction. Circulation. 1997;96(3): 827-833.
6. Deja MA, Grayburn PA, Sun B, et al. Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure trial. Circulation. 2012;125(21):2639-2648.
7. Calafiore AM, Mazzei V, Iacò AL, et al. Impact of ischemic mitral regurgitation on long-term outcome of patients with ejection fraction above 0.30 undergoing first isolated myocardial revascularization. Ann Thorac Surg. 2008;86(2): 458-464.
8. Aronson D, Goldsher N, Zukermann R, et al. Ischemic mitral regurgitation and risk of heart failure after myocardial infarction. Arch Intern Med. 2006;166(21):2362-2368.
9. Mallidi HR, Pelletier MP, Lamb J, et al. Late outcomes in patients with uncorrected mild to moderate mitral regurgitation at the time of isolated coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2004;127(3):636-644.
10. Bursi F, Enriquez-Sarano M, Nkomo VT, et al. Heart failure and death after myocardial infarction in the community: the emerging role of mitral regurgitation. Circulation. 2005;111(3):295-301.
11. Hillis GS, Møller JE, Pellikka PA, Bell MR, Casaclang-Verzosa GC, Oh JK. Prognostic significance of echocardiographically defined mitral regurgitation early after acute myocardial infarction. Am Heart J. 2005;150(6):1268-1275.
12. Grayburn PA, Appleton CP, DeMaria AN, et al; BEST Trial Echocardiographic Substudy Investigators. Echocardiographic predictors of morbidity and mortality in patients with advanced heart failure: the Beta-blocker Evaluation of Survival Trial (BEST). J Am Coll Cardiol. 2005;45(7): 1064-1071.
13. Cioffi G, Tarantini L, De Feo S, et al. Functional mitral regurgitation predicts 1-year mortality in elderly patients with systolic chronic heart failure. Eur J Heart Fail. 2005;7(7):1112-1117.
14. Rossi A, Dini FL, Faggiano P, et al. Independent prognostic value of functional mitral regurgitation in patients with heart failure: a quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart. 2011;97(20): 1675-1680.
15. Patel JB, Borgeson DD, Barnes ME, Rihal CS, Daly RC, Redfield MM. Mitral regurgitation in patients with advanced systolic heart failure. J Card Fail. 2004;10(4):285-291.
16. Boriani G, Gasparini M, Landolina M, et al; InSync/InSync ICD Italian Registry Investigators. Impact of mitral regurgitation on the outcome of patients treated with CRT-D: data from the InSync ICD Italian Registry. Pacing Clin Electrophysiol. 2012; 35(2):146-154.
17. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
18. Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs /clinical_epidemiology/oxford.asp. Published 2009. Accessed July 26, 2017.
19. Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med. 2004;23(11):1663-1682.
20. Patsopoulos NA, Evangelou E, Ioannidis JP. Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol. 2008;37(5): 1148-1157.
21. Gargiulo G, Sannino A, Capodanno D, et al. Transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and meta-analysis. Ann Intern Med. 2016; 165(5):334-344.
22. Sannino A, Schiattarella GG, Toscano E, et al. Meta-analysis of effect of body mass index on outcomes after transcatheter aortic valve implantation. Am J Cardiol. 2017;119(2): 308-316.
23. Sannino A, Gargiulo G, Schiattarella GG, et al. A meta-analysis of the impact of pre-existing and new-onset atrial fibrillation on clinical outcomes in patients undergoing transcatheter aortic valve implantation. EuroIntervention. 2016;12(8): e1047-e1056.
24. Abate E, Hoogslag GE, Al Amri I, et al. Time course, predictors, and prognostic implications of significant mitral regurgitation after ST-segment elevation myocardial infarction. Am Heart J. 2016; 178:115-125.
25. Agricola E, Ielasi A, Oppizzi M, et al. Long-term prognosis of medically treated patients with functional mitral regurgitation and left ventricular dysfunction. Eur J Heart Fail. 2009;11(6):581-587.
26. Agricola E, Stella S, Figini F, et al. Non-ischemic dilated cardiopathy: prognostic value of functional mitral regurgitation. Int J Cardiol. 2011;146(3): 426-428.
27. Barra S, Providência R, Paiva L, et al. Mitral regurgitation during a myocardial infarction: new predictors and prognostic significance at two years of follow-up. Acute Card Care. 2012;14(1):27-33.
28. Bruch C, Klem I, Breithardt G, Wichter T, Gradaus R. Diagnostic usefulness and prognostic implications of the mitral E/E′ ratio in patients with heart failure and severe secondary mitral regurgitation. Am J Cardiol. 2007;100(5):860-865.
29. Bursi F, Barbieri A, Grigioni F, et al. Prognostic implications of functional mitral regurgitation according to the severity of the underlying chronic heart failure: a long-term outcome study. Eur J Heart Fail. 2010;12(4):382-388.
30. Engström AE, Vis MM, Bouma BJ, et al. Mitral regurgitation is an independent predictor of 1-year mortality in ST-elevation myocardial infarction patients presenting in cardiogenic shock on admission. Acute Card Care. 2010;12(2):51-57.
31. Faris R, Coats AJ, Henein MY. Echocardiography-derived variables predict outcome in patients with nonischemic dilated cardiomyopathy with or without a restrictive filling pattern. Am Heart J. 2002;144(2):343-350.
32. Fattouch K, Sampognaro R, Speziale G, et al. Impact of moderate ischemic mitral regurgitation after isolated coronary artery bypass grafting. Ann Thorac Surg. 2010;90(4):1187-1194.
33. Feinberg MS, Schwammenthal E, Shlizerman L, et al. Prognostic significance of mild mitral regurgitation by color Doppler echocardiography in acute myocardial infarction. Am J Cardiol. 2000; 86(9):903-907.
34. García-Cosío Carmena MD, Roig Minguell E, Ferrero-Gregori A, Vázquez García R, Delgado Jiménez J, Cinca J; investigators of the REDINSCOR research network. Prognostic implications of functional mitral regurgitation in patients with heart failure and reduced ejection fraction [published online January 23, 2017]. Rev Esp Cardiol (Engl Ed). 2017;S1885-5857(16)30456-X. doi:10 .1016/j.rec.2016.12.033
35. Grigioni F, Detaint D, Avierinos JF, Scott C, Tajik J, Enriquez-Sarano M. Contribution of ischemic mitral regurgitation to congestive heart failure after myocardial infarction. J Am Coll Cardiol. 2005;45 (2):260-267.
36. Hickey MS, Smith LR, Muhlbaier LH, et al. Current prognosis of ischemic mitral regurgitation: implications for future management. Circulation. 1988;78(3, pt 2):I51-I59.
37. Kajimoto K, Takano T. Role of functional mitral regurgitation in heart failure with preserved ejection fraction: an unrecognized protagonist?: reply. Eur J Heart Fail. 2017;19(2):291.
38. Karatolios K, Holzendorf V, Richter A, Schieffer B, Pankuweit S; Competence Network Heart Failure Germany. Long-term outcome and predictors of outcome in patients with non-ischemic dilated cardiomyopathy. Int J Cardiol. 2016;220: 608-612.
39. Koelling TM, Aaronson KD, Cody RJ, Bach DS, Armstrong WF. Prognostic significance of mitral regurgitation and tricuspid regurgitation in patients with left ventricular systolic dysfunction. Am Heart J. 2002;144(3):524-529.
40. Lancellotti P, Gérard PL, Piérard LA. Long-term outcome of patients with heart failure and dynamic functional mitral regurgitation. Eur Heart J. 2005; 26(15):1528-1532.
41. Lehmann KG, Francis CK, Dodge HT; TIMI Study Group. Mitral regurgitation in early myocardial infarction: incidence, clinical detection, and prognostic implications. Ann Intern Med. 1992;117 (1):10-17.
42. López-Pérez M, Estévez-Loureiro R, López-Sainz A, et al. Long-term prognostic value of mitral regurgitation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. Am J Cardiol. 2014;113(6):907-912.
43. MacHaalany J, Bertrand OF, O’Connor K, et al. Predictors and prognosis of early ischemic mitral regurgitation in the era of primary percutaneous coronary revascularisation. Cardiovasc Ultrasound. 2014;12:14.
44. Mentias A, Raza MQ, Barakat AF, et al. Prognostic significance of ischemic mitral regurgitation on outcomes in acute ST-elevation myocardial infarction managed by primary percutaneous coronary intervention. Am J Cardiol. 2017;119(1):20-26.
45. Naser N, Dzubur A, Kusljugic Z, et al. Echocardiographic assessment of ischaemic mitral regurgitation, mechanism, severity, impact on treatment strategy and long term outcome. Acta Inform Med. 2016;24(3):172-177.
46. Nesković AN, Marinković J, Bojić M, Popović AD. Early mitral regurgitation after acute myocardial infarction does not contribute to subsequent left ventricular remodeling. Clin Cardiol. 1999;22(2):91-94.
47. Núñez-Gil IJ, Estrada I, Pérez de Isla L, et al. Functional mitral regurgitation after a first non–ST segment elevation acute coronary syndrome: very-long-term follow-up, prognosis and contribution to left ventricular enlargement and atrial fibrillation development. Heart. 2013;99(20): 1502-1508.
48. Pastorius CA, Henry TD, Harris KM. Long-term outcomes of patients with mitral regurgitation undergoing percutaneous coronary intervention. Am J Cardiol. 2007;100(8):1218-1223.
49. Pérez de Isla L, Zamorano J, Quezada M, et al. Functional mitral regurgitation after a first non–ST-segment elevation acute coronary syndrome: contribution to congestive heart failure. Eur Heart J. 2007;28(23):2866-2872.
50. Persson A, Hartford M, Herlitz J, Karlsson T, Omland T, Caidahl K. Long-term prognostic value of mitral regurgitation in acute coronary syndromes. Heart. 2010;96(22):1803-1808.
51. Rihal CS, Nishimura RA, Hatle LK, Bailey KR, Tajik AJ. Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy: relation to symptoms and prognosis. Circulation. 1994;90(6): 2772-2779.
52. Tcheng JE, Jackman JD Jr, Nelson CL, et al. Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction. Ann Intern Med. 1992;117(1):18-24.
53. Trichon BH, Felker GM, Shaw LK, Cabell CH, O’Connor CM. Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure. Am J Cardiol. 2003;91(5):538-543.
54. Uddin AM, Henry TD, Hodges JS, Haq Z, Pedersen WR, Harris KM. The prognostic role of mitral regurgitation after primary percutaneous coronary intervention for acute ST-elevation myocardial infarction. Catheter Cardiovasc Interv. 2012;80(5):779-786.
55. Upadhyay GA, Chatterjee NA, Kandala J, et al. Assessing mitral regurgitation in the prediction of clinical outcome after cardiac resynchronization therapy. Heart Rhythm. 2015;12(6):1201-1208.
56. Kaneko H, Suzuki S, Uejima T, et al. Prevalence and the long-term prognosis of functional mitral regurgitation in Japanese patients with symptomatic heart failure. Heart Vessels. 2014;29 (6):801-807.
57. Kwon DH, Kusunose K, Obuchowski NA, et al. Predictors and prognostic impact of progressive ischemic mitral regurgitation in patients with advanced ischemic cardiomyopathy: a multimodality study. Circ Cardiovasc Imaging. 2016;9(7):pii:e004577.
58. Di Mauro M, Di Giammarco G, Vitolla G, et al. Impact of no-to-moderate mitral regurgitation on late results after isolated coronary artery bypass grafting in patients with ischemic cardiomyopathy. Ann Thorac Surg. 2006;81(6):2128-2134.
59. Okura H, Takada Y, Kubo T, et al. Functional mitral regurgitation predicts prognosis independent of left ventricular systolic and diastolic indices in patients with ischemic heart disease. J Am Soc Echocardiogr. 2008;21(4):355-360.
60. Stolfo D, Tonet E, Barbati G, et al. Acute hemodynamic response to cardiac resynchronization in dilated cardiomyopathy: effect on late mitral regurgitation. Pacing Clin Electrophysiol. 2015;38(11):1287-1296.
61. Verhaert D, Popović ZB, De S, et al. Impact of mitral regurgitation on reverse remodeling and outcome in patients undergoing cardiac resynchronization therapy. Circ Cardiovasc Imaging. 2012;5(1):21-26.
62. Yalonetsky S, Eden H, Lessick J, et al. Impact of functional mitral regurgitation on right ventricular function and outcome in patients with right ventricular infarction. Am J Cardiol. 2014;114(1): 36-41.
63. Acker MA, Parides MK, Perrault LP, et al; CTSN. Mitral-valve repair versus replacement for severe ischemic mitral regurgitation. N Engl J Med. 2014; 370(1):23-32.
64. Zoghbi WA, Adams D, Bonow RO, et al. Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2017;30(4):303-371.
65. clinicaltrials.gov. Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) (COAPT). NCT01626079. https://clinicaltrials.gov/ct2/show/NCT01626079. Accessed July 24, 2017.
66. Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC focused update of the 2014 AHA/ACC guidelines for the management of patients with valvular heart disease. J Am Coll Cardiol. 2017;70(2): 252-289.
67. Grayburn PA, Carabello B, Hung J, et al. Defining “severe” secondary mitral regurgitation: emphasizing an integrated approach. J Am Coll Cardiol. 2014;64(25):2792-2801.