Quantification of global mitochondrial DNA methylation levels and inverse correlation with age at two CpG sites

Aging

Volumn 8, Issue 4, 2016, Pages 636-641

  Mawlood, Shakhawan K ^a   Dennany, Lynn ^a   Watson, Nigel ^a   Dempster, John ^a   Pickard, Benjamin S ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Age prediction; Ageing; Epigenetics; Illumina NGS; Mitochondrial DNA

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; AGE; AGED; AGING; CPG ISLAND; DNA METHYLATION; FEMALE; GENETICS; HUMAN; MALE; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CPG ISLANDS; DNA METHYLATION; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 85028749198     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100892     Document Type: Article

References (30)

1. Yi SH, Xu LC, Mei K, Yang RZ, Huang DX. Isolation and identification of age-related DNA methylation markers for forensic age-prediction. Forensic Science International: Genetics. 2014; 11:117-125
2. Burgess DJ. Human epigenetics: Showing your age. Nature Reviews Genetics. 2012; 14:6
3. Bocklandt S, Lin W, Sehl M, Sánchez F, Sinsheimer J. Epigenetic Predictor of Age. PLoS ONE. 2011; 6:e14821
4. Koch CM, Wagner W. Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY). 2011; 3:1018-10127
5. Weidner CI, Lin Q, Koch CM, Eisele L, Beier F, Ziegler P, et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biology. 2014; 15:R24
6. Manev H, Dzitoyeva S, Chen H. Mitochondrial DNA: a blind spot in neuroepigenetics. Biomolecular concepts. 2012; 3:107-115
7. Hong EE, Okitsu CY, Smith AD, Hsieh C-L. Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA. Molecular and cellular biology. 2013; 33:2683-90
8. Maekawa M, Taniguchi T, Higashi H, Sugimura H, Sugano K, Kanno T. Methylation of mitochondrial DNA is not a useful marker for cancer detection. Clinical chemistry. 2004; 50:1480-1481
9. Stewart SA, Weinberg RA. Senescence: does it all happen at the ends? Oncogene. 2002; 21:627-630
10. Stewart SA, Weinberg RA. Telomeres: cancer to human aging. Annu Rev Cell Dev Biol. 2006; 22:531-557
11. Shock LS, Thakkar PV, Peterson EJ, Moran RG, Taylor SM. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proceedings of the National Academy of Sciences. 2011; 108:3630-3635
12. Chinnery PF, Elliott HR, Hudson G, Samuels DC, Relton CL. Epigenetics, epidemiology and mitochondrial DNA diseases. International journal of epidemiology. 2012; 41:177-187
13. Iacobazzi V, Castegna A, Infantino V, Andria G. Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Molecular Genetics and Metabolism. 2013; 110:25-34
14. Bellizzi D, D'Aquila P, Scafone T, Giordano M, Riso V, Riccio A, et al. The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern. DNA Research. 2013; dst029
15. Byun H-M, Panni T, Motta V, Hou L, Nordio F, Apostoli P, et al. Effects of airborne pollutants on mitochondrial DNA methylation. Part Fibre Toxicol. 2013; 10:18
16. O'Sullivan M, Rutland P, Lucas D, Ashton E, Hendricks S, Rahman S, et al. Mitochondrial m. 1584A 12S m62A rRNA methylation in families with m. 1555A> G associated hearing loss. Human molecular genetics. 2014; ddu518
17. Metodiev MD, Lesko N, Park CB, Cámara Y, Shi Y, Wibom R, et al. Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. Cell metabolism. 2009; 9:386-397
18. Rebelo AP, Williams SL, Moraes CT. In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions. Nucleic acids research. 2009; gkp727
19. Feng S, Xiong L, Ji Z, Cheng W, Yang H. Correlation between increased ND2 expression and demethylated displacement loop of mtDNA in colorectal cancer. Molecular medicine reports. 2012; 6:125-130
20. Pirola CJ, Gianotti TF, Burgueño AL, Rey-Funes M, Loidl CF, Mallardi P, et al. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut. 2012; gutjnl-2012-302962
21. Komaki H, Akanuma J, Iwata H, Takahashi T, Mashima Y, Nonaka I, et al. A novel mtDNA C11777A mutation in Leigh syndrome. Mitochondrion. 2003; 2:293-304
22. Harding A, Holt I, Sweeney M, Brockington M, Davis M. Prenatal diagnosis of mitochondrial DNA8993 T-G disease. American journal of human genetics. 1992; 50:629
23. Holt I, Harding A, Petty R, Morgan-Hughes J. A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. American journal of human genetics. 1990; 46:428
24. Butler JM. Forensic DNA typing biology, technology, and genetics of STR markers. Amsterdam; Boston: Elsevier Academic Press. 2005
25. RESEARCH Z. EZ DNA Methylation-Direct™ Kit. Zymo Research. 2014
26. Ghosh S, Sengupta S, Scaria V. Comparative analysis of human mitochondrial methylomes shows distinct patterns of epigenetic regulation in mitochondria. Mitochondrion. 2014; 18:58-62
27. Xu C, Qu H, Wang G, Xie B, Shi Y, Yang Y, et al. A novel strategy for forensic age prediction by DNA methylation and support vector regression model. Scientific reports. 2014; 5:17788
28. Giordano M, Cristiani C, Crocco P, D'Aquila P, De Rango F, Pisani F, et al. Methylation of the human mitochondrial 12S rRNA gene is correlated with aging. 12th International FISV Congress, Rome, Italy. 2012; 9.5
29. Park J-L, Kwon O-H, Kim JH, Yoo H-S, Lee H-C, Woo K-M, et al. Identification of body fluid-specific DNA methylation markers for use in forensic science. Forensic Science International: Genetics. 2014; 13:147-53
30. Antunes JP, Madi T, Balamurugan K, Bombardi R, Duncan G, McCord B. DNA methylation markers as a powerful technique to discriminate body fluids present in crime scenes. Proceedings of the 24th International Symposium on Human Identification. 2014