Mindfulness mediates the physiological markers of stress: Systematic review and meta-analysis

Journal of Psychiatric Research

Volumn 95, Issue , 2017, Pages 156-178

  Pascoe, Michaela C ^a   Thompson, David R ^c,d   Jenkins, Zoe M ^b   Ski, Chantal F ^b,c  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Anxiety; Depression; Inflammation; Meditation; Mood; Stress

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; HYDROCORTISONE; INTERLEUKIN 6; NORADRENALIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; CYTOKINE;

ARTICLE; ATTENTION; BLOOD PRESSURE; FOCUSED ATTENTION; GLUCOSE BLOOD LEVEL; HEART RATE; HEART RATE VARIABILITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MEDITATION; META ANALYSIS; MINDFULNESS; NORADRENALIN BLOOD LEVEL; OPEN MONITORING; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SELF TRANSCENDENCE; SYSTEMATIC REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; THERAPY;

BLOOD PRESSURE; CYTOKINES; HEART RATE; HUMANS; HYDROCORTISONE; MEDITATION; MINDFULNESS; STRESS, PSYCHOLOGICAL;

EID: 85028456068     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2017.08.004     Document Type: Article

References (84)

1. Andresen, J., Meditation meets behavioural medicine: the story of experimental research on meditation. J. Conscious. Stud. 7:11–12 (2000), 17–73.
2. Azam, M.A., Katz, J., Mohabir, V., Ritvo, P., Individuals with tension and migraine headaches exhibit increased heart rate variability during post-stress mindfulness meditation practice but a decrease during a post-stress control condition - a randomized, controlled experiment. Int. J. Psychophysiol. 110 (2016), 66–74.
3. Barnes, V.A., Davis, H.C., Murzynowski, J.B., Treiber, F.A., Impact of meditation on resting and ambulatory blood pressure and heart rate in youth. Psychosom. Med. 66:6 (2004), 909–914.
4. Barnes, V.A., Pendergrast, R.A., Harshfield, G.A., Treiber, F.A., Impact of breathing awareness meditation on ambulatory blood pressure and sodium handling in prehypertensive African American adolescents. Ethn. Dis. 18:1 (2008), 1–5.
5. Barnes, V.A., Treiber, F.A., Davis, H., Impact of Transcendental Meditation on cardiovascular function at rest and during acute stress in adolescents with high normal blood pressure. J. Psychosom. Res. 51:4 (2001), 597–605.
6. Barnes, V.A., Treiber, F.A., Johnson, M.H., Impact of transcendental meditation on ambulatory blood pressure in African-American adolescents. Am. J. Hypertens. 17:4 (2004), 366–369.
7. Bertisch, S.M., Wee, C.C., Phillips, R.S., McCarthy, E.P., Alternative mind-body therapies used by adults with medical conditions. J. Psychosom. Res. 66:6 (2009), 511–519.
8. Black, D.S., Cole, S.W., Irwin, M.R., Breen, E., St Cyr, N.M., Nazarian, N., Khalsa, D.S., Lavretsky, H., Yogic meditation reverses NF-kappaB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology 38:3 (2013), 348–355.
9. Borenstein, M., Hedges, L.V., Higgins, J.P.T., Rothstein, H.R., Introduction to Meta-analysis. 2009, Wiley, Chichester.
10. Cahn, B.R., Polich, J., Meditation states and traits: EEG, ERP, and neuroimaging studies. Psychol. Bull. 132:2 (2006), 180–211.
11. Carissoli, C., Villani, D., Riva, G., Does a meditation protocol supported by a mobile application help people reduce stress? Suggestions from a controlled pragmatic trial. Cyberpsychol. Behav. Soc. Netw. 18:1 (2015), 46–53.
12. Carlson, L.E., Beattie, T.L., Giese-Davis, J., Faris, P., Tamagawa, R., Fick, L.J., Degelman, E.S., Speca, M., Mindfulness-based cancer recovery and supportive-expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors. Cancer 121:3 (2015), 476–484.
13. Carlson, L.E., Doll, R., Stephen, J., Faris, P., Tamagawa, R., Drysdale, E., Speca, M., Randomized controlled trial of Mindfulness-based cancer recovery versus supportive expressive group therapy for distressed survivors of breast cancer. J. Clin. Oncol. Offic. J. Am. Soc. Clin. Oncol. 31:25 (2013), 3119–3126.
14. Chacko, S.A., Yeh, G.Y., Davis, R.B., Wee, C.C., A mindfulness-based intervention to control weight after bariatric surgery: preliminary results from a randomized controlled pilot trial. Compl. Ther. Med. 28 (2016), 13–21.
15. Chambers, R., Gullone, E., Allen, N.B., Mindful emotion regulation: an integrative review. Clin. Psychol. Rev. 29:6 (2009), 560–572.
16. Chhatre, S., Metzger, D.S., Frank, I., Boyer, J., Thompson, E., Nidich, S., Montaner, L.J., Jayadevappa, R., Effects of behavioral stress reduction Transcendental Meditation intervention in persons with HIV. AIDS Care 25:10 (2013), 1291–1297.
17. Chiesa, A., Malinowski, P., Mindfulness-based approaches: are they all the same?. J. Clin. Psychol. 67:4 (2011), 404–424.
18. Chopra Centre, What is primordial sound meditation?. http://www.chopra.com/articles/what-is-primordial-sound-meditation#sm.001kfymhr145ddzfv8y211twkeurp, 2017 accessed date 10 July 2017 2017.
19. Cochrane Collaboration, Higgins, J., Green, S., (eds.) Cochrane Handbook for Systematic Reviews of Interventions, 2011.
20. Cohen, D.L., Boudhar, S., Bowler, A., Townsend, R.R., Blood pressure effects of yoga, alone or in combination with lifestyle measures: results of the lifestyle modification and blood pressure study (LIMBS). J. Clin. Hypertens. (Greenwich) 18:8 (2016), 809–816.
21. Creswell, J.D., Taren, A.A., Lindsay, E.K., Greco, C.M., Gianaros, P.J., Fairgrieve, A., Marsland, A.L., Brown, K.W., Way, B.M., Rosen, R.K., Ferris, J.L., Alterations in resting-state functional connectivity link mindfulness meditation with reduced Interleukin-6: a randomized controlled trial. Biol. Psychiatr. 80:1 (2016), 53–61.
22. Curiati, J.A., Bocchi, E., Freire, J.O., Arantes, A.C., Braga, M., Garcia, Y., Guimaraes, G., Fo, W.J., Meditation reduces sympathetic activation and improves the quality of life in elderly patients with optimally treated heart failure: a prospective randomized study. J. Altern. Complement. Med. 11:3 (2005), 465–472.
23. Dantzer, R., Depression and inflammation: an intricate relationship. Biol. Psychiatr. 71:1 (2012), 4–5.
24. Daubenmier, J., Moran, P.J., Kristeller, J., Acree, M., Bacchetti, P., Kemeny, M.E., Dallman, M., Lustig, R.H., Grunfeld, C., Nixon, D.F., Milush, J.M., Goldman, V., Laraia, B., Laugero, K.D., Woodhouse, L., Epel, E.S., Hecht, F.M., Effects of a mindfulness-based weight loss intervention in adults with obesity: a randomized clinical trial. Obes. (Silver Spring) 24:4 (2016), 794–804.
25. Epel, E.S., Puterman, E., Lin, J., Blackburn, E.H., Lum, P.Y., Beckmann, N.D., Zhu, J., Lee, E., Gilbert, A., Rissman, R.A., Tanzi, R.E., Schadt, E.E., Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl. Psychiatry, 6(8), 2016, e880.
26. Fan, Y., Tang, Y.Y., Ma, Y., Posner, M.I., Mucosal immunity modulated by integrative meditation in a dose-dependent fashion. J. Altern. Complement. Med. 16:2 (2010), 151–155.
27. Fan, Y., Tang, Y.Y., Posner, M.I., Cortisol level modulated by integrative meditation in a dose-dependent fashion. Stress Health 30:1 (2014), 65–70.
28. Feingold, K.R., Grunfeld, C., De Groot, L.J., Chrousos, G., Dungan, K., Feingold, K.R., Grossman, A., Hershman, J.M., Koch, C., Korbonits, M., McLachlan, R., New, M., Purnell, J., Rebar, R., Singer, F., Vinik, A., (eds.) The Effect of Inflammation and Infection on Lipids and Lipoproteins, 2000, Endotext, South Dartmouth (MA).
29. Franco, A., Malhotra, N., Simonovits, G., Social science. Publication bias in the social sciences: unlocking the file drawer. Science 345:6203 (2014), 1502–1505.
30. Gainey, A., Himathongkam, T., Tanaka, H., Suksom, D., Effects of Buddhist walking meditation on glycemic control and vascular function in patients with type 2 diabetes. Compl. Ther. Med. 26 (2016), 92–97.
31. Garland, E.L., Froeliger, B., Howard, M.O., Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology 231:16 (2014), 3229–3238.
32. Goldberg, S.B., Manley, A.R., Smith, S.S., Greeson, J.M., Russell, E., Van Uum, S., Koren, G., Davis, J.M., Hair cortisol as a biomarker of stress in mindfulness training for smokers. J. Altern. Complement. Med. 20:8 (2014), 630–634.
33. Grant, C., Hobkirk, A., Persons, E., Hwang, V., Danoff-Burg, S., Cardiovascular reactivity to and recovery from stressful tasks following a mindfulness analog in college students with a family history of hypertension. J. Altern. Complement. Med. 19:4 (2013), 341–346.
34. Gregoski, M.J., Barnes, V.A., Tingen, M.S., Harshfield, G.A., Treiber, F.A., Breathing awareness meditation and LifeSkills Training programs influence upon ambulatory blood pressure and sodium excretion among African American adolescents. J. Adolesc. Health 48:1 (2011), 59–64.
35. Grossman, P., Deuring, G., Walach, H., Schwarzer, B., Schmidt, S., Mindfulness-based intervention does not influence cardiac autonomic control or pattern of physical activity in Fibromyalgia during daily life: an ambulatory, multi-measure randomized controlled trial. Clin. J. Pain 33:5 (2016), 385–394.
36. Harinath, K., Malhotra, A.S., Pal, K., Prasad, R., Kumar, R., Kain, T.C., Rai, L., Sawhney, R.C., Effects of Hatha yoga and Omkar meditation on cardiorespiratory performance, psychologic profile, and melatonin secretion. J. Altern. Complement. Med. 10:2 (2004), 261–268.
37. Hayney, M.S., Coe, C.L., Muller, D., Obasi, C.N., Backonja, U., Ewers, T., Barrett, B., Age and psychological influences on immune responses to trivalent inactivated influenza vaccine in the meditation or exercise for preventing acute respiratory infection (MEPARI) trial. Hum. Vaccin. Immunother. 10:1 (2014), 83–91.
38. Helal, I., Zerelli, L., Krid, M., ElYounsi, F., Ben Maiz, H., Zouari, B., Adelmoula, J., Kheder, A., Comparison of C-reactive protein and high-sensitivity C-reactive protein levels in patients on hemodialysis. Saudi J. kidney Dis. Transplant. Offic. Publ. Saudi Cent. Organ Transplant. Saudi Arab. 23:3 (2012), 477–483.
39. Hsiao, F.-H., Jow, G.-M., Kuo, W.-H., Yang, P.-S., Lam, H.-B., Chang, K.-J., Lee, J.-J., Huang, C.-S., Lai, Y.-M., Chen, Y.-T., Liu, Y.-F., Chang, C.-H., The long-term effects of mindfulness added to family resilience-oriented couples support group on psychological well-being and cortisol responses in breast cancer survivors and their partners. Mindfulness 7:6 (2016), 1365–1376.
40. Iwata, M., Ota, K.T., Duman, R.S., The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav. Immun. 31 (2013), 105–114.
41. Jayadevappa, R., Johnson, J.C., Bloom, B.S., Nidich, S., Desai, S., Chhatre, S., Raziano, D.B., Schneider, R., Effectiveness of transcendental meditation on functional capacity and quality of life of African Americans with congestive heart failure: a randomized control study. Ethn. Dis. 17:1 (2007), 72–77.
42. Jedel, S., Hoffman, A., Merriman, P., Swanson, B., Voigt, R., Rajan, K.B., Shaikh, M., Li, H., Keshavarzian, A., A randomized controlled trial of mindfulness-based stress reduction to prevent flare-up in patients with inactive ulcerative colitis. Digestion 89:2 (2014), 142–155.
43. Jensen, C.G., Vangkilde, S., Frokjaer, V., Hasselbalch, S.G., Mindfulness training affects attention–or is it attentional effort?. J. Exp. Psychol. Gen. 141:1 (2012), 106–123.
44. Jung, H.Y., Lee, H., Park, J., Comparison of the effects of Korean mindfulness-based stress reduction, walking, and patient education in diabetes mellitus. Nurs. Health Sci. 17:4 (2015), 516–525.
45. Kingston, J., Chadwick, P., Meron, D., Skinner, T.C., A pilot randomized control trial investigating the effect of mindfulness practice on pain tolerance, psychological well-being, and physiological activity. J. Psychosom. Res. 62:3 (2007), 297–300.
46. Lavretsky, H., Epel, E.S., Siddarth, P., Nazarian, N., Cyr, N.S., Khalsa, D.S., Lin, J., Blackburn, E., Irwin, M.R., A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity. Int. J. Geriatr. Psychiatr. 28:1 (2013), 57–65.
47. Lipschitz, D.L., Kuhn, R., Kinney, A.Y., Donaldson, G.W., Nakamura, Y., Reduction in salivary alpha-amylase levels following a mind-body intervention in cancer survivors–an exploratory study. Psychoneuroendocrinology 38:9 (2013), 1521–1531.
48. Lipschitz, D.L., Kuhn, R., Kinney, A.Y., Grewen, K., Donaldson, G.W., Nakamura, Y., An exploratory study of the effects of mind-body interventions targeting sleep on salivary oxytocin levels in cancer survivors. Integr. Cancer Ther. 14:4 (2015), 366–380.
49. Lutz, A., Slagter, H.A., Dunne, J.D., Davidson, R.J., Attention regulation and monitoring in meditation. Trends Cogn. Sci. 12:4 (2008), 163–169.
50. MacLean, C.R.K., Walton, K.G., Wenneberg, S.R., Levitsky, D.K., Mandarino, J.P., Waziri, R., Hillis, S.L., Schneider, R.H., Effects of the transcendental meditation program on adaptive mechanisms: changes in hormone levels and responses to stress after 4 months of practice. Psychoneuroendocrinology 22:4 (1997), 277–295.
51. Macleod, M.R., Lawson McLean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-Fonseca, C., Potluru, A., Thomson, A., Baginskaite, J., Egan, K., Vesterinen, H., Currie, G.L., Churilov, L., Howells, D.W., Sena, E.S., Risk of bias in reports of in vivo research: a focus for improvement. PLoS Biol., 13(10), 2015, e1002273.
52. Masi, G., Brovedani, P., The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS Drugs 25:11 (2011), 913–931.
53. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Group, P., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int. J. Surg. 8:5 (2010), 336–341.
54. Nesse, R.M., Bhatnagar, S., Ellis, B., Evolutionary Origins and Functions of the Stress Response System, Stress: Concepts, Cognition, Emotion, and Behavior Handbook of Stress Series. 2016, Academic Press, 95–101.
55. Oken, B.S., Fonareva, I., Haas, M., Wahbeh, H., Lane, J.B., Zajdel, D., Amen, A., Pilot controlled trial of mindfulness meditation and education for dementia caregivers. J. Altern. Complement. Med. 16:10 (2010), 1031–1038.
56. Ospina, M.B., Bond, K., Karkhaneh, M., Tjosvold, L., Vandermeer, B., Liang, Y., Bialy, L., Hooton, N., Buscemi, N., Dryden, D.M., Klassen, T.P., Meditation practices for health: state of the research. Evid. Rep. Technol. Assess.(155), 2007, 1–263.
57. Palta, P., Page, G., Piferi, R.L., Gill, J.M., Hayat, M.J., Connolly, A.B., Szanton, S.L., Evaluation of a mindfulness-based intervention program to decrease blood pressure in low-income African-American older adults. J. Urban Health 89:2 (2012), 308–316.
58. Parswani, M.J., Sharma, M.P., Iyengar, S., Mindfulness-based stress reduction program in coronary heart disease: a randomized control trial. Int. J. Yoga 6:2 (2013), 111–117.
59. Pascoe, M., Crewther, S., A Systematic Review of Randomised Control Trials Examining the Effects of Mindfulness on Stress and Anxious Symptomatology, Anxiety Disorders. 2016, SMGroup.
60. Pascoe, M.C., Crewther, S.G., Carey, L.M., Crewther, D.P., Inflammation and depression: why poststroke depression may be the norm and not the exception. Int. J. Stroke 6:2 (2011), 128–135.
61. Patel, C., North, W.R., Randomised controlled trial of yoga and bio-feedback in management of hypertension. Lancet 2:7925 (1975), 93–95.
62. Paul-Labrador, M., Polk, D., Dwyer, J.H., Velasquez, I., Nidich, S., Rainforth, M., Schneider, R., Merz, C.N., Effects of a randomized controlled trial of transcendental meditation on components of the metabolic syndrome in subjects with coronary heart disease. Arch. Intern Med. 166:11 (2006), 1218–1224.
63. Prakhinkit, S., Suppapitiporn, S., Tanaka, H., Suksom, D., Effects of Buddhism walking meditation on depression, functional fitness, and endothelium-dependent vasodilation in depressed elderly. J. Altern. Complement. Med. 20:5 (2014), 411–416.
64. Raffone, A., Srinivasan, N., An adaptive workspace hypothesis about the neural correlates of consciousness: insights from neuroscience and meditation studies. Prog. Brain Res. 176 (2009), 161–180.
65. Raffone, A., Srinivasan, N., The exploration of meditation in the neuroscience of attention and consciousness. Cogn. Process 11:1 (2010), 1–7.
66. Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function. Proc. Natl. Acad. Sci. U. S. A. 98:2 (2001), 676–682.
67. Raichle, M.E., Snyder, A.Z., A default mode of brain function: a brief history of an evolving idea. NeuroImage 37:4 (2007), 1083–1090 discussion 1097–1089.
68. Rifai, N., Ballantyne, C.M., Cushman, M., Levy, D., Myers, G.L., Point: high-sensitivity C-reactive protein and cardiac C-reactive protein assays: is there a need to differentiate?. Clin. Chem. 52:7 (2006), 1254–1256.
69. Schonert-Reichl, K.A., Oberle, E., Lawlor, M.S., Abbott, D., Thomson, K., Oberlander, T.F., Diamond, A., Enhancing cognitive and social-emotional development through a simple-to-administer mindfulness-based school program for elementary school children: a randomized controlled trial. Dev. Psychol. 51:1 (2015), 52–66.
70. Simkin, D.R., Black, N.B., Meditation and mindfulness in clinical practice. Child. Adolesc. Psychiatr. Clin. N. Am. 23:3 (2014), 487–534.
71. Srinivasan, N., Baijal, S., Concentrative meditation enhances preattentive processing: a mismatch negativity study. Neuroreport 18:16 (2007), 1709–1712.
72. Steffen, P.R., Larson, M.J., A brief mindfulness exercise reduces cardiovascular reactivity during a laboratory stressor paradigm. Mindfulness 6:4 (2015), 803–811.
73. Tall, A.R., Yvan-Charvet, L., Cholesterol, inflammation and innate immunity. Nat. Rev. Immunol. 15:2 (2015), 104–116.
74. Tang, Y.Y., Holzel, B.K., Posner, M.I., The neuroscience of mindfulness meditation. Nat. Rev. Neurosci. 16:4 (2015), 213–225.
75. Tomasino, B., Chiesa, A., Fabbro, F., Disentangling the neural mechanisms involved in Hinduism- and Buddhism-related meditations. Brain Cogn. 90 (2014), 32–40.
76. Tomasino, B., Fregona, S., Skrap, M., Fabbro, F., Meditation-related activations are modulated by the practices needed to obtain it and by the expertise: an ALE meta-analysis study. Front. Hum. Neurosci., 6, 2012, 346.
77. Travis, F., Parim, N., Default mode network activation and transcendental meditation practice: focused attention or automatic self-transcending?. Brain Cogn. 111 (2017), 86–94.
78. Travis, F., Shear, J., Focused attention, open monitoring and automatic self-transcending: categories to organize meditations from Vedic, Buddhist and Chinese traditions. Conscious. Cognit. 19:4 (2010), 1110–1118.
79. Vandana, B., Vaidyanathan, K., Saraswathy, L.A., Sundaram, K.R., Kumar, H., Impact of integrated amrita meditation technique on adrenaline and cortisol levels in healthy volunteers. Evid Based Compl. Alt., 2011, 1–6.
80. Ventriglio, A., Gentile, A., Baldessarini, R.J., Bellomo, A., Early-life stress and psychiatric disorders: epidemiology, neurobiology and innovative pharmacological targets. Curr. Pharm. Des. 21:11 (2015), 1379–1387.
81. Wahbeh, H., Goodrich, E., Goy, E., Oken, B.S., Mechanistic pathways of mindfulness meditation in combat veterans with posttraumatic stress disorder. J. Clin. Psychol. 72:4 (2016), 365–383.
82. Wang, D.J., Rao, H., Korczykowski, M., Wintering, N., Pluta, J., Khalsa, D.S., Newberg, A.B., Cerebral blood flow changes associated with different meditation practices and perceived depth of meditation. Psychiatry Res. 191:1 (2011), 60–67.
83. Wenneberg, S.R., Schneider, R.H., Walton, K.G., Maclean, C.R., Levitsky, D.K., Salerno, J.W., Wallace, R.K., Mandarino, J.V., Rainforth, M.V., Waziri, R., A controlled study of the effects of the Transcendental Meditation program on cardiovascular reactivity and ambulatory blood pressure. Int. J. Neurosci. 89:1–2 (1997), 15–28.
84. Xue, C.C., Zhang, A.L., Lin, V., Da Costa, C., Story, D.F., Complementary and alternative medicine use in Australia: a national population-based survey. J. Altern. Complement. Med. 13:6 (2007), 643–650.