-
1
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F.S., O'Day, S.J., McDermott, D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:8 (2010), 711–723.
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
2
-
-
84862882003
-
Tumor immunotherapy directed at PD-1
-
Ribas, A., Tumor immunotherapy directed at PD-1. N Engl J Med 366:26 (2012), 2517–2519.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2517-2519
-
-
Ribas, A.1
-
3
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S.L., Hodi, F.S., Brahmer, J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366:26 (2012), 2443–2454.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
4
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373:1 (2015), 23–34.
-
(2015)
N Engl J Med
, vol.373
, Issue.1
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
-
5
-
-
85029406475
-
Pembrolizumab-ipilimumab combo is highly active in advanced melanoma
-
Available at:
-
London, S., Pembrolizumab-ipilimumab combo is highly active in advanced melanoma. Dermatology News, 2016 Available at: http://www.mdedge.com/edermatologynews/article/110395/melanoma/pembrolizumab-ipilimumab-combo-highly-active-advanced.
-
(2016)
Dermatology News
-
-
London, S.1
-
6
-
-
85029412779
-
Pembrolizumab plus ipilimumab safe, effective for advanced melanoma
-
Available at:
-
Kelsall, C., Pembrolizumab plus ipilimumab safe, effective for advanced melanoma. Perspective, 2016 Available at: http://www.healio.com/hematology-oncology/melanoma-skin-cancer/news/online/%7Bcdd6fd97-0007-4195-aac2-127abb0729d6%7D/pembrolizumab-plus-ipilimumab-safe-effective-for-advanced-melanoma.
-
(2016)
Perspective
-
-
Kelsall, C.1
-
7
-
-
85029423261
-
Highlights of prescribing information: Opdivo
-
Highlights of prescribing information: Opdivo. US Food and Drug Administration, 2017, 61.
-
(2017)
US Food and Drug Administration
, pp. 61
-
-
-
8
-
-
85015755043
-
Pembrolizumab as second-line therapy for advanced urothelial carcinoma
-
Bellmunt, J., de Wit, R., Vaughn, D.J., et al. Pembrolizumab as second-line therapy for advanced urothelial carcinoma. N Engl J Med 376:11 (2017), 1015–1026.
-
(2017)
N Engl J Med
, vol.376
, Issue.11
, pp. 1015-1026
-
-
Bellmunt, J.1
de Wit, R.2
Vaughn, D.J.3
-
9
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer, R.J., Escudier, B., McDermott, D.F., et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 373:19 (2015), 1803–1813.
-
(2015)
N Engl J Med
, vol.373
, Issue.19
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
10
-
-
85029406747
-
Emerging role of combination immunotherapy regimens in metastatic renal cell carcinoma
-
McKay, R.R., Choueiri, T.K., Emerging role of combination immunotherapy regimens in metastatic renal cell carcinoma. ASCO Annual Meeting, 2016 https://am.asco.org/daily-news/emerging-role-combination-immunotherapy-regimens-metastatic-renal-cell-carcinoma.
-
(2016)
ASCO Annual Meeting
-
-
McKay, R.R.1
Choueiri, T.K.2
-
11
-
-
84994802263
-
Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer
-
Reck, M., Rodríguez-Abreu, D., Robinson, A.G., et al. Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer. N Engl J Med 375:19 (2016), 1823–1833.
-
(2016)
N Engl J Med
, vol.375
, Issue.19
, pp. 1823-1833
-
-
Reck, M.1
Rodríguez-Abreu, D.2
Robinson, A.G.3
-
12
-
-
85029429463
-
Appraisal consultation document: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
-
Appraisal consultation document: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer. Excellence NIFHAC, 2017, 1–29.
-
(2017)
Excellence NIFHAC
, pp. 1-29
-
-
-
13
-
-
27644487803
-
Randomized trials stopped early for benefit: a systematic review
-
Montori, V.M., Devereaux, P.J., Adhikari, N.K., et al. Randomized trials stopped early for benefit: a systematic review. JAMA 294:17 (2005), 2203–2209.
-
(2005)
JAMA
, vol.294
, Issue.17
, pp. 2203-2209
-
-
Montori, V.M.1
Devereaux, P.J.2
Adhikari, N.K.3
-
14
-
-
85029424510
-
Nivolumab misses PFS endpoint in frontline phase III NSCLC study
-
Available at:
-
Inman, S., Nivolumab misses PFS endpoint in frontline phase III NSCLC study. OncLive, 2016 Available at: http://www.onclive.com/web-exclusives/frontline-nivolumab-misses-pfs-endpoint-in-phase-iii-nsclc-study.
-
(2016)
OncLive
-
-
Inman, S.1
-
16
-
-
85024132052
-
Few people actually benefit from ‘breakthrough’ cancer immunotherapy
-
First Opinion. Available at:
-
Gay, N., Prasad, V., Few people actually benefit from ‘breakthrough’ cancer immunotherapy. STAT, 2017 First Opinion. Available at: https://www.statnews.com/2017/03/08/immunotherapy-cancer-breakthrough/.
-
(2017)
STAT
-
-
Gay, N.1
Prasad, V.2
-
17
-
-
84919725208
-
Unintended consequences of expensive cancer therapeutics—the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture
-
Fojo, T., Mailankody, S., Lo, A., Unintended consequences of expensive cancer therapeutics—the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture. JAMA Otolaryngol Head Neck Surg 140:12 (2014), 1225–1236.
-
(2014)
JAMA Otolaryngol Head Neck Surg
, vol.140
, Issue.12
, pp. 1225-1236
-
-
Fojo, T.1
Mailankody, S.2
Lo, A.3
-
18
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non–small-cell lung cancer
-
Brahmer, J., Reckamp, K.L., Baas, P., et al. Nivolumab versus docetaxel in advanced squamous-cell non–small-cell lung cancer. N Engl J Med 373:2 (2015), 123–135.
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
19
-
-
85029426018
-
Preliminary results from KEYNOTE-055: Pembrolizumab after platinum and cetuximab failure in head and neck squamous cell carcinoma (HNSCC) [Video]
-
Preliminary results from KEYNOTE-055: Pembrolizumab after platinum and cetuximab failure in head and neck squamous cell carcinoma (HNSCC) [Video]. ASCO University, 2016.
-
(2016)
ASCO University
-
-
-
20
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non–small-cell lung cancer
-
Borghaei, H., Paz-Ares, L., Horn, L., et al. Nivolumab versus docetaxel in advanced nonsquamous non–small-cell lung cancer. N Engl J Med 373:17 (2015), 1627–1639.
-
(2015)
N Engl J Med
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
21
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Herbst, RS., Baas, P., Kim, D-W, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387:10027 (2016), 1540–1550.
-
(2016)
Lancet
, vol.387
, Issue.10027
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.-W.3
-
22
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert, C., Schachter, J., Long, G.V., et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372:26 (2015), 2521–2532.
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
-
23
-
-
85010904121
-
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial
-
Sharma, P., Retz, M., Siefker-Radtke, A, et al. Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial. Lancet Oncol 18:3 (2017), 312–322.
-
(2017)
Lancet Oncol
, vol.18
, Issue.3
, pp. 312-322
-
-
Sharma, P.1
Retz, M.2
Siefker-Radtke, A.3
-
24
-
-
85029405731
-
With 20 agents, 803 trials, and 166,736 patient slots, is pharma investing too heavily in PD-1 drug development?
-
Brawley, L., With 20 agents, 803 trials, and 166,736 patient slots, is pharma investing too heavily in PD-1 drug development?. Cancer Lett, 42(37), 2016.
-
(2016)
Cancer Lett
, vol.42
, Issue.37
-
-
Brawley, L.1
-
25
-
-
85005959718
-
Advances in cancer immunotherapy in solid tumors
-
Menon, S., Shin, S., Dy, G., Advances in cancer immunotherapy in solid tumors. Cancers (Basel), 8(12), 2016.
-
(2016)
Cancers (Basel)
, vol.8
, Issue.12
-
-
Menon, S.1
Shin, S.2
Dy, G.3
-
26
-
-
85029431074
-
-
Drug Information. 2012. Available at:
-
Drug Information. 2012. Available at: http://apps.who.int/medicinedocs/documents/s19565en/s19565en.pdf.
-
-
-
-
27
-
-
85029439595
-
-
Assessment report: Opdivo. European Medicines Agency; April 23, 2015. Available at:
-
Assessment report: Opdivo. European Medicines Agency; April 23, 2015. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_Public_assessment_report/human/003985/WC500189767.pdf.
-
-
-
-
28
-
-
85029451858
-
-
Assessment Report: Keytruda. European Medicines Agency; May 21, 2015. Available at:
-
Assessment Report: Keytruda. European Medicines Agency; May 21, 2015. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR-Public_assessment_report/human/003820/WC500190992.pdf.
-
-
-
-
29
-
-
85029430530
-
Division Director Summary Review: Pembrolizumab
-
Available at:
-
Keegan, P., Division Director Summary Review: Pembrolizumab. Center for Drug Evaluation and Research, 2014 Available at: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/125514Orig1s000SumR.pdf.
-
(2014)
Center for Drug Evaluation and Research
-
-
Keegan, P.1
|